Uricase 40 Tablet belongs to a class of anti-gout medications, also known as xanthine oxidase inhibitors, widely used to prevent severe gout attacks or flares. Gout is a chronic condition that occurs due to the deposition of uric acid crystals in the joints. It is characterized by intense pain and swelling at the affected joints. Uricase 40 Tablet prevents the sudden attacks of pain caused by severe gout and decreases pain, swelling, and inflammation.

Uricase 40 Tablet contains febuxostat. It works by inhibiting the enzyme xanthine oxidase (an enzyme that helps your body make uric acid), thereby reducing the level of uric acid in your body. Thus, it reduces the inflammation caused by uric acid crystals in affected joints, thereby reducing pain, swelling and inflammation. Uricase 40 Tablet is used to prevent gout attacks or flares.

Your doctor will advise you on how often you take off the Uricase 40 Tablet based on your medical condition. The common side effects of Uricase 40 Tablet nausea, rash, dizziness, diarrhoea, pain, rash, inaccurate liver function test results, gout flare-ups (intense joint pain that comes on suddenly, often in the middle of the night), localized swelling due to retention of fluids in tissues (oedema). Most of these side effects of Uricase 40 Tablet do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

Do not stop taking a Uricase 40 Tablet of your own. Stopping it may worsen your condition and increase the risk of increased uric acid levels and future gout attacks. Inform your doctor if you have allergic to Uricase 40 Tablet or any other medicines, have a heart problem (Uricase 40 Tablet may cause heart problems that can lead to heart attack), or have kidney/liver disease. Some people experience more gout flare-ups when you start taking Uricase 40 Tablet . You should continue taking this drug even if gout flare-ups occur. Your doctor may give you combination therapy to prevent flare-ups when you start Uricase 40 Tablet . The safety and effectiveness of children under 18 years of age have not been established, so Uricase 40 Tablet should not be given to them. If you are pregnant or breastfeeding, it is advised to inform your doctor before using Uricase 40 Tablet .

Uricase 40 Tablet is a class of medications called xanthine oxidase (enzyme that helps your body to make the uric acid) inhibitors. It works by inhibiting the enzyme xanthine oxidase, thereby reducing the level of uric acid that is made in your body. Thus, it reduces the inflammation caused by uric acid crystals in affected joints, thereby reducing pain, swelling and inflammation. Uricase 40 Tablet is used to prevent gout attacks or flares.

• Nausea
• Rash
• Dizziness
• Diarrhoea
• Joint pain
• Rash,
• Inaccurate liver function test results
• Gout flare-ups (intense joint pain that comes on suddenly, often in the middle of the night)
• Localized swelling due to retention of fluids in tissues (oedema)

You should avoid taking Uricase 40 Tablet if you are allergic to Uricase 40 Tablet , or have heart-related problems, as it increases the risk of a heart attack. It should be used cautiously in patients with kidney problems and blood disorders. Caution is required before taking Uricase 40 Tablet if you are pregnant, planning to become pregnant, or already a breastfeeding mother. The safety and effectiveness of children under 18 years of age have not been established, so Uricase 40 Tablet should not be given to them.

Drug-Drug Interactions: Uricase 40 Tablet interacts with anticancer medications (mercaptopurine, methotrexate), immunosuppressant medications (azathioprine), antidiabetic medications (rosiglitazone), and antiasthma medications (theophylline).

Drug-Food Interactions: Intake of alcohol may increase the risk of side effects, so avoid taking alcohol with Uricase 40 Tablet . Limit the purine-rich diet.

Drug-Disease Interactions: Brief your doctor if you have a medical history of allergic reactions to medicines,  hyperuricemia (an abnormally high level of uric acid in the blood), heart diseases, liver or kidney diseases before taking Uricase 40 Tablet .

• MERCAPTOPURINE
• METHOTREXATE
• AZATHIOPRINE
• THEOPHYLLINE
• ROSIGLITAZONE

• Include more glucosamine, chondroitin sulfate, vitamin D, and calcium-enriched supplements. Besides this, turmeric and fish can help in reducing inflammation in the tissue.

• Please do not go for heavy exercise as it may increase your joint pain in arthritis. Instead, you can do low-impact aerobic movements like walking on a treadmill and swimming. You can also strengthen your muscles by lifting light weights.
• Your sitting posture is important, especially when you have pain and inflammation. Try to sit as little as possible and only for a short duration of time. Long-term immobility is harmful in conditions like arthritis. Use back support like a rolled-up towel to minimise pain at the back of your spine curve. Keep your knees and hips at a right angle. Besides this, you can also use a footrest if required.
• Avoid a high purine-rich diet, including organ meats (kidneys, liver, and sweetbreads) and oily fish (sardines, anchovies, and herring).
• Limit meat in favour of plant-based proteins like beans and legumes.
• Eat complex carbohydrates, such as whole-grain bread, fruits, and vegetables, rather than sugary sweets and refined carbohydrates like white bread.
• Avoid drinking beer and alcoholic beverages and drink plenty of water or other nonalcoholic beverages.

• Please consult your doctor and check your levels of uric acid two weeks after starting Uricase 40 Tablet . Your goal is a uric acid level in your blood that is less than 6 mg/dL.

Gout: Gout is a type of arthritis called 'gouty arthritis'. It is caused by a build-up of a naturally occurring chemical (uric acid) in your body (hyperuricemia). The excess uric acid deposit and crystallize in the joints leading to pain and inflammation. The general signs and symptoms of gout include sudden, severe attacks of pain, swelling, redness, and tenderness in the joints, mostly in the joint at the base of the big toe. Patients with gout may often experience acute attacks that result in sudden and severe pain, often waking you up in the middle of the night with the sensation that your big toe is on fire.