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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
TYROKININ 150MG TABLET is used to treat lung and pancreatic cancer. It contains Erlotinib which works by stopping the action of an abnormal protein that causes the multiplication of cancerous cells. In some cases, this medicine may cause side effects such as abdominal pain, bone pain, constipation, cough, diarrhoea, fatigue, fever, and infection. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.
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Composition :

ERLOTINIB-150MG

Manufacturer/Marketer :

Dr Reddy's Laboratories Ltd

Consume Type :

ORAL

Return Policy :

3 Days Returnable

Expires on or after :

Jan-27

About TYROKININ 150MG TABLET

TYROKININ 150MG TABLET belongs to the group of medicine called ‘anti-cancer’ primarily used for lung and pancreatic cancer treatment. Lung cancer is the uncontrolled growth of abnormal cells in one or both lungs. These abnormal cells do not carry out normal lung cell functions and do not develop into healthy lung tissue. In this disease, cells of the lung grow uncontrollably, and if not detected at an early stage may spread to other body parts, including the brain. Pancreatic cancer is an uncontrolled cancerous growth in the pancreas, usually in the cells that produce insulin.

TYROKININ 150MG TABLET contains 'Erlotinib' that belongs to the group of medicines known as 'kinase inhibitors'. It works by stopping the action of an abnormal protein that causes the multiplication of cancerous cells. In this way, it prevents the spread of cancerous cells.

Take TYROKININ 150MG TABLET as prescribed by your doctor. You are suggested to take TYROKININ 150MG TABLET as long as your doctor has prescribed it after checking your medical condition.  In some cases, you may experience certain common side-effects such as abdominal pain, bone pain, breathlessness, constipation, cough, diarrhea, edema (swelling), fatigue, fever, infection, muscle pain, nausea, rash, stomatitis (inflammation of the mouth), vomiting, weight loss abnormal blood tests for the liver function. Most of these side-effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side-effects persistently.

To treat your condition effectually, continue taking TYROKININ 150MG TABLET for as long as your doctor has prescribed. Do not take TYROKININ 150MG TABLET if you are pregnant or planning for pregnancy and breastfeeding as TYROKININ 150MG TABLET causes serious congenital disabilities. Older adults are more sensitive to medicine so that they may adjust the dosage according to the condition. While taking TYROKININ 150MG TABLET, you might become more sensitive to sunlight, so it is important to protect your skin with a high sun protection factor (SPF). Regular blood tests are required to monitor liver function and blood cells in the blood while taking TYROKININ 150MG TABLET. Avoid consuming alcohol along with TYROKININ 150MG TABLET as it could lead to increased dizziness.

Uses of TYROKININ 150MG TABLET

Treatment of Lung cancer, Pancreatic cancer.

Directions for Use

Swallow it as a whole with water; do not crush, break or chew it.

Medicinal Benefits

TYROKININ 150MG TABLET is prescribed to the patients dealing with nonsmall cell lung cancer and pancreatic cancer. Cancer of this type tends to spread quickly in other parts of the body. TYROKININ 150MG TABLET travel through the bloodstream and effectively destroy cancerous cells of the lung, pancreas, and other body parts. TYROKININ 150MG TABLET contains Erlotinib is a 'tyrosine kinase inhibitor (TKI)' that stops the uncontrolled growth and spread of cancerous cells. It acts by blocking the abnormal protein's action that is responsible for the multiplication of cancerous cells. Whenever a new healthy cell is formed, it undergoes a usual process of maturity. Cancerous cells form new cells more quickly, so TYROKININ 150MG TABLET targets cancerous cells and block the action of Tyrosine kinases enzymes (responsible for causing cancer). It also decreases the blood supply to cancer tumors to slow down the growth of the tumor. In this way, TYROKININ 150MG TABLET stops the production, spread, and growth of cancerous cells in the body. 

How TYROKININ 150MG TABLET Works

TYROKININ 150MG TABLET contains 'Erlotinib' that belongs to the group of medicines known as 'kinase inhibitors'. It works by stopping the action of an abnormal protein that causes the multiplication of cancerous cells. In this way, it prevents the spread of cancerous cells.

Storage

Store in a cool and dry place away from sunlight

Side Effects of TYROKININ 150MG TABLET

  • ​​​​Stomach pain
  • Bone pain
  • Breathlessness
  • Constipation
  • Cough
  • Diarrhea
  • Loss of appetite
  • Edema (swelling)
  • Fatigue
  • Fever
  • Infection
  • Muscle pain
  • Nausea
  • Rash
  • Changes in vision
  • Partial hair loss (by strands, not typically in clumps)
  • Stomatitis (Inflammation of the mouth)
  • Weight loss
  • Abnormal blood tests for the liver function

What if I have taken an overdose of TYROKININ 150MG TABLET

Take TYROKININ 150MG TABLET only as prescribed by the physician. Avoid exceeding the recommended dose as it could lead to an overdose. Symptoms of overdose may include diarrhoea and rash. If you experience these symptoms or suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

Do not take TYROKININ 150MG TABLET if you are allergic to TYROKININ 150MG TABLET or any of its ingredients. While taking TYROKININ 150MG TABLET, you might become more sensitive to sunlight, so it is important to protect your skin with a high sun protection factor (SPF) while going out as it can lead to a skin rash if you are not using a strong SPF. TYROKININ 150MG TABLET can cause leg swelling and water retention or fluid overload (edema), so if you have unexpected rapid weight gain, please consult your doctor. Do not take TYROKININ 150MG TABLET if you are pregnant or planning to get pregnant and breastfeeding as it could harm the unborn baby. Use effective birth control measures while taking this medication and for at least 1 month after your last dose. TYROKININ 150MG TABLET is not recommended for children and adolescents. You are advised to stop smoking while taking TYROKININ 150MG TABLET as smoking could decrease this medication's effect. TYROKININ 150MG TABLET may make you more susceptible to infections, consult your doctor if you develop any signs of infections, fever, sore throat, breathlessness, jaundice, unexplained bleeding, or bruising.  TYROKININ 150MG TABLET may cause blurry vision and dizziness, so do not drive or operate any machinery which requires concentration. Before undergoing any surgery, it is advised to tell the medical professional who performs the procedure about all the medicines you are taking. 

Drug-Drug Interactions

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ErlotinibOmeprazole
Critical
ErlotinibRabeprazole
Critical

Drug-Drug Interactions

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ErlotinibOmeprazole
Critical
How does the drug interact with TYROKININ 150MG TABLET 10S:
Omeprazole can make TYROKININ 150MG TABLET 10S less effective by reducing its absorption in the body. This can lead to low treatment outcomes.

How to manage the interaction:
Taking Omeprazole and TYROKININ 150MG TABLET 10S together is not recommended as it can result in an interaction; it should be taken only if a doctor has advised it. Do not stop using any medications without talking to a doctor.
ErlotinibRabeprazole
Critical
How does the drug interact with TYROKININ 150MG TABLET 10S:
When used in combination with TYROKININ 150MG TABLET 10S, Rabeprazole may prevent the absorption of TYROKININ 150MG TABLET 10S into the circulation, which might make TYROKININ 150MG TABLET 10S less effective in treating cancer.

How to manage the interaction:
Taking Rabeprazole with TYROKININ 150MG TABLET 10S is not recommended as it can result in an interaction, it should be taken only if a doctor has advised it. Do not stop using any medications without consulting a doctor.
ErlotinibRifabutin
Severe
How does the drug interact with TYROKININ 150MG TABLET 10S:
Taking Rifabutin and TYROKININ 150MG TABLET 10S may significantly reduce the blood levels of TYROKININ 150MG TABLET 10S.

How to manage the interaction:
Co-administration of TYROKININ 150MG TABLET 10S with Rifabutin can result in an interaction, but it can be taken if your doctor has advised it. If you experience any unusual symptoms, consult a doctor. Do not stop using any medications without a doctor's advice.
ErlotinibLeflunomide
Severe
How does the drug interact with TYROKININ 150MG TABLET 10S:
When TYROKININ 150MG TABLET 10S is taken with leflunomide, it increases the risk of causing liver problems.

How to manage the interaction:
Although there is a possible interaction between TYROKININ 150MG TABLET 10S and Leflunomide, you can take these medicines together if advised by your doctor. If you have any of these symptoms like fever, chills, joint pain, swelling, bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark colored urine, liver damage, or bleeding, it's important to contact your doctor right away. Do not discontinue any medications without first consulting your doctor.
ErlotinibAtorvastatin
Severe
How does the drug interact with TYROKININ 150MG TABLET 10S:
Coadministration of TYROKININ 150MG TABLET 10S with Atorvastatin can raise the chance of side effects (liver injury and rhabdomyolysis, an uncommon but serious illness that causes the breakdown of skeletal muscle tissue. Rhabdomyolysis occasionally results in kidney injury).

How to manage the interaction:
Taking TYROKININ 150MG TABLET 10S with Atorvastatin together can result in an interaction, it can be taken if a doctor has advised it. However, if you notice any unexplained muscle pain, muscle stiffness or tenderness, fever, dark-colored urine, or weakness, you should contact a doctor immediately. Do not stop using any medications without talking to a doctor.
ErlotinibPantoprazole
Severe
How does the drug interact with TYROKININ 150MG TABLET 10S:
Taking TYROKININ 150MG TABLET 10S with Pantoprazole may interfere with the absorption of TYROKININ 150MG TABLET 10S into the bloodstream, and reduce its effectiveness.

How to manage the interaction:
Taking Pantoprazole with TYROKININ 150MG TABLET 10S together can possibly result in an interaction, but it can be taken if a doctor has advised it. A doctor can recommend other options that won't cause any problems when taken together. Do not stop using any medications without a doctor's advice.
ErlotinibMitotane
Severe
How does the drug interact with TYROKININ 150MG TABLET 10S:
When TYROKININ 150MG TABLET 10S is taken with mitotane, it reduces the blood levels of TYROKININ 150MG TABLET 10S.This can lead to low treatment outcomes.

How to manage the interaction:
Co-administration of TYROKININ 150MG TABLET 10S with Mitotane can possibly result in an interaction, but it can be taken if your doctor has advised it. Do not stop using any medications without a doctor's advice.
ErlotinibKetoconazole
Severe
How does the drug interact with TYROKININ 150MG TABLET 10S:
TYROKININ 150MG TABLET 10S's effects and blood levels could both be enhanced by ketoconazole.

How to manage the interaction:
Although taking Ketoconazole and TYROKININ 150MG TABLET 10S together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, if you develop severe or ongoing diarrhea, nausea, vomiting, lack of appetite, skin rash, shortness of breath, cough, or fever, consult a doctor.
ErlotinibFosphenytoin
Severe
How does the drug interact with TYROKININ 150MG TABLET 10S:
When TYROKININ 150MG TABLET 10S is taken with Fosphenytoin, it can cause the body to process TYROKININ 150MG TABLET 10S faster. This reduces the levels and treatment outcomes.

How to manage the interaction:
There may be a possibility of interaction between TYROKININ 150MG TABLET 10S and Fosphenytoin, but it can be taken if prescribed by a doctor. Do not stop using any medications without first talking to your doctor.
ErlotinibCarbamazepine
Severe
How does the drug interact with TYROKININ 150MG TABLET 10S:
Taking carbamazepine and TYROKININ 150MG TABLET 10S may significantly reduce the blood levels of TYROKININ 150MG TABLET 10S, which may make the medication less effective.

How to manage the interaction:
Although taking carbamazepine and TYROKININ 150MG TABLET 10S together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience any unusual symptoms contact your doctor immediately. Do not stop using any medications without first talking to your doctor.

Drug-Food Interactions

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ERLOTINIB-150MGGrapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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ERLOTINIB-150MGGrapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Grapefruit Juice

How to manage the interaction:
Grapefruit juice can increase the absorption of TYROKININ 150MG TABLET 10S which may lead to higher blood levels of TYROKININ 150MG TABLET 10S and possibly increased side effects. Avoid or limit the consumption of Grapefruit juice or Grapefruit while taking TYROKININ 150MG TABLET 10S as it can lead to increased risk or severity of side effects. However, if you notice any Burning, tingling, numbness or pain in the hands, arms, feet, or legs, cough or hoarseness, or severe diarrhea, you should contact your doctor immediately. Do not stop using any medications without first talking to your doctor.

Diet & Lifestyle Advise

  • ​​​​​​Physical activity helps in strengthening muscles, reduce fatigue, aids in weight loss, and give strength. Gentle exercises like 20-30 minutes of walking or swimming would be helpful.
  • Performing yoga and other relaxation techniques may also improve physical and mental health and reduce stress levels.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Get adequate sleep as resting helps in improving your health, mental ability and improves attention.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath, or listen to soothing music.
  • Eat food rich in antioxidants such as berries, spinach, kidney beans, dark chocolate, etc.
  • Foods containing fiber help in better digestion. These include beans, peas, lentils, whole grains,  nuts, and seeds.
  • Avoid smoking and alcohol consumption. 

Habit Forming

No

Therapeutic Class

ANTINEOPLASTIC

TYROKININ 150MG TABLET Substitute

Substitutes safety advice
  • Erlonat 150 mg Tablet 30's

    255.65per tablet
  • Zyceva 150 mg Tablet 30's

    by AYUR

    100.04per tablet
  • Erlosam 150 mg Tablet 10's

    574.00per tablet
  • Tarceva 150mg 30 Tablets

    3304.60per tablet
  • ERLEVA 150MG TABLET

    4715.00per tablet
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Alcohol

Unsafe

You are recommended to avoid alcohol consumption with TYROKININ 150MG TABLET as it may increase the risk of side effects such as dizziness, drowsiness, or difficulty in concentrating.

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Pregnancy

Unsafe

TYROKININ 150MG TABLET is restricted to use in pregnancy. A woman needs to have a negative pregnancy test before starting treatment with this medicine. It is better to use effective birth control methods to prevent pregnancy while taking this medicine or at least 6 months after taking the last dose of TYROKININ 150MG TABLET.

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Breast Feeding

Unsafe

TYROKININ 150MG TABLET should not be taken by breastfeeding mothers as it passes into breast milk and may cause a possible risk to the infant.

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Driving

Caution

It is not known if TYROKININ 150MG TABLET affects your driving ability or not. Drive only if you are physically stable and mentally focussed. If you experience drowsiness after taking this medication, you should not drive or operate any machinery or vehicles.

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Liver

Caution

TYROKININ 150MG TABLET should be taken with caution in patients dealing with liver disease. The doctor may adjust the dose according to the medical condition of the patient.

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Kidney

Caution

TYROKININ 150MG TABLET is safe to take by patients dealing with kidney disease as prescribed by their doctor. The doctor may adjust the dose according to the medical condition of the patient.

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Children

Unsafe

TYROKININ 150MG TABLET is not recommended for children below 18 years as the safety and effectiveness were not established.

FAQs

TYROKININ 150MG TABLET is used to treat lung and pancreatic cancer.
TYROKININ 150MG TABLET contains Erlotinib, an anti-cancer medication that works by preventing the activity of a protein called epidermal growth factor receptor (EGFR) and hence induces cell death (apoptosis). As a result, the growth and spread of cancer cells in stopped or slowed down.
The most common sign of lung cancer is a cough that lasts long and gets worse with time. Sometimes, a patient may notice blood in the cough. Chest pain is also a sign of lung cancer followed by coughing.
TYROKININ 150MG TABLET is safe to be taken by a diabetic person. However, take TYROKININ 150MG TABLET only after asking with a doctor as they may adjust the dosing according to the patient's condition.
In elderly patients, the risk of side effects is more if you are taking TYROKININ 150MG TABLET. For the patients who are elderly, dose adjustment might be required or your doctor might prescribe any other medication safe for the elderly.
TYROKININ 150MG TABLET can make you more likely to get infections or may worsen any current infections. Avoid contact with people who have infections that may spread to others (such as chickenpox, measles, flu). Consult your doctor if you have been exposed to an infection or for more details.
No, It is advised to maintain a gap between both the medicines, as use of antacids along with TYROKININ 150MG TABLET may affect the way the TYROKININ 150MG TABLET works. Consult your doctor for further information.
TYROKININ 150MG TABLET should be used with caution in patients using anticoagulants. TYROKININ 150MG TABLET may increase your tendency to bleed. Talk to your doctor, he will need to regularly monitor you with some blood tests.
TYROKININ 150MG TABLET is not recommended for children under 18 years of age, as its safety and efficacy were not established.
No, you should not take TYROKININ 150MG TABLET if you are pregnant or planning to become pregnant as it may cause harm to an unborn baby. Consult the doctor if you have any concerns.
No, do not take TYROKININ 150MG TABLET with food. It can be taken orally on an empty stomach, at least 1 hour before or 2 hours after meals.
TYROKININ 150MG TABLET is a targeted therapy used to treat specific types of non-small cell lung cancer that spread to nearby tissues or any other parts of the body in patients who have previously undergone at least one chemotherapy treatment without improvement.
TYROKININ 150MG TABLET should be taken for as long as your doctor has prescribed it, depending on your medical condition. Please consult the doctor if you have any concerns regarding the duration of treatment.
Yes, Smoking may interfere with TYROKININ 150MG TABLET. It lowers the levels of TYROKININ 150MG TABLET in the blood, potentially reducing its effectiveness in treating the cancer. Avoid smoking while on treatment with TYROKININ 150MG TABLET to treat your condition effectively.
Inform the doctor if you notice a rash while taking TYROKININ 150MG TABLET as it could be a symptom of an allergic reaction.
TYROKININ 150MG TABLET may harm the foetus. Therefore, it is not recommended to become pregnant during treatment with TYROKININ 150MG TABLET. Use effective birth control while taking TYROKININ 150MG TABLET and for at least one month after your final dose. Talk to the doctor if you plan to become pregnant; the doctor will provide guidance on the same.
TYROKININ 150MG TABLET may cause sparse eyelashes (thinning of eyelashes), blepharitis (inflammation of eyelids), and diffuse conjunctival congestion (redness of the eye). Consult the doctor if you notice any eye problems.
Call your doctor if you experience severe diarrhoea, nausea, vomiting, loss of appetite, worsening shortness of breath or cough, new or worsening rash, blistering or peeling of the skin, eye irritation or any changes in smoking habits during treatment with TYROKININ 150MG TABLET.

Country of origin

India

Manufacturer/Marketer address

Dr. Reddy's Laboratories Ltd., 8-2-337, Road No. 3, Banjara Hills, Hyderabad, Telangana 500034, INDIA
Other Info - TYR0013

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