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Written By ,
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Last Updated Dec 7, 2024 | 2:19 PM IST

Trumab 150 Injection is used to treat Breast Cancer and Stomach Cancer. Trumab 150 Injection contains Trastuzumab, which works by attaching itself to the HER2 proteins so that the cancer cells are no longer stimulated to grow. It also helps the body's immune system to destroy breast cancer cells. It should not be taken during pregnancy as it might cause fetal harm. Inform your doctor immediately if you are conceiving while on therapy. Advise women not to breastfeed while taking Trumab 150 Injection .

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Prescription drug

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Prescription drug
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Manufacturer/Marketer

Glenmark Pharmaceuticals Ltd

Consume Type

PARENTERAL

Return Policy

Not Returnable

Expires on or after

Apr-26

for this medicine

About Trumab 150 Injection

Trumab 150 Injection is an anti-cancer medicine used in the treatment of HER2-positive Breast cancer and HER2-positive metastatic gastric or gastroesophageal junction adenocarcinoma. Cancer is a disease where the cells grow abnormally and divide uncontrollably. It can also be used when the cancer has spread to other parts of the body.

Trumab 150 Injection contains Trastuzumab as an active ingredient, which belongs to the class of monoclonal antibodies. It works by inhibiting the abnormal growth of cancer cells and, finally, causes the initiation of programmed cell death.

Trumab 150 Injection may cause certain side effects such as abdominal pain, chills, diarrhoea, fatigue, nausea, back pain, bone pain, edema, insomnia, fever, dizziness, headache, vomiting, cough, rash, and injection site reactions. If the side effects persist or bother you, please consult your doctor. Trumab 150 Injection will be administered by a trained doctor. Hence, do not self-administer.

Avoid taking it and inform your doctor if you are allergic to Trumab 150 Injection or its components. Inform your doctor if you have any cardiovascular conditions, lung problems, or liver/kidney disease, as it can cause adverse effects. Trumab 150 Injection is known to cause embryo-fetal toxicity. Hence, if you are pregnant or breastfeeding, inform your doctor beforehand.

Uses of Trumab 150 Injection

Treatment of Breast Cancer and Stomach Cancer

Medicinal Benefits

Trumab 150 Injection contains Trastuzumab, which is used for treating patients with HER2-positive breast cancer and HER2-positive metastatic gastroesophageal adenocarcinoma. This medicine works by inhibiting the excess production of a human epidermal growth factor receptor 2 (HER2) protein in the mammalian cells. This causes inhibition of the cancer cell growth and, finally, initiation of programmed cell death.

Directions for Use

A doctor who is trained or experienced in the administration of chemotherapeutic agents will administer Trumab 150 Injection . Do not self-administer.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Trumab 150 Injection

  • Nausea
  • Vomiting
  • Diarrhoea
  • Myalgia
  • Bone pain
  • Headache
  • Fatigue
  • Injection site reactions
  • Pain at the site of injection
  • Dizziness
  • Edema
  • Cough
  • Rash
  • Insomnia

Drug Warnings

Trumab 150 Injection should be avoided if you are allergic to it or any other components of this medicine. Inform your doctor if you have any lung problems, cardiovascular conditions or liver/kidney disease, as it can cause adverse effects. Trumab 150 Injection may cause left ventricular ejection fraction, cardiomyopathy, pulmonary toxicity, exacerbations of chemotherapy-induced neutropenia, and hypersensitivity reactions during the treatment. Hence, careful observation should be performed for any reactions in the patient. Trumab 150 Injection may cause embryo-fetal toxicity. Hence, if you are pregnant or planning to become pregnant, inform your doctor beforehand. Breastfeeding should be discontinued in nursing mothers during the treatment. Trumab 150 Injection is not recommended for use in children as the safety and efficacy are not established.

Drug Interactions

Drug-Drug Interactions: Trumab 150 Injection may interact with monoclonal antibodies (etanercept, golimumab, infliximab, natalizumab), antiviral drugs (indinavir, efavirenz, atazanavir), live vaccines, etc.

Drug-Food Interactions: No interaction found.

Drug-Disease Interactions: Inform your doctor if you have cardiac problems, lung disease, liver/kidney disease or allergic reactions.

Drug-Drug Interactions Checker List

  • ETANERCEPT
  • NATALIZUMAB
  • INDINAVIR
  • EFAVIRENZ
  • ATAZANAVIR
  • GOLIMUMAB

Habit Forming

No

Diet & Lifestyle Advise

  • Meditation and yoga have been proven very effective in helping cancer patients maintain a healthy attitude and body.
  • Eat more lean meats, healthy fats, fruits, vegetables, and whole-grain foods to give you more energy. 
  • Stay hydrated by drinking plenty of water, as dehydration is often seen in cancers.
  • Taking a stroll in the garden or spending 30 minutes of your time doing some light physical activity can be very useful. However, do not over-exert yourself if you feel too tired. 
  • Avoid smoking and alcohol consumption.

Special Advise

  • Avoid intercourse while on treatment with Trumab 150 Injection .
  • Regular, complete blood count monitoring is advised during the treatment.
  • All patients should be tested for HER2 test before starting the treatment regimen.
  • Liver function tests (LFT) and pulmonary function tests (PFT) should be performed before starting the treatment and every 4 to 6 weeks during the treatment.
  • Regular ECG and electrolytes should be monitored while taking the medicine.

Disease/Condition Glossary

Breast Cancer: Breast cancer is a type of cancer with abnormal growth in the cells of the breast. There are different kinds of breast cancer, such as cancer occurring in lobules (glands that produce milk), ducts of the breast (the pathway that brings milk from glands to the nipple), and in the fatty tissue or the fibrous connective tissue within the breast. Symptoms of breast cancer include a lump in the breast, breast pain, redness, swelling, nipple discharge other than breast milk, bloody discharge, a lump or swelling under the arm, unexplained change in shape, size or appearance of the breast, peeling, flaking or scaling of the skin. 

Stomach Cancer (Gastric adenocarcinoma)It is a type of cancer that develops from the stomach lining. When the cancer cells spread to other organs of the body, it is called metastatic. This condition can occur mainly due to smoking, a highly processed or salty diet, and severe bacterial infection of H. pylori. Symptoms of stomach cancer include feeling bloated after eating, feeling full after eating small amounts of food, nausea, heartburn or indigestion.

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Alcohol

Unsafe

Avoid consumption of alcohol as it may cause serious side effects.

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Pregnancy

Unsafe

Trumab 150 Injection is not recommended for use in pregnancy as it may harm your foetus. Hence, if you are pregnant or planning pregnancy, inform your doctor before receiving Trumab 150 Injection . Use reliable methods of birth control while on treatment with Trumab 150 Injection .

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Breast Feeding

Unsafe

Avoid nursing your child while on treatment with Trumab 150 Injection as it can cause serious side effects to the baby.

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Driving

Not applicable

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Liver

Caution

If you have a pre-existing or a history of liver disease, inform your doctor before receiving Trumab 150 Injection . Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.

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Kidney

Caution

Limited data are available on the effect of Trumab 150 Injection in kidney-impaired patients. Hence, if you have a pre-existing or a history of kidney disease, inform your doctor.

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Children

Unsafe

Trumab 150 Injection is not recommended for use in children as the safety and efficacy are not established.

Country of origin

India

Manufacturer/Marketer address

Glenmark Pharmaceuticals Limited, B/2, Mahalaxmi Chambers, 22, Bhulabhai Desai Road, Mumbai €“ 400 026.
Other Info - TRU0758

FAQs

Trumab 150 Injection is used to treat Breast Cancer and Stomach Cancer.
Trumab 150 Injection contains Trastuzumab, which works by inhibiting the excess production of a protein called human epidermal growth factor receptor 2 (HER2) in mammalian cells. This causes inhibition of the cancer cell growth.
Inform your doctor whether you have received any other cancer treatment. Trumab 150 Injection may cause a decrease in left ventricular ejection fraction, cardiomyopathy, hypersensitivity reactions, pulmonary toxicity, and embryo-fetal toxicity during the treatment. Hence, inform your oncologist if you have any cardiovascular conditions, liver/kidney disease, lung problems, are pregnant, are planning to become pregnant, or are breastfeeding before receiving Trumab 150 Injection .
Consult the doctor immediately, if you experience symptoms of an infection, such as a high temperature, chills, or feeling unwell despite a normal temperature. It could be due to a reduced white blood cell count caused by Trumab 150 Injection , increasing your risk of severe infections. Additionally, swollen feet or ankles, stomach pain, or lower back pain may indicate heart problems.
It is recommended to wait at least 6 months after completing Trumab 150 Injection therapy before trying to get pregnant. This is because the medication can remain in the body for some time and may potentially affect pregnancy. However, it is essential to consult the doctor for personalized advice and to ensure that it is safe for you to become pregnant after this treatment.
The duration of treatment with Trumab 150 Injection will depend on an individual treatment plan, which your doctor will determine based on your specific condition. It may vary based on personal medical conditions and how you respond to the therapy. In some cases, the treatment duration may be shorter or longer. Always attend follow-up appointments as instructed by the doctor for effective treatment.
Fasting is not typically required before administering Trumab 150 Injection . However, it is always best to follow the doctor's specific instructions regarding preparations before treatment. If fasting is necessary, your doctor will provide detailed guidance.
Trumab 150 Injection should be administered through subcutaneous (SC) or intravenous (IV) routes by the doctor or nurse. Do not self-administer.
Trumab 150 Injection should not be administered to patients with HER2-negative cancer cells as it is a monoclonal antibody that specifically targets a protein called human epidermal growth factor receptor 2 (HER2), which is present in high amounts on the surface of specific cancer cells.
The doctor may recommend heart investigations while you are taking Trumab 150 Injection as it may potentially affect heart function. It has been associated with heart-related side effects, including a decrease in left ventricular ejection fraction, which could lead to heart failure in some patients. Monitoring heart health helps detect any issues early, ensuring prompt action to manage the risk. Always follow the doctor's recommendations for regular check-ups during treatment.
During treatment with Trumab 150 Injection for advanced-stage disease, cardiac monitoring was conducted every 3 to 8 months for up to 2 years. However, the doctor will adjust the frequency of heart investigations based on your specific condition and response to treatment. It's essential to follow their advice for optimal monitoring and early detection of any heart-related issues.
The side effects of Trumab 150 Injection include abdominal pain, chills, headache, diarrhoea, fatigue, nausea, back pain, bone pain, oedema, insomnia, fever, dizziness, vomiting, cough, rash, and injection site reactions. Consult the doctor if any of these side effects persist or worsen.

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