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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Trugaba-NT 400 Tablet is used for the management of neuropathic pain. It contains Gabapentin and Nortriptyline, which prolongs the effect of serotonin and noradrenaline and prevents movements of pain signals in the brain. Thus, it helps in relieving nerve pain. It may cause common side effects, such as dizziness, sleepiness, tiredness, headache, nausea, vomiting, blurred vision, dry mouth, and tingling sensations. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.
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Manufacturer/Marketer :

Mankind Pharma Pvt Ltd

Consume Type :

ORAL

Return Policy :

3 Days Returnable

Expires on or after :

Jan-27

About Trugaba-NT 400 Tablet

Trugaba-NT 400 Tablet is used for the management of neuropathic pain, a chronic progressive nerve disease that causes nerve pain. Symptoms include spontaneous, untriggered pain, unpleasant feeling, shooting, burning or stabbing pain, difficulty resting or sleeping, and evoked pain (pain caused by events that are usually not painful).

Trugaba-NT 400 Tablet contains Gabapentin and Nortriptyline. Gabapentin works by binding to the specific site on voltage-gated calcium channels; this helps in relieving nerve pain. Nortriptyline prolongs the effect of serotonin and noradrenaline and prevents movements of pain signals in the brain.

In some cases, you may experience certain common side effects, such as dizziness, sleepiness, tiredness, headache, nausea, vomiting, blurred vision, dry mouth, and tingling sensations. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Consult your doctor if you are pregnant or breastfeeding. Trugaba-NT 400 Tablet may cause drowsiness and dizziness, so drive only if you are alert. Trugaba-NT 400 Tablet should not be given to children unless prescribed by the doctor. Avoid consuming alcohol along with Trugaba-NT 400 Tablet as it could lead to increased dizziness and sleepiness. Keep your doctor informed about your health condition and medicines to rule out any side effects.

Uses of Trugaba-NT 400 Tablet

Treatment of Neuropathic pain

Directions for Use

Take Trugaba-NT 400 Tablet with or without food. Swallow Trugaba-NT 400 Tablet as a whole with a glass of water; do not chew or break it.

Medicinal Benefits

Trugaba-NT 400 Tablet is used to treat neuropathic pain. Trugaba-NT 400 Tablet is a combination of two drugs: Gabapentin and Nortriptyline. Gabapentin belongs to a class of drugs called anti-convulsants, whereas Nortriptyline belongs to tricyclic antidepressants. Gabapentin works by binding to the specific site on voltage-gated calcium channels; this helps in relieving nerve pain and lowers the risk of seizures. On the other hand, Nortriptyline works by preventing the released chemical messenger in the brain (serotonin and noradrenaline) from being reabsorbed back into the nerve cells (neurons) in the brain. As a result, it prolongs the effect of serotonin and noradrenaline in the brain and prevents the movement of pain signals in the brain.

How Trugaba-NT 400 Tablet Works

Trugaba-NT 400 Tablet contains Gabapentin and Nortriptyline. Gabapentin works by binding to the specific site on voltage-gated calcium channels; this helps in relieving nerve pain. Nortriptyline prolongs the effect of serotonin and noradrenaline and prevents movements of pain signals in the brain.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Trugaba-NT 400 Tablet

  • Dizziness
  • Sleepiness
  • Tiredness
  • Headache
  • Nausea
  • Vomiting
  • Blurred vision
  • Dry mouth

What if I have taken an overdose of Trugaba-NT 400 Tablet

Do not take more than the prescribed dose of Trugaba-NT 400 Tablet as it may cause overdose. If you suspect you have taken overdose, please consult a doctor immediately.

Drug Warnings

Do not take Trugaba-NT 400 Tablet if you are allergic to any of its contents. Inform your doctor before taking Trugaba-NT 400 Tablet if you have/had heart problems or bipolar syndrome. Consult your doctor if you are pregnant or breastfeeding. Trugaba-NT 400 Tablet may cause drowsiness and dizziness, so drive only if you are alert. Avoid consuming alcohol along with Trugaba-NT 400 Tablet as it could lead to increased dizziness and sleepiness. Keep your doctor informed about your health condition and medicines to rule out any side-effects.

Drug-Drug Interactions

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NortriptylineLinezolid
Critical
NortriptylineTranylcypromine
Critical

Drug-Drug Interactions

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NortriptylineLinezolid
Critical
How does the drug interact with Trugaba-NT 400 Tablet 10's:
Coadministration of Trugaba-NT 400 Tablet 10's with Linezolid might raise serotonin hormone levels in the body, affecting the brain and nerve cells. Increased serotonin hormone can lead to side effects.

How to manage the interaction:
Taking Trugaba-NT 400 Tablet 10's with Linezolid together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremors, incoordination, stomach cramps, nausea, vomiting, and diarrhea contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
NortriptylineTranylcypromine
Critical
How does the drug interact with Trugaba-NT 400 Tablet 10's:
Coadministration of Trugaba-NT 400 Tablet 10's with Tranylcypromine can increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Trugaba-NT 400 Tablet 10's with Tranylcypromine together can result in an interaction, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and diarrhea. Do not discontinue any medications without consulting your doctor.
NortriptylineZiprasidone
Critical
How does the drug interact with Trugaba-NT 400 Tablet 10's:
Coadministration of Trugaba-NT 400 Tablet 10's with Ziprasidone can increase the risk or severity of irregular heart rhythm.

How to manage the interaction:
Taking Trugaba-NT 400 Tablet 10's with Ziprasidone together can result in an interaction, it can be taken if your doctor has advised it. However, contact a doctor immediately if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, severe or prolonged diarrhea, or vomiting. Do not discontinue any medications without consulting a doctor.
NortriptylineIsocarboxazid
Critical
How does the drug interact with Trugaba-NT 400 Tablet 10's:
Using Trugaba-NT 400 Tablet 10's together with Isocarboxazid can increase the risk of serotonin syndrome (A condition resulting from the accumulation of high levels of serotonin in the body. Serotonin is especially a mood stabilizer).

How to manage the interaction:
Taking Isocarboxazid with Trugaba-NT 400 Tablet 10's is not recommended, please consult your doctor before taking it. However, if you experience increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasms or stiffness, tremors, incoordination, stomach cramps, nausea, vomiting, and diarrhea call a doctor. Do not discontinue any medications without consulting a doctor.
NortriptylinePotassium citrate
Critical
How does the drug interact with Trugaba-NT 400 Tablet 10's:
Coadministration of Trugaba-NT 400 Tablet 10's with Potassium citrate can increase the risk or severity of gastric bleeding, ulceration, and rarely, perforation leading to serious blood loss.

How to manage the interaction:
Taking Trugaba-NT 400 Tablet 10's with Potassium citrate together is not recommended as it can result in an interaction, it can be taken if your doctor has advised it. However, if you notice any unusual bleeding or bruising, dizziness, lightheadedness, abdominal pain, bloating, decreased hunger, red or black tarry stools, coughing up or vomiting blood, severe headache, and weakness, you should contact a doctor immediately. Do not stop using any medications without talking to a doctor.
NortriptylineSelegiline
Critical
How does the drug interact with Trugaba-NT 400 Tablet 10's:
Co-administration of Trugaba-NT 400 Tablet 10's with Selegiline might raise serotonin hormone levels in the body (A condition in which a chemical called serotonin builds up in your body).

How to manage the interaction:
Taking Trugaba-NT 400 Tablet 10's with Selegiline together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience confusion, hallucination, fits, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremors, incoordination, stomach cramps, nausea, vomiting, and diarrhea, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
NortriptylineSafinamide
Critical
How does the drug interact with Trugaba-NT 400 Tablet 10's:
Coadministration of Trugaba-NT 400 Tablet 10's with Safinamide may increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Trugaba-NT 400 Tablet 10's with Safinamide together can result in an interaction, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting your doctor.
NortriptylineCyclobenzaprine
Severe
How does the drug interact with Trugaba-NT 400 Tablet 10's:
Taking Cyclobenzaprine with Trugaba-NT 400 Tablet 10's might raise serotonin hormone levels which can increase the risk of developing side effects.

How to manage the interaction:
Taking Cyclobenzaprine with Trugaba-NT 400 Tablet 10's can possibly lead to an interaction. It can be taken if prescribed by doctor. However, if you experience fever, palpitations, excessive sweating, muscle spasm, or vomiting, contact a doctor immediately. Do not discontinue the medications without consulting a doctor.
NortriptylineFluoxetine
Severe
How does the drug interact with Trugaba-NT 400 Tablet 10's:
Co-administration of Trugaba-NT 400 Tablet 10's with Fluoxetine can reduce the metabolism and increase the levels of Trugaba-NT 400 Tablet 10's in the body. This can increase the risk or severity of side effects.

How to manage the interaction:
Taking Trugaba-NT 400 Tablet 10's with Fluoxetine together can result in an interaction, it can be taken if your doctor has advised it. However, if you notice any symptoms of headaches, dry mouth, sleepiness, irritation, confusion, edema, fatigue, palpitations, or constipation, you should contact a doctor immediately. Do not stop using any medications without talking to a doctor.
NortriptylineMirtazapine
Severe
How does the drug interact with Trugaba-NT 400 Tablet 10's:
Using Trugaba-NT 400 Tablet 10's together with mirtazapine might raise serotonin hormone levels in the body, affecting the brain and nerve cells. Increased serotonin hormone can lead to severe side effects.

How to manage the interaction:
Taking Trugaba-NT 400 Tablet 10's with Mirtazapine together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremors, incoordination, stomach cramps, nausea, vomiting, and diarrhea contact a doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Include food rich in vitamins B and D in your diet.

  • Include cayenne pepper in your diet, as it can help lower neuropathic pain.

  • Exercising regularly helps in improving overall health and combating pain. 

  • Rest well, and get plenty of sleep.

  • Try taking a warm bath, as it can be soothing.

  • Avoid smoking and alcohol consumption.

  • Meditation and yoga can help lower stress, decrease pain sensitivity and improves coping skills.

  • Acupuncture can be helpful by stimulating pressure points.

  • Using essential oils for massages can help increase circulation.

Habit Forming

No

Therapeutic Class

ANTICONVULSANT

Trugaba-NT 400 Tablet Substitute

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  • Laregab NT Tablet 10's

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Alcohol

Unsafe

Avoid consumption of alcohol while taking Trugaba-NT 400 Tablet as it may increase dizziness and sleepiness.

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Pregnancy

Caution

Please consult your doctor if you have any concerns regarding this, your doctor will prescribe only if the benefits outweigh the risks.

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Breast Feeding

Caution

Consult your doctor before taking Trugaba-NT 400 Tablet ; your doctor will decide whether Trugaba-NT 400 Tablet can be taken by breastfeeding mothers or not.

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Driving

Caution

Trugaba-NT 400 Tablet may cause drowsiness, sleepiness and tiredness. Do not drive or operate machinery unless you are alert.

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Liver

Caution

Dose adjustment may be needed in patients with liver impairment. Please consult your doctor if you have a liver impairment or any concerns regarding this.

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Kidney

Caution

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Caution

Trugaba-NT 400 Tablet should not be given to children unless prescribed by the doctor.

FAQs

Trugaba-NT 400 Tablet is indicated for the management of neuropathic pain.
Trugaba-NT 400 Tablet contains Gabapentin and Nortriptyline. Gabapentin works by binding to the specific site on voltage-gated calcium channels; this helps in relieving nerve pain. Nortriptyline prolongs the effect of serotonin and noradrenaline and prevents movements of pain signals in the brain.
To treat your condition effectually, continue taking Trugaba-NT 400 Tablet for as long as prescribed. Do not be reluctant to speak with your doctor if you feel any difficulty while taking Trugaba-NT 400 Tablet ; your doctor will reduce the dose gradually.
Trugaba-NT 400 Tablet may cause dry mouth. In that case, you can drink water or fluids, suck hard candy or ice, chew (sugarless) gum, or use a saliva substitute.
Trugaba-NT 400 Tablet helps in the treatment of diabetic neuropathy (nerve damage in diabetic patients). However, please consult your doctor before starting Trugaba-NT 400 Tablet if you have diabetes.
Trugaba-NT 400 Tablet should be swallowed as a whole with water; do not crush or chew it.
Stopping Trugaba-NT 400 Tablet suddenly may cause withdrawal symptoms such as nausea, anxiety, sweating, sleeping difficulties, and pain. Therefore, do not discontinue Trugaba-NT 400 Tablet without consulting your doctor.
Trugaba-NT 400 Tablet may cause side effects, such as dizziness, sleepiness, tiredness, headache, nausea, vomiting, blurred vision, dry mouth, and tingling sensations. Talk to your doctor if you the side effects persist or worsen.
Trugaba-NT 400 Tablet is a combination of two drugs: Gabapentin (anticonvulsant) and Nortriptyline (tricyclic antidepressant).
Trugaba-NT 400 Tablet is a combination medicine used to treat neuropathic pain.
Eating a balanced meal and exercising regularly may help manage weight gain associated with the use of Trugaba-NT 400 Tablet .
Yes, the use of Trugaba-NT 400 Tablet may affect your sexual life. Trugaba-NT 400 Tablet may cause problems like erectile dysfunction, lower sexual desire and inability to reach orgasm. Consult the doctor if you have any concerns regarding this.
Trugaba-NT 400 Tablet may cause serious side effects like hallucination, blurred or double vision, uncontrollably jerky eye movements, difficulty seeing, signs of frequent infections such as fever, severe chills, sore throat, or mouth ulcers, weakness, unsteadiness when walking, reduced coordination or slowed reactions, and unusual mood or behavioural changes (such as restlessness, nervousness, or excitement). Consult the doctor if you notice these signs.
Trugaba-NT 400 Tablet starts working within 2 weeks. However, it might take 2-3 months to notice the full benefits.
If you miss a dose of Trugaba-NT 400 Tablet take it as soon as you remember, However, if it is almost time for the scheduled dose, skip the missed dose and take the next dose at the scheduled time.
Taking too much of Trugaba-NT 400 Tablet may cause an overdose. Symptoms of overdose include drowsiness, weakness, double vision, unsteadiness when walking, dizziness, blurred vision, fever, and difficulty breathing. Consult the doctor if you experience these symptoms or if you have taken an overdose.
Trugaba-NT 400 Tablet may cause drowsiness and dizziness. Avoid driving or operating machinery until you know how this medicine affects you. Do not consume alcohol along with Trugaba-NT 400 Tablet as it could lead to increased dizziness and sleepiness.
You might need to visit your doctor on a regular basis. If the recommended dosage of Trugaba-NT 400 Tablet does not alleviate your symptoms or if you continue to have unpleasant side effects that interfere with your daily activities, you should speak with your physician.
Trugaba-NT 400 Tablet may cause drowsiness and sleepiness. Avoid driving or operating machinery until you know how this medicine affects you.
No, taking more than the recommended dose will not be more effective but cause unpleasant side effects. Therefore, do not exceed the recommended dose.
Store Trugaba-NT 400 Tablet at room temperature, in a dry place. Keep out of sight and reach of children.

Country of origin

India

Manufacturer/Marketer address

208, Okhla Industrial Estate, Phase 3, New Delhi - 110020.
Other Info - TRU0654

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