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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Trizonia Plus Tablet is used to treat schizophrenia. It contains Trifluoperazine and Trihexyphenidyl which work by inhibiting a chemical messenger (dopamine) in the brain that regulates mood. In some cases, this medicine may cause side effects such as nausea, constipation, dryness in the mouth, sedation, weight gain, and dizziness. Before taking this medicine, inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.
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Consume Type :

ORAL

Return Policy :

3 Days Returnable

Expires on or after :

Jan-27

About Trizonia Plus Tablet

Trizonia Plus Tablet belongs to a class of drugs called 'antipsychotics' used to prevent and treat schizophrenia (a mental illness). Additionally, Trizonia Plus Tablet may be used to anxiety and depression over a short period. Schizophrenia is a mental disorder that affects a person's ability to feel, think and behave clearly. Anxiety is a mental health disorder associated with fear, worry, and excessive nervousness that may interfere with daily activities. Depression is a mood disorder associated with symptoms such as sadness, unable to sleep properly or enjoy life as you used to do.

Trizonia Plus Tablet combination composed of two different medicines, namely, Trifluoperazine and Trihexyphenidyl. Trifluoperazine inhibits the dopamine (chemical messenger) receptors in the brain. Dopamine is involved in regulating mood, behaviour, and emotions. Thereby, Trizonia Plus Tablet helps in controlling psychotic illness, relieving depression, lightening the mood, and relieving anxiety symptoms such as fear and panic. On the other hand, Trihexyphenidyl is an anticholinergic agent that acts on the nervous system and corrects some of the chemical imbalances that cause some side effects such as shaking of hands and muscle spasms due to Trifluoperazine.

Take Trizonia Plus Tablet as prescribed by your doctor. You are advised to take Trizonia Plus Tablet for as long as your doctor has prescribed it for you based on your medical condition. Some people may experience nausea, constipation, dryness in the mouth, sedation, weight gain, orthostatic hypotension (sudden lowering of blood pressure on standing), urinary retention, increased prolactin level in the blood, dizziness, blurred vision, and nervousness. Most of these side effects of Trizonia Plus Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are allergic to Trizonia Plus Tablet or any other medicines, please tell your doctor. Avoid taking Trizonia Plus Tablet if you are pregnant, especially in the third trimester, as it may cause adverse effects in the baby such as breathing problems, muscle stiffness or weakness, shaking, etc. Please consult a doctor if you are pregnant or breastfeeding. Trizonia Plus Tablet should be used with caution in elderly patients above 65 years, as there is an increased risk of adverse reactions. Avoid consuming alcohol along with Trizonia Plus Tablet as it could lead to increased drowsiness and dizziness. Consult your doctor before giving this medicine to your child. Keep your doctor informed about your medicines and health condition and rule out any side effects. 

Uses of Trizonia Plus Tablet

Treatment of Schizophrenia, Anxiety, Depression.

Directions for Use

Swallow Trizonia Plus Tablet as a whole with water; do not crush, break or chew it.

Medicinal Benefits

Trizonia Plus Tablet combination composed of two different medicines, namely; Trifluoperazine and Trihexyphenidyl used to prevent and treat relapses of schizophrenia (a mental illness). Additionally, Trizonia Plus Tablet may be used to anxiety and depression over a short period. Trifluoperazine inhibits the dopamine (chemical messenger) receptors in the brain. Dopamine is involved in regulating mood, behavior, and emotions. Thereby, Trizonia Plus Tablet helps in controlling psychotic illness, relieving depression, lighten the mood, and relieve anxiety symptoms such as fear and panic. However, it may cause side effects such as involuntary movements (shaking of hands, muscle spasms, etc.). On the other hand, Trihexyphenidyl is used to treat and prevent side effects such as involuntary movements (shaking of hands, muscle spasms) caused by Trifluoperazine. Trihexyphenidyl exerts a direct inhibitory effect upon the parasympathetic nervous system. It works by relaxing the muscles and nerve impulses that control muscle functioning. Trizonia Plus Tablet improves muscle control and reduces stiffness, thereby helps the muscles move naturally. 

How Trizonia Plus Tablet Works

Trizonia Plus Tablet combination composed of two different medicines, namely, Trifluoperazine and Trihexyphenidyl. Trifluoperazine inhibits the dopamine (chemical messenger) receptors in the brain. Dopamine is involved in regulating mood, behaviour, and emotions. Thereby, Trizonia Plus Tablet helps in controlling psychotic illness, relieving depression, lightening the mood, and relieving anxiety symptoms such as fear and panic.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Trizonia Plus Tablet

  • Nausea
  • Constipation
  • Dry mouth
  • Sedation
  • Weight gain
  • Orthostatic hypotension (sudden lowering of blood pressure on standing)
  • Urinary retention
  • Increased prolactin level in the blood
  • Dizziness
  • Abdominal Pain
  • Excessive sweating
  • Decreased blood pressure
  • Urine retention
  • Blurred vision
  • Nervousness

What if I have taken an overdose of Trizonia Plus Tablet

Take Trizonia Plus Tablet only as prescribed by the physician. Do not exceed the recommended dose, as it might cause an overdose. If you suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

If you are allergic to Trizonia Plus Tablet or any other medicines, please tell your doctor. Avoid taking Trizonia Plus Tablet if you are pregnant, especially in the third trimester, as it may cause adverse effects in the baby such as breathing problems, muscle stiffness or weakness, shaking, etc. Please consult a doctor if you are pregnant or breastfeeding. Trizonia Plus Tablet should be used with caution in elderly patients above 65 years, as there is an increased risk of adverse reactions. Do not discontinue Trizonia Plus Tablet on your own. Inform your doctor before taking Trizonia Plus Tablet if you have glaucoma, prostate problems, urination problems, stomach ulcers, acidity, myasthenia gravis (muscle problems), tardive dyskinesia (involuntary facial movements), alcoholism, high blood pressure, heart, liver, or kidney problems. Talk to your doctor immediately if you experience hallucinations. Trizonia Plus Tablet may make you sweat less, making you more likely to get heatstroke. Avoid doing things that may cause you to overheat, such as hard work or exercise in hot weather or using hot tubs. When the weather is hot, drink a lot of fluids and dress lightly. Trizonia Plus Tablet may cause drowsiness and dizziness, do not drive unless you are alert. Avoid consuming alcohol along with Trizonia Plus Tablet as it could lead to increased drowsiness and dizziness. 

Drug-Drug Interactions

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TrihexyphenidylPotassium citrate
Critical
TrihexyphenidylPotassium chloride
Critical

Drug-Drug Interactions

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TrihexyphenidylPotassium citrate
Critical
How does the drug interact with Trizonia Plus Tablet 10's:
Co-administration of Trizonia Plus Tablet 10's with potassium citrate may increase the risk of stomach ulcers, bleeding, and gastrointestinal injury.

How to manage the interaction:
Taking Trizonia Plus Tablet 10's with potassium citrate is not recommended as it can possibly result in an interaction, it can be taken if prescribed by a doctor. However, if you experience abdominal pain, bloating, sudden dizziness or lightheadedness, nausea, vomiting (especially with blood), loss of appetite, or black stools contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
TrihexyphenidylPotassium chloride
Critical
How does the drug interact with Trizonia Plus Tablet 10's:
Co-administration of Trizonia Plus Tablet 10's with potassium chloride can increase the risk of stomach ulcers, bleeding, and gastrointestinal injury.

How to manage the interaction:
Taking Trizonia Plus Tablet 10's with potassium chloride is not recommended as it can possibly result in an interaction, it can be taken if prescribed by a doctor. However, if you experience abdominal pain, bloating, sudden dizziness or lightheadedness, nausea, vomiting (especially with blood), loss of appetite, black stools contact a doctor immediately. Do not discontinue any medications without consulting to a doctor.
TrifluoperazineZiprasidone
Critical
How does the drug interact with Trizonia Plus Tablet 10's:
Co-administration of Trizonia Plus Tablet 10's with Ziprasidone can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Trizonia Plus Tablet 10's with Ziprasidone together can possibly result in an interaction, but it can be taken if a doctor has advised it. However, consult a doctor immediately if you experience any symptoms such as sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not discontinue any medications without consulting a doctor.
TrifluoperazineMetoclopramide
Critical
How does the drug interact with Trizonia Plus Tablet 10's:
Co-administration of Metoclopramide with Trizonia Plus Tablet 10's can increase the risk of side effects like uncontrolled movement disorder.

How to manage the interaction:
Taking Metoclopramide with Trizonia Plus Tablet 10's is generally avoided as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience muscle spasms or movements that you can't stop or control, such as lip smacking, chewing, puckering, frowning or scowling, tongue thrusting, teeth clenching, jaw twitching, blinking, eye-rolling, shaking or jerking of arms and legs, tremor, jitteriness, restlessness, pacing, and foot tapping., contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
TrihexyphenidylZonisamide
Severe
How does the drug interact with Trizonia Plus Tablet 10's:
Coadministration of Trizonia Plus Tablet 10's with Zonisamide can increase the risk or severity of Zonisamide side effects like increased body temperature and decreased sweating especially in warm weather.

How to manage the interaction:
Taking Trizonia Plus Tablet 10's with Zonisamide together is not recommended as it can result in an interaction, but it can be taken if your doctor has advised it. However, if you experience increased heart rate, fever, or excessive sweating, contact a doctor immediately. Make sure to hydrate yourself during warm weather or after exercise. Do not discontinue any medications without consulting a doctor.
TrihexyphenidylAmantadine
Severe
How does the drug interact with Trizonia Plus Tablet 10's:
Coadministration of Allopurinol with Trizonia Plus Tablet 10's may increase side effects such as heat intolerance, dry mouth, confusion, constipation, difficulty urinating, and blurred vision especially in the elderly or those with a debilitating (physically weak) condition.

How to manage the interaction:
If you are supposed to take Allopurinol and Trizonia Plus Tablet 10's together, your doctor may adjust the dose or monitor you more frequently to safely use both medications.
TrihexyphenidylTopiramate
Severe
How does the drug interact with Trizonia Plus Tablet 10's:
Taking Trizonia Plus Tablet 10's with topiramate can increase the risk of increase body temperature and reduced sweating.

How to manage the interaction:
Co-administration of Trizonia Plus Tablet 10's with Topiramate can result in an interaction, but it can be taken if your doctor has advised it. However, if you experience dizziness or lightheaded, increase body temperature contact your doctor right away. Do not discontinue any medications without first consulting your doctor.
TrihexyphenidylEsketamine
Severe
How does the drug interact with Trizonia Plus Tablet 10's:
Taking Trizonia Plus Tablet 10's with esketamine can increase the risk of other side effects.

How to manage the interaction:
Although there is a interaction between Trizonia Plus Tablet 10's and esketamine, but can be taken together if prescribed by your doctor. However, if you experience drowsiness, confusion, difficulty concentrating, and impairment in thinking contact your doctor right away. Do not stop using any medications without talking to your doctor.
TrihexyphenidylKetamine
Severe
How does the drug interact with Trizonia Plus Tablet 10's:
Taking Trizonia Plus Tablet 10's with Ketamine can increase the risk of side effects.

How to manage the interaction:
Although there is a interaction between Trizonia Plus Tablet 10's and ketamine, but it can be taken together if prescribed by your doctor. However, if you experience drowsiness, confusion, difficulty concentrating, and impairment in thinking contact your doctor right away. Do not stop using any medications without talking to your doctor.
TrifluoperazineDisopyramide
Severe
How does the drug interact with Trizonia Plus Tablet 10's:
The combined use of Trizonia Plus Tablet 10's and Disopyramide can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Co-administration of Trizonia Plus Tablet 10's and Disopyramide can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, heart palpitations, diarrhea, or vomiting, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Maintain a healthy diet and exercise regularly.

  • Include a diet rich in iron, folate, and magnesium. 

  • Regularly attend therapy sessions.

  • Perform meditation and yoga.

  • Follow a regular sleep pattern.

  • Avoid smoking and alcohol consumption.

  • Learn about your condition, understand the risk factors and follow the doctor’s treatment plan.

Habit Forming

No

Therapeutic Class

ANTIPSYCHOTICS

Trizonia Plus Tablet Substitute

Substitutes safety advice
  • Trinicalm Plus Tablet 10's

    2.66per tablet
  • Parkin Plus Tablet 10's

    3.51per tablet
  • Trazine-S Tablet 10's

    2.30per tablet
  • Lacalm Plus Tablet 10's

    1.62per tablet
  • Pacipeace Forte Tablet 10's

    2.90per tablet
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Alcohol

Unsafe

Avoid consumption of alcohol with Trizonia Plus Tablet as it may increase the risk of drowsiness and other adverse effects.

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Pregnancy

Unsafe

Trizonia Plus Tablet is not recommended for use during pregnancy, especially in the third trimesters as it may cause adverse effects in the baby. Please consult a doctor if you are pregnant or planning for pregnancy.

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Breast Feeding

Caution

Trizonia Plus Tablet may be unsafe to use during breastfeeding. Please consult a doctor if you are breastfeeding.

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Driving

Unsafe

Trizonia Plus Tablet may cause dizziness, double vision or drowsiness in some people. Therefore, avoid driving if you feel drowsy, dizzy or experience any vision problems after taking Trizonia Plus Tablet .

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Liver

Unsafe

Trizonia Plus Tablet is not recommended for patients suffering from Liver diseases/conditions. Please consult a doctor if you have any concerns regarding this.

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Kidney

Caution

Take Trizonia Plus Tablet with caution, especially if you have a history of Kidney diseases/conditions. The dose may be adjusted by your doctor as required.

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Children

Unsafe

Please consult your paediatrician. Your child's doctor may weigh the benefits and risks before prescribing this medicine to your child.

FAQs

Trizonia Plus Tablet is used to prevent and treat schizophrenia (a mental illness). Additionally, it may be used for anxiety and depression over a short period.
Trizonia Plus Tablet contains Trifluoperazine and Trihexyphenidyl. Trifluoperazine is a typical antipsychotic which works by blocking the action of a chemical messenger (dopamine) in the brain that affects thoughts and mood. However, it may cause side effects such as involuntary movements (shaking of hands, muscle spasms). Trihexyphenidyl is used to treat and prevent side effects such as involuntary movements (shaking of hands, muscle spasms) caused by Trifluoperazine.
Dry mouth could be a side-effect of Trizonia Plus Tablet . Limiting caffeine intake, avoiding smoking and mouthwashes containing alcohol, drinking water regularly, and chewing sugar-free gum/candy might help in stimulating saliva and thereby prevents drying of the mouth.
Antidepressants should be avoided while taking Trizonia Plus Tablet as it might increase sedative effects. Consult your doctor before taking Trizonia Plus Tablet if you are using depressants.
Trizonia Plus Tablet can cause decreased sweating which results in rising in body temperature (hyperthermia). This serious side effect is greater in hot weather so it is advisable to drink plenty of water fluids, especially in summer. However, kidney patients should consult a doctor before drinking any fluid.
Hallucination is a medical condition in which the person may feel, hear or believe things that are not true, see things that are not there, feel unusually suspicious or confused. Trihexyphenidyl in Trizonia Plus Tablet may cause hallucination in some cases if taken for a prolonged time. So, if you experience hallucinations while taking Trizonia Plus Tablet , please talk to your doctor immediately.
Trizonia Plus Tablet should be avoided by dementia (decline in memory, behaviour, thinking and ability to do daily activities) patients as it may increase the risk of severe adverse effects. Therefore, inform your doctor if you are suffering from dementia before taking Trizonia Plus Tablet .
Though Trizonia Plus Tablet starts working within a few hours, it might take 2-3 weeks to notice the full benefits. Keep taking Trizonia Plus Tablet for the prescribed duration for effective treatment.
No, you should not stop taking Trizonia Plus Tablet even though you feel better as it may cause withdrawal symptoms. Consult the doctor if you experience any difficulties while taking Trizonia Plus Tablet ; the doctor might lower the dose gradually.
Trizonia Plus Tablet does not cause sleepiness. However, it may cause sleepiness if you take alcohol with Trizonia Plus Tablet . Therefore, avoid consuming alcohol while taking Trizonia Plus Tablet . Trizonia Plus Tablet might cause dizziness and drowsiness in some people. Avoid driving or operating machinery if you experience these symptoms.
Yes, Trizonia Plus Tablet may cause dry mouth as a side effect. If you experience dry mouth manage it by limiting caffeine intake, staying hydrated, and using a humidifier.
Trizonia Plus Tablet can be stored in a cool and dry place away from sunlight. Keep it out of sight and reach of children.
The side effects of Trizonia Plus Tablet include dizziness, nausea, abdominal pain, blurred vision, constipation, decreased blood pressure, urine retention, dry mouth, weight gain, and excessive sweating. Consult the doctor if any of these side effects persist or worsen.

Country of origin

India

Manufacturer/Marketer address

70/1, Dharampur , Nr, Epip Phase -Ii , Baddi- 173205, Himachal Pradesh
Other Info - TRI1639

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