Trisertain 40 Tablet belongs to a group of medications called 'anti-hypertensives' primarily used for lowering high blood pressure (hypertension) by removing extra fluid (electrolytes) from the body. High blood pressure is a chronic condition in which the blood's force against the artery wall is high. As a result, it increases the risk of heart-related diseases like heart attack, heart failure, stroke, irregular heartbeat, and other complications.

Trisertain 40 Tablet is a combination of three medicines: Olmesartan medoximil, Amlodipine, and Hydrochlorothiazide. Olmesartan medoximil is a prodrug and breaks down into active form, i.e., olmesartan once absorbed in the GIT (Gastrointestinal tract). An angiotensin receptor blocker (ARB) blocks the hormone angiotensin, thereby relaxing and widening the narrowed blood vessels. Amlodipine is a calcium channel blocker; it reduces the heart's workload and makes it more efficient at pumping blood throughout the body. Hydrochlorothiazide is a diuretic or water pill that removes extra water/fluid and certain electrolyte overload from the body. Together, Trisertain 40 Tablet lowers fluid overload, raises blood pressure, improves blood flow, and reduces the future risk of a heart attack and stroke.

Depending upon your medical condition, you are advised to take Trisertain 40 Tablet for as long as your doctor has prescribed it for you. The most common side effects of Trisertain 40 Tablet are nausea, upset stomach, dehydration, headache, diarrhoea, electrolyte imbalance, headache, feeling exhausted, swollen ankles, dizziness, and decreased blood pressure in some cases. Most of these side effects of Trisertain 40 Tablet do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

Do not use potassium supplements or salt substitutes unless your doctor tells you. In rare cases, Trisertain 40 Tablet can cause a condition that results in a skeletal muscle problem, leading to further kidney failure. If you notice unexplained muscle pain, dark-coloured urine, tenderness, or weakness, especially if you also have a fever or unexplained tiredness, immediately contact the doctor. Try not to stop taking this medicine of your own. Let your doctor know about this, as it may cause a rise in blood pressure and increase heart disease and stroke risk. Inform your doctor if you are suffering from kidney, liver, heart disease, or diabetes. If you are pregnant or breastfeeding, do not take Trisertain 40 Tablet as it is a category D pregnancy drug and may harm the baby. Do not use the Trisertain 40 Tablet if you cannot urinate, are dehydrated, have low blood pressure (hypotension), or have had cardiogenic shock (sudden stopping blood flow to the heart). Please tell your doctor if you are taking any other medicines or are allergic to this medicine. Reducing table salt (sodium chloride) in your food often helps lower blood pressure.

Trisertain 40 Tablet belongs to a group of medications called 'anti-hypertensives' primarily used for lowering high blood pressure (hypertension) by removing extra fluid (electrolytes) from the body. Trisertain 40 Tablet is a combination of three medicines: Olmesartan medoximil, Amlodipine, and Hydrochlorothiazide. Olmesartan medoximil is a prodrug and breaks down into active form, i.e., olmesartan once absorbed in the GIT (Gastrointestinal tract). An angiotensin receptor blocker (ARB) blocks the hormone angiotensin, thereby relaxing and widening the narrowed blood vessels. Amlodipine is a calcium channel blocker; it reduces the heart's workload and makes it more efficient at pumping blood throughout the body. Hydrochlorothiazide is a diuretic or water pill that removes extra water/fluid and certain electrolyte overload from the body. Together, Trisertain 40 Tablet lowers fluid overload, raises blood pressure, improves blood flow, and reduces the future risk of a heart attack and stroke.

• Nausea

• Upset stomach

• Dehydration

• Headache

• Dry mouth

• Muscle cramps/weakness

• Fast/slow/irregular heartbeat

• Diarrhoea

• Electrolyte imbalance

• Headache

• Feeling exhausted

• Swollen ankles

• Dizziness

• Decreased blood pressure

Do not use Trisertain 40 Tablet if you are pregnant, planning for pregnancy, or unable to urinate (anuria). If you have diabetes and taking Trisertain 40 Tablet with other blood pressure-lowering pills like 'aliskiren,' immediately stop taking both together and consult a doctor. Besides this, it is contraindicated in low blood pressure (hypotension), cardiogenic shock (sudden stopping of blood flow to the heart), and aortic stenosis (heart valve problem). Trisertain 40 Tablet may pass into breast milk, so before starting Trisertain 40 Tablet , either you need to stop nursing or you should not take Trisertain 40 Tablet while breastfeeding. Please inform your doctor before surgery if you are taking Trisertain 40 Tablet as it needs to be stopped because it might lower the blood pressure further if taken along with local anaesthesia. Avoid potassium salt or its substitute intake while using Trisertain 40 Tablet to avoid any electrolyte imbalance. Trisertain 40 Tablet can pass into breast milk, but its effect on the baby is unknown. So, it is better to tell your doctor if you take Trisertain 40 Tablet and breastfeeding.

Drug-drug interactions: Trisertain 40 Tablet may interact with an antidepressant (lithium), heart rhythm controlling medicines (digoxin), blood thinner (aspirin), antidiabetic drugs (metformin, insulin), medications used to treat erectile dysfunction (sildenafil), medicines used to lower cholesterol levels (simvastatin), immunosuppressants (cyclosporine), and other anti-hypertensive medicines (atenolol, aliskiren, enalapril, lisinopril, ramipril, metoprolol), pain killers (ibuprofen), medicines for treating stomach ulcers (carbenoxolone).

Drug-food Interactions: Trisertain 40 Tablet may interact with high potassium-containing food and drinks. So, if you are using any of the OTC items, please tell your doctor. Also, alcohol should not be consumed while taking Trisertain 40 Tablet .

Drug-Disease Interactions: The efficacy of Trisertain 40 Tablet is affected, and the disease condition may even worsen if taken in patients with a recent or history of heart attack, low blood pressure, low potassium level, low electrolytes (sodium, potassium, calcium, etc.), anuria (non-passage of urine), angioedema (an allergic condition with swelling under the skin), lupus (an autoimmune disease), kidney disease, liver disease, asthma, diabetes.

• LITHIUM
• DIGOXIN
• ASPIRIN
• METFORMIN
• INSULIN
• SILDENAFIL
• SIMVASTATIN
• CYCLOSPORINE
• ATENOLOL
• ALISKIREN
• ENALAPRIL
• LISINOPRIL
• RAMIPRIL
• METOPROLOL
• IBUPROFEN
• CARBENOXOLONE

• Create a well-balanced and healthy diet that includes vegetables, fruits, whole grains, legumes, omega-3-rich foods, and lean protein sources.

• Keep your weight under control with a BMI of 19.5-24.9.

• Avoid chronic stress, as it can raise your blood pressure.

• Spend time with your loved ones to cope with stress and practice mindfulness techniques.

• Be mindful of salt; consume no more than 2,300 mg each day.

• Limit or avoid alcohol consumption.

• Quitting smoking is the best strategy to lower the risk of heart disease.

Hypertension: It is a chronic condition when blood pressure is too high. This condition can lead to hardened arteries (blood vessels), decreasing the blood and oxygen flow to the heart. Blood pressure is the measurement of the force our heart uses to pump blood to all body parts. Raised blood pressure can cause chest pain (angina) and heart attack (when the blood supply to the heart is blocked). High blood pressure also causes brain damage (stroke) and kidney failure. High blood pressure can be diagnosed with the help of a blood pressure monitor or sphygmomanometer. Systolic pressure is the pressure when the heart pumps blood out. On the other hand, diastolic pressure is when your heart is at the resting stage between heartbeats. If your blood pressure is 140/90 mm of Hg, it means the systolic pressure is 140 mm of Hg, and diastolic pressure is 90 mm of Hg. Ideal blood pressure should be between 90/60 mm of Hg and 120/80 mm of Hg.