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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Triomune 30 Tablet is used to treat HIV infection. It works by inhibiting the reverse transcriptase enzyme which is required for viral reproduction. In some cases, this medicine may cause side effects such as headache, difficulty sleeping, nausea, diarrhoea, dry mouth, fever, and peripheral neuropathy (tingling and numbness of feet and hands). Before taking this medicine, inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.
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Manufacturer/Marketer :

Cipla Ltd

Consume Type :

ORAL

Return Policy :

3 Days Returnable

Expires on or after :

Jan-27

About Triomune 30 Tablet

Triomune 30 Tablet belongs to the class of medications called ‘antiretroviral agents’ used in the treatment of HIV infection. HIV is a virus that attacks the immune cells of the body leading to decreased immunity. It spreads through body fluids such as semen, vaginal fluid, and blood. Symptoms include fever, chills, rash, night sweats, muscle aches, tiredness and sore throat that usually last for days to several weeks.

Triomune 30 Tablet is a combination of three medicines: Stavudine, lamivudine and nevirapine. They work by inhibiting the reverse transcriptase enzyme from working, which is required by the HIV-infected cells to make new viruses. This effect helps to inhibit viral replication.

You should take this medicine exactly as prescribed by the doctor. Triomune 30 Tablet may cause side effects such as headache, insomnia (difficulty in sleeping), nausea, diarrhea, dry mouth, fever, rash, and peripheral neuropathy (tingling and numbness of feet and hands). Inform your doctor if any of these side effects persist or get worse.

It is not recommended to take Triomune 30 Tablet if you are allergic to any contents of it. Before taking Triomune 30 Tablet , inform your doctor if you have any liver disease, hepatitis B or C (liver infections), a history of mental illness, seriously overweight and have kidney disease. Inform your doctor if you are pregnant or breastfeeding. Triomune 30 Tablet should be used with caution in children and elderly patients. Alcohol consumption may increase the risk of side effects. Triomune 30 Tablet may cause dizziness, so do not drive or operate heavy machinery if you feel dizzy.

Uses of Triomune 30 Tablet

Treatment of HIV infection

Directions for Use

Take Triomune 30 Tablet with food or after a meal as advised by the doctor. Swallow it as a whole with a glass of water. Do not crush, chew or break it.

Medicinal Benefits

Triomune 30 Tablet belongs to the group of medicines called antiretroviral therapy (ART). Triomune 30 Tablet contains stavudine, lamivudine, and nevirapine. Triomune 30 Tablet work by inhibiting the reverse transcriptase enzyme from working, which is required by the HIV-infected cells to make new viruses. Thereby preventing viral replication and controlling the infection. It helps in improving the quality of life of a patient with HIV.

How Triomune 30 Tablet Works

Triomune 30 Tablet is a combination of three medicines: Stavudine, lamivudine and nevirapine. They work by inhibiting the reverse transcriptase enzyme from working, which is required by the HIV-infected cells to make new viruses. This effect helps to inhibit viral replication.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Triomune 30 Tablet

  • Headache
  • Tiredness
  • Insomnia (difficulty in sleeping)
  • Diarrhea
  • Dryness in mouth
  • Fever
  • Peripheral neuropathy (tingling and numbness of feet and hand)

What if I have taken an overdose of Triomune 30 Tablet

Take Triomune 30 Tablet only as prescribed by the physician. Do not exceed the recommended dose, as it might cause an overdose. If you suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

Inform your doctor if you develop persistent diarrhea or vomiting, as it may affect the effectiveness of Triomune 30 Tablet . Triomune 30 Tablet may cause pancreatitis (inflammation of the pancreas), so inform your doctor if you develop symptoms such as nausea (feeling sick), vomiting or stomach pain. Triomune 30 Tablet may lead to opportunistic infections (infections that occur frequently or severely in patients with weak immune systems), so inform your doctor immediately if you experience symptoms of infection such as muscle weakness, weakness beginning in the hands and feet that progress towards the trunk, palpitations (pounding heartbeat) and tremors. Triomune 30 Tablet may destroy bone leading to symptoms such as joint stiffness or pain. It may also cause muscle pain, tenderness, or weakness. Speak with your doctor about the precautions to follow to avoid infecting other people as one can still pass on HIV while on this medicine, although the risk is somewhat lowered by antiretroviral therapy, it can spread through sexual contact with a person who already has the infection or by transfer of infected blood. Triomune 30 Tablet does not cure HIV infection. Triomune 30 Tablet can make hormonal contraceptives less effective or less likely to work. So, use other effective methods for contraception, including a barrier form (cervical cap, condom, diaphragm, or contraceptive sponge) to prevent pregnancy as advised by your doctor. Do not breastfeed while taking this medicine. Triomune 30 Tablet is not recommended in pregnancy as could harm the unborn baby or cause birth defects. You may need frequent medical tests while on Triomune 30 Tablet .

Drug-Drug Interactions

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NevirapineAtazanavir
Critical
NevirapineRanolazine
Critical

Drug-Drug Interactions

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NevirapineAtazanavir
Critical
How does the drug interact with Triomune 30 Tablet 30's:
When Atazanavir is taken with Triomune 30 Tablet 30's, it can reduce the levels and side effects of atazanavir & increase the blood levels and effects of Triomune 30 Tablet 30's.

How to manage the interaction:
Taking Triomune 30 Tablet 30's with Atazanavir is generally avoided as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience a rash on any parts of your body, loss of appetite, nausea, vomiting, jaundice (yellowing of the skin and/or eyes), dark-coloured urine, pale-coloured stools, or pain or ache in the right abdominal area below your ribs, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
NevirapineRanolazine
Critical
How does the drug interact with Triomune 30 Tablet 30's:
Co-administration of Triomune 30 Tablet 30's with Ranolazine may significantly reduce the blood levels of Ranolazine. This can lead to low treatment outcomes.

How to manage the interaction:
Taking Triomune 30 Tablet 30's with Ranolazine is generally avoided as it can lead to an interaction, they can be taken together if advised by a doctor. However, contact a doctor if you experience any symptoms. Do not stop taking any medications without consulting a doctor.
LamivudineEmtricitabine
Critical
How does the drug interact with Triomune 30 Tablet 30's:
Combining these two medications may reduce overall effectiveness due to potential antagonistic effects (opposite actions).

How to manage the interaction:
Taking Emtricitabine with Triomune 30 Tablet 30's is not recommended, but it can be taken if your doctor prescribes it. Contact your doctor if your symptoms do not improve. Do not stop taking any medication without consulting your doctor.
NevirapineHydrocodone
Severe
How does the drug interact with Triomune 30 Tablet 30's:
Co-administration of Triomune 30 Tablet 30's with Hydrocodone may reduce the blood levels of Hydrocodone. This can lead to low treatment outcomes.

How to manage the interaction:
Co-administration of Triomune 30 Tablet 30's with Hydrocodone can result in an interaction, but it can be taken if your doctor has advised it. If you're having any of these symptoms like pain, watery eyes, runny nose, sneezing, yawning, sweating, fever, chills, restlessness, irritability, anxiety, depression, big pupils, shaking, fast heartbeat, twitching, loss of appetite, feeling sick, throwing up, diarrhoea, losing weight or taking too much medicine, it's important to contact a doctor right away. Do not stop using any medications without a doctor's advice.
NevirapineOlaparib
Severe
How does the drug interact with Triomune 30 Tablet 30's:
When Olaparib is taken with Triomune 30 Tablet 30's may reduce the blood levels of Olaparib. This can lead to low treatment outcomes.

How to manage the interaction:
There may be a possibility of interaction between Triomune 30 Tablet 30's and Olaparib, but it can be taken if prescribed by a doctor. Do not discontinue any medications without first consulting a doctor.
NevirapineDolutegravir
Severe
How does the drug interact with Triomune 30 Tablet 30's:
Taking dolutegravir with Triomune 30 Tablet 30's can reduce the effectiveness of dolutegravir.

How to manage the interaction:
Although taking Dolutegravir and Triomune 30 Tablet 30's together can possibly result in an interaction, they can be taken together if prescribed by your doctor. Do not discontinue using any medications without consulting a doctor.
NevirapineUlipristal
Severe
How does the drug interact with Triomune 30 Tablet 30's:
When Ulipristal is taken with Triomune 30 Tablet 30's may reduce the blood levels of Ulipristal. This can lead to low treatment outcomes.

How to manage the interaction:
Although taking Triomune 30 Tablet 30's and Ulipristal together can cause an interaction, it can be taken if your doctor has suggested it. Do not discontinue any medications without consulting a doctor.
NevirapineRifampicin
Severe
How does the drug interact with Triomune 30 Tablet 30's:
Taking Triomune 30 Tablet 30's with rifampicin can decrease the blood levels of Triomune 30 Tablet 30's, which may make the medication less effective.

How to manage the interaction:
Although there is an interaction between Triomune 30 Tablet 30's and rifampicin, they can be taken together if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.
NevirapineLeflunomide
Severe
How does the drug interact with Triomune 30 Tablet 30's:
Coadministration of Triomune 30 Tablet 30's and leflunomide can increase the risk of liver problems.

How to manage the interaction:
Although there is an interaction between leflunomide and Triomune 30 Tablet 30's, they can be taken together if prescribed by a doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, or yellowing of the skin or eyes, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
NevirapineMipomersen
Severe
How does the drug interact with Triomune 30 Tablet 30's:
Coadministration of Triomune 30 Tablet 30's and Mipomersen can increase the risk and severity of liver problems.

How to manage the interaction:
Although taking Triomune 30 Tablet 30's and Mipomersen together can evidently cause an interaction, it can be taken if your doctor has suggested it. If you have any symptoms like fever, chills, joint pain, swelling, bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark urine, or bleeding make sure to contact your doctor immediately. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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STAVUDINE-30MG+LAMIVUDINE-150MG+NEVIRAPINE-200MGHigh fat foods
Mild

Drug-Food Interactions

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STAVUDINE-30MG+LAMIVUDINE-150MG+NEVIRAPINE-200MGHigh fat foods
Mild
Common Foods to Avoid:
Frozen Meals, Cheese, Red Meat, Potato Chips, Hamburgers, Hot Dogs, Ice Cream

How to manage the interaction:
Taking Triomune 30 Tablet 30's with high fatty foods can reduce the effectiveness of Triomune 30 Tablet 30's Avoid taking high-fat food while taking Triomune 30 Tablet 30's, as this can lead to interaction.

Diet & Lifestyle Advise

  • Eat a healthy and balanced diet. Eat vitamin and nutrient-rich food such as dark green, yellow, orange and red vegetables, and fruit as it helps to boost your immune system. Option for lean protein and whole grains.
  • Avoid eating raw meat and eggs. Consume properly boiled and cooked meat, poultry or seafood.
  • Eat bland and low-fat foods and avoid spicy or oily foods if you experience nausea or vomiting.
  • Try to reduce emotional and physical stress by spending time with family or whatever makes you happy.
  • Drink more fluids and avoid alcoholic beverages to prevent dehydration. 
  • Wash your hands properly before and after eating.
  • Make sure you sleep at least 8 hours a day.

Habit Forming

No

Therapeutic Class

ANTIRETROVIRAL AGENTS

Triomune 30 Tablet Substitute

Substitutes safety advice
  • Nevilast 30 Tablet 60's

    17.42per tablet
  • Emtri Tablet 60's

    14.26per tablet
  • Nevilast 30 mg Tablet 10's

    17.37per tablet
  • VIROLANS 30MG TABLET

    10.72per tablet
  • Nevilast 30EP Tablet 30's

    34.83per tablet
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Alcohol

Caution

Avoid drinking alcohol while on Triomune 30 Tablet as it may increase the risk of liver damage.

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Pregnancy

Caution

Triomune 30 Tablet should be used with caution in pregnant women. It is given only if clinically needed and when benefits outweigh the risk.

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Breast Feeding

Caution

If Triomune 30 Tablet is prescribed during breastfeeding, the doctor may advise you to stop breastfeeding as this medicine can pass into breast milk.

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Driving

Caution

Triomune 30 Tablet may cause dizziness, so do not drive or operate heavy machinery if you feel dizzy.

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Liver

Caution

Triomune 30 Tablet should be used with caution in patients with liver diseases. The dose may have to be adjusted by your doctor.

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Kidney

Caution

Triomune 30 Tablet should be used with caution in patients with kidney diseases. The dose may have to be adjusted by your doctor.

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Children

Caution

Dose adjustment may be necessary for use in children when prescribed by a child specialist.

FAQs

Triomune 30 Tablet is used to treat HIV infection.
Triomune 30 Tablet is a combination of three medicines: Stavudine, lamivudine and nevirapine. These three drugs work by inhibiting the reverse transcriptase enzyme from working, which is required by the HIV-infected cells to make new viruses. Thereby preventing viral replication and controlling the infection.
Triomune 30 Tablet may cause side-effects such as muscle pain and discomfort, difficulty in sleeping, stomach pains, allergic reactions, feeling sick, vomiting, inflammation of the liver, changes in the shape or location of body fat. Inform your doctor if any of these side-effects persist or get worse.
Triomune 30 Tablet may cause lactic acidosis (excess of lactic acid in the blood), a rare but a severe side effect, especially in women who are very obese. However, if you experience stomach pain, vomiting or nausea while taking Triomune 30 Tablet , please consult a doctor immediately.
Triomune 30 Tablet doesn’t cure HIV infection. However, it helps to control the disease and prevent opportunistic infections.
No, Triomune 30 Tablet should be taken in the dose and duration as advised by the doctor. If you take it in more than the recommended dose, it might cause unpleasant side effects. If you think your symptoms are not improving, please consult your doctor.
If you miss a dose of Triomune 30 Tablet , take the missed dose as soon as you remember it. However, if it's almost time for the next dose, do not take a double dose to make up for a missed one.
Do not stop taking Triomune 30 Tablet without talking to your doctor. If you suddenly stop taking Triomune 30 Tablet , you may experience confusion, fever, mental state changes or severe muscle stiffness. Your doctor will probably decrease your dose gradually depending upon your disease condition.

Country of origin

India

Manufacturer/Marketer address

Cipla House, Peninsula Business Park, Ganpatrao Kadam Marg, Lower Parel, Mumbai-400013
Other Info - TRI0064

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