Trilopace Tablet is an 'anti-hypertensive' medication primarily used in the treatment of high blood pressure (hypertension). High blood pressure or hypertension is a chronic condition in which the blood's force against the walls of blood vessels, is consistently too high. As a result, this can ultimately lead to heart-related conditions like heart failure, stroke, and irregular heartbeat.

Trilopace Tablet is a combination of three medicines namely: Amlodipine, Hydrochlorothiazide, and Losartan. Amlodipine belongs to class medicines known as calcium channel blocker that dilates (widens) blood vessels and increases blood flow. It helps to lower blood pressure, reduce chest pain (angina), and other complications caused by coronary artery disease. Hydrochlorothiazide is a diuretic or water pill that works by removing extra water/fluid and certain electrolytes overload from the body. Losartan belongs to class medicines known as angiotensin receptor blocker (ARB) that works by blocking the hormone angiotensin, thereby relaxing and widening the narrowed blood vessels. This allows the blood to flow more smoothly in the blood vessels, and the heart can pump more efficiently. Thus, all together Trilopace Tablet helps in controlling high blood pressure.

You may experience nausea, altered taste, diarrhea, stomach upset, dizziness, flushing (sense of warmth in the face, ears, neck, and trunk), headache, numbness (lost, reduced, or altered sensation) of extremity in some cases. Most of these side effects of Trilopace Tablet do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

Do not use potassium supplements or salt substitutes unless the doctor has told you. If you notice unexplained muscle pain, dark color urine, tenderness, or weakness, especially if you also have a fever or unexplained tiredness, immediately contact the doctor. Try not to stop taking this medicine on your own. Let your doctor know about this, as stopping abruptly may provoke rapid upswings in blood pressure. Inform your doctor before starting this medication course if you are suffering from kidney, liver, or heart disease. Pregnant and breastfeeding women should not take Trilopace Tablet without proper consultation or inputs from their OB/GYN.

Trilopace Tablet is a combination of three medicines, namely: Amlodipine, Hydrochlorothiazide, and Losartan. Amlodipine belongs to class medicines known as calcium channel blockers. Amlodipine is known to work by inhibiting the entry of calcium ions across cardiac (heart) and smooth muscle causing relaxation and dilation (widening) of these muscles. Amlodipine does not change serum calcium concentrations. Hydrochlorothiazide is a diuretic or water pill. Hydrochlorothiazide works by inhibiting the sodium chloride transport in the distal convoluted tubule (a portion of the kidney nephron). Along with accompanying fluid, more sodium is then excreted in the kidney. This increases the flow of urine and reduces the amount of water in the body, thereby helps in lowering blood pressure. Losartan is an angiotensin receptor blocker (ARB) that works by blocking the hormone angiotensin, thereby relaxing and widening the narrowed blood vessels. This allows the blood to flow more smoothly in the blood vessels, and the heart can pump more efficiently. Thus, all together Trilopace Tablet helps in controlling high blood pressure.

• Nausea
• Altered taste
• Stomach upset
• Dizziness
• Decreased blood pressure
• Diarrhoea
• Headache

Do not use Trilopace Tablet if you are pregnant, planning for pregnancy, or if you are unable to urinate (anuria). Trilopace Tablet may pass into breast milk, so before starting Trilopace Tablet , either you need to stop nursing, or you should not take Trilopace Tablet while breastfeeding. Please inform your doctor/surgeon before surgery that you are on Trilopace Tablet as it needs to be stopped because it might lower the blood pressure further if taken along with certain anesthesia medication. Avoid intake of potassium salt or its substitute while using Trilopace Tablet to avoid any electrolytes imbalance. Trilopace Tablet should be used with extreme caution in patients with liver, kidney, cardiovascular diseases and diabetic patients. Use only if the potential benefit justifies the potential risk. Your doctor will weigh the benefits and any potential risks before prescribing it to you.

Drug-Drug interaction: This medicine may interact with depression medication (lithium, duloxetine), anxiety medication (alprazolam), antidiabetic medicines (metformin), and other anti-hypertensive medicines(metoprolol), pain killers (ibuprofen, aspirin).

Drug-Food Interaction: No interactions found/established.

Drug-Disease Interaction: The efficacy of Trilopace Tablet is affected, and the disease condition may even worsen if taken in patients with a recent or history of heart attack, kidney disease, liver disease, anuria (unable to urinate), asthma, pregnant women, or planning to get pregnant and breastfeeding women, diabetes.

• LITHIUM
• DULOXETINE
• ALPRAZOLAM
• METFORMIN
• METOPROLOL
• ASPIRIN
• IBUPROFEN

• Do regular physical activity or exercise for at least 150 minutes per week, or about 30 minutes most days of the week. Doing this can help you to lower your raised blood pressure by about 5 mm of Hg.
• Keep your weight under control with BMI of 19.5-24.9.
• Limit intake of sodium chloride (table salt) in your daily diet to 2300 mg per day or less than 1500 mg is ideal for most adults.
• Quitting smoking is the best strategy to lower the risk of heart disease.
• Avoid chronic stress as it can raise your blood pressure. Try to enjoy and spent time with your loved ones to cope with stress and practice mindfulness techniques.
• Monitor your blood pressure daily and if there is too much fluctuation, then immediately contact your doctor.
• Try to include heart-healthy omega 3 fatty acids-containing food drinks in your daily diet. You can also use low-fat cooking oil like olive oil, soybean oil, canola oil, and coconut oil to lower your elevated blood pressure.
• Option for a diet rich in whole grains, fruits, veggies, and low-fat dairy products.

Keep a check on your daily blood pressure, and if you notice any fluctuations, please consult a doctor. A low salt/sodium diet and regular exercise are recommended along with Trilopace Tablet for effective results.

Hypertension: It is a chronic condition when blood pressure is consistently measures >130 mmHg systolic and >80 mmHg diastolic. Hypertension can lead to hardened arteries (blood vessels), decreasing the blood and oxygen flow to the heart. Blood pressure is the measurement of the force that our heart uses to pump blood to all parts of the body. Raised blood pressure can cause chest pain (angina) and heart attack (when blood supply to the heart is blocked). Additionally, high blood pressure also causes brain damage (stroke) and kidney failure. High blood pressure can be diagnosed with the help of a blood pressure monitor or sphygmomanometer. Systolic pressure is the pressure when the heart pumps blood out. Diastolic pressure is when the heart is at the resting stage between heartbeats. If your blood pressure is 140/90 mm of Hg, it means the systolic pressure is 140 mm of Hg, and diastolic pressure is 90 mm of Hg. Ideal blood pressure should be between 90/60 mm of Hg and 120/80 mm of Hg.