TORISEL 25MG INJECTION

TORISEL 25MG INJECTION belongs to the group of anti-cancer medicines called kinase inhibitors used to treat advanced renal cell carcinoma (a type of cancer that begins in the kidney). It may also be used for previously treated mantle cell lymphoma (a type of cancer affecting the lymph nodes).

TORISEL 25MG INJECTION contains Temsirolimus, which works by blocking the action of abnormal proteins needed for cancer cells to multiply. This helps slow the growth of tumours. Thereby, it helps treat kidney cancer.

In some cases, TORISEL 25MG INJECTION may cause side effects such as diarrhoea, nausea, vomiting, constipation, headache, fever, and decreased appetite. Most of these side effects may not require medical attention and resolve over time. Do not be reluctant to talk with your doctor if any of these side effects persist or worsen.

Consult the doctor if you are pregnant or breastfeeding. TORISEL 25MG INJECTION is not recommended for children below 18 years as the effectiveness has not been established. Keep your doctor informed about your health condition and medications to rule out any side effects/interactions.

TORISEL 25MG INJECTION belongs to the group of anti-cancer medicines called kinase inhibitors used to treat advanced renal cell carcinoma (a type of cancer that begins in the kidney). It may also be used for previously treated mantle cell lymphoma (a type of cancer affecting the lymph nodes). TORISEL 25MG INJECTION contains Temsirolimus, a selective inhibitor of the enzyme mTOR (mammalian target of rapamycin) that blocks tumour cell growth and division. Thereby, it helps treat kidney cancer.

• Nausea
• Vomiting
• Diarrhoea
• Constipation
• Headache
• Fever
• Loss of appetite
• Sores or inflammation in the mouth
• Cough

Do not use TORISEL 25MG INJECTION if you are allergic to any of its components if you are allergic to sirolimus (immunosuppressant), or if you have mantle cell lymphoma or liver problems. Inform the doctor if you are allergic to or cannot use anti-histamines if you have/had a tumour in the brain or spinal cord, bruising/bleeding problems, infections, inflammation of lungs, liver or kidney problems, high cholesterol levels, diabetes, eye problems, if you are taking anticoagulants if you drink alcohol or are alcoholic if you are due to undergo any vaccination or surgery, or if you are over 65 years of age. Consult the doctor if you are pregnant or breastfeeding. TORISEL 25MG INJECTION is not recommended for children below 18 years as the effectiveness has not been established.

Drug-Drug Interactions: Inform the doctor if you are taking protease inhibitors, antibiotics (rifampicin), anti-fungal (itraconazole, ketoconazole, voriconazole), anti-depressant (nefazodone), anti-epileptics (carbamazepine, phenytoin, phenobarbital), anti-HIV (rifabutin), herbal medicine (St. John’s wort), ACE inhibitors (enalapril, ramipril, lisinopril), calcium channel blocker (amlodipine), anti-arrhythmic agents (amiodarone), medicines for high cholesterol (statins), or chemotherapy agent (sunitinib).

Drug-Food Interactions: Avoid grapefruit/grapefruit juice while on treatment with TORISEL 25MG INJECTION as these might increase the amount of TORISEL 25MG INJECTION in blood.

Drug-Disease Interactions: Inform the doctor if you have diabetes, high cholesterol, kidney, lung, or liver problems, tumours in the brain or spinal cord, bowel perforation, bleeding problems, or wound healing complications.

• RIFAMPICIN
• ITRACONAZOLE
• KETOCONAZOLE
• VORICONAZOLE
• NEFAZODONE
• CARBAMAZEPINE
• PHENYTOIN
• PHENOBARBITAL
• RIFABUTIN
• ST JOHN'S WORT
• ENALAPRIL
• RAMIPRIL
• LISINOPRIL
• AMLODIPINE
• AMIODARONE
• SUNITINIB

• Eat a healthy diet and exercise regularly to maintain proper weight.
• Avoid smoking and alcohol consumption.
• Include vegetables, whole grains and fruits in your diet.
• Avoid fast, fried foods, processed meats, highly processed foods and beverages, and salty snacks.
• Get optimal sleep; rest well.

Females of reproductive potential and males with partners of reproductive potential must use effective contraception during treatment and for three months after the last dose.

Renal cell carcinoma: Renal cell carcinoma, also known as kidney cancer or renal cell adenocarcinoma, is a type of cancer in which cancer cells are found in the lining of tubules in the kidney. Smoking and certain pain medicines may affect the risk of renal cell cancer. Symptoms include blood in the urine, a lump in the abdomen, pain in the side that does not go away, anaemia, loss of appetite, and weight loss for no known reason.