Topride 2 Tablet belongs to a class of antidiabetic called 'sulfonylureas' used to lower raised blood sugar levels in Type 2 diabetes mellitus (non-insulin-dependent diabetes mellitus - NIDDM). Type 2 diabetes develops if the body does not produce enough insulin or when your body's insulin does not work as well as it should. Insulin is a substance that helps to lower the level of sugar in your blood, especially after meals.

The Topride 2 Tablet contains Glimepiride which acts on insulin-secreting cells called beta cells inside the pancreas and activates calcium channels on cells which lets insulin pass out of the cell. This insulin then makes each cell in the body take up glucose and utilize it, thus lowering raised blood glucose. Therefore, it prevents symptoms of type 2 diabetes.

Take Topride 2 Tablet as prescribed by your doctor. Some people may experience an allergic reaction (skin rash, hives & sensitivity to sun rays), liver dysfunction (jaundice, bile duct blockage, and hepatitis), seizures, coma & low glucose levels. Most of these side effects of Topride 2 Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor. 

Topride 2 Tablet should not be stopped even if you feel better without consulting your doctor as the sugar level keeps changing. If you stop taking Topride 2 Tablet abruptly, it may increase your sugar levels which could further increase the risk of eyesight loss (retinopathy), kidney (nephropathy) and nerve damage (neuropathy). Topride 2 Tablet should not be taken if you have type 1 diabetes mellitus or severe kidney or liver disease. Please inform your doctor if you have any heart disease or plan to get pregnant or breastfeed.

Topride 2 Tablet is used in people with type 2 diabetes to minimize elevated blood sugar levels with a balanced diet and exercise in combination. Topride 2 Tablet  can be combined with insulin or other forms of oral antidiabetic medication. Topride 2 Tablet decreases blood sugar levels in a diabetic patient by increasing the production and secretion of insulin from the pancreas beta cells. Thus, it helps in controlling increased blood sugar levels after the meal.

• Allergic reactions

• Headache

• Nausea

• Blood pressure drop

• Shock

• Abnormal liver function

• Including skin and eye yellowing (jaundice)

• Bile flow issues (cholestasis)

• Liver inflammation (hepatitis) or failure of the liver

Before taking Topride 2 Tablet , inform your doctor if you are healing from injury, had or going to have surgery, have fever infections or other sources of stress, then contact your doctor as it might be appropriate to adjust care temporarily. If you have a serious kidney/liver disease, breastfeeding or pregnant, consult the doctor before using Topride 2 Tablet . Do not take Topride 2 Tablet if you are allergic to sulpha drugs, glimepiride, or any other antidiabetic medicines or have a deficiency of glucose 6-phosphate dehydrogenase (G6PD). A heart disease patient should consult a doctor before taking the Topride 2 Tablet as it may worsen the heart disease's current conditions. Do not take Topride 2 Tablet with oral contraceptives as it may increase blood sugar levels. On the other hand, taking Topride 2 Tablet with pain killers like aspirin or ibuprofen can lower your blood sugar.

Drug-Drug interactions: Topride 2 Tablet interacts with Vitamins D3, Vitamin C, Vitamin B12, antidiabetic drugs (liraglutide, rosuvastatin, dapagliflozin, metformin, glyburide, insulin, canagliflozin, sitagliptin, empagliflozin), blood pressure-lowering drugs (furosemide, atorvastatin), pain killers (aspirin, ibuprofen, naproxen) & blood thinners (clopidogrel, warfarin).

Drug-Food interactions: Topride 2 Tablet should not be taken with Fish Oil (omega-3 polyunsaturated fatty acids) & alcohol. Alcohol intake can increase or decrease the blood sugar reduction action of Topride 2 Tablet . 

Drug-Disease interactions: Patients with liver/kidney function disorder, heart diseases, low blood sugar, G6PD deficiency and electrolytes imbalance (like low sodium levels in the blood) should avoid intake of Topride 2 Tablet .

• ASPIRIN
• ROSUVASTATIN
• DULOXETINE
• DAPAGLIFLOZIN
• GLYBURIDE
• INSULIN
• CANAGLIFLOZIN
• SITAGLIPTIN
• EMPAGLIFLOZIN
• FUROSEMIDE
• ATORVASTATIN
• PREGABALIN
• METFORMIN
• NAPROXEN
• CLOPIDOGREL
• IBUPROFEN
• WARFARIN

• Do regular exercise such as cycling, walking, jogging, dancing or swimming for a minimum of 30 minutes per day. Invest at least 150 minutes of your week in exercise.

• Maintain healthy body weight as obesity is also related to the onset of diabetes.

• Maintain a low fat and a low sugar diet. Replace carbohydrates containing foods with whole grains, fruits and vegetables as carbohydrates turn to sugars leading to high blood sugar.

• Avoid consumption of alcohol and quit smoking.

Type 2 diabetes: It is a chronic (long-lasting) condition that keeps the body from properly utilizing insulin. Hence, people affected with type 2 diabetes either do not produce enough insulin, or there is resistance to the action of insulin. Middle-aged or older are most likely to suffer from type 2 diabetes, so it is also known as adult-onset diabetes. Symptoms of type 2 diabetes include increased thirst, frequent urination at night, slow wound healing, increased hunger, fatigue, and blurred vision. In some cases, there may be weight gain while in rare cases weight loss may be observed. The complication of type 2 diabetes also includes nerve problems, kidney problems, the damaged retina of eyes or blindness, loss of limbs, sexual dysfunction, and an increased chance of heart attack or stroke.