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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Last Updated Jan 1, 2025 | 2:45 PM IST
Topoquis 4 mg Injection 4 ml contains topotecan which is used in the treatment of ovarian and small cell lung cancer. It is an anticancer medicine which works by binding to the cell's DNA, and stops it from naturally dividing and functioning, ultimately destroying it. This medicine can sometimes be used for treating other cancer conditions aswell. Common side effects inculde nausea, diarrhoea, vomiting, thrombocytopenia (a low platelet count), peripheral neuropathy and electrolyte disturbance.
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Composition :

TOPOTECAN-4MG

Manufacturer/Marketer :

Fresenius Kabi India Pvt Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

About Topoquis 4 mg Injection 4 ml

Topoquis 4 mg Injection 4 ml belongs to a group of medicines called 'anti-cancer/anti-neoplastic agents', used to treat ovarian and small cell lung cancer. On the other hand, it may use to treat advanced cervical cancer if surgery or radiotherapy treatment is not possible. It may sometimes be used to treat other cancers. Ovarian cancer begins in the ovaries (a pair of female reproductive glands in which the ova, or eggs, are formed). Small-cell lung cancer is a disease in which malignant (cancer) cells form in the lung tissues.

Topoquis 4 mg Injection 4 ml contains 'Topotecan'. It works by penetrating into the cell wall and binding to the cell's DNA, stopping it from naturally dividing and functioning, ultimately destroying it. These medicines target cancer cells because they often affect rapidly dividing cells.

The amount of medicine that you will receive depends on many factors, including your height and weight, your general health or other health problems, and the type of cancer or condition being treated. Your doctor will determine your dose and schedule. Topoquis 4 mg Injection 4 ml is prescribed by a doctor experienced in the use of medications to treat cancer. You may sometimes experience nausea, diarrhoea, vomiting, thrombocytopenia (a low platelet count), peripheral neuropathy (nerves malfunction), nephrotoxicity at high doses, and electrolyte disturbances. Most of these side effects of Topoquis 4 mg Injection 4 ml do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

To treat your condition effectually, continue taking Topoquis 4 mg Injection 4 ml for as long as your doctor has prescribed. Do not stop using the Topoquis 4 mg Injection 4 ml midway. Talk to your doctor before taking Topoquis 4 mg Injection 4 ml if you have severe allergic reactions to Topoquis 4 mg Injection 4 ml or other medicines or suffer from severe lung problems, Infections, renal dysfunction, hepatic disorders and blood cell counts are too low. Avoid taking Topoquis 4 mg Injection 4 ml if you are pregnant or breastfeeding because this Topoquis 4 mg Injection 4 ml can cause harmful effects on the unborn baby. Both women and men using this Topoquis 4 mg Injection 4 ml should use birth control to avoid pregnancy.

Uses of Topoquis 4 mg Injection 4 ml

Treatment of Ovarian cancer and Small cell lung cancer

Medicinal Benefits

Topoquis 4 mg Injection 4 ml contains 'Topotecan', which belongs to a group of anti-cancer medicines used to treat ovarian cancer and small cell lung cancer. It works by damaging the genetic material (DNA) of the cancer cells, which stops their growth and multiplication. It can be used alone or together with other chemotherapy drugs depending on the type of cancer you have.

Side Effects of Topoquis 4 mg Injection 4 ml

  • Feeling generally weak and tired (temporary anaemia)
  • Low white blood cell count (neutropenia)
  • Unusual bruising or bleeding
  • Weight loss and loss of appetite (anorexia)
  • Tiredness
  • Weakness
  • Feeling sick (nausea)
  • Being sick (vomiting)
  • Diarrhoea
  • Stomach pain
  • Constipation
  • Inflammation and ulcers of the mouth, tongue or gums
  • Inflammation and ulcers of the mouth, tongue or gums
  • High body temperature (fever)
  • Hair loss
  • Headache
  • Allergic or hypersensitivity reactions (rash)
  • Yellow skin
  • Itching sensation
  • Feeling unwell (malaise)
  • Deficiency of the blood (pancytopenia)

Directions for Use

Topoquis 4 mg Injection 4 ml will be administered by a qualified healthcare professional. Hence, do not self-administer.

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

Topoquis 4 mg Injection 4 ml will be administered by a healthcare professional. To treat your condition effectually, continue taking Topoquis 4 mg Injection 4 ml for as long as your doctor has prescribed. Do not stop Topoquis 4 mg Injection 4 ml midway. Talk to your doctor before taking Topoquis 4 mg Injection 4 ml if you have severe allergic reactions to Topoquis 4 mg Injection 4 ml or other medicines or suffer from severe lung problems, Infections, renal dysfunction, thrombocytopenia (a low platelet count), neutropenia (low white blood cell count), hepatic disorders. Topoquis 4 mg Injection 4 ml should not be employed in patients with severe bone marrow depression or significant bleeding. Avoid taking Topoquis 4 mg Injection 4 ml if you are pregnant or breastfeeding because this Topoquis 4 mg Injection 4 ml can cause harmful effects on the unborn baby. Both women and men using this Topoquis 4 mg Injection 4 ml should use birth control to avoid pregnancy. Peripheral blood counts should be frequently monitored during Topoquis 4 mg Injection 4 ml treatment and appropriate until recovery is achieved. Do not receive any kind of immunization or vaccination without your doctor's approval while taking the Topoquis 4 mg Injection 4 ml.

Therapeutic Class

ANTINEOPLASTIC

Drug-Drug Interactions

verifiedApollotooltip
TopotecanCarboplatin
Severe
TopotecanEtanercept
Severe

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Diet & Lifestyle Advise

  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
  • Performing yoga may also help in improving both physical and mental health.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Eat a healthy diet and exercise regularly to maintain proper weight.
  • Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, and herbs.
  • Get optimal sleep; rest well.
  • Avoid smoking and alcohol consumption.
  • Avoid fast food, fried food, processed meats, refined carbs and added sugars.

Habit Forming

No

How Topoquis 4 mg Injection 4 ml Works

Topoquis 4 mg Injection 4 ml contains 'Topotecan'. It works by penetrating into the cell wall and binding to the cell's DNA, stopping it from naturally dividing and functioning, ultimately destroying it. These medicines target cancer cells because they often affect rapidly dividing cells.

What if I have taken an overdose of Topoquis 4 mg Injection 4 ml

Topoquis 4 mg Injection 4 ml is a parenteral formulation, hence the chance of overdose may be less. However, keep track of your medicine as an overdose of Topoquis 4 mg Injection 4 ml may cause serious side effects such as myelosuppression, increased hepatic enzymes, etc. Seek immediate medical attention if you observe any of these side effects. If an overdose is suspected, observe the patient.
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Alcohol

Unsafe

Avoid alcohol consumption while on treatment with Topoquis 4 mg Injection 4 ml.

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Pregnancy

Unsafe

Topoquis 4 mg Injection 4 ml should not be used during pregnancy because it can harm your fetus (newborn baby). Both women of childbearing potential and men must use an effective contraception method while taking Topoquis 4 mg Injection 4 ml and at least for six months later treatment. Your doctor will weigh the benefits and risks before prescribing this medicine.

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Breast Feeding

Unsafe

Topoquis 4 mg Injection 4 ml should not be used during breastfeeding as it passes into the breastmilk and may harm your baby. Hence, if you are breastfeeding, inform your doctor before receiving this medicine.

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Driving

Caution

Topoquis 4 mg Injection 4 ml may affect your reactions and your ability to drive.Note: Possible side effects of chemotherapy with Topoquis 4 mg Injection 4 ml may occur, such as nausea and vomiting. If you are affected by these side effects, do not drive and/or operate machines that require your alertness.

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Liver

Caution

If you have had a history or evidence of liver impairment, please inform your doctor before taking the Topoquis 4 mg Injection 4 ml. Your doctor may adjust the dose or prescribe a suitable alternative if necessary based on your condition.

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Kidney

Caution

If you have had a history or evidence of kidney diseases, please inform your doctor before taking the Topoquis 4 mg Injection 4 ml. Your doctor may adjust the dose or prescribe a suitable alternative if necessary based on your condition.

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Children

Unsafe

The safety and effectiveness of Topoquis 4 mg Injection 4 ml in pediatric patients have not been established. Please consult your doctor. Your doctor will weigh the benefits and any potential risks before prescribing this medicine.

Country of origin

India

Manufacturer/Marketer address

Fresenius Kabi Ag , Else-Krã¶Ner-Straãÿe 1 , 61352 Bad Homburg , Germany
Other Info - TOP0558

Author Details

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FAQs

Topoquis 4 mg Injection 4 ml belongs to a group of medicines called anti-cancer drugs used in the treatment of ovarian cancer and small cell lung cancer. It is also used to treat advanced cervical cancer if surgery or radiotherapy treatment is not possible.
Topoquis 4 mg Injection 4 ml contains 'Topotecan'. Topotecan works by breaching the cellular wall and binding to the cell’s DNA, preventing the cell from dividing and functioning normally, which eventually kills the cell.
If you are allergic to topotecan or any other ingredients in this medication, are breastfeeding, or have too low blood cell counts, you should not use Topoquis 4 mg Injection 4 ml.
Yes, Topoquis 4 mg Injection 4 ml can cause low neutrophils levels, a type of white blood cells that help fight infections. If your white blood cells become low, you can be at higher risk for infections. Tell your doctor if you develop a fever or have an infection.
Avoid taking Topoquis 4 mg Injection 4 ml if you are pregnant because Topoquis 4 mg Injection 4 ml can cause harmful effects on the unborn baby. Females should follow effective birth control methods during treatment and at least six months after the final dose of Topoquis 4 mg Injection 4 ml.
The live vaccine may not work while on treatment with Topoquis 4 mg Injection 4 ml. Do not have immunizations/vaccinations without talking to your doctor first. Also, avoid contact with people who recently had immunizations /vaccinations.
Topoquis 4 mg Injection 4 ml is used to treat ovarian or small cell lung cancer that has come back after chemotherapy. On the other hand, it can also treat advanced cervical cancer if surgery or radiotherapy treatment is not possible. When treating cervical cancer, Topoquis 4 mg Injection 4 ml is used with another medication called cisplatin.

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