Topiroxo 40 Tablet is used to treat and manage hyperuricemia (excess uric acid in the blood) and gout. Gout is a chronic condition due to the deposition of uric acid in the joints. It is characterized by intense pain and swelling at the affected joints.

Topiroxo 40 Tablet contains Topiroxostat, which works by inhibiting the enzyme xanthine oxidase (an enzyme essential for the degradation of purine nucleotides to create uric acid), thereby reducing the uric acid level in your body. Thus, it reduces the inflammation caused by uric acid in affected joints, thereby reducing pain, swelling and inflammation.

Topiroxo 40 Tablet should be taken as prescribed by your doctor. The dose of this medicine will be decided by your doctor, depending on your medical condition. This medicine may cause some common side effects such as liver enzyme elevations, upset stomach, diarrhoea, nausea, drowsiness, headache, and vomiting. Most of these side effects are temporary, do not require medical attention, and gradually resolve over time. However, if the side effects persist or worsen, contact your doctor.

Avoid taking Topiroxo 40 Tablet if you are allergic to any of the substances in it. To avoid potential interactions, inform your doctor about your medical and medication history, including herbal and vitamin supplements, before using this medication. Also, inform your doctor if you are pregnant, planning a pregnancy, or breastfeeding. Limited information about using Topiroxo 40 Tablet in children is available, so do not use it without a doctor's advice. Avoid consumption of alcohol while taking Topiroxo 40 Tablet as consuming alcohol may worsen your condition.

Topiroxo 40 Tablet contains Topiroxostat, a selective xanthine oxidase inhibitor medicine used to treat and manage hyperuricemia (excess of uric acid in the blood) and gout. It works by inhibiting the enzyme xanthine oxidase (an enzyme essential for the degradation of purine nucleotides to create uric acid), thereby reducing the level of uric acid in your body. Thus, it reduces the inflammation caused by uric acid crystals in affected joints, thereby reducing pain, swelling and inflammation.

• Liver enzyme elevations
• Upset stomach
• Diarrhea
• Nausea
• Drowsiness
• Headache
• Vomiting

Do not take Topiroxo 40 Tablet if you are allergic to its ingredients. The safety of Topiroxo 40 Tablet in pregnant women is uncertain. As a result, inform your doctor; your doctor will consider the benefits and potential hazards before giving this medication. Topiroxo 40 Tablet is not known if it is excreted in human milk. It should not be used if the potential advantages outweigh the hazards to the newborn. If you are breastfeeding, consult with your doctor before using this medication. This medication may increase your chances of significant heart and blood vessel problems, such as unstable chest discomfort, heart attack, or stroke. Contact your doctor immediately if you experience chest pain, difficulty breathing, a sudden or severe headache, or problems with vision, speech, or walking.

Drug-Drug Interactions: Topiroxo 40 Tablet is known to interact with immunosuppressive medication (e.g. Azathioprine, Methotrexate), anticancer medications (e.g. Mercaptopurine), medicines used to prevent cardiovascular disease (e.g. Rosuvastatin) and medications used to treat asthma and chronic obstructive pulmonary disease (e.g. Theophylline).

Drug-Food Interactions: Topiroxo 40 Tablet is known to interact with alcohol.

Drug-Disease Interactions: The presence of other medical issues may interfere with the usage of this medication. Inform your doctor about all your medical problems, including cancers, brain or blood vessel illness, diabetes, heart disease, kidney or liver disease, or organ transplant.

• AZATHIOPRINE
• METHOTREXATE
• MERCAPTOPURINE
• ROSUVASTATIN
• THEOPHYLLINE

• Adopting a balanced diet is an important lifestyle component in gout therapy or management.
• A healthy diet generally includes plant-based foods such as vegetables, fruits, legumes, and whole grains.
• Stay well-hydrated by drinking water.
• Consume uric acid-lowering foods.  Low-fat dairy products are one example. Calcium-rich foods may help reduce gout attacks while also protecting your bones.
• Citrus fruits and other vitamin C-rich foods (such as strawberries and peppers) may benefit people with gout. Eating cherries or juice can help minimize gout episodes and pain.
• Being overweight raises the risk of having gout, while reducing weight reduces the risk.
• Avoiding purine-rich meals such as red meat, some seafood, and alcohol may help you lower uric acid levels in your blood and lessen your risk of gout attacks.
• Avoid meals and beverages containing high fructose, and restrict your consumption of naturally sweet fruit juices.
• Avoid drinking alcohol and quit smoking.

• The doctor will monitor your kidney function constantly before and during treatment with Topiroxo 40 Tablet .
• A liver function test should be done regularly to monitor liver enzymes as Topiroxo 40 Tablet can cause liver enzyme fluctuations.
• If you are undergoing a urine test, inform the lab technician or the doctor about using Topiroxo 40 Tablet .

Gout: Gout is an inflammatory (allergic reaction) condition that forms uric acid crystals and accumulates inside feet, knuckles, and surrounding bone joints. This occurs due to high uric acid levels in the blood, resulting in immense joint pain. The pain may be severe, but the condition improves with medication. Repeated gout attacks can require long-term medication to avoid bone and cartilage damage and weakening of the kidneys. Chronic gout sufferers can feel small hard lumps forming over time in the soft flesh in areas such as the wrists, elbows, feet, or earlobes. These deposits are concentrations of uric acid crystals, called tophi, and can cause pain and stiffness over time.