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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Last Updated Oct 9, 2024 | 10:52 AM IST

Topimac 40 Tablet treats and manages hyperuricemia (excess uric acid in the blood) and gout. It contains Topiroxostat, which works by inhibiting the enzyme xanthine oxidase (an enzyme essential for the degradation of purine nucleotides to create uric acid), thereby reducing the uric acid level in your body. Thus, it reduces the inflammation caused by uric acid in affected joints, thereby reducing pain, swelling and inflammation.

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Composition

TOPIROXOSTAT-40

Manufacturer/Marketer

Macleods Pharmaceuticals Ltd

Consume Type

ORAL

Return Policy

Not Returnable

Expires on or after

Jan-27

for this medicine

About Topimac 40 Tablet

Topimac 40 Tablet is used to treat and manage hyperuricemia (excess uric acid in the blood) and gout. Gout is a chronic condition due to the deposition of uric acid in the joints. It is characterized by intense pain and swelling at the affected joints.

Topimac 40 Tablet contains Topiroxostat, which works by inhibiting the enzyme xanthine oxidase (an enzyme essential for the degradation of purine nucleotides to create uric acid), thereby reducing the uric acid level in your body. Thus, it reduces the inflammation caused by uric acid in affected joints, thereby reducing pain, swelling and inflammation.

Topimac 40 Tablet should be taken as prescribed by your doctor. The dose of this medicine will be decided by your doctor, depending on your medical condition. This medicine may cause some common side effects such as liver enzyme elevations, upset stomach, diarrhoea, nausea, drowsiness, headache, and vomiting. Most of these side effects are temporary, do not require medical attention, and gradually resolve over time. However, if the side effects persist or worsen, contact your doctor.

Avoid taking Topimac 40 Tablet if you are allergic to any of the substances in it. To avoid potential interactions, inform your doctor about your medical and medication history, including herbal and vitamin supplements, before using this medication. Also, inform your doctor if you are pregnant, planning a pregnancy, or breastfeeding. Limited information about using Topimac 40 Tablet in children is available, so do not use it without a doctor's advice. Avoid consumption of alcohol while taking Topimac 40 Tablet as consuming alcohol may worsen your condition.

Uses of Topimac 40 Tablet

Treatment of Hyperuricemia (excess of uric acid in the blood) and gout

Medicinal Benefits

Topimac 40 Tablet contains Topiroxostat, a selective xanthine oxidase inhibitor medicine used to treat and manage hyperuricemia (excess of uric acid in the blood) and gout. It works by inhibiting the enzyme xanthine oxidase (an enzyme essential for the degradation of purine nucleotides to create uric acid), thereby reducing the level of uric acid in your body. Thus, it reduces the inflammation caused by uric acid crystals in affected joints, thereby reducing pain, swelling and inflammation.

Directions for Use

Swallow the medicine as a whole with a glass of water. Do not crush, chew, or break it.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Topimac 40 Tablet

  • Liver enzyme elevations
  • Upset stomach
  • Diarrhea
  • Nausea
  • Drowsiness
  • Headache
  • Vomiting

Drug Warnings

Do not take Topimac 40 Tablet if you are allergic to its ingredients. The safety of Topimac 40 Tablet in pregnant women is uncertain. As a result, inform your doctor; your doctor will consider the benefits and potential hazards before giving this medication. Topimac 40 Tablet is not known if it is excreted in human milk. It should not be used if the potential advantages outweigh the hazards to the newborn. If you are breastfeeding, consult with your doctor before using this medication. This medication may increase your chances of significant heart and blood vessel problems, such as unstable chest discomfort, heart attack, or stroke. Contact your doctor immediately if you experience chest pain, difficulty breathing, a sudden or severe headache, or problems with vision, speech, or walking.

Drug Interactions

Drug-Drug Interactions: Topimac 40 Tablet is known to interact with immunosuppressive medication (e.g. Azathioprine, Methotrexate), anticancer medications (e.g. Mercaptopurine), medicines used to prevent cardiovascular disease (e.g. Rosuvastatin) and medications used to treat asthma and chronic obstructive pulmonary disease (e.g. Theophylline).

Drug-Food Interactions: Topimac 40 Tablet is known to interact with alcohol.

Drug-Disease Interactions: The presence of other medical issues may interfere with the usage of this medication. Inform your doctor about all your medical problems, including cancers, brain or blood vessel illness, diabetes, heart disease, kidney or liver disease, or organ transplant.

Drug-Drug Interactions Checker List

  • AZATHIOPRINE
  • METHOTREXATE
  • MERCAPTOPURINE
  • ROSUVASTATIN
  • THEOPHYLLINE

Habit Forming

No

Diet & Lifestyle Advise

  • Adopting a balanced diet is an important lifestyle component in gout therapy or management.
  • A healthy diet generally includes plant-based foods such as vegetables, fruits, legumes, and whole grains.
  • Stay well-hydrated by drinking water.
  • Consume uric acid-lowering foods.  Low-fat dairy products are one example. Calcium-rich foods may help reduce gout attacks while also protecting your bones.
  • Citrus fruits and other vitamin C-rich foods (such as strawberries and peppers) may benefit people with gout. Eating cherries or juice can help minimize gout episodes and pain.
  • Being overweight raises the risk of having gout, while reducing weight reduces the risk.
  • Avoiding purine-rich meals such as red meat, some seafood, and alcohol may help you lower uric acid levels in your blood and lessen your risk of gout attacks.
  • Avoid meals and beverages containing high fructose, and restrict your consumption of naturally sweet fruit juices.
  • Avoid drinking alcohol and quit smoking.

Special Advise

  • The doctor will monitor your kidney function constantly before and during treatment with Topimac 40 Tablet .
  • A liver function test should be done regularly to monitor liver enzymes as Topimac 40 Tablet can cause liver enzyme fluctuations.
  • If you are undergoing a urine test, inform the lab technician or the doctor about using Topimac 40 Tablet .

Disease/Condition Glossary

Gout: Gout is an inflammatory (allergic reaction) condition that forms uric acid crystals and accumulates inside feet, knuckles, and surrounding bone joints. This occurs due to high uric acid levels in the blood, resulting in immense joint pain. The pain may be severe, but the condition improves with medication. Repeated gout attacks can require long-term medication to avoid bone and cartilage damage and weakening of the kidneys. Chronic gout sufferers can feel small hard lumps forming over time in the soft flesh in areas such as the wrists, elbows, feet, or earlobes. These deposits are concentrations of uric acid crystals, called tophi, and can cause pain and stiffness over time.

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Alcohol

Consult your doctor

It is not known whether consumption of alcohol is safe while taking Topimac 40 Tablet . Please consult your doctor for more information.

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Pregnancy

Consult your doctor

The safety of Topimac 40 Tablet in pregnant women is unknown. Therefore, please consult your doctor; your doctor will weigh the benefits and potential risks before prescribing this medicine.

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Breast Feeding

Consult your doctor

It is unknown whether Topimac 40 Tablet is excreted in human milk. It should not be used while breastfeeding unless the possible benefits outweigh the risks to the infant. If you are breastfeeding, inform your doctor before using this medicine.

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Driving

Consult your doctor

It is not known whether Topimac 40 Tablet alters the ability to drive. Please consult your doctor if you experience any symptoms that affect your alertness.

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Liver

Consult your doctor

Limited information is available about using Topimac 40 Tablet in patients with liver disease. Inform your doctor before receiving the Topimac 40 Tablet if you have a history of liver diseases. Your doctor will prescribe only if the benefits outweigh the risks.

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Kidney

Consult your doctor

Limited information is available about using Topimac 40 Tablet in patients with kidney disease. Inform your doctor before receiving the Topimac 40 Tablet if you have a history of kidney problems. Your doctor will prescribe only if the benefits outweigh the risks.

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Children

Consult your doctor

Limited information about using Topimac 40 Tablet in children is available, so do not use it without a doctor's advice.

Country of origin

India

Manufacturer/Marketer address

Atlanta Arcade, Marol Church Road, Andheri (East), Mumbai - 400059, India.
Other Info - TOP0505

Author Details

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FAQs

Topimac 40 Tablet is used to treat and control hyperuricemia (excess uric acid in the blood) and gout. Gout is a chronic condition due to the deposition of uric acid in the joints. It is characterized by intense pain and swelling at the affected joints.
Topimac 40 Tablet contains Topiroxostat, a selective xanthine oxidase inhibitor medicine used to treat and manage hyperuricemia (excess of uric acid in the blood) and gout. It works by inhibiting the enzyme xanthine oxidase (an enzyme essential for the degradation of purine nucleotides to create uric acid), thereby reducing the level of uric acid in your body. Thus, it reduces the inflammation caused by uric acid crystals in affected joints, thereby reducing pain, swelling and inflammation.
This medication is only available with a doctor's prescription. You must use it only if your doctor prescribes it.
It may take several weeks for your uric acid levels to drop or notice a major reduction.
It is possible to completely control the disease by using medication and diet; lifestyle changes can help cure it.
Changing your diet and lifestyle, such as lowering weight, restricting alcohol, and avoiding foods high in purines (such as red meat or organ meat, which can promote gout flares), may help prevent future attacks.

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