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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Tonact EZ 10 Tablet is used to treat high cholesterol levels. It contains Atorvastatin and Ezetimibe, which helps to decrease the production of cholesterol that may build up on the blood vessels (arteries) of the heart, brain, and other parts of the body. By lowering cholesterol levels, it prevents the risk of heart diseases such as heart attacks and strokes in the future. Also, it prevents the absorption of cholesterol from the intestines. It may cause side effects such as nausea, stomach pain, constipation, muscle pain, or headache. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.
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Manufacturer/Marketer :

Lupin Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

Jan-27

About Tonact EZ 10 Tablet

Tonact EZ 10 Tablet belongs to a class of medications called HMG-CoA reductase inhibitors (statins)’ and ‘sterol absorption inhibitor’ Tonact EZ 10 Tablet is primarily used to treat high cholesterol levels. Dyslipidaemia (high cholesterol level) is the deposition of unhealthy levels of fats (lipid) in the blood. In this condition, there is always a high level of low-density lipoprotein (LDL or bad cholesterol), triglycerides (TG), and a low level of high-density lipoprotein (HDL or good cholesterol).

Tonact EZ 10 Tablet is a combination of two medicines: Atorvastatin (HMG-CoA reductase inhibitors (statins)) and Ezetimibe (sterol absorption inhibitor). Atorvastatin helps to decrease the production of cholesterol that may build up on the blood vessels (arteries) of the heart, brain, and other parts of the body. By lowering cholesterol levels, they help prevent the chance of having heart diseases such as heart attacks and strokes in the future. On the other hand, Ezetimibe is a cholesterol absorption inhibitor that avoids the absorption of cholesterol from the intestines. Together, they provide a better decrease in cholesterol in your body.

Take Tonact EZ 10 Tablet as prescribed by your doctor. You are advised to take Tonact EZ 10 Tablet for as long as your doctor has prescribed it for you depending on your medical conditions. You may experience nausea, stomach pain, constipation, muscle pain, headache, the increased glucose level in the blood, increased liver enzymes. Most of these side effects of Tonact EZ 10 Tablet do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. You should contact a doctor before if you have liver or kidney problems, severe lung disease. If you have a muscle problem, inform your doctor. If you are pregnant, planning to become pregnant, or breastfeeding then immediately inform your doctor because Tonact EZ 10 Tablet contains Atorvastatin that may harm an unborn baby. Do not take this Tonact EZ 10 Tablet if you have a previous heart attack or stroke caused by bleeding in the brain, have hypothyroidism, drink more than 2 servings of alcohol per day, and have a muscle disorder (fibromyalgia). The efficiency of Tonact EZ 10 Tablet can be increased by taking low fat or cholesterol-containing food and drinks. 

Uses of Tonact EZ 10 Tablet

Treatment of Lowering of an increased level of cholesterol.

Directions for Use

Swallow Tonact EZ 10 Tablet as a whole with water; do not crush, break or chew it.

Medicinal Benefits

Tonact EZ 10 Tablet taken with dietary measures helps in the treatment of high cholesterol, especially for heart patients when initial dietary measures fail to lower cholesterol. Tonact EZ 10 Tablet contains Atorvastatin, which helps lower the bad cholesterol (LDL) and increases the level of good cholesterol (HDL) in the state of dyslipidemia or hyperlipidemia. Tonact EZ 10 Tablet also lowers the amount of fat or cholesterol deposition (plaque) in the arteries of the heart, thereby reducing the chance of having a heart attack or stroke in the future. Tonact EZ 10 Tablet contains Ezetimibe which is a cholesterol absorption inhibitor that avoids absorption of cholesterol from the intestines. Together, they provide a better decrease in cholesterol in your body.

How Tonact EZ 10 Tablet Works

Tonact EZ 10 Tablet is a combination of two medicines: Atorvastatin (HMG-CoA reductase inhibitors (statins)) and Ezetimibe (sterol absorption inhibitor). Atorvastatin helps to decrease the production of cholesterol that may build up on the blood vessels (arteries) of the heart, brain, and other parts of the body. By lowering cholesterol levels, they help prevent the chance of having heart diseases such as heart attacks and strokes in the future. On the other hand, Ezetimibe is a cholesterol absorption inhibitor that avoids the absorption of cholesterol from the intestines. Together, they provide a better decrease in cholesterol in your body.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Tonact EZ 10 Tablet

  • Nausea
  • Stomach pain
  • Constipation
  • Muscle pain
  • Headache
  • Increased glucose level in blood
  • Increased liver enzymes.

What if I have taken an overdose of Tonact EZ 10 Tablet

Do not take more than the prescribed dose of Tonact EZ 10 Tablet as it may cause overdose. If you suspect you have taken overdose, please consult a doctor immediately.

Drug Warnings

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. You should contact a doctor before if you have liver or kidney problems, severe lung disease. If you have a muscle problem, inform your doctor. Do not take this Tonact EZ 10 Tablet if you have a previous heart attack or stroke caused by bleeding in the brain, have hypothyroidism, drink more than 2 servings of alcohol per day, and have a muscle disorder (fibromyalgia). The efficiency of Tonact EZ 10 Tablet can be increased by taking low fat or cholesterol-containing food and drinks. Tonact EZ 10 Tablet is not safe for children as safety and efficacy of Tonact EZ 10 Tablet in children have not established. Tonact EZ 10 Tablet has Ezetimibe which contains a sugar called lactose. If you have been told by your doctor that you have an intolerance to some sugars, talk to your doctor before taking this Tonact EZ 10 Tablet . If you are pregnant, planning to become pregnant, then immediately inform your doctor because Tonact EZ 10 Tablet contains Atorvastatin that may harm an unborn baby. If you are a breastfeeding mother, then immediately contact your doctor as it is unknown if this Tonact EZ 10 Tablet passes into breast milk.

Drug-Drug Interactions

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AtorvastatinPosaconazole
Critical
AtorvastatinColchicine
Severe

Drug-Drug Interactions

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AtorvastatinPosaconazole
Critical
How does the drug interact with Tonact EZ 10 Tablet:
Taking Tonact EZ 10 Tablet with Posaconazole can increase the blood levels of Tonact EZ 10 Tablet. This can increase the risk of side effects.

How to manage the interaction:
Although there is an interaction between posaconazole with Tonact EZ 10 Tablet, they can be taken together if advised by your doctor. However, contact the doctor if you experience unexplained muscle pain, weakness, fever, chills, joint pain or swelling, unusual bleeding, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark coloured urine, or yellowing of the skin or eyes. Do not discontinue any medications without consulting a doctor.
AtorvastatinColchicine
Severe
How does the drug interact with Tonact EZ 10 Tablet:
coadministration of Tonact EZ 10 Tablet with colchicine can increase the risk of kidney problems.

How to manage the interaction:
Co-administration of Tonact EZ 10 Tablet with colchicine can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience abdominal pain, nausea, vomiting, diarrhea, muscle pain, weakness, fatigue, and/or numbness or tingling in your hands and feet, consult the doctor. Do not stop using any medications without talking to a doctor.
AtorvastatinRitonavir
Severe
How does the drug interact with Tonact EZ 10 Tablet:
Using Tonact EZ 10 Tablet with ritonavir may increase Tonact EZ 10 Tablet levels in the blood. This can raise the chance of side effects (liver injury and rhabdomyolysis - an uncommon but serious illness that causes the breakdown of skeletal muscle tissue. Rhabdomyolysis occasionally results in kidney injury).

How to manage the interaction:
Taking Tonact EZ 10 Tablet and ritonavir together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience muscle pain, tenderness, or weakness especially accompanied by fever or dark colored urine, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark colored urine, light colored stools, and/or yellowing of the skin or eyes, you should consult the doctor. Do not stop using any medications without talking to a doctor.
AtorvastatinClarithromycin
Severe
How does the drug interact with Tonact EZ 10 Tablet:
Co-administration of Tonact EZ 10 Tablet with Clarithromycin possibly enhances Tonact EZ 10 Tablet levels in the blood. This can raise the chance of side effects (liver damage and rhabdomyolysis, an uncommon but serious illness that causes the breakdown of skeletal muscle tissue. Rhabdomyolysis occasionally results in kidney injury).

How to manage the interaction:
Although there is a possible interaction, clarithromycin can be taken with Tonact EZ 10 Tablet if prescribed by the doctor. However, if you experience muscle pain, tenderness, or weakness, accompanied by fever or dark colored urine, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark colored urine, light colored stools, and/or yellowing of the skin or eyes, you should consult the doctor. Do not stop using any medications without talking to a doctor.
AtorvastatinClofibrate
Severe
How does the drug interact with Tonact EZ 10 Tablet:
Using clofibrate together with Tonact EZ 10 Tablet can increase the risk of side effects.

How to manage the interaction:
Co-administration of Clofibrate with Tonact EZ 10 Tablet can result in an interaction, but it can be taken if a doctor has advised it. It's important to keep an eye on your health and contact a doctor right away if you notice any of these signs - liver problems, muscle damage, kidney problems, complications, pain, weakness, fever, dark urine, chills, joint pain, swelling, bruising, rash, itching, loss of appetite, tiredness, feeling sick, throwing up, or bleeding. Do not stop using any medications without a doctor's advice.
AtorvastatinFenofibrate
Severe
How does the drug interact with Tonact EZ 10 Tablet:
Coadministration of Fenofibrate with Tonact EZ 10 Tablet can raise the chance of side effects (liver injury and rhabdomyolysis - an uncommon but serious illness that causes the breakdown of skeletal muscle tissue. Rhabdomyolysis occasionally results in kidney injury).

How to manage the interaction:
Although taking Fenofibrate and Tonact EZ 10 Tablet together can cause an interaction, it can be taken if a doctor has suggested it. However, if you experience muscle pain, tenderness, or weakness, accompanied by fever or dark colored urine, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark colored urine, light colored stools, and/or yellowing of the skin or eyes, you should consult the doctor. Do not stop using any medications without talking to a doctor.
AtorvastatinFenofibrate
Severe
How does the drug interact with Tonact EZ 10 Tablet:
When Tonact EZ 10 Tablet is used with fenofibrate, it increases the risk of side effects such as liver damage, rhabdomyolosis (uncommon illness characterized by the breakdown of skeletal muscle tissue).

How to manage the interaction:
Although taking Fenofibrate and Tonact EZ 10 Tablet together can cause an interaction, it can be taken if a doctor has suggested it. However, if you experience muscle pain, tenderness, or weakness, accompanied by fever or dark colored urine, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark colored urine, light colored stools, and/or yellowing of the skin or eyes, you should consult the doctor. Do not stop using any medications without talking to a doctor.
AtorvastatinRifampicin
Severe
How does the drug interact with Tonact EZ 10 Tablet:
Taking Tonact EZ 10 Tablet with rifampicin can decrease the blood levels of Tonact EZ 10 Tablet, which may make the medication less effective.

How to manage the interaction:
Although there is an interaction between Tonact EZ 10 Tablet and rifampicin, they can be taken together if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.
AtorvastatinNefazodone
Severe
How does the drug interact with Tonact EZ 10 Tablet:
Using Tonact EZ 10 Tablet together with nefazodone may significantly increase the blood levels of Tonact EZ 10 Tablet.

How to manage the interaction:
Taking Tonact EZ 10 Tablet with Nefazodone together can result in an interaction, but it can be taken if a doctor has advised it. You should seek immediate medical attention if you develop fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark colored urine, and/or yellowing of the skin or eyes. Do not stop using any medications without a doctor's advice.
AtorvastatinCiclosporin
Severe
How does the drug interact with Tonact EZ 10 Tablet:
Taking Tonact EZ 10 Tablet and ciclosporin can significantly increase the blood levels of Tonact EZ 10 Tablet.

How to manage the interaction:
Taking Tonact EZ 10 Tablet and cyclosporine together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience muscle pain, tenderness, or weakness, accompanied by fever or dark colored urine, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of hunger, weakness, nausea, vomiting, dark colored urine, light colored stools, or yellowing of the skin or eyes, you should consult a doctor. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Try aromatherapy, yoga, meditation to help relax your body and mind.

  • Try to do breathing exercises to get more oxygen.

  • Eat a healthy diet especially rich in soluble fibre like beans, legumes, whole grain, flax, apples, and citrus fruits.

  • Try to replace most of your saturated fats with unsaturated fats that can reduce total cholesterol and LDL cholesterol in a short span of time. Foods like avocados, olive oil, fatty fish, and nuts contain lots of heart-healthy unsaturated fats, so it’s beneficial to eat them regularly.

  • Try to adopt a Mediterranean-style diet rich in olive oil, fruits, vegetables, nuts, whole grains, and fish, and low in red meat and most dairy.

  • Try to give priority to more fruits and veggies in your daily meal as these contain antioxidants that help to lower LDL

  • Minimize the intake of added sugar. The American Heart Association (ADA) recommends, one should not eat more than 100 calories (25 grams) of added sugar for women and children, and no more than 150 calories (37.5 grams) for men every day.

  • American Heart Association recommends the intake of sodium chloride (table salt) should not exceed more than 2,300 mg per day as part of a healthy eating pattern.

  • As a precautionary measure, do not consume alcohol and quit smoking.

Habit Forming

No

Therapeutic Class

ANTILIPEMICS

Tonact EZ 10 Tablet Substitute

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Alcohol

Unsafe

Do not drink too much while taking this medicine. drinking a lot of alcohol you may more likely to get muscle and liver side effects.

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Pregnancy

Unsafe

Tonact EZ 10 Tablet contains atorvastatin which is not recommended during pregnancy. Contact your doctor before taking Tonact EZ 10 Tablet .

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Breast Feeding

Caution

Breastfeeding is not recommended while taking Tonact EZ 10 Tablet because it is unknown if this Tonact EZ 10 Tablet passe into breast milk. Contact your doctor before taking Tonact EZ 10 Tablet .

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Driving

Unsafe

Tonact EZ 10 Tablet has negligible influence on the ability to drive and use machines.

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Liver

Caution

Tonact EZ 10 Tablet to be taken with caution, especially if you have a history of Liver diseases/conditions. The dose may have to be adjusted by your doctor.

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Kidney

Caution

Tonact EZ 10 Tablet to be taken with caution, especially if you have a history of Kidney diseases/conditions. The dose may have to be adjusted by your doctor.

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Children

Unsafe

Tonact EZ 10 Tablet is not recommended for children as safety and efficacy of Tonact EZ 10 Tablet has not established.

FAQs

Tonact EZ 10 Tablet is used to treat high cholesterol levels.

You should avoid alcohol while taking Tonact EZ 10 Tablet since it may rise your risk of getting side effects in the liver. Talk with your doctor if you have any troubles.

Yes. Muscle weakness can be the long-term side effects of Tonact EZ 10 Tablet . You may have muscle fatigue or muscle pain which affects your daily activity. Try to contact a doctor if you have muscle weakness or fatigue.

No, there is no evidence that Tonact EZ 10 Tablet is addictive. It is used for lowering cholesterol levels.

Tonact EZ 10 Tablet contains Atorvastatin that can raise your blood sugar a little. If you already have type 2 diabetes please consult your doctor. Your doctor may adjust the dosage of Tonact EZ 10 Tablet .

Country of origin

India

Manufacturer/Marketer address

Lupin Ltd, 3rd floor Kalpataru Inspire, Off. W E Highway, Santacruz (East), Mumbai 400 055. India Country of Origin: India
Other Info - TON0121

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