Tolol-XR 25 Tablet belongs to a group of medicines called “Antihypertensive” used alone or together with other drugs to treat high blood pressure (hypertension), symptoms caused by an overactive thyroid gland, heart-related chest pain (angina), heart rhythm disorder (arrhythmia). Besides this, it also helps in relieving symptoms of migraine-related headaches. High blood pressure adds to the workload of the heart and arteries. Hypertension or high blood pressure is a long-term force of the blood against the arteries that may lead to various heart diseases. It can damage the blood vessels (arteries) of the brain, heart, and kidneys if it continues for a long time, resulting in a stroke, heart failure or kidney failure. Lowering blood pressure reduces the risk of stroke, heart attack and heart-related chest pain (angina).

Tolol-XR 25 Tablet plays a vital role in relaxing blood vessels by blocking the action of certain natural substances in your body. It helps slow down the heart rate, making it easier for pumping more blood around the body. This lowers your blood pressure and reduces the risk of having a stroke, a heart attack, other heart problems or kidney problems in the future. Tolol-XR 25 Tablet needs to be taken regularly to be effective.

You are advised to take this medicine for as long as your doctor has prescribed it for you depending on your medical condition. In some cases, you may experience certain common side effects, such as tiredness, dizziness, stomach pain, nightmares, irregular heart rate and skin rash. Most of these side effects do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor. However, you are advised to talk to your doctor if you experience these side effects persistently.

Don't stop taking this medicine without talking to your doctor first. Stopping abruptly may cause changes in your heart rhythm and blood pressure, cause chest pain or a heart attack. Your doctor will lower your dose gradually over a period of time to help prevent these symptoms. Tolol-XR 25 Tablet should not be used to avoid heart attacks. You should not use Tolol-XR 25 Tablet if you have heart rhythm problems, diabetes, kidney disease or failure, COPD (Chronic Obstructive Pulmonary Disease). Avoid driving and operating heavy machinery as it may cause dizziness and drowsiness. Orthostatic hypotension (sudden lowering of blood pressure n standing) might occur so patients using Tolol-XR 25 Tablet should get up with caution. Before taking Tolol-XR 25 Tablet , inform your doctor if you are going to have surgery or an anaesthetic.

Tolol-XR 25 Tablet contains Metoprolol tartrate that works by blocking beta receptors, namely beta 1 and beta 2. Tolol-XR 25 Tablet blocks beta 1 receptor located in the heart cells that lower heart rate and decreases the heart's blood pumping frequency decreasing raised blood pressure. On the other hand, Tolol-XR 25 Tablet also blocks beta 2 receptors located in the lungs (bronchioles) and blood vessels of skeletal muscle narrowing it. This, in turn, lowers your overall body's blood pressure and helps in reducing the risk of having a stroke, heart problems, or kidney problems in the future. A Tolol-XR 25 Tablet also improves heart-related chest pain (angina) and may increase a person's stamina to exercise with angina. It also blocks the effects of epinephrine, which causes the heart to beat slower. Additionally, Tolol-XR 25 Tablet reduces symptoms of essential tremor (fits), and prevent migraine. Tolol-XR 25 Tablet can reduce symptoms of too much thyroid hormone (thyrotoxicosis) and can be taken together with thyroid-related medicines to treat an overactive thyroid.

• Tiredness
• Dizziness
• Headache
• Stomach pain
• Anxiety
• Irregular heart rate

Do not take Tolol-XR 25 Tablet if you are allergic (hypersensitive) to Tolol-XR 25 Tablet or any ingredients present in it. Please consult your doctor before taking Tolol-XR 25 Tablet if you are pregnant or planning to conceive, and breastfeeding. It should not be given to children. Don't stop taking Tolol-XR 25 Tablet without talking to your doctor first. Stopping Tolol-XR 25 Tablet gradually may cause changes in your heart rhythm and blood pressure, cause chest pain or a heart attack. Your doctor will lower your dose gradually over a period of time to help prevent these symptoms. Before taking Tolol-XR 25 Tablet , inform your doctor if you have diabetes mellitus, liver cirrhosis, myasthenia gravis, psoriasis, or if you have a slow heart rate or blood vessel disorder. Do not take Tolol-XR 25 Tablet with medicines like monoamine oxidase inhibitors (MAOIs) for depression, other blood pressure-lowering medicines such as nifedipine, verapamil, diltiazem disopyramide or quinidine (to treat irregular heartbeat). Inform your doctor about all your current ongoing medications before taking Tolol-XR 25 Tablet . Do not consume alcohol while on this medication.

Drug-Drug Interactions: Tolol-XR 25 Tablet may interact with other blood pressure medications (acebutolol, atenolol, bisoprolol, carteolol, esmolol, metoprolol, nadolol, nebivolol or sotalol), medicines for treating depression (isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, tranylcypromine), an ergot medicine (dihydroergotamine, ergonovine, ergotamine, methylergonovine), high blood pressure medications such as hydralazine, clonidine or prazosin; stomach ulcers medication such as cimetidine; epilepsy medication such as barbiturates; malaria medication such as mefloquine.

Drug-Food Interactions: Tolol-XR 25 Tablet may interact with alcohol, grapefruit and protein-enriched foods. Using Tolol-XR 25 Tablet together with ayurvedic, homoeopathy, Unani, herbal supplements or any other OTC items may decrease the effects of Tolol-XR 25 Tablet . Hence, it is better to maintain at least 2 hours gap between the administration of Tolol-XR 25 Tablet and these products.

Drug-Disease Interactions: Tolol-XR 25 Tablet is not recommended for people with heart rhythm problems, diabetes, liver or kidney disease or failure, or COPD (Chronic Obstructive Pulmonary Disease).

• ISOCARBOXAZID
• LINEZOLID
• PHENELZINE
• RASAGILINE
• SELEGILINE
• TRANYLCYPROMINE
• DIHYDROERGOTAMINE
• ERGOTAMINE
• HYDRALAZINE
• CLONIDINE
• PRAZOSIN
• CIMETIDINE
• MEFLOQUINE
• ERGONOVINE
• METHYLERGONOVINE

• Keep your weight under control with BMI 19.5-24.9.

• Do regular physical activity or exercise for at least 150 minutes per week, or about 30 minutes most days of the week.

• Doing this can help you to lower your raised blood pressure by about 5 mm of Hg.

• Option for a diet rich in whole grains, fruits, veggies, and low-fat dairy products.

• Limit intake of sodium chloride (table salt) in your daily diet to 2300 mg per day or less than 1500 mg is ideal for most adults.

• If you are taking alcohol, then only one serving for women and two servings for men is advisable.

• Quitting smoking is the best strategy to lower the risk of heart disease.

• Avoid chronic stress as it can raise your blood pressure. Try to enjoy and spent time with your loved ones to cope with stress and practice mindfulness techniques.

• Monitor your blood pressure daily and if there is too much fluctuation, then immediately contact your doctor.

• Try to include heart-healthy omega 3 fatty acid containing food drinks in your daily diet. You can also use low-fat cooking oil like olive oil, soybean oil, canola oil, and coconut oil to lower your elevated blood pressure.

• Tolol-XR 25 Tablet can hide symptoms of low blood sugar if you have diabetes. Monitor your blood sugar levels regularly.

• Do not stop taking Tolol-XR 25 Tablet suddenly as it can cause your blood pressure to rise suddenly, thereby increasing the risk of heart attack and stroke.

Hypertension: High blood pressure is a chronic condition when the blood pressure and the heart's workload is too high. This condition can lead to hardened arteries (blood vessels), decreasing the blood and oxygen flow to the heart. Raised blood pressure can cause chest pain (angina) and heart attack (when blood supply to the heart is blocked). Additionally, high blood pressure also causes brain damage (stroke) and kidney failure. High blood pressure can be diagnosed with the help of a blood pressure monitor or sphygmomanometer. Systolic pressure is the pressure when the heart pumps blood out. On the other hand, diastolic pressure is when your heart is at the resting stage between heartbeats. If your blood pressure is 140/90 mm of Hg, it means the systolic pressure is 140 mm of Hg and, diastolic pressure is 90 mm of Hg. Ideal blood pressure should be between 90/60 mm of Hg and 120/80 mm of Hg.