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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Tofashine Xr 11Mg Tab is used to treat rheumatoid arthritis, psoriatic arthritis, and ulcerative colitis. It contains Tofacitinib which works by lowering inflammation and symptoms associated with arthritis. In some cases, this medicine may cause side effects such as diarrhoea, headache, upper respiratory tract infection, nausea, and vomiting. Before taking this medicine, inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Whats That

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Composition :

TOFACITINIB-11MG

Manufacturer/Marketer :

Sun Pharmaceutical Industries Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

Jan-27

About Tofashine Xr 11Mg Tab

Tofashine Xr 11Mg Tab belongs to a group of medicines called Janus kinase inhibitors used to treat rheumatoid arthritis, psoriatic arthritis, and ulcerative colitis. Rheumatoid arthritis is an auto-immune disease (the body's immune system attacks its tissue) which leads to joint pain and damage. Psoriatic arthritis is an inflammatory condition of the joints, often associated with psoriasis. Ulcerative colitis is an inflammatory disease of the large intestine.
 
Tofashine Xr 11Mg Tab contains 'Tofacitinib' which works by blocking the Janus kinase enzyme, thereby lowering inflammation and symptoms associated with rheumatoid and psoriatic arthritis. 
 
In some cases, you may experience common side-effects such as diarrhoea, headache, upper respiratory tract infection, cold, nausea, and vomiting. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.
 
Inform your doctor if you have an active infection, if you have a condition that increases the chance of having infections, if you are taking immunosuppressants, medicines that affect the immune system or corticosteroids. Avoid taking Tofashine Xr 11Mg Tab if you are pregnant or breastfeeding. Tofashine Xr 11Mg Tab is not recommended for children below 18 years as safety and effectiveness have not been established. Keep your doctor informed about your health condition and medicines to rule out any side effects.

Uses of Tofashine Xr 11Mg Tab

Treatment of Rheumatoid arthritis, Psoriatic arthritis, Ulcerative colitis.

Directions for Use

Swallow Tofashine Xr 11Mg Tab as a whole with a glass of water; do not chew or break it.

Medicinal Benefits

Tofashine Xr 11Mg Tab belongs to a group of medicines called Janus kinase inhibitors used to treat rheumatoid arthritis, psoriatic arthritis, and ulcerative colitis. Tofashine Xr 11Mg Tab works by blocking Janus kinase enzyme, thereby lowering inflammation and symptoms associated with rheumatoid and psoriatic arthritis. Tofashine Xr 11Mg Tab is indicated for patients with moderate to severe rheumatic arthritis, and psoriatic arthritis who have had intolerance or inadequate response to methotrexate or DMARDs (Disease-Modifying Anti-Rheumatic Drugs).

How Tofashine Xr 11Mg Tab Works

Tofashine Xr 11Mg Tab contains 'Tofacitinib' which works by blocking the Janus kinase enzyme, thereby lowering inflammation and symptoms associated with rheumatoid and psoriatic arthritis.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Tofashine Xr 11Mg Tab

  • Headache
  • Diarrhoea
  • Vomiting
  • Nausea
  • Upper respiratory tract infection
  • Cold
  • High blood pressure

What if I have taken an overdose of Tofashine Xr 11Mg Tab

Take Tofashine Xr 11Mg Tab only as prescribed by the physician. Do not exceed the recommended dose, as it might cause an overdose. If you suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

Do not take Tofashine Xr 11Mg Tab if you are allergic to any of its components; if you have a severe infection, bloodstream infection, active tuberculosis, or if you have severe liver problems such as cirrhosis. Avoid taking Tofashine Xr 11Mg Tab if you are pregnant or breastfeeding. Inform your doctor if you have an infection, symptoms of infection, a condition that increases chances of infection, are taking any medicines that affect the immune system; have or had a history of tuberculosis, or were in close contact with someone who has/had tuberculosis; chronic lung disease, liver problems, hepatitis B/C, cancer, are at a high risk of developing skin cancer, inflammation/ulcers of the large intestine, kidney problems, planning to get vaccinated, heart problems, high cholesterol, high blood pressure, heart attack, diabetes, or blood clotting problems. If your white blood cell count or red blood cell count is low, avoid taking Tofashine Xr 11Mg Tab . Tofashine Xr 11Mg Tab is not recommended for children below 18 years as safety and effectiveness have not been established. Keep your doctor informed about your health condition and medicines to rule out any side effects.

Drug-Drug Interactions

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TofacitinibBortezomib
Severe
TofacitinibPemetrexed
Severe

Drug-Drug Interactions

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TofacitinibBortezomib
Severe
How does the drug interact with Tofashine XR 11 mg Tablet:
Taking Tofashine XR 11 mg Tablet and bortezomib may increase the risk of infections.

How to manage the interaction:
Although using Bortezomib and Tofashine XR 11 mg Tablet together can possibly result in an interaction, they can be taken together if advised by your doctor. However, contact a doctor if you experience fever, chills, diarrhea, sore throat, muscle aches, red or irritated skin, or burning during urination. Do not stop taking any medications without consulting a doctor.
TofacitinibPemetrexed
Severe
How does the drug interact with Tofashine XR 11 mg Tablet:
Taking Tofashine XR 11 mg Tablet with Pemetrexed may increase the risk of infection.

How to manage the interaction:
Although there is a possible interaction between Pemetrexed and Tofashine XR 11 mg Tablet, you can take these medicines together if prescribed by your doctor. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue any medications without first consulting your doctor.
TofacitinibVedolizumab
Severe
How does the drug interact with Tofashine XR 11 mg Tablet:
Taking Vedolizumab with Tofashine XR 11 mg Tablet may increase the risk of infection.

How to manage the interaction:
Taking Tofashine XR 11 mg Tablet with Vedolizumab together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination.Do not stop using any medications without a doctor's advice.
TofacitinibDactinomycin
Severe
How does the drug interact with Tofashine XR 11 mg Tablet:
Taking Tofashine XR 11 mg Tablet with Dactinomycin may increase the risk of serious infection.

How to manage the interaction:
Taking Dactinomycin with Tofashine XR 11 mg Tablet together can possibly result in an interaction, but it can be taken if your doctor has advised it. If you experience any complications, infections, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, or pain or burning when you pee, make sure to call your doctor right away. Do not stop using any medications without first talking to your doctor.
TofacitinibBetamethasone
Severe
How does the drug interact with Tofashine XR 11 mg Tablet:
Using Tofashine XR 11 mg Tablet with betamethasone may increase the risk of serious infections. It may also increase the risk of gastrointestinal bleeding.

How to manage the interaction:
Although there is an interaction between betamethasone and Tofashine XR 11 mg Tablet, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue any medications without consulting your doctor.
TofacitinibDocetaxel
Severe
How does the drug interact with Tofashine XR 11 mg Tablet:
When Tofashine XR 11 mg Tablet is taken with Docetaxel, the body's ability to break down Tofashine XR 11 mg Tablet may be reduced.

How to manage the interaction:
Although there is a possible interaction between Tofashine XR 11 mg Tablet and Docetaxel, you can take these medicines together if prescribed by your doctor. "If you are taking Tofashine XR 11 mg Tablet along with other drugs that weaken your immune system, it is important to be closely monitored for any signs of infection. This includes the possibility of getting tuberculosis, even if you tested negative for it before starting the medication." Do not stop using any medications without first talking to your doctor.
TofacitinibPromazine
Severe
How does the drug interact with Tofashine XR 11 mg Tablet:
Using Tofashine XR 11 mg Tablet together with promazine may increase the risk of serious infections.

How to manage the interaction:
There may be a possibility of interaction between Tofashine XR 11 mg Tablet and Promazine, but it can be taken if prescribed by a doctor. "If you are taking Tofashine XR 11 mg Tablet along with other drugs that weaken your immune system, it is important to be closely monitored for any signs of infection. Do not stop using any medications without a doctor's advice.
TofacitinibEpirubicin
Severe
How does the drug interact with Tofashine XR 11 mg Tablet:
Taking Tofashine XR 11 mg Tablet with Epirubicin may increase the risk of serious infection.

How to manage the interaction:
Co-administration of Epirubicin with Tofashine XR 11 mg Tablet can possibly result in an interaction, but it can be taken if your doctor has advised it. If you have any of these symptoms - infection, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, pain or burning during urination - make sure to call your doctor right away. Do not discontinue any medications without first consulting your doctor.
TofacitinibPrednisolone
Severe
How does the drug interact with Tofashine XR 11 mg Tablet:
Co-administration of Tofashine XR 11 mg Tablet and Prednisolone can increase the risk of serious infections, diverticular disease (development of small bulges in the lining of the intestine), or gastrointestinal bleeding or perforation.

How to manage the interaction:
Although taking Tofashine XR 11 mg Tablet and Prednisolone together can result in an interaction, it can be taken if a doctor has prescribed it. If you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in the coughing fluid, weight loss, red or inflamed skin, body sores, pain or burning when urinating, severe abdominal pain, fever, nausea, or vomiting, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
TofacitinibRitonavir
Severe
How does the drug interact with Tofashine XR 11 mg Tablet:
Taking Tofashine XR 11 mg Tablet with ritonavir may increase the blood levels of Tofashine XR 11 mg Tablet.

How to manage the interaction:
Although there is a possible interaction between Tofashine XR 11 mg Tablet and Ritonavir, but it can be taken together if prescribed by your doctor. However, consult your doctor if you experience fatigue, dizziness, fainting, fever, chills, loose stools, sore throat, muscle aches, shortness of breath, red or inflamed skin, body sores, and pain or burning during urination Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Physical activity helps in strengthening muscles and relieves joint stiffness. Gentle activities like 20-30minutes of walking or swimming would be helpful.

  • Performing yoga may also help in improving joint flexibility and pain management.

  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.

  • Get adequate sleep, as resting the muscles can help in reducing inflammation and swelling.

  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.

  • Acupuncture, massage and physical therapy may also be helpful.

  • Eat food rich in antioxidants such as berries, spinach, kidney beans, dark chocolate, etc.

  • Foods containing flavonoids help in reducing inflammation. These include soy, berries, broccoli, grapes and green tea.

  • Avoid smoking and alcohol consumption.

Habit Forming

No

Therapeutic Class

ANTIRHEUMATICS, DISEASE MODIFYING ANTIRHEUMATIC DRUGS (DMARDs)

Tofashine Xr 11Mg Tab Substitute

Substitutes safety advice
  • Tfct-Nib OD 11 Tablet 10's

    by Others

    78.17per tablet
  • Tofadoz-11 XR Tablet 10's

    by Others

    64.17per tablet
  • Aztofa XR 11 mg Tablet 10's

    by Others

    85.50per tablet
  • Exnib Od 11 mg Tablet 15's

    by Others

    67.50per tablet
  • Tofe-ER Tablet 10's

    by Others

    28.80per tablet
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Alcohol

Caution

It is not known if alcohol interacts with Tofashine Xr 11Mg Tab , so please consult a doctor.

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Pregnancy

Unsafe

Tofashine Xr 11Mg Tab must not be taken during pregnancy. If you are a woman of child-bearing potential, use effective contraception during the treatment with Tofashine Xr 11Mg Tab and for 4 weeks after discontinuation.

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Breast Feeding

Unsafe

Avoid breastfeeding while taking Tofashine Xr 11Mg Tab . Please consult a doctor if you have any concerns.

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Driving

Safe

Tofashine Xr 11Mg Tab generally does not affect your ability to drive. However, drive or operate machinery only if you are alert.

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Liver

Caution

Dose adjustment may be needed in patients with liver impairment. Please consult your doctor if you have a liver impairment or any concerns regarding this. Tofashine Xr 11Mg Tab is not recommended for patients with severe liver problems.

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Kidney

Caution

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Unsafe

Tofashine Xr 11Mg Tab is not recommended for children below 18 years as safety and effectiveness were not established.

FAQs

Tofashine Xr 11Mg Tab is used to treat rheumatoid arthritis, psoriatic arthritis, and ulcerative colitis.
Tofashine Xr 11Mg Tab works by blocking Janus kinase enzyme, thereby lowers inflammation and symptoms associated with rheumatoid and psoriatic arthritis.
Hypertension/high blood pressure could be a side-effect of Tofashine Xr 11Mg Tab . Consult your doctor before taking Tofashine Xr 11Mg Tab if you have high blood pressure or if you are taking anti-hypertensive medicines.
Diarrhoea might be a side-effect of Tofashine Xr 11Mg Tab . Eat non-spicy meals and drink plenty of fluids to prevent dehydration if you experience diarrhoea. If you find blood in stools (tarry stools) or if you experience severe diarrhoea, consult your doctor. Do not take anti-diarrheal medicine on your own.
Tofashine Xr 11Mg Tab might impair fertility in females of reproductive potential. It is not known if the effect is reversible. Therefore, talk to a doctor before starting Tofashine Xr 11Mg Tab if you are trying to become pregnant or if you have any concerns regarding this.
Tofashine Xr 11Mg Tab affects the immune system and might lower the ability of the immune system to fight infections. Inform your doctor if you have an active infection, if you have a condition that increases the chance of having infections, if you are taking immunosuppressants, medicines that affect the immune system or corticosteroids.
Tofashine Xr 11Mg Tab is not recommended for patients with severe liver impairment. Dose adjustment may be needed in patients with mild to moderate liver impairment. Please consult the doctor if you have liver problems.
Tofashine Xr 11Mg Tab may increase the risk of cancer by changing the way the immune system works. Inform the doctor if you ever had any type of cancer.
Tofashine Xr 11Mg Tab may begin working within 2-8 weeks after starting the treatment.
Tofashine Xr 11Mg Tab should not be taken along with tocilizumab as it might increase the risk of infections. Before starting Tofashine Xr 11Mg Tab , inform the doctor if you are taking tocilizumab.
Prior to starting Tofashine Xr 11Mg Tab , active or latent tuberculosis test, CBC (complete blood count), LFT (liver function test), and lipid profile tests should be done.

Country of origin

India

Manufacturer/Marketer address

Sun Pharmaceutical Industries Ltd., Sun House, Cts No. 201 B/1, Western Express Highway, Goregaon (E), Mumbai 400063
Other Info - TOF0057

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