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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Tofadoz 10 Tablet is used to treat rheumatoid arthritis, psoriatic arthritis, and ulcerative colitis. It contains Tofacitinib which works by lowering inflammation and symptoms associated with arthritis. In some cases, this medicine may cause side effects such as diarrhoea, headache, upper respiratory tract infection, nausea, and vomiting. Before taking this medicine, inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Composition :

TOFACITINIB-10MG

Manufacturer/Marketer :

Msn Laboratories Pvt Ltd

Consume Type :

ORAL

Return Policy :

3 Days Returnable

Expires on or after :

Jan-27

About Tofadoz 10 Tablet

Tofadoz 10 Tablet belongs to a group of medicines called Janus kinase inhibitors used to treat rheumatoid arthritis, psoriatic arthritis, and ulcerative colitis. Rheumatoid arthritis is an auto-immune disease (the body's immune system attacks its tissue) which leads to joint pain and damage. Psoriatic arthritis is an inflammatory condition of the joints, often associated with psoriasis. Ulcerative colitis is an inflammatory disease of the large intestine.
 
Tofadoz 10 Tablet contains 'Tofacitinib' which works by blocking the Janus kinase enzyme, thereby lowering inflammation and symptoms associated with rheumatoid and psoriatic arthritis. 
 
In some cases, you may experience common side-effects such as diarrhoea, headache, upper respiratory tract infection, cold, nausea, and vomiting. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.
 
Inform your doctor if you have an active infection, if you have a condition that increases the chance of having infections, if you are taking immunosuppressants, medicines that affect the immune system or corticosteroids. Avoid taking Tofadoz 10 Tablet if you are pregnant or breastfeeding. Tofadoz 10 Tablet is not recommended for children below 18 years as safety and effectiveness have not been established. Keep your doctor informed about your health condition and medicines to rule out any side effects.

Uses of Tofadoz 10 Tablet

Treatment of Rheumatoid arthritis, Psoriatic arthritis, Ulcerative colitis.

Directions for Use

Swallow Tofadoz 10 Tablet as a whole with a glass of water; do not chew or break it.

Medicinal Benefits

Tofadoz 10 Tablet belongs to a group of medicines called Janus kinase inhibitors used to treat rheumatoid arthritis, psoriatic arthritis, and ulcerative colitis. Tofadoz 10 Tablet works by blocking Janus kinase enzyme, thereby lowering inflammation and symptoms associated with rheumatoid and psoriatic arthritis. Tofadoz 10 Tablet is indicated for patients with moderate to severe rheumatic arthritis, and psoriatic arthritis who have had intolerance or inadequate response to methotrexate or DMARDs (Disease-Modifying Anti-Rheumatic Drugs).

How Tofadoz 10 Tablet Works

Tofadoz 10 Tablet contains 'Tofacitinib' which works by blocking the Janus kinase enzyme, thereby lowering inflammation and symptoms associated with rheumatoid and psoriatic arthritis.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Tofadoz 10 Tablet

  • Headache
  • Diarrhoea
  • Vomiting
  • Nausea
  • Upper respiratory tract infection
  • Cold
  • High blood pressure

What if I have taken an overdose of Tofadoz 10 Tablet

Take Tofadoz 10 Tablet only as prescribed by the physician. Do not exceed the recommended dose, as it might cause an overdose. If you suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

Do not take Tofadoz 10 Tablet if you are allergic to any of its components; if you have a severe infection, bloodstream infection, active tuberculosis, or if you have severe liver problems such as cirrhosis. Avoid taking Tofadoz 10 Tablet if you are pregnant or breastfeeding. Inform your doctor if you have an infection, symptoms of infection, a condition that increases chances of infection, are taking any medicines that affect the immune system; have or had a history of tuberculosis, or were in close contact with someone who has/had tuberculosis; chronic lung disease, liver problems, hepatitis B/C, cancer, are at a high risk of developing skin cancer, inflammation/ulcers of the large intestine, kidney problems, planning to get vaccinated, heart problems, high cholesterol, high blood pressure, heart attack, diabetes, or blood clotting problems. If your white blood cell count or red blood cell count is low, avoid taking Tofadoz 10 Tablet . Tofadoz 10 Tablet is not recommended for children below 18 years as safety and effectiveness have not been established. Keep your doctor informed about your health condition and medicines to rule out any side effects.

Drug-Drug Interactions

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TofacitinibMercaptopurine
Severe
TofacitinibZidovudine
Severe

Drug-Drug Interactions

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TofacitinibMercaptopurine
Severe
How does the drug interact with Tofadoz 10 Tablet 10's:
Taking Tofadoz 10 Tablet 10's and Mercaptopurine increases the risk of infection.

How to manage the interaction:
Although there is a possible interaction between Mercaptopurine and Tofadoz 10 Tablet 10's, you can take these medicines together if prescribed by your doctor. If you experience any of these symptoms - serious infections, complications, fever, chills, diarrhea, sore throat, muscle pain, difficulty breathing, weight loss, or pain or burning when you pee - contact your doctor right away. Do not stop using any medications without talking to a doctor.
TofacitinibZidovudine
Severe
How does the drug interact with Tofadoz 10 Tablet 10's:
Taking Zidovudine with Tofadoz 10 Tablet 10's may increase the risk of serious infection.

How to manage the interaction:
Although there is a possible interaction between Tofadoz 10 Tablet 10's and Zidovudine, you can take these medicines together if prescribed by your doctor. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without first talking to your doctor.
TofacitinibPosaconazole
Severe
How does the drug interact with Tofadoz 10 Tablet 10's:
Posaconazole can raise the levels of Tofadoz 10 Tablet 10's in the bloodstream. You may experience increased side effects, including low blood cell counts, anemia, severe infections, and elevated blood lipid levels.

How to manage the interaction:
Although using Posaconazole and Tofadoz 10 Tablet 10's together can possibly result in an interaction, they can be taken together if advised by your doctor. However, contact your doctor if you experience any side effects of Tofadoz 10 Tablet 10's, such as exhaustion, dizziness, fainting, fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not stop taking any medications without consulting a doctor.
TofacitinibVedolizumab
Severe
How does the drug interact with Tofadoz 10 Tablet 10's:
Taking Vedolizumab with Tofadoz 10 Tablet 10's may increase the risk of infection.

How to manage the interaction:
Taking Tofadoz 10 Tablet 10's with Vedolizumab together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination.Do not stop using any medications without a doctor's advice.
TofacitinibCapecitabine
Severe
How does the drug interact with Tofadoz 10 Tablet 10's:
Co-administration of Tofadoz 10 Tablet 10's with Capecitabine may increase the risk of serious and potential infections.

How to manage the interaction:
Although there is an interaction, Capecitabine can be taken with Tofadoz 10 Tablet 10's if prescribed by the doctor. Consult the prescriber if you develop signs and symptoms of infection such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning sensation during urination. Do not discontinue the medication without consulting a doctor.
TofacitinibProcarbazine
Severe
How does the drug interact with Tofadoz 10 Tablet 10's:
Taking Tofadoz 10 Tablet 10's with Procarbazine may increase the risk of severe infection.

How to manage the interaction:
There may be a possibility of interaction between Tofadoz 10 Tablet 10's and Procarbazine, but it can be taken if prescribed by a doctor. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without first talking to your doctor.
TofacitinibPhenytoin
Severe
How does the drug interact with Tofadoz 10 Tablet 10's:
Using Tofadoz 10 Tablet 10's together with phenytoin may reduce the blood levels and effects of Tofadoz 10 Tablet 10's.

How to manage the interaction:
Taking Tofadoz 10 Tablet 10's with Phenytoin together can result in an interaction, but it can be taken if your doctor has advised it. Doctors can recommend other options that won't cause any problems when taken together. Do not stop using any medications without talking to a doctor.
TofacitinibCabazitaxel
Severe
How does the drug interact with Tofadoz 10 Tablet 10's:
Using Tofadoz 10 Tablet 10's together with cabazitaxel may increase the risk of serious infections.

How to manage the interaction:
Taking Cabazitaxel with Tofadoz 10 Tablet 10's together can possibly result in an interaction, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue any medications without consulting your doctor.
TofacitinibLinezolid
Severe
How does the drug interact with Tofadoz 10 Tablet 10's:
When used with linezolid, Tofadoz 10 Tablet 10's may raise the risk of serious infections.

How to manage the interaction:
Although taking linezolid and Tofadoz 10 Tablet 10's together can result in an interaction, they can be taken if a doctor has prescribed it. However, if you develop a fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in sputum, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, contact a doctor immediately. Do not discontinue any medication without consulting a doctor.
TofacitinibTrastuzumab
Severe
How does the drug interact with Tofadoz 10 Tablet 10's:
Combining Trastuzumab with Tofadoz 10 Tablet 10's can increase the risk of neutropenia.

How to manage the interaction:
Although there is a possible interaction between Trastuzumab and Tofadoz 10 Tablet 10's, you can take these medicines together if prescribed by your doctor. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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TOFACITINIB-10MGGrapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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TOFACITINIB-10MGGrapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Grapefruit, Grapefruit Juice

How to manage the interaction:
Consuming grapefruit products while taking Tofadoz 10 Tablet 10's can increase the risk of side effects. Avoid consuming grapefruit products while being treated with Tofadoz 10 Tablet 10's, as it can lead to an interaction.

Diet & Lifestyle Advise

  • Physical activity helps in strengthening muscles and relieves joint stiffness. Gentle activities like 20-30minutes of walking or swimming would be helpful.

  • Performing yoga may also help in improving joint flexibility and pain management.

  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.

  • Get adequate sleep, as resting the muscles can help in reducing inflammation and swelling.

  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.

  • Acupuncture, massage and physical therapy may also be helpful.

  • Eat food rich in antioxidants such as berries, spinach, kidney beans, dark chocolate, etc.

  • Foods containing flavonoids help in reducing inflammation. These include soy, berries, broccoli, grapes and green tea.

  • Avoid smoking and alcohol consumption.

Habit Forming

No

Therapeutic Class

ANTIRHEUMATICS, DISEASE MODIFYING ANTIRHEUMATIC DRUGS (DMARDs)

Tofadoz 10 Tablet Substitute

Substitutes safety advice
  • Jaknat 10 Tablet 10's

    58.50per tablet
  • Tritonib 10 Tablet 10's

    51.30per tablet
  • Tofe-10 Tablet 10's

    48.15per tablet
  • Jakura 10 Tablet 10's

    81.00per tablet
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Alcohol

Caution

It is not known if alcohol interacts with Tofadoz 10 Tablet , so please consult a doctor.

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Pregnancy

Unsafe

Tofadoz 10 Tablet must not be taken during pregnancy. If you are a woman of child-bearing potential, use effective contraception during the treatment with Tofadoz 10 Tablet and for 4 weeks after discontinuation.

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Breast Feeding

Unsafe

Avoid breastfeeding while taking Tofadoz 10 Tablet . Please consult a doctor if you have any concerns.

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Driving

Safe

Tofadoz 10 Tablet generally does not affect your ability to drive. However, drive or operate machinery only if you are alert.

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Liver

Caution

Dose adjustment may be needed in patients with liver impairment. Please consult your doctor if you have a liver impairment or any concerns regarding this. Tofadoz 10 Tablet is not recommended for patients with severe liver problems.

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Kidney

Caution

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Unsafe

Tofadoz 10 Tablet is not recommended for children below 18 years as safety and effectiveness were not established.

FAQs

Tofadoz 10 Tablet is used to treat rheumatoid arthritis, psoriatic arthritis, and ulcerative colitis.
Tofadoz 10 Tablet works by blocking Janus kinase enzyme, thereby lowers inflammation and symptoms associated with rheumatoid and psoriatic arthritis.
Hypertension/high blood pressure could be a side-effect of Tofadoz 10 Tablet . Consult your doctor before taking Tofadoz 10 Tablet if you have high blood pressure or if you are taking anti-hypertensive medicines.
Diarrhoea might be a side-effect of Tofadoz 10 Tablet . Eat non-spicy meals and drink plenty of fluids to prevent dehydration if you experience diarrhoea. If you find blood in stools (tarry stools) or if you experience severe diarrhoea, consult your doctor. Do not take anti-diarrheal medicine on your own.
Tofadoz 10 Tablet might impair fertility in females of reproductive potential. It is not known if the effect is reversible. Therefore, talk to a doctor before starting Tofadoz 10 Tablet if you are trying to become pregnant or if you have any concerns regarding this.
Tofadoz 10 Tablet affects the immune system and might lower the ability of the immune system to fight infections. Inform your doctor if you have an active infection, if you have a condition that increases the chance of having infections, if you are taking immunosuppressants, medicines that affect the immune system or corticosteroids.
Tofadoz 10 Tablet is not recommended for patients with severe liver impairment. Dose adjustment may be needed in patients with mild to moderate liver impairment. Please consult the doctor if you have liver problems.
Tofadoz 10 Tablet may increase the risk of cancer by changing the way the immune system works. Inform the doctor if you ever had any type of cancer.
Tofadoz 10 Tablet may begin working within 2-8 weeks after starting the treatment.
Tofadoz 10 Tablet should not be taken along with tocilizumab as it might increase the risk of infections. Before starting Tofadoz 10 Tablet , inform the doctor if you are taking tocilizumab.
Prior to starting Tofadoz 10 Tablet , active or latent tuberculosis test, CBC (complete blood count), LFT (liver function test), and lipid profile tests should be done.

Country of origin

INDIA

Manufacturer/Marketer address

Msn Laboratories Pvt.Ltd., Msn House, Plot No: C-24, Industrial Estate, Sanathnagar, Hyderabad - 18 Telangana, India
Other Info - TOF0051

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