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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Tiskatel CA 40/5/12.5 Tablet is used to treat high blood pressure (hypertension). It widens blood vessels and increases blood flow, further improving the oxygen delivery to the heart tissue. Also, it decreases the amount of blood the heart pumps (cardiac output) and reduces body fluids outside the cells. It lowers blood pressure and increases blood flow by preventing the narrowing of blood vessels. It may cause side effects such as sleepiness, taste changes, ankle swelling, headache, flushing (feeling warmth in the face, ears, neck, and trunk), dizziness, tiredness, irregular heartbeat, and upset stomach. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Manufacturer/Marketer :

Tiska Life Sciences

Consume Type :

ORAL

Return Policy :

3 Days Returnable

Expires on or after :

Jan-27

About Tiskatel CA 40/5/12.5 Tablet

Tiskatel CA 40/5/12.5 Tablet is an anti-hypertensive drug primarily used to treat high blood pressure (hypertension). Hypertension is a medical condition in which blood pressure is elevated persistently in the arteries. It is considered an essential risk factor for cardiovascular diseases. 

Tiskatel CA 40/5/12.5 Tablet consists of three anti-hypertensive medicines, Amlodipine, Chlorthalidone, and Telmisartan. Amlodipine belongs to the class of calcium channel blockers. It is a vasodilator that dilates (widens) blood vessels and increases blood flow, further improving the oxygen delivery to the heart tissue. Chlorthalidone belongs to the class of diuretics (water pills) with antihypertensive activity. It inhibits sodium and chloride reabsorption from absorbing excess salts that cause fluid retention or build-up. Chlorthalidone lowers blood pressure by decreasing the amount of blood the heart pumps (cardiac output) and reducing plasma and extracellular fluid volume (body fluids outside the cells). Telmisartan belongs to a group of drugs called angiotensin II receptor antagonists (angiotensin is a hormone that constricts blood vessels and increases blood pressure). It lowers blood pressure and increases blood flow by preventing the narrowing of blood vessels. 

In some cases, Tiskatel CA 40/5/12.5 Tablet can cause side effects like sleepiness, taste changes, ankle swelling, headache, flushing (feeling warmth in the face, ears, neck, and trunk), dizziness, tiredness, palpitations (irregular heartbeat), and upset stomach. Most of these side effects of Tiskatel CA 40/5/12.5 Tablet do not require medical attention and gradually resolve over time. However, if these side effects persist longer, please consult your doctor.

If you are known to be allergic to Tiskatel CA 40/5/12.5 Tablet or any other medicines, please inform your doctor. Before taking Tiskatel CA 40/5/12.5 Tablet , let your doctor know if you have any heart, kidney, or liver problems, diabetes, electrolyte imbalance, and dehydration. Avoid potassium supplements with Tiskatel CA 40/5/12.5 Tablet as it may lead to high potassium levels in the blood. Pregnant or breastfeeding women should also consult their doctor before taking Tiskatel CA 40/5/12.5 Tablet . It is advised to complete the prescribed course, even if you feel better. Please do not stop taking Tiskatel CA 40/5/12.5 Tablet on your own, as it may lead to the recurrence of symptoms or worsen the disease. Do not consume alcohol with Tiskatel CA 40/5/12.5 Tablet as it may increase the risk of low blood pressure.

Uses of Tiskatel CA 40/5/12.5 Tablet

Treatment of Hypertension (high blood pressure).

Directions for Use

Swallow Tiskatel CA 40/5/12.5 Tablet as a whole with water; do not crush, break or chew it.

Medicinal Benefits

Tiskatel CA 40/5/12.5 Tablet is an anti-hypertensive drug that treats high blood pressure (hypertension). It contains Amlodipine, Chlorthalidone, and Telmisartan. Amlodipine is a calcium channel blocker that dilates (widens) blood vessels and increases blood flow. It is used to treat high blood pressure, chest pain (angina), and other conditions caused by coronary artery disease. Chlorthalidone is a diuretic (water pill). It prevents the body from absorbing excess salts that cause fluid retention or build-up. It effectively treats high blood pressure, fluid retention in patients with congestive heart failure, cirrhosis (chronic damage) of the liver, kidney disorders, or edema caused by steroids or estrogen therapy. Telmisartan is an angiotensin II receptor antagonist (angiotensin is a hormone that constricts blood vessels and increases blood pressure). It lowers blood pressure and increases blood flow by preventing the narrowing of blood vessels. It reduces the risk of stroke, heart attack, or death from heart problems.

How Tiskatel CA 40/5/12.5 Tablet Works

Tiskatel CA 40/5/12.5 Tablet consists of three anti-hypertensive medicines, Amlodipine, Chlorthalidone, and Telmisartan. Amlodipine belongs to the class of calcium channel blockers. It is a vasodilator that dilates (widens) blood vessels and increases blood flow, further improving the oxygen delivery to the heart tissue. Chlorthalidone belongs to the class of diuretics (water pills) with antihypertensive activity. It inhibits sodium and chloride reabsorption from absorbing excess salts that cause fluid retention or build-up. Chlorthalidone lowers blood pressure by decreasing the amount of blood the heart pumps (cardiac output) and reducing plasma and extracellular fluid volume (body fluids outside the cells). Telmisartan belongs to a group of drugs called angiotensin II receptor antagonists (angiotensin is a hormone that constricts blood vessels and increases blood pressure). It lowers blood pressure and increases blood flow by preventing the narrowing of blood vessels.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Tiskatel CA 40/5/12.5 Tablet

  • Sleepiness
  • Taste changes
  • Ankle swelling
  • Headache
  • Flushing (feeling warmth in the face, ears, neck, and trunk)
  • Dizziness
  • Tiredness
  • Palpitations (irregular heartbeat)
  • Altered blood glucose levels
  • Upset stomach 

What if I have taken an overdose of Tiskatel CA 40/5/12.5 Tablet

Do not take more than the prescribed dose of Tiskatel CA 40/5/12.5 Tablet as it may cause overdose. If you suspect you have taken overdose, please consult a doctor immediately.

Drug Warnings

Monitor your blood pressure levels regularly. If you are known to be allergic to Tiskatel CA 40/5/12.5 Tablet or have any kidney or liver problems or severe dehydration, please inform your doctor beforehand. Brief your medical history if you have low blood pressure, diabetes, gout, lupus (immune system disorder), hyperkalemia (high potassium levels), heart diseases (aortic stenosis, heart failure), angioedema (swelling of the lower layer of skin and tissue), anuria (low or no urine output), and asthma before starting Tiskatel CA 40/5/12.5 Tablet . Avoid potassium supplements with Tiskatel CA 40/5/12.5 Tablet as it may lead to high potassium levels in the blood. Too much sweating, diarrhea, or vomiting while using Tiskatel CA 40/5/12.5 Tablet may lead to dehydration; hence it is advised to drink enough fluids. Tiskatel CA 40/5/12.5 Tablet can affect and harm the developing baby during pregnancy. Consult your doctor before using Tiskatel CA 40/5/12.5 Tablet if you are a pregnant or breastfeeding mother. Complete the course strictly as suggested by the doctor, even if you feel better, to avoid disease recurrence. Avoid consumption of alcohol with Tiskatel CA 40/5/12.5 Tablet as it may increase the risk of low blood pressure. Safety and effectiveness of Tiskatel CA 40/5/12.5 Tablet in pediatric patients have not been established.

Drug-Drug Interactions

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chlorthalidoneCisapride
Critical
AmlodipineDantrolene
Critical

Drug-Drug Interactions

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chlorthalidoneCisapride
Critical
How does the drug interact with Tiskatel CA 40/5/12.5 Tablet 10's:
Co-administration of Tiskatel CA 40/5/12.5 Tablet 10's and cisapride may increase the risk or severity of an irregular heart rhythm that may be serious.

How to manage the interaction:
Taking Tiskatel CA 40/5/12.5 Tablet 10's with Cisapride is not recommended, please consult your doctor before taking it. Do not discontinue the medication without consulting a doctor.
AmlodipineDantrolene
Critical
How does the drug interact with Tiskatel CA 40/5/12.5 Tablet 10's:
Using Tiskatel CA 40/5/12.5 Tablet 10's together with dantrolene may increase the risk of hyperkalemia (high blood potassium).

How to manage the interaction:
Taking Tiskatel CA 40/5/12.5 Tablet 10's with Dantrolene can cause an interaction, consult a doctor before taking it. You should seek medical attention if you experience nausea, vomiting, weakness, confusion, tingling of the hands and feet, a weak pulse, or a slow or irregular heartbeat. Do not stop using any medications without talking to a doctor.
TelmisartanAliskiren
Critical
How does the drug interact with Tiskatel CA 40/5/12.5 Tablet 10's:
Co-administration of Aliskiren with Tiskatel CA 40/5/12.5 Tablet 10's can increase the risk of hyperkalemia (high potassium levels in the blood).

How to manage the interaction:
Taking Tiskatel CA 40/5/12.5 Tablet 10's with Aliskiren can possibly lead to an interaction, please consult a doctor before taking it. Do not discontinue the medications without consulting a doctor.
chlorthalidonePimozide
Severe
How does the drug interact with Tiskatel CA 40/5/12.5 Tablet 10's:
Co-administration of Tiskatel CA 40/5/12.5 Tablet 10's with pimozide can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Although there is an interaction, Tiskatel CA 40/5/12.5 Tablet 10's can be taken with pimozide if prescribed by the doctor. Consult the prescriber if you develop sudden dizziness, lightheadedness, fainting, or fast or pounding heartbeats during treatment with pimozide. Also, let the doctor know if you experience signs of electrolyte disturbance, such as weakness, tiredness, drowsiness, confusion, muscle pain, cramps, dizziness, nausea, or vomiting. Do not discontinue any medications without consulting a doctor.
chlorthalidoneAmiodarone
Severe
How does the drug interact with Tiskatel CA 40/5/12.5 Tablet 10's:
Coadministration of Tiskatel CA 40/5/12.5 Tablet 10's with amiodarone may increase the risk of abnormal heart rhythms.

How to manage the interaction:
Although taking Tiskatel CA 40/5/12.5 Tablet 10's with amiodarone may cause an interaction, it is safe to do so if your doctor has prescribed it. If you have a cardiac problem or electrolyte imbalances, you may be more vulnerable. If you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or a rapid heartbeat, consult a doctor. Do not stop taking any medications without visiting a doctor.
chlorthalidoneLithium
Severe
How does the drug interact with Tiskatel CA 40/5/12.5 Tablet 10's:
Co-administration of Tiskatel CA 40/5/12.5 Tablet 10's together with lithium can increase the effects of lithium.

How to manage the interaction:
Although there is a interaction between Tiskatel CA 40/5/12.5 Tablet 10's and lithium, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience diarrhea, vomiting, drowsiness, shaking of hands and legs, thirst, increased urination, lack of coordination, or muscle weakness. Do not discontinue any medications without consulting a doctor.
chlorthalidoneZiprasidone
Severe
How does the drug interact with Tiskatel CA 40/5/12.5 Tablet 10's:
Co-administration of Tiskatel CA 40/5/12.5 Tablet 10's with ziprasidone can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Although there is an interaction, Tiskatel CA 40/5/12.5 Tablet 10's can be taken with ziprasidone if prescribed by the doctor. but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, weakness, tiredness, drowsiness, confusion, muscle pain, cramps, nausea, or vomiting. Do not discontinue any medications without consulting a doctor.
chlorthalidoneArsenic trioxide
Severe
How does the drug interact with Tiskatel CA 40/5/12.5 Tablet 10's:
Taking Tiskatel CA 40/5/12.5 Tablet 10's can make the body eliminate Arsenic trioxide faster, leading to lower levels in the blood and potentially reducing its effectiveness.

How to manage the interaction:
Co-administration of Tiskatel CA 40/5/12.5 Tablet 10's with Arsenic trioxide can possibly result in an interaction, but it can be taken if a doctor has advised it. If you have any of these symptoms, it's important to contact a doctor right away: your heart beating irregularly, feeling dizzy or lightheaded, fainting, having a fast or pounding heartbeat, feeling weak or drowsy, being confused, experiencing muscle pain, or feeling nauseous or vomiting. Do not discontinue any medications without consulting a doctor.
chlorthalidoneDroperidol
Severe
How does the drug interact with Tiskatel CA 40/5/12.5 Tablet 10's:
Taking Droperidol can make Tiskatel CA 40/5/12.5 Tablet 10's less effective in lowering blood pressure.

How to manage the interaction:
Taking Tiskatel CA 40/5/12.5 Tablet 10's with Droperidol together can possibly result in an interaction, but it can be taken if your doctor has advised it. If you have any of these symptoms, it's important to contact your doctor right away. These symptoms include an irregular heart rhythm, severe or long-lasting diarrhea or vomiting, complications, sudden dizziness or lightheadedness, fainting, difficulty breathing, heart palpitations, weakness, feeling sleepy or confused, muscle pain, and feeling nauseous or vomiting. Do not stop using any medications without first talking to your doctor.
chlorthalidoneAminolevulinic acid
Severe
How does the drug interact with Tiskatel CA 40/5/12.5 Tablet 10's:
Co-administration of Aminolevulinic acid and Tiskatel CA 40/5/12.5 Tablet 10's may increase the risk of severe sunburn.

How to manage the interaction:
Taking Tiskatel CA 40/5/12.5 Tablet 10's with Aminolevulinic acid together can possibly result in an interaction, but it can be taken if a doctor has advised it. If you notice that your skin is very sensitive to sunlight or if you have a really bad sunburn, it's important to contact your doctor right away. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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CHLORTHALIDONE-12.50MG+AMLODIPINE-5MG+TELMISARTAN-40MGPotassium rich foods
Moderate

Drug-Food Interactions

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CHLORTHALIDONE-12.50MG+AMLODIPINE-5MG+TELMISARTAN-40MGPotassium rich foods
Moderate
Common Foods to Avoid:
Lentils, Orange Juice, Oranges, Raisins, Potatoes, Salmon Dried, Spinach, Tomatoes, Sweet Potatoes, Coconut Water, Beans, Beetroot, Broccoli, Bananas, Apricots, Avocado, Yogurt

How to manage the interaction:
Taking potassium rich food while on the treatment with Amlodipine, chlorthalidone and telmisartan can increase the levels of potassium salt in blood which lead to experience nausea, vomiting, weakness, confusion, tingling in hands or feet, feeling of heaviness in the legs, or slow or rapid heartbeat. Avoid or limit taking potassium rich food while on the treatment with Amlodipine, chlorthalidone and telmisartan

Diet & Lifestyle Advise

  • Reduce sodium intake in your diet to maintain your blood pressure.

  • Eat natural and healthy foods by cutting down on high on sodium processed foods.

  • Lose those extra pounds since being obese can be a risk factor for hypertension.

  • Exercise regularly to maintain good heart health.

  • Avoid smoking and alcohol intake.

  • Chronic stress may also cause high blood pressure. Therefore, avoid stress triggers and make time for yourself to relax and do activities that you enjoy.

  • Try to include heart-healthy omega-3 fatty acids-containing food drinks in your daily diet. You can also use low-fat cooking oil like olive oil, soybean oil, canola oil, and coconut oil to lower your elevated blood pressure.

  • Limit sodium chloride intake (table salt) in your daily diet to 2300 mg per day or less than 1500 mg is ideal for most adults.

Habit Forming

No

Therapeutic Class

ANTI- HYPERTENSIVES
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Alcohol

Unsafe

It is unsafe to consume alcohol since alcohol consumption with Tiskatel CA 40/5/12.5 Tablet may increase the risk of low blood pressure and cause adverse effects, such as dizziness, fainting, light-headedness, or headache.

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Pregnancy

Unsafe

Tiskatel CA 40/5/12.5 Tablet is not recommended and unsafe in pregnancy. It can affect and harm the developing baby. Consult your doctor before taking Tiskatel CA 40/5/12.5 Tablet if you plan to become pregnant or already pregnant. Your doctor will weigh the potential risks and benefits before prescribing Tiskatel CA 40/5/12.5 Tablet .

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Breast Feeding

Caution

There is no evidence on how Tiskatel CA 40/5/12.5 Tablet affects breastfeeding. Please consult your doctor before taking Tiskatel CA 40/5/12.5 Tablet if you are breastfeeding.

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Driving

Caution

Tiskatel CA 40/5/12.5 Tablet may cause side effects like dizziness, headaches, nausea, or tiredness, which can affect your ability to concentrate and drive. Hence, it is recommended not to drive or operate machinery until you are mentally alert.

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Liver

Caution

Let your doctor know if you have any history of liver diseases before taking Tiskatel CA 40/5/12.5 Tablet . The dosage will be initiated in lower doses and will be further increased in patients with liver diseases. However, Tiskatel CA 40/5/12.5 Tablet is not recommended in patients with severe hepatic impairment.

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Kidney

Caution

Tiskatel CA 40/5/12.5 Tablet may affect kidney functioning. Hence it is advised to seek doctor advice before starting Tiskatel CA 40/5/12.5 Tablet if you have kidney problems. However, it is not recommended in patients with severe renal impairment.

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Children

Unsafe

Safety and effectiveness of Tiskatel CA 40/5/12.5 Tablet in pediatric patients have not been established.

FAQs

Tiskatel CA 40/5/12.5 Tablet belongs to the anti-hypertensive drugs class, primarily used to treat high blood pressure (hypertension).
Tiskatel CA 40/5/12.5 Tablet consists of anti-hypertensive/ blood pressure-lowering drugs: Amlodipine, Chlorthalidone, and Telmisartan. These medicines collectively lower the blood pressure by preventing the fluid build-up and widening the blood vessels, thus improving the blood supply and oxygen delivery to the heart.
Yes, Tiskatel CA 40/5/12.5 Tablet can make you feel dizzy. Dizziness usually occurs when you suddenly stand up from a lying or sitting position. Try rising slowly when you change your posture to relieve dizziness. If the side effect persists longer, please seek medical help.
Tiskatel CA 40/5/12.5 Tablet may cause ankle swelling upon long-term use. Please try to keep your feet at elevated levels when sitting for long hours or sleeping. If the problem persists, consult your doctor and do as advised.
Tiskatel CA 40/5/12.5 Tablet can cause high potassium levels in the blood leading to hyperkalemia (high potassium levels in the blood). Hence it is not recommended to use potassium supplements along with Tiskatel CA 40/5/12.5 Tablet . However, consult your doctor if you are already taking other medicines before starting Tiskatel CA 40/5/12.5 Tablet .
Do not stop using Tiskatel CA 40/5/12.5 Tablet even if you feel better. It should be strictly used as advised by your doctor to avoid the recurrence of symptoms and worsening of the disease.
Please inform your doctor if you are taking Tiskatel CA 40/5/12.5 Tablet and need to undergo any surgery. Your doctor may ask you to stop using Tiskatel CA 40/5/12.5 Tablet or prescribe any alternate medication because blood pressure may be further lowered if taken along with general anesthesia.
Tiskatel CA 40/5/12.5 Tablet is not recommended and unsafe in pregnancy. It can affect and harm the developing baby. Consult your doctor before taking Tiskatel CA 40/5/12.5 Tablet if you plan to become pregnant or already pregnant. Your doctor will weigh the potential risks and benefits before prescribing Tiskatel CA 40/5/12.5 Tablet .

Country of origin

India

Manufacturer/Marketer address

Ahmedabad, Gujarat, India
Other Info - TIS0072

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