Tilstigmin Tablet is used to treat myasthenia gravis. Tilstigmin Tablet is also used when the normal movements of the intestine are absent and to treat post-operative urinary retention.

Tilstigmin Tablet contains 'Neostigmine.' It increases levels of a neurotransmitter called acetylcholine by stopping the excess cholinesterase activity (an enzyme required to break down acetylcholine) involved in communication between nerve impulses and muscle movements. Neurotransmitters are chemical messengers that transmit the message from one nerve cell to another nerve cell, muscle cell, or gland cell. Thus, Tilstigmin Tablet helps with proper muscle functioning and prevents muscle weakness.

Take this medicine as prescribed by your doctor. In some cases, you may experience common side effects, such as nausea, vomiting, abdominal cramps, diarrhoea, increased saliva production, dizziness, headache, trouble sleeping, and dry mouth. These side effects are not familiar to everyone and vary individually. If you notice any side effects that are not manageable, please consult your doctor.

Inform your doctor before using Tilstigmin Tablet if you have a history of liver, heart or kidney diseases, asthma, stomach ulcer, fits, Parkinson’s disease, overactive thyroid, and irritability of the vagus nerve (connects to the abdomen from the brain) that causes excess bowel contractions. Before starting this medicine, you must let your doctor know if you are pregnant, planning to conceive, or a breastfeeding mother. Avoid consuming alcohol during the course to prevent unwanted side effects. Tilstigmin Tablet can be given to children if prescribed by the doctor; the dose depends on the child’s age and weight.

Tilstigmin Tablet belongs to the group of medicines called 'anticholinesterase agents/cholinesterase inhibitors and is used to treat myasthenia gravis (muscle weakness). Tilstigmin Tablet contains 'Neostigmine'. It works by stopping the excessive activity of cholinesterase, helping the muscles work correctly. Additionally, Tilstigmin Tablet is used to treat urinary retention and reverses the effects of neuromuscular blocking agents (tubocurarine, metocurine, gallamine or pancuronium) after surgery. Neostigmine affects the body's chemicals, which are involved in communication between nerve impulses and muscle movements. Thereby, Tilstigmin Tablet treats associated muscle disorders by improving muscle strength.

• Nausea
• Vomiting
• Abdominal cramp
• Diarrhoea
• Increased saliva production
• Dizziness
• Headache
• Trouble sleeping
• Dry mouth

Brief your medical history if you have any liver or kidney diseases, heart diseases (coronary artery disease, irregular heartbeat), asthma, stomach ulcer, fits, urination problems, Parkinson's disease, overactive thyroid, and irritability of vagus nerve (connects to the abdomen from the brain) that causes excess bowel contractions before starting Tilstigmin Tablet . Please consult your doctor if you are pregnant, planning to conceive, or are a breastfeeding mother. Avoid consuming alcohol with Tilstigmin Tablet to get the maximum benefits of the medicine and prevent the aggravation of the disease. Drive or operate machinery only when you are alert and focused during the course.

Drug-Drug Interaction: Tilstigmin Tablet may interact with anaesthetics (halothane, cyclopropane), muscle relaxants (succinylcholine, suxamethonium), antibiotics (neomycin, streptomycin), muscle weakness treating drugs (amifampridine), antidepressants (bupropion), and dementia treating drugs (donepezil).

Drug-Food Interaction: Avoid or limit alcohol intake to prevent disease worsening and unwanted side effects.

Drug-Disease Interaction: Let your doctor know if you have asthma, bradycardia (slow heart rate), bronchospasm, fits, hyperthyroidism, stomach ulcer, coronary artery disease, urination problems, Parkinson's disease, or irritability of vagus nerve before starting Tilstigmin Tablet .

• HALOTHANE
• CYCLOPROPANE
• SUCCINYLCHOLINE
• SUXAMETHONIUM
• NEOMYCIN
• STREPTOMYCIN
• AMIFAMPRIDINE
• BUPROPION
• DONEPEZIL

• Maintain proper weight by following a healthy diet.
• Avoid smoking and alcohol consumption.
• Try to avoid stress by practising meditation or yoga.
• Include fruits and vegetables in your diet as they contain antioxidants.
• Eat warm meals rather than hot meals, as heat aggravates the disease.
• Try sipping a cold drink while having hot or warm meals.
• Avoid foods that require a lot of chewing, like tough meats.
• Exercise regularly to keep your muscles strong
• Limit foods with high cholesterol and saturated fats.
• Cut down on sugar, salt and processed foods.
• Drink plenty of water.

Tilstigmin Tablet might interfere with the effects of skeletal muscle relaxants used in the surgery.

Myasthenia gravis: It is an autoimmune neuromuscular disease that causes skeletal muscle weakness. The immune system mistakenly attacks its own healthy tissues, damaging the neuromuscular membrane. This reduces the effect of acetylcholine, a neurotransmitter that plays a major role in the communication between nerve cells and muscles. Myasthenia gravis occurs when the communication between nerve cells and muscles becomes impaired. This prevents muscle contractions, thereby leading to muscle weakness. The most affected muscles are those of the face and eyes. Symptoms of myasthenia gravis include double vision, drooping eyelids, difficulty chewing or swallowing, weakness, problems with lifting objects, and trouble talking and walking.