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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Last Updated Oct 30, 2024 | 5:55 AM IST

Thromplat 50 mg Tablet is used to treat low platelet count. It contains Eltrombopag which works by causing the cells in the bone marrow to produce more platelets. In some cases, this medicine may cause side effects such as nausea, diarrhoea, headache, muscle pain, tiredness, loss of appetite, fever, and cough. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Composition

ELTROMBOPAG-50MG

Manufacturer/Marketer

Aureate Healthcare

Consume Type

ORAL

Return Policy

Not Returnable

Expires on or after

Apr-26

for this medicine

About Thromplat 50 mg Tablet

Thromplat 50 mg Tablet is used to treat low blood platelet count in patients with idiopathic thrombocytopenic purpura (ITP) and hepatitis C virus (HCV) infections. Thromplat 50 mg Tablet is also used to treat severe aplastic anaemia (SAA) in adults. Idiopathic thrombocytopenic purpura is an immune condition associated with low levels of platelets. Hepatitis C is an infection and inflammation of the liver caused by the hepatitis C virus. Severe aplastic anaemia is a condition in which the bone marrow doesn't make enough blood cells.

Thromplat 50 mg Tablet contains 'Eltrombopag', which belongs to the class of 'thrombopoietin receptor agonists'. Thrombopoietin is a glycoprotein hormone that stimulates the formation of megakaryocytes (large bone marrow cells) and further regulates platelet production. Thromplat 50 mg Tablet works by increasing these large bone marrow cells responsible for the production of platelets. Thus, Thromplat 50 mg Tablet helps increase these bone marrow cells, thereby stimulating the number of platelets, which further lowers the risk of bleeding.

Take Thromplat 50 mg Tablet as prescribed by your doctor. In some cases, Thromplat 50 mg Tablet can cause common side effects like nausea, diarrhoea, headache, muscle pain, tiredness, loss of appetite, fever, anaemia (lack of blood cells), cough and tingling numbness. These side effects are not familiar to everyone who takes Thromplat 50 mg Tablet and vary individually. If you notice any side effects that are not manageable, please consult your doctor.

Let your doctor know if you have any allergic reactions to Thromplat 50 mg Tablet or any other medicines before starting Thromplat 50 mg Tablet . It is essential to inform your doctor if you have any heart, kidney or liver problems, blood disorders, blood clotting problems and cataracts before starting Thromplat 50 mg Tablet . Consult the doctor if you are pregnant or planning to conceive. Thromplat 50 mg Tablet is not indicated for use in breastfeeding since it passes into the breast milk. Thromplat 50 mg Tablet may make you dizzy; hence, drive or operate machinery only when you are mentally alert. 

Uses of Thromplat 50 mg Tablet

Thromplat 50 mg Tablet is used to treat Low platelet count and Severe aplastic anaemia (SAA).

Medicinal Benefits

Thromplat 50 mg Tablet contains 'Eltrombopag,' which belongs to the class of 'thrombopoietin receptor agonists' used to treat low blood platelet count in patients with immune (idiopathic) thrombocytopenic purpura (ITP), hepatitis C virus (HCV) infections and severe aplastic anaemia (SAA) in adults. Thromplat 50 mg Tablet works by increasing megakaryocytes, the large bone marrow cells responsible for the production of platelets. The increase in these bone marrow cells stimulates the production of platelets. Thus Thromplat 50 mg Tablet prevents bleeding episodes by increasing the number of platelets in the blood.

Directions for Use

Tablet: Swallow it as a whole with a glass of water. Take it on an empty stomach as prescribed by the doctor. Do not crush, chew or break it. Powder for suspension: Mix the powder with the prescribed amount of water. Take it with or without food with an oral syringe in the dose and duration prescribed by the doctor.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Thromplat 50 mg Tablet

  • Nausea
  • Diarrhoea
  • Headache
  • Muscle pain
  • Tiredness
  • Loss of appetite
  • Fever
  • Anaemia (lack of blood cells)
  • Cough
  • Tingling or numbness 

Drug Warnings

If you are known to be allergic to Thromplat 50 mg Tablet or other medicines, please inform your doctor in advance. Brief your medical history if you have blood clots, clotting disorders (Factor V Leiden), blood disorders like blood cancer, myelodysplastic syndrome, cataracts, liver or kidney diseases before starting Thromplat 50 mg Tablet . Take Thromplat 50 mg Tablet at least two hours before or four hours after consuming antacids, mineral and vitamin supplements (iron, calcium, magnesium, aluminium, selenium and zinc), dairy products, calcium-enriched foods and fortified juices since they interfere with the absorption of Thromplat 50 mg Tablet . Thromplat 50 mg Tablet is not recommended during pregnancy since it may have harmful effects on the foetus. Consult your doctor before using Thromplat 50 mg Tablet if you are a breastfeeding mother. Do not drive or operate machinery since Thromplat 50 mg Tablet may cause side effects like dizziness and tiredness, affecting your ability to concentrate and drive. Avoid or limit alcohol consumption with Thromplat 50 mg Tablet as it may affect the efficacy of Thromplat 50 mg Tablet . Thromplat 50 mg Tablet is not recommended for children less than one year of age in ITP and children less than two years of age in SAA. 

Drug Interactions

Drug-Drug Interactions: Thromplat 50 mg Tablet may interact with antacids, cholesterol-lowering drugs (statins), vitamin and mineral supplements (iron, calcium, magnesium, aluminium, selenium and zinc), anti-cancer drugs (methotrexate, topotecan), drugs for rheumatoid arthritis (ciclosporin, azathioprine), HIV/AIDS drugs (lopinavir, ritonavir), corticosteroids, and steroid hormones (danazol).

Drug-Food Interactions: Take Thromplat 50 mg Tablet at least two hours before or four hours after consuming dairy products, calcium-enriched foods, and fortified juices, as these interfere with the absorption of Thromplat 50 mg Tablet .

Drug-Disease Interactions: People with blood clots, clotting disorders (Factor V Leiden), blood disorders like blood cancer, myelodysplastic syndrome, cataracts, and liver or kidney diseases should consult the doctor before taking Thromplat 50 mg Tablet .

Drug-Drug Interactions Checker List

  • METHOTREXATE
  • TOPOTECAN
  • CICLOSPORIN
  • AZATHIOPRINE
  • LOPINAVIR
  • RITONAVIR
  • DANAZOL
  • IRON
  • CALCIUM
  • ZINC

Habit Forming

No

Diet & Lifestyle Advise

  • Eat natural and healthy foods by cutting down on fatty and sodium-processed foods.
  • Exercise regularly to maintain good health.
  • Avoid smoking and alcohol intake.
  • Avoid activities like contact sports and use sharp objects like nail cutters and razors to decrease bleeding risk.
  • A high-protein diet, such as lean meat, chicken, crab, turkey, beef, and fish, can help increase platelet count.
  • EatingPapayaa is the best natural remedy to increase your platelet count, and you can also usePapayaa leave's mixture.
  • Include iron-rich foods like pomegranate, beetroot, green leafy vegetables, carrots, raisins, oranges, peanuts, kidney beans, and black-eyed peas in your diet.
  • Vitamin C sources like guava, black currant, red pepper, kiwi, green peppers, orange, strawberries, pineapple, peas, mango, grapefruit and broccoli can also boost your platelet count.

Special Advise

  • Please monitor your daily blood pressure and blood sugar levels, and if you notice any fluctuations, please consult a doctor.
  • Since Thromplat 50 mg Tablet affects liver enzymes, your doctor may suggest liver function tests to check your aspartate aminotransferase (AST), alanine aminotransferase (ALT) and bilirubin levels before starting treatment and every two weeks after the treatment with Thromplat 50 mg Tablet .
  • Thromplat 50 mg Tablet may also interfere with creatinine and bilirubin lab tests; hence, please inform your doctor and laboratory staff in advance.

Disease/Condition Glossary

Immune (idiopathic) thrombocytopenic purpura (ITP): It is an immune condition associated with low levels of platelets, and the blood doesn't clot normally. It occurs when the immune system mistakenly attacks its own platelets. ITP also occurs in children, followed by a viral infection. Symptoms of ITP may include easy bruising, bleeding from gums and nose, blood in urine and stools, heavy menstrual flow and pinpoint-sized reddish-purple spots on the lower legs.

Hepatitis C: It is an infection and inflammation of the liver caused by the hepatitis C virus. This virus can cause both acute and chronic hepatitis. Acute hepatitis C is a short-term illness that may last for six months. Chronic hepatitis C is a long-lasting disease that may lead to other severe liver cancer problems or cirrhosis (inflammation of the liver). Symptoms of hepatitis C include fatigue, nausea, loss of appetite and yellowing of the eyes and skin.

Severe aplastic anaemia (SAA): Aplastic anaemia is also called bone marrow aplasia. It is a condition in which the bone marrow doesn't make enough blood cells. SAA is commonly caused due to the damage of bone marrow. This damage can be a congenital disability or may occur because of radiation, chemotherapy, toxic chemicals, certain drugs and infections. Symptoms of SAA include fatigue, frequent infections, rapid heart rate and bleeding.

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Alcohol

Caution

Limit alcohol intake, along with Thromplat 50 mg Tablet , to attain the maximum efficacy of Thromplat 50 mg Tablet and rule out any possibility of worsening of side effects.

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Pregnancy

Unsafe

Thromplat 50 mg Tablet is not recommended in pregnancy. It may affect and harm the developing baby. Please consult your doctor if you are pregnant or planning to conceive.

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Breast Feeding

Caution

It is not known if Thromplat 50 mg Tablet is excreted into the breast milk. Please consult your doctor for more information before taking Thromplat 50 mg Tablet if you are a nursing mother.

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Driving

Caution

Thromplat 50 mg Tablet may cause dizziness and tiredness affecting your ability to concentrate and drive. Hence, it is recommended not to drive or operate machinery until you are mentally alert.

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Liver

Caution

Let your doctor know if you have any history of liver diseases before taking Thromplat 50 mg Tablet . Thromplat 50 mg Tablet may cause an increase in liver enzymes. Your doctor may start the treatment with a lower dose of Thromplat 50 mg Tablet .

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Kidney

Caution

Thromplat 50 mg Tablet should be used with caution in cases of renal impairment. It is advised to seek doctor advice before starting Thromplat 50 mg Tablet if you have any kidney problems.

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Children

Caution

Thromplat 50 mg Tablet is not recommended for children less than one year of age in ITP and children less than two years of age in SAA.

Country of origin

India

Manufacturer/Marketer address

S-40, 2Nd Floor, Janta Market, Rajouri Garden, New Delhi - 110 027. India
Other Info - THR0193

Author Details

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FAQs

Thromplat 50 mg Tablet is used to treat low blood platelet count in patients with idiopathic thrombocytopenic purpura (ITP) and hepatitis C virus (HCV) infections. It is also used to treat severe aplastic anaemia (SAA) in adults.
Thromplat 50 mg Tablet contains Eltrombopag that stimulates platelet's production (helps in clotting) from megakaryocytes (bone marrow cells). Thus Thromplat 50 mg Tablet lowers the risk of bleeding episodes in diseases like immune (idiopathic) thrombocytopenic purpura (ITP), hepatitis C virus (HCV) infections and severe aplastic anaemia (SAA).
Do not stop using Thromplat 50 mg Tablet even if you feel better. It should be strictly used as advised by your doctor to avoid the recurrence of symptoms and worsening of the disease.
Thromplat 50 mg Tablet should be used with caution and only under doctor's supervision in cases of any allergic reactions, blood clots, clotting disorders (Factor V Leiden), blood disorders like blood cancer, myelodysplastic syndrome, cataracts, liver or kidney diseases.
Thromplat 50 mg Tablet decreases the risk of bleeding by increasing the platelet count in your body. However, you are advised to stay away from activities that may increase your risk of bleeding like contact sports and using sharp objects like razors and nail cutters.
It is advised to take Thromplat 50 mg Tablet on an empty stomach. Please take Thromplat 50 mg Tablet at least two hours before or four hours after consuming antacids, mineral and vitamin supplements (iron, calcium, magnesium, aluminium, selenium and zinc), dairy products, calcium-enriched foods and fortified juices since they interfere with the absorption of Thromplat 50 mg Tablet .
Thromplat 50 mg Tablet should be swallowed whole. Do not chew or crush the tablets.
It is usually taken once a day on an empty stomach, at least 1 hour before or 2 hours after eating. Take Thromplat 50 mg Tablet at around the same time every day.
It may take up to 2 weeks for patients to respond to Thromplat 50 mg Tablet .
Thromplat 50 mg Tablet should not be taken with foods, beverages, or other medicines that contain high concentrations of aluminium, calcium, iron, magnesium, selenium and zinc.
Thromplat 50 mg Tablet should be stored in a cool and dry place away from sunlight. Keep out of sight and reach of children.
Thromplat 50 mg Tablet can cause or increase the risk of severe liver issues. Check with your doctor straight away if you or your child experience nausea or vomiting, dark urine, light-coloured stools, right upper stomach pain, unusual exhaustion, or yellow eyes or skin while taking this medication.
Please take the missed dose as soon as possible. However, if it is time for the next dose, skip the missed dose and go back to your regular dosing schedule.

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