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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Santoshini Reddy G , M Pharmacy
Temonat 250mg 5 Capsule is an anti-cancer medicine used in the treatment of brain tumours such as glioblastoma multiforme (a type of tumour that grows and spreads rapidly) in adults and malignant glioma, including glioblastoma multiforme or anaplastic astrocytoma. This medicine works by inhibiting the production of DNA (deoxyribonucleic acid-genetic material of the cell), thereby affecting cell growth and division. Common side effects include loss of appetite, anxiety, confusion, headache, vomiting, nausea, diarrhoea, constipation, muscle weakness, muscle aches, and fever.
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Composition :

TEMOZOLOMIDE-250MG

Manufacturer/Marketer :

Natco Pharma Ltd

Consume Type :

ORAL

Return Policy :

3 Days Returnable

Expires on or after :

Jan-27

About Temonat 250mg 5 Capsule

Temonat 250mg 5 Capsule belongs to a class of medicines called 'anti-cancer/ antitumor agent', used to treat specific forms of brain tumours such as glioblastoma multiforme (a type of tumour that grows and spreads rapidly) in adults and malignant glioma, including glioblastoma multiforme or anaplastic astrocytoma (a rare malignant brain tumour) in patients older than 3years. A brain tumour is an uncontrolled and unregulated proliferation of cells in the brain. 

Temonat 250mg 5 Capsule contains Temozolomide which works by inhibiting the production of DNA (deoxyribonucleic acid-genetic material of the cell), thereby affecting cell growth and division. Thus, Temonat 250mg 5 Capsule prevents tumours from growing.

Take Temonat 250mg 5 Capsule as prescribed. In some cases, Temonat 250mg 5 Capsule may cause loss of appetite, anxiety, confusion, headache, vomiting, nausea, diarrhoea, constipation, muscle weakness, muscle aches, and fever. Most of these side effects of Temonat 250mg 5 Capsule do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

Let your doctor know if you are allergic to any of the contents. Temonat 250mg 5 Capsule is not recommended for patients with severe bone marrow depression or significant bleeding. Avoid taking Temonat 250mg 5 Capsule if you are pregnant or breastfeeding. Both women and men using Temonat 250mg 5 Capsule should use birth control to avoid pregnancy and fathering a child. It would be best not to drive and/or operate machines that require alertness as Temonat 250mg 5 Capsule may cause tiredness or sleepiness.

Uses of Temonat 250mg 5 Capsule

Treatment of Brain tumour

Directions for Use

Swallow it as a whole with water; do not crush, break or chew it.

Medicinal Benefits

Temonat 250mg 5 Capsule belongs to a class of medicines called anti-cancer/antitumor agents used to treat specific forms of brain tumours such as glioblastoma multiforme (a type of tumour that grows and spreads rapidly) in adults and malignant glioma, including glioblastoma multiforme or anaplastic astrocytoma (a rare malignant brain tumour) in patients older than 3years. It contains Temozolomide which works by binding to the DNA (deoxyribonucleic acid-genetic material of the cell) and interfering with cell growth and division. Thus, Temonat 250mg 5 Capsule prevents tumours from growing.

How Temonat 250mg 5 Capsule Works

Temonat 250mg 5 Capsule contains Temozolomide which works by inhibiting the production of DNA (deoxyribonucleic acid-genetic material of the cell), thereby affecting cell growth and division. Thus, Temonat 250mg 5 Capsule prevents tumours from growing.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Temonat 250mg 5 Capsule

  • Loss of appetite
  • Difficulty speaking
  • Headache
  • Vomiting
  • Nausea
  • Diarrhoea
  • Constipation
  • Rash
  • Hair loss
  • Tiredness
  • Infections
  • Fever
  • Increased blood sugar
  • Dry skin
  • Swelling
  • Weight loss/gain
  • Frequent urination

What if I have taken an overdose of Temonat 250mg 5 Capsule

Do not take more than the prescribed dose of Temonat 250mg 5 Capsule as it may cause overdose. The symptoms of overdose include unusual bleeding or bruising; red/black/tarry stools; red/dark brown/pink urine; coughing up or vomiting blood or material that looks like coffee grounds; sore throat, fever, ongoing congestion and cough, or other signs of infection. If you suspect you have taken overdose or notice signs of overdose, please consult a doctor immediately.

Drug Warnings

Temonat 250mg 5 Capsule should be taken under strict medical supervision. The doctor will regularly monitor your condition while taking Temonat 250mg 5 Capsule. To treat your condition effectually, continue taking Temonat 250mg 5 Capsule for as long as your doctor has prescribed. Do not stop Temonat 250mg 5 Capsule midway under any circumstances without consulting the healthcare professional. Inform your doctor if you have an allergy to any components of Temonat 250mg 5 Capsule. Inform your doctor before taking Temonat 250mg 5 Capsule if you have allergic reactions, infections, lung, renal or hepatic disorders or low blood count (including neutropenia, lymphopenia, thrombocytopenia). Temonat 250mg 5 Capsule is not recommended for patients with severe bone marrow depression or significant bleeding. Avoid taking Temonat 250mg 5 Capsule if you are pregnant or breastfeeding. Both women and men using Temonat 250mg 5 Capsule should use birth control to avoid pregnancy or fathering a child. Do not receive any vaccinations or immunizations without your doctor's approval while taking Temonat 250mg 5 Capsule.

Drug-Drug Interactions

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TemozolomideThalidomide
Severe
TemozolomideFingolimod
Severe

Drug-Drug Interactions

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TemozolomideThalidomide
Severe
How does the drug interact with Temonat 250mg 5 Capsule:
Taking thalidomide with Temonat 250mg 5 Capsule can increase the risk of blood clots.

How to manage the interaction:
Although taking Temonat 250mg 5 Capsule and thalidomide together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, and/or pain, redness or swelling in an arm or leg. Do not stop using any medications without consulting doctor.
TemozolomideFingolimod
Severe
How does the drug interact with Temonat 250mg 5 Capsule:
Taking Temonat 250mg 5 Capsule with Fingolimod can increase the risk of infection.

How to manage the interaction:
Although taking Temonat 250mg 5 Capsule and fingolimod together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without consulting doctor.
TemozolomideVoclosporin
Severe
How does the drug interact with Temonat 250mg 5 Capsule:
Taking voclosporin with Temonat 250mg 5 Capsule, may increase the risk of serious infections.

How to manage the interaction:
Although taking Temonat 250mg 5 Capsule and voclosporin together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without consulting doctor.
TemozolomideInfliximab
Severe
How does the drug interact with Temonat 250mg 5 Capsule:
Taking Temonat 250mg 5 Capsule with Infliximab can increase the risk of infections.

How to manage the interaction:
Although taking Temonat 250mg 5 Capsule and infliximab together can result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without consulting a doctor.
TemozolomideAdalimumab
Severe
How does the drug interact with Temonat 250mg 5 Capsule:
Using adalimumab together with Temonat 250mg 5 Capsule may increase the risk of serious infections.

How to manage the interaction:
Although taking Temonat 250mg 5 Capsule and Adalimumab together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without first talking to your doctor.
TemozolomideCladribine
Severe
How does the drug interact with Temonat 250mg 5 Capsule:
Using cladribine together with Temonat 250mg 5 Capsule may increase the risk of serious infections.

How to manage the interaction:
Although taking Temonat 250mg 5 Capsule and cladribine together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without consulting doctor.
TemozolomideLeflunomide
Severe
How does the drug interact with Temonat 250mg 5 Capsule:
Taking Temonat 250mg 5 Capsule with Leflunomide can increase the risk of infections.

How to manage the interaction:
Although taking Temonat 250mg 5 Capsule and leflunomide together can result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, red or inflamed skin, body sores, pain or burning during urination, vomiting, dark-colored urine, light-colored stools, and/or yellowing of the skin or eyes. Do not stop using any medications without consulting a doctor.
TemozolomideBaricitinib
Severe
How does the drug interact with Temonat 250mg 5 Capsule:
Taking baricitinib and Temonat 250mg 5 Capsule can increase the risk of developing serious infections.

How to manage the interaction:
Although there is an interaction, baricitinib can be taken with Temonat 250mg 5 Capsule if prescribed by the doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in your coughing fluid, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not stop using any medications without talking to a doctor.
TemozolomideClozapine
Severe
How does the drug interact with Temonat 250mg 5 Capsule:
Taking Temonat 250mg 5 Capsule with clozapine may increase the risk of serious infections.

How to manage the interaction:
Although taking Temonat 250mg 5 Capsule and clozapine together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without consulting doctor.
TemozolomideEtanercept
Severe
How does the drug interact with Temonat 250mg 5 Capsule:
Taking Temonat 250mg 5 Capsule with Etanercept can increase the risk of infections.

How to manage the interaction:
Although taking Temonat 250mg 5 Capsule and etanercept together can result in an interaction, it can be taken if a doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without consulting doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
  • Performing yoga may also help in improving both physical and mental health.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Eat a healthy diet and exercise regularly to maintain proper weight.
  • Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, and herbs in your diet.
  • Get optimal sleep; rest well.
  • Avoid smoking and alcohol consumption.
  • Avoid fast food, fried food, processed meats, refined carbs and added sugars.

Habit Forming

No

Therapeutic Class

ANTINEOPLASTIC

Temonat 250mg 5 Capsule Substitute

Substitutes safety advice
  • Temoside 250 Capsule 5's

    1173.58per tablet
  • Gliotem 250 Capsule 1's

    3952.40per tablet
  • Gliotem 250 mg Capsule 10's

    352.52per tablet
  • TEMOLON 250MG CAPSULE

    3952.56per tablet
  • Axiotem 250 Capsule 5's

    3487.30per tablet
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Alcohol

Caution

You are recommended to avoid alcohol consumption while taking Temonat 250mg 5 Capsule. It could lead to unpleasant side effects.

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Pregnancy

Caution

Please consult your doctor if you have any concerns about this. Temonat 250mg 5 Capsule should not be used during pregnancy unless prescribed by your doctor. Women of childbearing potential must use effective contraception during the treatment and for 6months after completion of the treatment.

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Breast Feeding

Unsafe

Temonat 250mg 5 Capsule should not be taken during breastfeeding as it passes into the breastmilk and may harm the baby.

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Driving

Caution

Temonat 250mg 5 Capsule may make you feel tired or sleepy. Drive and/or operate machines only if you are alert.

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Liver

Caution

If you have had a history or evidence of any liver-related diseases, please consult the doctor before using Temonat 250mg 5 Capsule. Your doctor will weigh the benefits and potential risks before prescribing Temonat 250mg 5 Capsule.

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Kidney

Caution

If you have had a history or evidence of any kidney-related diseases, please consult the doctor before using Temonat 250mg 5 Capsule. Your doctor will weigh the benefits and potential risks before prescribing Temonat 250mg 5 Capsule.

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Children

Caution

Safety and effectiveness of Temonat 250mg 5 Capsule in paediatric patients under the age of three have not been established.

FAQs

Temonat 250mg 5 Capsule belongs to a class of medicines called anti-cancer agents, used to treat specific forms of brain tumours such as glioblastoma multiforme (a type of tumour that grows and spreads rapidly) in adults and malignant glioma, including glioblastoma multiforme or anaplastic astrocytoma (a rare malignant brain tumour) in patients older than 3years.
Temonat 250mg 5 Capsule works by binding to the DNA (deoxyribonucleic acid-genetic material of the cell) and interfering with cell growth and division. Thus, Temonat 250mg 5 Capsule prevents tumours from growing.
Temonat 250mg 5 Capsule may cause permanent infertility. Male patients should use effective contraception and refrain from fathering a child for up to three months after treatment is completed. Prior to treatment, it is recommended to seek sperm conservation advice from your doctor.
Yes, Temonat 250mg 5 Capsule can cause neutropenia (low white blood cells count), lymphopenia (low lymphocytes count), thrombocytopenia (low platelet count). As a part of therapy, your doctor may monitor your blood profile.
Temonat 250mg 5 Capsule may lead to hyperglycemia (Increased blood sugar). Consult your doctor if you are diabetic. Regularly monitor your blood sugar levels while taking Temonat 250mg 5 Capsule.
The live vaccine may interact with Temonat 250mg 5 Capsule. Do not have vaccinations or immunisations without talking to your doctor first.

Country of origin

India

Manufacturer/Marketer address

Natco House, Road No.2, Banjara Hills, Hyderabad-500 034, India
Other Info - TEM0078

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