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Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Tazar 4.5 gm Injection is used to treat bacterial infections. It is used to treat various hospital-acquired and ventilator-associated pneumonia, urinary tract infections, intra-abdominal infections, skin and soft tissue infections (like diabetic foot infections) and uterine infections. It contains Piperacillin and Tazobactam, which kills bacteria. It may cause side effects such as nausea, constipation, diarrhoea, headache, and trouble sleeping. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.
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Manufacturer/Marketer :

Lupin Ltd

Consume Type :

PARENTERAL

Return Policy :

3 Days Returnable

Expires on or after :

Jan-27

About Tazar 4.5 gm Injection

Tazar 4.5 gm Injection belongs to the 'Antibiotics' class of drugs, primarily used to treat bacterial infections. It is used to treat various hospital-acquired and ventilator-associated pneumonia, urinary tract infections, intra-abdominal infections, skin and soft tissue infections (like diabetic foot infections) and uterine infections. Bacterial infection occurs when harmful bacteria grow in the body and causes illness. It can infect any part of the body and multiply very quickly.

Tazar 4.5 gm Injection contains two medicines, namely: Piperacillin (Penicillin antibiotic) and Tazobactam (beta-lactamase inhibitor). Piperacillin belongs to the class of 'Penicillin antibiotics.' It has bactericidal (ability to kill bacteria) activity against gram-positive and gram-negative aerobic (requires oxygen to survive) and anaerobic (survives with little or no oxygen) bacteria. Piperacillin acts by binding to the penicillin-binding proteins (PBPs) inside the bacterial cell wall and inhibits its cell wall synthesis. Tazobactam is a beta-lactamase inhibitor. Beta-lactamases are the enzymes produced by bacteria to gain multi-resistance to β-lactam antibiotics, such as penicillins and cephalosporins. Tazobactam prevents the breakdown of other antibiotics by beta-lactamase enzyme-producing organisms. In Tazar 4.5 gm Injection, Tazobactam works by preventing bacteria from destroying Piperacillin.

Tazar 4.5 gm Injection will be administered by a healthcare professional. Like all medicines, Tazar 4.5 gm Injection also causes side effects, although not everybody gets them. Common side effects of Tazar 4.5 gm Injection include nausea, constipation, diarrhoea, headache, and trouble sleeping. If any of these effects persist or worsen, seek medical advice promptly. 

Brief your medical history to the doctor if you have any allergic reactions to antibiotics. Please inform your doctor if you have any liver, kidney diseases, bleeding disorders, and fits before using Tazar 4.5 gm Injection. Do not use Tazar 4.5 gm Injection while having vaccinations with live bacterial vaccines (typhoid vaccine) since Tazar 4.5 gm Injection may affect vaccines' activity. Tazar 4.5 gm Injection should be used during pregnancy only if the doctor advises you. It is also excreted into breast milk in small amounts. Hence, it is recommended to consult your doctor if you are pregnant or breastfeeding before taking Tazar 4.5 gm Injection. 

Uses of Tazar 4.5 gm Injection

Treatment of Bacterial infections, hospital-acquired and ventilator-associated pneumonia, urinary tract infections, intra-abdominal infections, skin and soft tissue infections, and uterine infections.

Directions for Use

Tazar 4.5 gm Injection will be administered by a healthcare professional; do not self-administer.

Medicinal Benefits

Tazar 4.5 gm Injection contains two medicines, namely: Piperacillin and Tazobactam. Piperacillin is a Penicillin antibiotic. It acts by binding to the penicillin-binding proteins (PBPs) inside the bacterial cell wall and inhibits its cell wall synthesis. Tazobactam is a beta-lactamase inhibitor that prevents the breakdown of other antibiotics by beta-lactamase enzyme-producing organisms. In Tazar 4.5 gm Injection, Tazobactam works by preventing bacteria from destroying Piperacillin. Thus, Tazar 4.5 gm Injection helps treat various bacterial infections of the stomach, lungs, skin and uterus.

How Tazar 4.5 gm Injection Works

Tazar 4.5 gm Injection contains two medicines, namely: Piperacillin (Penicillin antibiotic) and Tazobactam (beta-lactamase inhibitor). Piperacillin belongs to the class of 'Penicillin antibiotics.' It has bactericidal (ability to kill bacteria) activity against gram-positive and gram-negative aerobic (requires oxygen to survive) and anaerobic (survives with little or no oxygen) bacteria. Piperacillin acts by binding to the penicillin-binding proteins (PBPs) inside the bacterial cell wall and inhibits its cell wall synthesis. Tazobactam is a beta-lactamase inhibitor. Beta-lactamases are the enzymes produced by bacteria to gain multi-resistance to β-lactam antibiotics, such as penicillins and cephalosporins. Tazobactam prevents the breakdown of other antibiotics by beta-lactamase enzyme-producing organisms. In Tazar 4.5 gm Injection, Tazobactam works by preventing bacteria from destroying Piperacillin.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Tazar 4.5 gm Injection

  • Nausea
  • Constipation
  • Diarrhoea
  • Headache
  • Trouble sleeping 

What if I have taken an overdose of Tazar 4.5 gm Injection

The overdose of Tazar 4.5 gm Injection is unlikely as it is administered by a doctor. However, in case of overdose, it may cause vomiting, nausea and diarrhoea. If you suspect you have taken overdose or notice signs of overdose, please consult a doctor immediately.

Drug Warnings

If you have a history of any cystic fibrosis (damaged lungs and digestive system), kidney disease, fits, colitis (inflammation of the colon), bleeding disorders, or heart or liver diseases, please inform your doctor before starting Tazar 4.5 gm Injection. Please seek medical advice if you are pregnant or breastfeeding before taking Tazar 4.5 gm Injection. Patients aged above 65 years are not at an increased risk of having side effects. However, the dosage should be adjusted if the patient has a history of renal impairment. Safety and efficacy of Tazar 4.5 gm Injection in children less than two months of age have not been established.

Drug-Drug Interactions

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PiperacillinVancomycin
Severe
PiperacillinHeparin
Severe

Drug-Drug Interactions

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PiperacillinVancomycin
Severe
How does the drug interact with Tazar 4.5 gm Injection 1's:
Coadministration of Vancomycin with Tazar 4.5 gm Injection 1's can increase the risk or severity of kidney problems.

How to manage the interaction:
Taking Vancomycin with Tazar 4.5 gm Injection 1's may result in an interaction, they can be taken together if prescribed by a doctor. However, contact a doctor immediately if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. Do not discontinue any medication without consulting a doctor.
PiperacillinHeparin
Severe
How does the drug interact with Tazar 4.5 gm Injection 1's:
When used together Tazar 4.5 gm Injection 1's will raise the amount of anticoagulant(blood thinners, are chemical substances that prevent or reduce clotting of blood) effect of heparin.

How to manage the interaction:
Although there is a possible interaction between Tazar 4.5 gm Injection 1's and Heparin, you can take these medicines together if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Include more fibre-enriched food in your diet, as it can be easily digested by your gut bacteria, which helps stimulate their growth. Thus, fibre foods may help restore healthy gut bacteria after a course of antibiotics. Whole grains like whole-grain bread, and brown rice should be included in your diet. 
  • Eating grapefruit during antibiotics treatment can prevent the body from utilizing Tazar 4.5 gm Injection properly. So, avoid intake of grapefruit or grapefruit juice with the antibiotic. 
  • Avoid intake of alcoholic beverages with Tazar 4.5 gm Injection as it can make you dehydrated and affect your sleep. This can make it more challenging for your body to aid the Tazar 4.5 gm Injection in fighting off infections.
  • Manage stress, eat healthily, drink plenty of water, exercise regularly, and get plenty of sleep.
  • Do not walk barefoot at places like gym showers to prevent bacterial infections. 

Habit Forming

No

Therapeutic Class

ANTIBIOTIC COMBINATION

Tazar 4.5 gm Injection Substitute

Substitutes safety advice
  • Piptaz 4.5gm Injection

    397.40per tablet
  • Pipzo 4.5 gm Injection 1's

    307.80per tablet
  • Piptazen 4.5 gm Injection 1's

    402.30per tablet
  • TAZIN INJECTION 4.5GM

    358.20per tablet
  • Tazotum 4.5gm Injection 1's

    402.30per tablet
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Alcohol

Caution

Avoid alcohol consumption while taking Tazar 4.5 gm Injection to prevent unpleasant side-effects, such as nausea and vomiting.

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Pregnancy

Caution

Tazar 4.5 gm Injection should be used with caution during pregnancy since it crosses the placenta in humans. Please consult your doctor before taking Tazar 4.5 gm Injection if you are pregnant or planning to conceive.

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Breast Feeding

Caution

There is limited data on how Tazar 4.5 gm Injection affects breastfed infants. Tazar 4.5 gm Injection is excreted into breast milk. Please consult your doctor before taking Tazar 4.5 gm Injection if you are breastfeeding.

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Driving

Caution

It is unknown whether Tazar 4.5 gm Injection affects your ability to drive and operating machinery. Drive only if you are physically stable and mentally focussed. If you experience dizziness or fatigue after taking Tazar 4.5 gm Injection, do not drive or operate any machinery.

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Liver

Caution

Let your doctor know if you have any history of liver diseases before taking Tazar 4.5 gm Injection. Your doctor will prescribe Tazar 4.5 gm Injection only if the benefits outweigh the risk.

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Kidney

Caution

Penicillin antibiotics are easily removed by dialysis. Beta-lactam antibiotics like Tazobactam should be cautiously administered in patients with renal impairment. Prolonged use of Tazar 4.5 gm Injection may cause nephrotoxicity and alterations in renal function, hence please let your doctor know if you have any history of kidney diseases before taking Tazar 4.5 gm Injection. Your doctor will prescribe Tazar 4.5 gm Injection only if the benefits outweigh the risk.

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Children

Caution

Safety and efficacy of Tazar 4.5 gm Injection in children less than two months of age have not been established.

FAQs

Tazar 4.5 gm Injection is used to treat bacterial infections. It is used to treat various hospital-acquired and ventilator-associated pneumonia, urinary tract infections, intra-abdominal infections, skin and soft tissue infections (like diabetic foot infections) and uterine infections.
Tazar 4.5 gm Injection contains Piperacillin and Tazobactam. Piperacillin inhibits bacterial cell wall synthesis, and Tazobactam prevents the bacteria from gaining resistance against Piperacillin. Thus Tazar 4.5 gm Injection helps in treating various bacterial infections.
Tazar 4.5 gm Injection should be used with proper caution and doctor consultation if you have any cystic fibrosis (damaged lungs and digestive system), kidney disease, fits, colitis (inflammation of the colon), bleeding disorders, heart or liver diseases and undergoing dialysis.
Tazar 4.5 gm Injection can affect live vaccines like typhoid vaccine and decrease their effectiveness. Please consult a doctor before you start Tazar 4.5 gm Injection if you are undergoing any vaccinations.
It is recommended to complete the course of Tazar 4.5 gm Injection even if you feel better as it is an antibiotic, and stopping it midway may lead to recurring infections. Continue taking Tazar 4.5 gm Injection for as long as your doctor has prescribed to treat your condition effectually.
Tazar 4.5 gm Injection is used to treat bacterial infections, including hospital-acquired and ventilator-associated pneumonia, urinary tract infections, intra-abdominal infections, skin and soft tissue infections, and uterine infections.

Country of origin

India

Manufacturer/Marketer address

Lupin Ltd, 3rd floor Kalpataru Inspire, Off. W E Highway, Santacruz (East), Mumbai 400 055. India.
Other Info - TAZ0016

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