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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Syntran SB Capsule is an antifungal medicine used to treat fungal infections of the mouth, throat, toenails, fingernails or lungs. It contains Itraconazole, which works by killing fungi. Some people may experience side effects such as nausea, headache, diarrhoea, tiredness, cough, cold, throat pain, back pain and stomach pain. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.
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Composition :

ITRACONAZOLE-50MG

Manufacturer/Marketer :

Glenmark Pharmaceuticals Ltd

Consume Type :

ORAL

Return Policy :

3 Days Returnable

Expires on or after :

Jan-27

About Syntran SB Capsule

Syntran SB Capsule is an antifungal medicine used to treat fungal infections of the mouth, throat, toenails, fingernails or lungs. Fungal infection is a disease in which a fungus attacks the tissue and causes infection. Fungal infections may be contagious (spread from one person to another).

Syntran SB Capsule contains Itraconazole, an antifungal that works by inhibiting the production of ergosterol (a main component of cell membranes of fungi). Thereby, weakens and damages the fungal cell membranes that are essential for their survival as they prevent the entry of unwanted substances into the cells and stop the leakage of cell contents. Thus, it causes the main components of fungal cells to leak out, kill fungi, and clear the fungal infection.

Take Syntran SB Capsule as prescribed. Your doctor will advise you on how often you take Syntran SB Capsule based on your medical condition. Some people may experience nausea, headache, diarrhoea, tiredness, cough, cold, throat pain, back pain and stomach pain. Most of these side effects of Syntran SB Capsule do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are known to be allergic to Syntran SB Capsule or any other medicines, please tell your doctor. Syntran SB Capsule is a pregnancy category C drug and may cause harm to the unborn baby. However, if you are pregnant, planning for pregnancy or a nursing mother, it is advised to consult a doctor before using Syntran SB Capsule . Do not take Syntran SB Capsule if you have or have heart failure, as it may cause severe life-threatening adverse effects. If you have kidney, liver, heart or lung problems, inform your doctor before taking Syntran SB Capsule . Avoid taking fentanyl (a strong opioid narcotic medicine) with Syntran SB Capsule as it may cause severe breathing problems and can even lead to death. If you experience numbness or tingling in your hands or feet, stop taking Syntran SB Capsule and consult your doctor immediately as they might be symptoms of nerve damage.

Uses of Syntran SB Capsule

Treatment of Fungal infections

Directions for Use

Tablet: Take it with food to avoid stomach upset or as advised by the doctor. Swallow the whole tablet with a glass of water. Do not break, crush or chew it. If you are taking any stomach acid suppressor or have achlorhydria (stomach does not produce hydrochloric acid), take Syntran SB Capsule with cola.

Medicinal Benefits

Syntran SB Capsule is an antifungal used to treat fungal infections of the mouth, throat, toenails, fingernails or lungs. The fungal cell membranes are essential for their survival as they prevent the entry of unwanted substances into the cells and stop the leakage of cell contents. Syntran SB Capsule inhibits the production of ergosterol (a main component of cell membranes of fungi). Thereby weakening and damaging the fungal cell membranes, causing the main components of fungal cells to leak out. Thus, it kills fungi and clears the fungal infection.

How Syntran SB Capsule Works

Syntran SB Capsule contains Itraconazole, an antifungal that works by inhibiting the production of ergosterol (a main component of cell membranes of fungi). Thereby, weakens and damages the fungal cell membranes that are essential for their survival as they prevent the entry of unwanted substances into the cells and stop the leakage of cell contents. Thus, it causes the main components of fungal cells to leak out, kill fungi, and clear the fungal infection.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Syntran SB Capsule

  • Nausea
  • Headache
  • Diarrhoea
  • Tiredness
  • Cough
  • Cold
  • Throat pain
  • Back pain
  • Stomach pain

What if I have taken an overdose of Syntran SB Capsule

Do not take more than the prescribed dose of Syntran SB Capsule as it may cause overdose. If you suspect you have taken overdose, please consult a doctor immediately.

Drug Warnings

If you are known to be allergic to Syntran SB Capsule or any other medicines, please tell your doctor. Syntran SB Capsule is a pregnancy category C drug and may cause harm to the unborn baby. However, if you are pregnant, planning for pregnancy, or are a nursing mother, it is advised to consult a doctor before using Syntran SB Capsule . Avoid taking fentanyl (a strong opioid pain killer narcotic medicine) with Syntran SB Capsule , as it may cause severe breathing problems and can even lead to death. Do not take Syntran SB Capsule if you had heart failure as it may cause severe life-threatening adverse effects. If you experience a yellow colour change of your eyes or skin, dark coloured urine, stomach pain, pale stools, loss of appetite, unusual tiredness, vomiting or nausea, stop taking Syntran SB Capsule and consult a doctor immediately as they might be symptoms of liver failure. If you have kidney, liver, heart, or lung problems, inform your doctor before taking Syntran SB Capsule .

Drug-Drug Interactions

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ItraconazoleAvanafil
Critical
ItraconazoleFelodipine
Critical

Drug-Drug Interactions

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ItraconazoleAvanafil
Critical
How does the drug interact with Syntran SB Capsule 10's:
Co-administartion of avanafil and Syntran SB Capsule 10's may considerably raise the blood levels of Avanafil.

How to manage the interaction:
Although combining avanafil and Syntran SB Capsule 10's may possibly lead to an interaction, they can be taken if prescribed by a doctor. Consult a physician if you develop any side effects, including priapism (prolonged and painful erection unrelated to sexual activity), low blood pressure, fainting, visual problems, including loss of vision, ringing in the ears, hearing loss, and low blood pressure. Without consulting a doctor, never stop taking any medication.
ItraconazoleFelodipine
Critical
How does the drug interact with Syntran SB Capsule 10's:
The blood levels and effects of felodipine may be considerably increased by taking Syntran SB Capsule 10's together with felodipine.

How to manage the interaction:
Although there is a possible interaction between felodipine and Syntran SB Capsule 10's, they can be taken if prescribed by a doctor. Consult a physician if you have an irregular heartbeat, Edema (accumulation of fluid in hands or legs), or abnormally low blood pressure. Without first consulting a doctor, never stop taking medicines.
ItraconazoleTolvaptan
Critical
How does the drug interact with Syntran SB Capsule 10's:
Co-administration of Tolvaptan and Syntran SB Capsule 10's may significantly raise Tolvaptan blood levels and effects.

How to manage the interaction:
There may be a possibility of interaction between Tolvaptan and Syntran SB Capsule 10's, but it can be taken if prescribed by a doctor. If you notice any of these signs -difficulty swallowing, trouble speaking, muscle weakness, trouble controlling body movements, confusion, mood changes, seizures, call a doctor right away. Do not stop using any medications without a doctor's advice.
ItraconazoleNisoldipine
Critical
How does the drug interact with Syntran SB Capsule 10's:
The blood levels and effects of nisoldipine may be greatly increased when used with Syntran SB Capsule 10's.

How to manage the interaction:
Nisoldipine and Syntran SB Capsule 10's may interact, but if prescribed by a doctor, they can be used together. Consult a physician if you have symptoms that include an irregular heartbeat, accumulation of fluid in legs or hands, or abnormally low blood pressure. Without consulting a doctor, never stop taking any medication.
ItraconazoleSolifenacin
Critical
How does the drug interact with Syntran SB Capsule 10's:
The blood levels and effects of solifenacin may be greatly increased when combined with Syntran SB Capsule 10's.

How to manage the interaction:
Solifenacin and Syntran SB Capsule 10's may interact, however, if recommended by a physician, they are safe to consume. Consult a doctor if you feel sleepy, or uneasy, have an irregular heartbeat, have blurry vision, have trouble urinating, have a dry mouth, a headache, have digestive problems, or have constipation. Without consulting a doctor, never stop taking any medication.
ItraconazoleSimvastatin
Critical
How does the drug interact with Syntran SB Capsule 10's:
Simvastatin's blood levels and effects may be greatly increased when combined with Syntran SB Capsule 10's.

How to manage the interaction:
Simvastatin and Syntran SB Capsule 10's may interact, but if prescribed by a doctor, they can be used together. Consult a doctor if you have side effects such unexplained pain in the muscles or tenderness, muscle weakness, fever or flu-like symptoms, or dark urine. Without consulting a doctor, never stop taking any medication.
ItraconazoleSilodosin
Critical
How does the drug interact with Syntran SB Capsule 10's:
Coadministration of Syntran SB Capsule 10's with Silodosin can increase the blood levels and effects of Silodosin, which may lead to side effects including extremely low blood pressure and increased heart rate.

How to manage the interaction:
Taking Syntran SB Capsule 10's with Silodosin together is not recommended as it can possibly result in an interaction, but it can be taken if a doctor has advised it. However, consult a doctor immediately if you experience any symptoms such as dizziness, lightheadedness, fainting, headache, flushing, nasal congestion, or heart palpitation. Do not discontinue any medications without consulting a doctor.
ItraconazoleEplerenone
Critical
How does the drug interact with Syntran SB Capsule 10's:
The blood levels and effects of eplerenone may be greatly increased when combined with Syntran SB Capsule 10's.

How to manage the interaction:
Although there is a possible interaction between Eplerenone and Syntran SB Capsule 10's, it is not recommended; they can be taken if prescribed by a doctor. Consult a doctor if you have complications such as hyperkalemia (high blood potassium), which in extreme circumstances can result in kidney problems, muscle paralysis, and an irregular heartbeat. Without first consulting your doctor, never stop taking medicines.
ItraconazoleRanolazine
Critical
How does the drug interact with Syntran SB Capsule 10's:
The blood levels and effects of Ranolazine may be greatly increased when it is used with Syntran SB Capsule 10's.

How to manage the interaction:
Although Ranolazine and Syntran SB Capsule 10's may interact, but if prescribed by a doctor, they can be used together. Consult a doctor if you develop any negative symptoms, including fainting, lightheadedness, dizziness, or rapid heartbeat. Without consulting a doctor, never stop taking any medication.
ItraconazoleAlprazolam
Critical
How does the drug interact with Syntran SB Capsule 10's:
Alprazolam's blood levels may be significantly raised when combined with Syntran SB Capsule 10's.

How to manage the interaction:
Although combining Alprazolam and Syntran SB Capsule 10's may lead to an interaction, they can be taken if prescribed by a doctor. Consult a doctor if you get extremely drowsy and your breathing becomes slow. Without consulting a doctor, never stop taking any medication.

Drug-Food Interactions

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ITRACONAZOLE-50MGGrapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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ITRACONAZOLE-50MGGrapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Grapefruit Juice, Grapefruit

How to manage the interaction:
Consuming Grapefruit, Grapefruit juice with Syntran SB Capsule 10's may impair the absorption of Syntran SB Capsule 10's, resulting in decreased antifungal effects. Avoid consuming Grapefruit and grapefruit juice with Syntran SB Capsule 10's.

Diet & Lifestyle Advise

  • Regularly change your socks and wash your feet. Avoid shoes that make your feet sweaty and hot.
  • In wet places such as changing rooms and gym showers, don’t walk on barefoot to prevent fungal infections.
  • Do not scratch the affected area of skin as it can spread the infection to other body parts.
  • Avoid sharing towels, combs, bedsheets, shoes or socks with others.
  • Wash your bed sheets and towels regularly.

Habit Forming

No

Therapeutic Class

ANTIFUNGALS

Syntran SB Capsule Substitute

Substitutes safety advice
  • Itaspor SB Capsule 10's

    by AYUR

    10.80per tablet
  • Alcros-SB 50 Capsule 10's

    12.78per tablet
  • I-Win SB 50 Capsule 10's

    11.70per tablet
  • Subawin Capsule 10's

    by AYUR

    10.80per tablet
  • Itratuf SB Capsule 10's

    23.76per tablet
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Alcohol

Unsafe

Avoid consumption of alcohol with Syntran SB Capsule as it may increase the risk of liver problems and other adverse effects.

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Pregnancy

Unsafe

Syntran SB Capsule is category C pregnancy drug and is unsafe for pregnant women as it may cause harm to the unborn baby. Therefore, inform your doctor if you are pregnant or planning for pregnancy before taking Syntran SB Capsule .

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Breast Feeding

Caution

Syntran SB Capsule is excreted in human milk and may harm the baby. Therefore, Syntran SB Capsule is given to breastfeeding mothers only if doctor thinks benefits are greater than risks.

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Driving

Caution

Syntran SB Capsule may cause dizziness, hearing loss, double or blurred vision in some people. Therefore, drive only if you alert after taking Syntran SB Capsule .

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Liver

Caution

Take Syntran SB Capsule with caution, especially if you have a history of Liver diseases/conditions. The dose may be adjusted by your doctor as required.

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Kidney

Caution

Take Syntran SB Capsule with caution, especially if you have a history of Liver diseases/conditions. The dose may be adjusted by your doctor as required.

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Children

Unsafe

Syntran SB Capsule is not recommended for children below 12 years as the safety and effectiveness were not established.

FAQs

Syntran SB Capsule is used to treat fungal infections of the mouth, throat, toenails, fingernails or lungs. It works by inhibiting the production of ergosterol (a main component of cell membranes of fungi). Thereby killing fungi and clearing the fungal infection.
You are not recommended to take Syntran SB Capsule with simvastatin as co-administration of these two medicines may cause muscle weakness, unexplained muscle pain or tenderness, dark coloured urine, fever or flu symptoms. However, please consult a doctor before using Syntran SB Capsule with other medicines.
No, Syntran SB Capsule is not recommended for use during pregnancy as it may cause harm to the fetus. Also, it is advised to use effective contraceptive measures while taking Syntran SB Capsule and after 2 months of stopping treatment with Syntran SB Capsule . However, please inform your doctor if you are pregnant, planning for pregnancy or breastfeeding before taking Syntran SB Capsule .
Syntran SB Capsule may cause temporary or permanent hearing loss in some people. It is not necessary for everyone taking Syntran SB Capsule to experience this adverse effect. However, if you notice any changes in hearing, stop taking Syntran SB Capsule and consult a doctor immediately.
You are advised to take antacids (drugs used to reduce acid in the stomach) such as omeprazole, pantoprazole and esomeprazole at least 1 hour before or 2 hours after taking Syntran SB Capsule as co-administration of these medicines at the same time may reduce the effectiveness of Syntran SB Capsule because antacids decrease the absorption and blood levels of Syntran SB Capsule . However, please consult a doctor before taking other medicines with Syntran SB Capsule .
Yes, fungal infection is a contagious skin condition which spreads from one person to another through direct skin to skin contact or by contact with contaminated soil or surfaces and infected animals. Therefore, it is recommended to avoid close direct contact until the infection is clear and avoid sharing things with the infected person as it can also spread the infection.
You are not recommended to stop taking Syntran SB Capsule without consulting your doctor as it may cause recurring infection. Therefore, take Syntran SB Capsule for as long as your doctor has prescribed it, and if you experience any difficulty while taking Syntran SB Capsule , please consult your doctor.
Inform your doctor if you are sexually active and discuss effective contraception methods. Syntran SB Capsule may reduce the effectiveness of oral contraceptive pills. Thus, you are advised to use barrier methods of contraception like condoms, if you are taking Syntran SB Capsule .
Inform the doctor about your detailed medical and surgical history, if you have liver, kidney or heart disease or fits and if you are pregnant, breastfeeding or planning pregnancy. Inform your doctor if you are taking any other medicines including supplements or herbal products as Syntran SB Capsule may interact with other medicines. Also, let your doctor know if you are stopping any medicine.
Syntran SB Capsule contains Itraconazole, an antifungal that works by inhibiting the production of ergosterol (a main component of cell membranes of fungi). Thereby, weakens and damages the fungal cell membranes that are essential for their survival as they prevent the entry of unwanted substances into the cells and stop the leakage of cell contents. Thus, it causes the main components of fungal cells to leak out, kill fungi, and clear the fungal infection.
Yes, you should swallow the capsule whole with a glass of water. Do not crush, chew or break it.
The side effects of Syntran SB Capsule include nausea, headache, diarrhoea, stomach pain, fatigue (overtiredness), back pain, cough, and sore throat. If these side effects persist or worsen, please consult your doctor.
If you have taken overdose of Syntran SB Capsule , please consult your doctor immediately.
Store Syntran SB Capsule at room temperature. Protect from light and moisture. Keep out of reach and sight of children.

Country of origin

India

Manufacturer/Marketer address

Glenmark Pharmaceuticals Limited, B/2, Mahalaxmi Chambers, 22, Bhulabhai Desai Road, Mumbai – 400 026.
Other Info - SYN0316

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