Synmega 250mg/125mg Tablet belongs to the group of medications called ‘antibiotics’ used to treat bacterial infections. Bacterial infections are caused by the multiplication of harmful bacteria inside or on the body. These harmful bacteria produce chemicals known as toxins, which can damage tissue and make you sick. Symptoms of bacterial infection vary depending on the organ affected by bacteria.

Synmega 250mg/125mg Tablet contains Ampicillin and Sulbactam. Ampicillin is a penicillin antibiotic. It has bactericidal action (kills bacteria). It works by preventing the formation of the cell wall (the outer protective layer of bacteria, which is essential for its survival) by preventing protein synthesis. Sulbactam is a beta-lactamase inhibitor. It broadens the spectrum of antibacterial activity by inhibiting the action of beta-lactamase, an enzyme produced by bacteria that can destroy antibiotics. Synmega 250mg/125mg Tablet is recommended for only bacterial infections and doesn’t treat viral infections.

Take this medicine exactly as prescribed by the doctor. The common side effects of Synmega 250mg/125mg Tablet are nausea, vomiting, headache, stomach pain and diarrhoea. These side effects are usually mild and temporary. However, if any of these side effects persist or get worse, inform your doctor immediately.

It is not recommended to take Synmega 250mg/125mg Tablet if you are allergic to penicillin, any other antibiotics, or the contents of Synmega 250mg/125mg Tablet. Synmega 250mg/125mg Tablet should not be given to people with infectious mononucleosis (viral infection with a sore throat and fever) and colitis (inflammation of the intestine). It should be used with caution in patients with kidney impairment. Do not discontinue or abruptly stop the medication, as it may lead to antibiotic resistance, a condition in which bacteria become resistant to antibiotics. Synmega 250mg/125mg Tablet should be used with caution in children, pregnant women, breastfeeding mothers and elderly people. It is not known whether Synmega 250mg/125mg Tablet can interact with alcohol or may affect your ability to drive. So, please discuss with your doctor the possible risks and benefits before taking this medicine.

Synmega 250mg/125mg Tablet contains Ampicillin and Sulbactam. Ampicillin is a penicillin antibiotic that treats the infection by killing the bacteria. Sulbactam is a beta-lactamase (an enzyme produced by bacteria that can destroy antibiotics) inhibitor and prevents the destruction of ampicillin from the bacteria. Synmega 250mg/125mg Tablet has broad-spectrum activity and is effective against both gram-positive and gram-negative bacteria. It is used to treat bacterial infections such as skin infections, gynaecological infections and intra-abdominal infections.

• Nausea
• Vomiting
• Headache
• Stomach pain
• Diarrhoea

If you notice watery and bloody stools with or without stomach cramps and fever, inform your doctor immediately as Synmega 250mg/125mg Tablet may cause diarrhoea, like many antibiotics. This condition usually resolves after the discontinuation of treatment. However, some patients may experience this condition even after two or more months after the antibiotic treatment. In addition, the severity of diarrhoea may range from mild conditions to severe colitis (inflammation of the intestine). Do not discontinue or abruptly stop the medication, as it may lead to antibiotic resistance, a condition in which bacteria become resistant to antibiotics. Synmega 250mg/125mg Tablet should not be used in patients with mononucleosis (viral infection with a sore throat and fever), as this medicine causes a skin rash. Synmega 250mg/125mg Tablet may cause superinfection (an additional infection that occurs with other microbes) on prolonged use. So, please do not use it for longer periods than your doctor intended.

Drug-Drug Interactions: Inform your doctor if you are taking medicines used to treat gout (probenecid, allopurinol), anticancer drugs (methotrexate), aminoglycosides, anticoagulants (blood thinners), antibiotics (erythromycin, sulphonamides, chloramphenicol, tetracyclines), or estrogen-containing oral contraceptives.

Drug-Food interactions: No interactions found.

Drug-Disease Interactions: Patients with rare hereditary problems of sucrase-isomaltase insufficiency, fructose intolerance or glucose-galactose malabsorption should avoid taking Synmega 250mg/125mg Tablet. If you have mononucleosis (a contagious disease), or severe kidney impairment, inform your doctor before taking Synmega 250mg/125mg Tablet.

• PROBENECID
• ALLOPURINOL
• METHOTREXATE
• ERYTHROMYCIN
• CHLORAMPHENICOL

• Probiotics should be taken after taking the full course of Synmega 250mg/125mg Tablet to restore some healthy bacteria in the intestines that may have been killed. Taking probiotics after antibiotic treatment can reduce the risk of antibiotic-associated diarrhoea. Certain fermented foods like yoghurt, cheese, sauerkraut, kombucha and kimchi can help restore the intestine's good bacteria.
• Include more fibre-enriched food in your diet, as it can be easily digested by gut bacteria, which helps stimulate their growth. Thus, fibre-rich foods may help restore healthy gut bacteria after a course of antibiotics. Whole grains like whole-grain bread and brown rice should be included in your diet.
• Avoid alcoholic beverages as they can make you dehydrated and may affect your sleep.  This can make it harder for your body to aid the antibiotic in fighting off infections.

• Synmega 250mg/125mg Tablet may cause false-positive results when a urine test is performed for the presence of glucose.

Bacterial infections: A bacterial infection is a condition in which harmful bacteria enter, multiply and infect the body. It can target any organ of the body and multiply very quickly. Many give off chemicals called toxins, which can damage tissue and make you sick. Bacterial infections vary from minor illnesses (like sore throat and ear infections) to severe brain infections (like meningitis and encephalitis). When you get infected with bacteria, you may experience generalized symptoms like fever, chills and fatigue. A few harmful bacteria that commonly cause infections include Streptococcus, Staphylococcus and E. coli. Anyone can get a bacterial infection, but people with a weak immune system or taking immunosuppressive medicines like steroids are more prone to infections.