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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
SYNCLAR 500MG TABLET is used to treat a wide range of bacterial infections, including chest infections such as bronchitis and pneumonia, skin problems such as cellulitis (potentially serious bacterial skin infection, the affected skin appears swollen and red and is typically painful and warm to the touch), and ear infections. Besides this, it is also used in combination with other medicines to treat duodenal ulcers caused by H. pylori. It contains Clarithromycin, which inhibits the growth of bacteria. It may cause some common side effects, such as nausea, diarrhoea, vomiting, loss of appetite, bloating, indigestion, headaches and difficulty sleeping. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.
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Manufacturer/Marketer :

Cipla Ltd

Consume Type :

ORAL

Return Policy :

3 Days Returnable

Expires on or after :

Jan-27

About SYNCLAR 500MG TABLET

SYNCLAR 500MG TABLET is used to treat a wide range of bacterial infections, including chest infections such as bronchitis and pneumonia, skin problems such as cellulitis (potentially serious bacterial skin infection, the affected skin appears swollen and red and is typically painful and warm to the touch), and ear infections. Besides this, SYNCLAR 500MG TABLET is also used in combination with other medicines to treat duodenal ulcers caused by H. pylori.

SYNCLAR 500MG TABLET contains Clarithromycin (antibiotic). It inhibits the protein synthesis process required for the growth of the bacterial cell. As a result, bacterial cells are not able to reproduce and grow. Thus, SYNCLAR 500MG TABLET helps prevent infections.

SYNCLAR 500MG TABLET should only be if your doctor has prescribed you. SYNCLAR 500MG TABLET should not be stopped even if you feel better as it is an antibiotic medication, and completing the full course is necessary; otherwise, the infection might re-appear in a more severe form. Like all medicines, SYNCLAR 500MG TABLET may cause some common side effects, including feeling sick (nausea), diarrhoea and being sick (vomiting), losing your appetite, bloating and indigestion, headaches and difficulty sleeping. These side effects are temporary and may get resolved after some time; however, if this side persists, let your doctor know about this if you notice any sudden wheeziness, tightness in the chest or throat, difficulty in breathing, swelling of the eyelids, face or lips, rash or itching (especially affecting your whole body) STOP TAKING your medicine and go to a doctor immediately.

Do not take SYNCLAR 500MG TABLET if allergic to azithromycin, other macrolide antibiotics, or any components present in SYNCLAR 500MG TABLET. SYNCLAR 500MG TABLET isn't normally recommended during pregnancy and while breastfeeding. But your doctor may prescribe it if the benefits of taking it are greater than the risks. Do not consume alcohol as it may cause excessive drowsiness when taken along with SYNCLAR 500MG TABLET. Before using the SYNCLAR 500MG TABLET, tell your doctor if you ever had an allergy to SYNCLAR 500MG TABLET have kidney problems, liver problems, swollen food pipe (oesophagitis), lupus disease (an autoimmune disease), or muscle disease (myasthenia gravis). Do not drink alcohol with SYNCLAR 500MG TABLET as it may increase the unpleasant side effects like drowsiness and dizziness.

Uses of SYNCLAR 500MG TABLET

Treatment of Bacterial infections

Directions for Use

Tablet/capsule: Swallow it as a whole with water; do not crush, break or chew it.Dispersible Tablet: Check the label for directions before use. Disperse the tablet in the prescribed amount of water and swallow the contents. Do not crush, chew or swallow as a whole.

Medicinal Benefits

SYNCLAR 500MG TABLET is a type of macrolide class of antibiotic which is effective against a wide range of bacteria, including gram-negative and gram-positive bacteria, anaerobes, and some parasites (like Balantidium coli and Entamoeba species). It is prescribed for treating various bacterial infections, including chest infections such as pneumonia, skin problems such as cellulitis, and ear infections; on the other hand, It is also used in combination with other medicines to treat duodenal ulcers caused by H. pylori (Helicobacter pylori). SYNCLAR 500MG TABLET is sometimes used by people who have an allergy to penicillin and antibiotics similar to penicillin, such as amoxicillin.

How SYNCLAR 500MG TABLET Works

SYNCLAR 500MG TABLET contains Clarithromycin (antibiotic). It inhibits the protein synthesis process required for the growth of the bacterial cell. As a result, bacterial cells are not able to reproduce and grow. Thus, SYNCLAR 500MG TABLET helps prevent infections.

Storage

Store in a cool and dry place away from sunlight

Side Effects of SYNCLAR 500MG TABLET

  • Headache

  • Diarrhoea

  • Being sick (vomiting)

  • Nausea (feeling sick)

  • Loss of appetite

  • Taste change

  • Bloating

  • Indigestion

  • Abdominal pain

  • Insomnia (difficulty sleeping)

What if I have taken an overdose of SYNCLAR 500MG TABLET

Do not take more than the prescribed dose of SYNCLAR 500MG TABLET as it may cause overdose. The symptoms of overdose include diarrhoea, vomiting, nausea and stomach pain. If you suspect you have taken overdose or notice signs of overdose, please consult a doctor immediately.

Drug Warnings

Iron and antacid (like magnesium hydroxide and aluminium hydroxide) may bind to SYNCLAR 500MG TABLET in the gastrointestinal tract, lowering its efficiency. So, a gap of at least 2 hours should be maintained between intake of SYNCLAR 500MG TABLET and iron supplements and antacids. Besides this, in some cases, the use of SYNCLAR 500MG TABLET causes antibiotic-associated diarrhoea. SYNCLAR 500MG TABLET may cause sensitive skin to sunlight and ultraviolet rays, causing an exaggerated sunburn reaction. Hence it is advisable to apply sunscreen before going outside. Its use has also been associated with an increased risk of fungal skin infections like (vaginal candidiasis - thrush). Tetracycline and SYNCLAR 500MG TABLET can form a stable calcium complex in bone-forming tissue, thereby affecting the growth of fibula bones in young children and bone development in the foetus. Using a SYNCLAR 500MG TABLET with isotretinoin should be avoided as it has been reported to cause pseudotumor cerebri (increased pressure inside the brain). Long-term use of SYNCLAR 500MG TABLET may affect your blood, kidney, and liver health, so yearly diagnostics test of these parameters is recommended.

Drug-Drug Interactions

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ClarithromycinThioridazine
Critical
ClarithromycinLomitapide
Critical

Drug-Drug Interactions

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ClarithromycinThioridazine
Critical
How does the drug interact with SYNCLAR 500MG TABLET:
Combining SYNCLAR 500MG TABLET with Thioridazine can increase the risk of irregular heart rhythm.

How to manage the interaction:
Co-administration of SYNCLAR 500MG TABLET and Thioridazine can lead to an interaction, it can be taken if advised by a doctor. However, if you experience any symptoms like dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
ClarithromycinLomitapide
Critical
How does the drug interact with SYNCLAR 500MG TABLET:
When Lomitapide is taken with SYNCLAR 500MG TABLET, it can lower the metabolism of Lomitapide.

How to manage the interaction:
Co-administration of SYNCLAR 500MG TABLET and Lomitapide can lead to an interaction, it can be taken if advised by a doctor. However, if you experience any symptoms like diarrhea, nausea, vomiting, stomach pain or discomfort, indigestion, gas, constipation, and liver damage, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
ClarithromycinMesoridazine
Critical
How does the drug interact with SYNCLAR 500MG TABLET:
Co-administration of SYNCLAR 500MG TABLET and Mesoridazine may increase the risk of an irregular heart rhythm.

How to manage the interaction:
Co-administration of SYNCLAR 500MG TABLET and Mesoridazine can lead to an interaction, it can be taken if advised by a doctor. However, if you experience any symptoms like dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
ClarithromycinDroperidol
Critical
How does the drug interact with SYNCLAR 500MG TABLET:
Co-administration of Droperidol with SYNCLAR 500MG TABLET can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking SYNCLAR 500MG TABLET with Droperidol can result in an interaction, it should be taken only if a doctor has advised it. However, if you experience dizziness, lightheadedness, fainting, shortness of breath, or heart palpitation, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
ClarithromycinErgotamine
Critical
How does the drug interact with SYNCLAR 500MG TABLET:
When Ergotamine is taken with SYNCLAR 500MG TABLET, the amount of Ergotamine in the blood can go up.

How to manage the interaction:
Taking SYNCLAR 500MG TABLET with Ergotamine can result in an interaction, it should be taken only if a doctor has advised it. However, if you experience abdominal pain, nausea, vomiting, numbness or tingling, muscle pain or weakness, blue or purple discoloration of fingers or toes, pale or cold skin, chest pain or tightness, irregular heartbeat, severe headache, shortness of breath, blurred vision, confusion, and/or slurred speech, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
ClarithromycinPimozide
Critical
How does the drug interact with SYNCLAR 500MG TABLET:
Combining SYNCLAR 500MG TABLET with Pimozide can increase the risk of heart rhythm problems.

How to manage the interaction:
Co-administration of SYNCLAR 500MG TABLET and Pimozide can lead to an interaction, it can be taken if advised by a doctor. However, if you experience any symptoms like irregular heartbeat, chest tightness, blurred vision or nausea, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
ClarithromycinTerfenadine
Critical
How does the drug interact with SYNCLAR 500MG TABLET:
When Terfenadine is taken with SYNCLAR 500MG TABLET, the amount of Terfenadine in the blood can go up.

How to manage the interaction:
Co-administration of SYNCLAR 500MG TABLET and Terfenadine can lead to an interaction, it can be taken if advised by a doctor. However, if you experience any symptoms like dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
ClarithromycinAlfuzosin
Critical
How does the drug interact with SYNCLAR 500MG TABLET:
When Alfuzosin and SYNCLAR 500MG TABLET can increase the risk or severity of side effects like low blood pressure or irregular heart rates.

How to manage the interaction:
Taking SYNCLAR 500MG TABLET with alfuzosin is not recommended as it can result in an interaction; it should be taken only if your doctor has advised it. However, if you experience dizziness, headache, palpitations, or chest discomfort, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
ClarithromycinQuinidine
Critical
How does the drug interact with SYNCLAR 500MG TABLET:
When Quinidine is taken with SYNCLAR 500MG TABLET, can increase the blood levels and effects of Quinidine. This may increase the risk of an irregular heart rhythm.

How to manage the interaction:
Co-administration of SYNCLAR 500MG TABLET and Quinidine can lead to an interaction, it can be taken if advised by a doctor. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or fast or pounding heartbeats. However, if you experience any symptoms like headache, confusion, vomiting, diarrhea, ringing in the ears, hearing loss, blurred or double vision, or sensitivity to light, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
ClarithromycinBepridil
Critical
How does the drug interact with SYNCLAR 500MG TABLET:
Co-administration of Bepridil with SYNCLAR 500MG TABLET may increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking SYNCLAR 500MG TABLET with Bepridil is not recommended as it can result in an interaction, it should be taken only if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, or rapid heartbeat, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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CLARITHROMYCIN-500MGGrapefruit and Grapefruit Juice
Mild

Drug-Food Interactions

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CLARITHROMYCIN-500MGGrapefruit and Grapefruit Juice
Mild
Common Foods to Avoid:
Grapefruit Juice

How to manage the interaction:
Grapefruit juice may delay the gastrointestinal absorption of SYNCLAR 500MG TABLET. Avoid grapefruit juice while on treatment with SYNCLAR 500MG TABLET.

Diet & Lifestyle Advise

  • Probiotics and prebiotics can also help to reduce the side effects of antibiotics.

  • Include more fibre-enriched food in your diet, as it can be easily digested by your gut bacteria, which helps stimulate their growth. Thus, fibre foods may help restore healthy gut bacteria after a course of antibiotics. Whole grains like whole-grain bread and brown rice should be included in your diet. 

  • Eating grapefruit during antibiotics treatment can prevent the body from utilizing SYNCLAR 500MG TABLET properly. So, avoid intake of grapefruit or grapefruit juice with the antibiotic. 

  • Avoid taking too much calcium, iron-enriched foods and drinks as it might affect the working of SYNCLAR 500MG TABLET. 

  • Avoid intake of alcoholic beverages with SYNCLAR 500MG TABLET as it can make you dehydrated and affect your sleep. This can make it harder for your body to aid the SYNCLAR 500MG TABLET in fighting off infections.

Habit Forming

No

Therapeutic Class

ANTI- BACTERIALS

SYNCLAR 500MG TABLET Substitute

Substitutes safety advice
  • Claribid 500 Tablet 10's

    40.14per tablet
  • Clarinova-500 Tablet 10's

    33.80per tablet
  • Clarigard 500 Tablet 10's

    by AYUR

    31.32per tablet
  • Cloff 500 Tablet 10's

    40.14per tablet
  • Clarimin 500mg Tablet 4's

    34.88per tablet
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Alcohol

Unsafe

SYNCLAR 500MG TABLET should not be taken until prescribed if you are taking alcohol. Keep your doctor informed if you drink alcohol.

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Pregnancy

Caution

SYNCLAR 500MG TABLET should be used in pregnant women only if clinically needed, and the benefits outweigh the risks.

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Breast Feeding

Caution

Let your doctor know if you are a nursing mother before taking SYNCLAR 500MG TABLET; your doctor will decide whether SYNCLAR 500MG TABLET can be taken by breastfeeding mothers or not.

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Driving

Unsafe

Not enough scientific data available for SYNCLAR 500MG TABLET, hence it is advised to consult your doctor.

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Liver

Caution

SYNCLAR 500MG TABLET to be taken with caution, especially if you have a history of liver diseases/conditions. The dose may have to be adjusted by your doctor.

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Kidney

Caution

SYNCLAR 500MG TABLET to be taken with caution, especially if you have a history of kidney diseases/conditions. The dose may have to be adjusted by your doctor.

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Children

Safe if prescribed

SYNCLAR 500MG TABLET can be given safely to children in the form of suspension only, dose to be adjusted and recommended by a child specialist only.

FAQs

SYNCLAR 500MG TABLET is used to treat bacterial infections, including chest infections, skin infections, and ear infections. Besides this, SYNCLAR 500MG TABLET is also used in combination with other medicines to treat duodenal ulcers caused by H. pylori.
SYNCLAR 500MG TABLET contains Clarithromycin (antibiotic). It inhibits the protein synthesis process required for the growth of the bacterial cell. As a result, bacterial cells are not able to reproduce and grow. Thus, SYNCLAR 500MG TABLET helps in the prevention of infections.
You should avoid taking iron supplements, multivitamins, calcium supplements, antacids, or laxatives within 2 hours before or after taking SYNCLAR 500MG TABLET. Avoid taking any other antibiotics containing SYNCLAR 500MG TABLET unless your doctor has prescribed you.
After taking antibiotics such as SYNCLAR 500MG TABLET, some people get thrush, a fungal infection. This is due to the fact that antibiotics kill the regular, harmless bacteria that serve to protect you from thrush.
SYNCLAR 500MG TABLET treats only bacterial infections. It will not work for viral infections (such as common cold, flu).
No, SYNCLAR 500MG TABLET is a macrolide antibiotic. It can be taken by people who are allergic to penicillin with doctor advice only.
Side-effects are rare with SYNCLAR 500MG TABLET and do not usually last long. They will get better after a day or two. if those side effects persist reach out to the doctor immediately.​
No, SYNCLAR 500MG TABLET should not be stopped even if you feel better as it is an antibiotic medication and completing the full course if very necessary; otherwise, the infection might re-appear in a more severe form.

Country of origin

India

Manufacturer/Marketer address

Cipla House, Peninsula Business Park, Ganpatrao Kadam Marg, Lower Parel, Mumbai-400013
Other Info - SYN0071

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