Syncapone 50 Tablet is used in treating Parkinson's disease with its symptoms including tremors, spasms, muscle stiffness and poor muscle control. Parkinson's disease is a disorder of the central nervous system that affects movement and locomotion, which causes stiffness, shaking, and difficulty in walking, coordination and balance. In Parkinson's patients, there are low dopamine levels as the nerve cells of the brain (neurons) that produce dopamine begin to die.

Syncapone 50 Tablet contains Carbidopa, Levodopa, and Entacapone. Levodopa belongs to the central nervous system agents, while Carbidopa is a decarboxylase inhibitor. The medicinal component Levodopa changes into dopamine in the brain and helps to control movement. Carbidopa prevents the breakdown of Levodopa in the bloodstream so that more Levodopa can reach the brain. On the other hand, Entacapone belongs to a class of COMT (catechol-o-methyltransferase enzyme) inhibitors which causes higher and more sustained levels of Levodopa in the blood that more Levodopa can reach the brain, leading to greater relief from the symptoms of Parkinson's disease.

Take Syncapone 50 Tablet as prescribed by your doctor. You are suggested to take $ame as long as your doctor has prescribed it after checking your medical condition. The most common side effects of Syncapone 50 Tablet are nausea, vomiting, loss of appetite, light-headedness, lowered blood pressure, confusion, and dyskinesia (uncontrolled/involuntary muscle movement). Most of these side effects of Syncapone 50 Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are known to be allergic to Syncapone 50 Tablet or any other medicines, please tell your doctor. Do not take Syncapone 50 Tablet if you are pregnant or breastfeeding unless prescribed by the doctor. Syncapone 50 Tablet should not be given to children as safety and effectiveness have not been established. Syncapone 50 Tablet may cause hallucinations (seeing or hearing things that are not there) in some cases if taken for a prolonged time. So, if you experience hallucinations while taking Syncapone 50 Tablet , please talk to your doctor immediately. Keep your doctor informed about your medicines and health condition and rule out any side effects.

Syncapone 50 Tablet is an antiparkinson agent that is used in the treatment of Parkinson’s disease. Syncapone 50 Tablet is a combination of three medicines: Carbidopa, Levodopa, and Entacapone. Levodopa belongs to the class of medications named central nervous system agents, While Carbidopa falls in decarboxylase inhibitors. The medicinal component Levodopa changes into dopamine in the brain and helps to control movement. At the same time, Carbidopa acts by preventing the breakdown of Levodopa in the bloodstream so that more Levodopa can effectively reach the brain to block acetylcholine (a chemical messenger in the brain). Entacapone blocks a certain natural substance, catechol-o-methyltransferase (COMT) (an enzyme that breaks down the levodopa in the body), which causes higher and more sustained levels of levodopa in the blood, so that more Levodopa can reach the brain, leading to greater relief from the symptoms of Parkinson’s disease. This effect allows the levodopa to last longer in the body so that it doesn't wear off before the next dose.

• Nausea

• Muscle pain

• Diarrhoea

• Lightheadedness

• Dizziness

• Stomach upset

• Blurred vision

• Anaemia

• Hypotension (low blood pressure)

• Dyskinesias (uncontrolled movement)

• Urine discolouration

Do not stop taking Syncapone 50 Tablet suddenly without talking to your doctor. It may result in a serious neuroleptic malignant syndrome (NMS) that causes fever, muscle cramps or stiffness, unusual body movements, fast heartbeat, sweating, change in thinking, and confusion. Do not take Syncapone 50 Tablet if you are allergic to Syncapone 50 Tablet or any of its ingredients. Tell your doctor if you have any medical history of diabetes, heart attacks, mental illness, stomach ulcers, heart disease, or have recently undergone a surgical procedure. Syncapone 50 Tablet may cause dizziness, lightheadedness, and fainting when you get up too quickly from a lying position, especially when you start taking Syncapone 50 Tablet so please get up gradually. Besides this, a prolonged intake of Syncapone 50 Tablet may lead to greater neuropathy chances (nerve damage). Syncapone 50 Tablet should be given with caution in patients with eye problems (narrow-angle glaucoma), irregular heartbeat (arrhythmia), gastrointestinal bleeding, and psychosis. The use of Syncapone 50 Tablet is restricted if a person takes monoamine oxidase inhibitors (MAOs) or antidepressant drugs like isocarboxazid, phenelzine, selegiline, and tranylcypromine because it can lead to high blood pressure (hypertension) crisis.

Drug-Drug Interactions: Syncapone 50 Tablet may have interaction with other antiparkinson’s drugs (rasagiline, selegiline, pramipexole, apomorphine), medicines used to treat depression (moclobemide, amitriptyline, desipramine, maprotiline, venlafaxine, paroxetine, rimiterole, isoprenaline), medicines used to treat respiratory diseases or allergic reactions (adrenaline, noradrenaline) medicines used to treat high blood pressure (methyldopa)  water pills or diuretics (furosemide), high cholesterol-lowering drugs (atorvastatin), vitamins (pyridoxine), and anticonvulsants (phenytoin ), medicines used to relax the muscles (papaverine), dopamine D2 receptor blocker (metoclopramide, phenothiazines, butyrophenones, risperidone), antibiotics (erythromycin, rifampicin, ampicillin, chloramphenicol), a medicine used to treat TB (isoniazid).

Drug-Food Interactions: Syncapone 50 Tablet may interact with proteins in the food. Therefore, avoid intake of high protein food such as chicken, beef, pork, eggs, and fish as they may reduce the effectiveness of Syncapone 50 Tablet . Do not take vitamin supplements with Syncapone 50 Tablet unless prescribed by a doctor. Also, avoid alcohol intake as it may increase side effects such as drowsiness, dizziness, or difficulty in concentrating.

Drug-Disease Interactions: If you have glaucoma, asthma, nausea, dizziness, mental illness, breathing problems, daytime sleepiness, or involuntary muscle movements, inform your doctor before taking Syncapone 50 Tablet .

• RASAGILINE
• SELEGILINE
• PRAMIPEXOLE
• APOMORPHINE
• MOCLOBEMIDE
• AMITRIPTYLINE
• DESIPRAMINE
• MAPROTILINE
• VENLAFAXINE
• PAROXETINE
• ISOPRENALINE
• ADRENALINE
• METHYLDOPA
• FUROSEMIDE
• ATORVASTATIN
• PYRIDOXINE (VITB6)
• PHENYTOIN
• METOCLOPRAMIDE
• PHENOTHIAZINE
• RISPERIDONE
• ERYTHROMYCIN
• RIFAMPICIN
• AMPICILLIN
• CHLORAMPHENICOL
• ISONIAZID
• NORADRENALINE
• RIMITEROLE
• PAPAVERINE
• BUTYROPHENONES

• Drink plenty of water to avoid headaches due to dehydration. 

• Limit the consumption of sugar-containing food or food with too many calories but fewer nutrients, as it may cause tooth decay.

• Engaging in physical activity like dancing or exercising will boost the metabolism and make a person more energetic.

• Avoid intake of alcoholic beverages with Syncapone 50 Tablet as it can make a person dehydrated and may affect their sleep. This can make it harder for a person’s body to aid the Syncapone 50 Tablet in fighting off infections.

• Do not exceed more than 1 dose (2 capsules) for any off period (recurring symptoms in between regular doses).

• If you have unusual urges like gambling, spending money, overeating, or increased sexual urges, please inform your doctor before taking the Syncapone 50 Tablet .