Synate 10mg Injection belongs to a group of medicines called loop diuretics used to treat oedema. It may also be used in the treatment of extremely high blood pressure that may lead to life-threatening conditions (hypertensive crisis). Oedema, also known as fluid overload, occurs due to the build-up of fluid in spaces between the tissues leading to swelling. Hypertension or high blood pressure is a chronic condition in which the force exerted by the blood against the artery wall increases.

Synate 10mg Injection contains Furosemide, which works by increasing the amount of urine that is passed out from the kidneys. It effectively reduces excess fluid levels in the body and treats oedema (swelling) associated with heart, liver, kidney, or lung disease. This reduces the workload on the heart and makes the heart more efficient at pumping blood throughout the body. Thus, it helps to lower high blood pressure, reducing the chances of heart attack or stroke.

Synate 10mg Injection will be administered by a qualified healthcare professional. Kindly do not self-administer. In some cases, you may experience frequent urination (peeing more than normal), feeling thirsty, dry mouth, headache, feeling confused or dizzy, nausea or vomiting. Most of these side effects of Synate 10mg Injection do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

Let your doctor know if you are allergic to any of the components in Synate 10mg Injection. Inform your doctor if you are suffering from kidney, liver, or heart disease. Consult your doctor if you are pregnant or breastfeeding. Do not drive or operate machinery as Synate 10mg Injection may cause dizziness. Synate 10mg Injection is recommended for children and adolescents under the age of 15 only in exceptional cases. Avoid alcohol intake while on treatment with Synate 10mg Injection as it may cause excessive lowering of blood pressure.

Synate 10mg Injection contains furosemide, a loop diuretic which increases the excretion of salt and water through urine by acting on a targeted or specific part of the kidney called the loop of Henle. Thereby decreasing fluid in the tissues, and aiding in treating swelling (oedema). It also helps reduce the workload on the heart and makes the heart more efficient at pumping blood throughout the body. Thus, treats high blood pressure, reducing the chances of heart attack or stroke.

• Frequent urination
• Feeling thirsty
• Dry mouth
• Headache
• Feeling confused or dizzy
• Feeling or being sick (nausea or vomiting)

Inform your doctor if you have/had low blood pressure (hypotension), liver disease, diabetes, any difficulty peeing, Addison's disease (a rare disorder of the adrenal glands), gout, dehydration (being thirsty, having a dry mouth), and electrolyte imbalance. Consult your doctor if you are pregnant or planning for pregnancy; your doctor will weigh the benefits and potential risks before prescribing Synate 10mg Injection. Do not drive or operate machinery as Synate 10mg Injection may cause dizziness. Avoid alcohol intake while on treatment with Synate 10mg Injection as it may cause excessive lowering of blood pressure.

Drug-Drug Interactions: Synate 10mg Injection may interact with anti-cancer medications (arsenic trioxide, dolasetron), aminoglycoside antibiotics (amikacin, gentamicin, kanamycin, neomycin, netilmicin, plazomicin, streptomycin, tobramycin), photosensitizing agents (aminolevulinic acid), antiarrhythmic medicines (amiodarone, dronedarone, dofetilide), hormones (desmopressin), antipsychotic medication (droperidol, pimozide, ziprasidone), diuretic medicines (ethacrynic acid), opioids (levomethadyl acetate), anti-manic medicines (lithium), skeletal muscle relaxants (tizanidine), drugs used to treat secondary hyperparathyroidism (etelcalcetide), and medications used to treat GERD (cisapride).

Drug-Food Interactions: You are recommended to limit or quit the consumption of alcohol.

Drug-Disease Interactions: Inform your doctor if you have ototoxicity (hearing loss), chronic liver or kidney disease, electrolyte abnormalities, anuria (patients with nil urine output), low blood pressure, certain autoimmune diseases (systemic lupus erythematosus), gout (a type of arthritis), diabetics, and Addison's disease (adrenal gland disorder).

• ARSENIC TRIOXIDE
• DOLASETRON
• AMIKACIN
• AMIKACIN LIPOSOME
• GENTAMICIN
• KANAMYCIN
• NEOMYCIN
• NETILMICIN
• PLAZOMICIN
• STREPTOMYCIN
• TOBRAMYCIN
• AMINOLEVULINIC ACID
• AMIODARONE
• DRONEDARONE
• DOFETILIDE
• DESMOPRESSIN
• DROPERIDOL
• PIMOZIDE
• ZIPRASIDONE
• ETHACRYNIC ACID
• LEVOMETHADYL ACETATE
• LITHIUM
• TIZANIDINE
• ETELCALCETIDE
• CISAPRIDE

• Consume antioxidant-rich food. Blueberries, cherries, tomatoes, squash, and bell peppers are high in antioxidants.
• Eat natural diuretic foods such as Asparagus, beets, green beans, grapes, onion, leafy greens, pineapple, pumpkin, and garlic.
• Use healthy cooking oils like soybean, olive, canola, and coconut oil.
• You should avoid refined foods such as white bread, spaghetti, sugar, and red meat.
• Reduce or eliminate trans fatty acids, which are found in commercially baked items such as cookies, cakes, crackers, French fries, onion rings, doughnuts, and processed foods.
• Avoid consumption of too much salt or salty food.
• Regular physical activity or exercise like walking improves the blood flow.
• Whenever possible, elevate your legs or the swollen area on a chair or pillows.
• Avoid standing or sitting for extended periods of time.
• Avoid chronic stress as it can raise your blood pressure.
• Spend time with your loved ones to cope with stress and practice mindfulness techniques.
• Quitting smoking and alcohol consumption is the best strategy to lower the risk of many health complications.

• Monitor your blood pressure daily, and if there is too much fluctuation, immediately contact the doctor.
• If you plan to have a procedure that includes radiocontrast, do not take Synate 10mg Injection (as taking Synate 10mg Injection may increase the risk of kidney damage).
• Regular monitoring of blood levels for electrolytes and kidney function is advised.

Oedema: Oedema, also known as fluid overload, occurs due to the build-up of fluid in the tissues. Oedema can occur due to medical conditions or lifestyle factors. Shortness of breath, chest pain (angina), abnormal heart rhythms (arrhythmia), and swelling in hands or abdominal areas are the symptoms of oedema.

Hypertension: It is a chronic condition when blood pressure is too high. This condition can lead to hardened arteries (blood vessels), decreasing the blood and oxygen flow to the heart. Blood pressure is the measurement of the force the heart uses to pump blood to all body parts. Raised blood pressure can cause chest pain (angina) and heart attack (when blood supply to the heart is blocked). Additionally, high blood pressure also causes brain damage (stroke) and kidney failure. High blood pressure can be diagnosed with the help of a blood pressure monitor or sphygmomanometer. Systolic pressure is the pressure when the heart pumps blood out. On the other hand, diastolic pressure is the pressure when the heart is at the resting stage between heartbeats. If your blood pressure is 140/90 mm of Hg, it means the systolic pressure is 140 mm of Hg, and diastolic pressure is 90 mm of Hg. Ideal blood pressure is around 120/80 mm of Hg.