Sprycel 70mg Tablet
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Sprycel 70mg Tablet is an anti-cancer medicine used in the treatment of Leukemia. Leukemia, also known as blood cancer, is a cancer of blood cells or blood-forming tissues. It causes excessive production of immature white blood cells by the bone marrow and reduces the body’s ability to fight infections. There are different types of blood cancers. Sprycel 70mg Tablet is used in the treatment of chronic myelogenous leukemia (CML) in patients with chronic, accelerated, or blast phase Ph+ (Philadelphia chromosome-positive) who are resistant or intolerant to prior therapy, in patients with newly diagnosed chronic Ph+ chronic myelogenous leukemia (CML). This medicine is also used in the treatment of Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL).
Sprycel 70mg Tablet contains Dasatinib, which belongs to the class of kinase inhibitors. It works by inhibiting the action of abnormal proteins that cause the multiplication of cancerous cells. This helps stop the abnormal growth of cancer cells and thus reduce the further spread to other parts of the body.
Sprycel 70mg Tablet may cause certain side effects, such as skin rash, fatigue, headache, musculoskeletal pain, decreased platelet count, nausea, vomiting, diarrhea, abdominal pain, dizziness, GI bleeding, muscle inflammation, myalgia, and difficulty breathing. These side effects do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor. Sprycel 70mg Tablet should be taken as advised by your doctor. Do not take more than the recommended dose of medicine. Your doctor will decide the dose of Sprycel 70mg Tablet based on the severity of your condition.
Sprycel 70mg Tablet should be avoided if you are allergic to it or any other components present in it. Before taking Sprycel 70mg Tablet, caution should be exercised if you have/had liver/kidney disease, gastrointestinal disorders, cardiac problems, and myelosuppression as may cause serious side effects or worsen such conditions. This medicine is known to cause embryo-fetal toxicity. Hence, inform your doctor if you are pregnant or are planning to become pregnant before starting the treatment with Sprycel 70mg Tablet. Breastfeeding should be discontinued in nursing mothers during the treatment.
Sprycel 70mg Tablet contains Dasatinib, which belongs to the class of kinase inhibitors. It works by inhibiting the action of abnormal proteins (BCR-ABL tyrosine kinase) that cause the multiplication of cancerous cells. This helps stop the abnormal growth of cancer cells and thus reduce the further spread to other parts of the body. Sprycel 70mg Tablet is used in the treatment of Philadelphia chromosome-positive chronic myeloid leukemia and acute lymphoblastic leukemia.
Sprycel 70mg Tablet should be avoided if you are allergic to it or any other components present in it. Let your doctor know about your complete medical history, including current medication, to rule out any side effects/interactions. Before taking, inform your doctor if you have liver/kidney disease, diabetes, cardiac problems, increased blood pressure, or gastrointestinal disorders, as the use of Sprycel 70mg Tablet in these patients may cause serious side effects. Sprycel 70mg Tablet may cause myelosuppression, fluid retention, gastrointestinal haemorrhage, QT prolongation, congestive heart failure, Left ventricular dysfunction and Myocardial infarction. This medicine is known to cause embryo-fetal toxicity. Hence, inform your doctor if you are pregnant or are planning to become pregnant before starting the treatment. Breastfeeding should be discontinued in nursing mothers during the treatment. Sprycel 70mg Tablet is given in children above one year of age only if prescribed by the doctor. Avoid alcohol consumption and smoking, as it can lead to serious adverse effects.
Drug-Drug Interactions: Sprycel 70mg Tablet may interact with vaccines, proton pump inhibitors (pantoprazole, esomeprazole), CYP3A inhibitors (ritonavir, itraconazole, ketoconazole, clarithromycin, erythromycin), CYP3A inducers (rifampin, phenytoin, phenobarbitone, carbamazepine), antacids (aluminium hydroxide, magnesium hydroxide).
Drug-Food Interactions: Avoid alcohol consumption and smoking.
Drug-Disease Interactions: Inform your doctor if you have kidney or liver disease, gastrointestinal disorders, diabetes, and cardiac disorders before taking Sprycel 70mg Tablet.
Philadelphia chromosome-positive (Ph+) chronic myeloid leukemia: Leukemia, also known as blood cancer, is a cancer of blood cells or blood-forming tissues. It causes excessive production of immature white blood cells by the bone marrow and reduces the body’s ability to fight infections. Chronic Myelogenous Leukemia is a type of blood cancer that originates in the myeloid cells or stem cells in your bone marrow. Ph+ chronic myeloid leukemia is a common form of CML that occurs when specific chromosomes swap position. This causes a chromosome abnormality, creating the Philadelphia chromosome. The abnormal chromosomes produce an abnormal protein called Bcr-Abl tyrosine kinase, which then triggers a signal to produce abnormal white blood cells in the bone marrow. Symptoms may include fatigue, fever, weight loss, and loss of appetite.
Philadelphia chromosome-positive (Ph+) Acute Lymphoblastic Leukemia (ALL): ALL is a type of blood cancer that primarily affects your blood and bone marrow. It mainly targets the white blood cells which can interfere with your body’s ability to combat infections. Ph+ Acute Lymphoblastic Leukemia is a form of ALL that occurs when specific chromosomes swap position. This causes a chromosome abnormality, creating the Philadelphia chromosome. The abnormal chromosomes produce a BCR-ABL tyrosine kinase protein, which triggers a signal to produce abnormal white blood cells in the bone marrow. Symptoms may include fever, weight loss, abnormal blood cell count, bruising, and loss of appetite.
Alcohol
Unsafe
Avoid alcohol consumption while on treatment with Sprycel 70mg Tablet to prevent serious adverse effects.
Pregnancy
Unsafe
When given to a pregnant woman, Sprycel 70mg Tablet may cause fetal harm. There have been no sufficient and well-controlled investigations of Sprycel 70mg Tablet in pregnant women. Women of reproductive potential should avoid becoming pregnant while undergoing treatment with this medicine.
Breast Feeding
Unsafe
It is not known if Sprycel 70mg Tablet passes into your breast milk. Inform your doctor if you are breastfeeding. You should not breastfeed while taking this medicine and for 2 weeks of the treatment with Sprycel 70mg Tablet. Your doctor may prescribe an alternative based on the symptoms and health condition.
Driving
Unsafe
Sprycel 70mg Tablet may cause dizziness and may make you feel drowsy. Hence, avoid driving or operating machines after taking Sprycel 70mg Tablet or until you become alert.
Liver
Caution
Use Sprycel 70mg Tablet with caution if you have liver disease. Your doctor may monitor your liver function while taking this medicine. No dose adjustments are necessary in patients with liver impairment.
Kidney
Caution
There are presently no clinical investigations with Sprycel 70mg Tablet in patients with compromised renal function. If you have kidney problems, inform your doctor before taking this medicine.
Children
Consult your doctor
Sprycel 70mg Tablet is safe for use in children above one year of age if prescribed by the doctor.
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