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Reviewed By Santoshini Reddy G , M Pharmacy
Last Updated Jan 1, 2025 | 2:46 PM IST
Spegra Tablet belongs to the class of antiretroviral drugs used in the treatment of HIV-1 infection. This combination medicine work by inhibiting the HIV-1 reverse transcriptase enzyme production, which is necessary for the multiplication of the viruses. Common side effects include dizziness, headache, diarrhoea, nausea, vomiting, rashes, trouble sleeping, and feeling weak
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Prescription drug

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Manufacturer/Marketer :

Emcure Pharmaceuticals Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

Apr-26

About Spegra Tablet

Spegra Tablet is used for the treatment of HIV-1 infection in adults and children above 12 years weighing at least 40kgs. HIV is a virus that attacks the body's immune system, making it compromised and susceptible to various infections and diseases.

Spegra Tablet contains 'Dolutegravir, Emtricitabine and Tenofovir alafenamide'. Spegra Tablet works by interfering with the work of HIV-1 reverse transcriptase enzymes, which are necessary for the replication of the virus. Together, Spegra Tablet helps in treating HIV infection.

Take Spegra Tablet as prescribed. In some cases, Spegra Tablet may cause certain side effects such as trouble sleeping, headache, nausea, and tiredness. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if these side effects persist. 

Consult your doctor if you are pregnant, or planning to get pregnant. Avoid breastfeeding while taking Spegra Tablet . Spegra Tablet does not help reduce the risk of getting HIV-1 infection by sexual contact; therefore, it is important to practise safe sex to avoid transmitting HIV to your partner. Avoid alcohol consumption while on treatment with Spegra Tablet .

Uses of Spegra Tablet

Treatment of HIV-1 infection

Medicinal Benefits

Spegra Tablet is an anti-retroviral drug used in the treatment of HIV-1 infection. Spegra Tablet works by interfering with the replication of HIV and preventing its further progression. It contains Dolutegravir, Emtricitabine and Tenofovir alafenamide. Dolutegravir works by blocking HIV integrase, which is responsible for integrating viral DNA into the host cell. Thus, it inhibits the integration of the viral component into the human body cells. Emtricitabine works by inhibiting reverse transcriptase, which is responsible for transcribing RNA to DNA. By blocking this action, emtricitabine prevents the proliferation of the virus. Tenofovir alafenamide blocks the enzyme polymerase, thereby preventing aggregation of viral components and terminating the DNA chain, thus effectively nipping viral replication in the bud.

Side Effects of Spegra Tablet

  • Headache
  • Tiredness
  • Trouble sleeping
  • Nausea

Directions for Use

Swallow Spegra Tablet as a whole with water. Do not crush, chew or break it.

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

Inform the doctor if you are allergic to any of the components of Spegra Tablet . Consult your doctor if you are pregnant, or planning to get pregnant before taking Spegra Tablet . Avoid breastfeeding while on treatment with Spegra Tablet . Avoid alcohol consumption. It is important to practise safe sex to avoid transmitting HIV to your partner. Inform your doctor if you have liver problems, hepatitis infections, heart or kidney problems. Keep your doctor informed about your health condition and medications to rule out any interactions.

Therapeutic Class

ANTIVIRALS

Drug-Drug Interactions

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DolutegravirDofetilide
Critical
EmtricitabineLamivudine
Critical

Drug-Food Interactions

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TENOFOVIR ALAFENAMIDE-25MG+EMTRICITABINE-200MG+DOLUTEGRAVIR-50MGHerbal products/medicines
Moderate

Diet & Lifestyle Advise

  • Practise safe sex to prevent transmitting HIV to your partner. Educate yourself and your partner about pre and post-exposure prophylaxis and ART (anti-retroviral therapy). Use a condom as far as possible.

  • Meditation and yoga have also proven very effective in helping HIV patients maintain a healthy attitude and body.

  • Eat more lean meats, healthy fats, fruits, vegetables and whole-grain foods.

  • Take good care of your oral hygiene. HIV often affects the mouth and causes sores. See a dentist regularly. Brush, floss and scrape your tongue well and keep your mouth clean.

  • Taking a stroll in the garden, or spending 30 minutes of your time doing some light physical activity can be very useful. However, do not over-exert yourself if you feel too tired. 

Habit Forming

No

How Spegra Tablet Works

Spegra Tablet contains 'Dolutegravir, Emtricitabine and Tenofovir alafenamide'. Spegra Tablet works by interfering with the work of HIV-1 reverse transcriptase enzymes, which are necessary for the replication of the virus. Together, Spegra Tablet helps in treating HIV infection.

What if I have taken an overdose of Spegra Tablet

Do not take more than the prescribed dose of Spegra Tablet as it may cause overdose. If you suspect you have taken overdose, please consult a doctor immediately.
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Alcohol

Unsafe

It is not recommended to consume alcohol with Spegra Tablet . Please consult your doctor if you have any concerns.

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Pregnancy

Caution

Please consult your doctor if you are pregnant. Your doctor will prescribe if the benefits are found to outweigh the risks.

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Breast Feeding

Unsafe

Avoid breastfeeding while on treatment with Spegra Tablet .

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Driving

Caution

Spegra Tablet may cause dizziness and tiredness. Do not drive if you experience any side effects after using Spegra Tablet .

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Liver

Caution

Exercise caution before using Spegra Tablet in case of established liver disease. Please consult your doctor to address any concerns.

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Kidney

Caution

Exercise caution before using Spegra Tablet in case of established kidney disease. Please consult your doctor to address any concerns.

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Children

Unsafe

Spegra Tablet is not recommended for use in children under 12 years of age. Please consult your doctor in case of any concerns.

Country of origin

India

Manufacturer/Marketer address

A €“ 504, Shapath-4, B/S Hotel Crowne Plaza, Opp. Karnavati Club, S. G. Highway ,Ahmedabad 380 051 Gujarat
Other Info - SPE0220

Author Details

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FAQs

Spegra Tablet is indicated for the treatment of HIV-1 infection.
Spegra Tablet works by inhibiting the replication of viral DNA and by preventing it from being integrated into the human body. Thereby, Spegra Tablet helps treat HIV infection.
It is not known if Spegra Tablet is safe for patients who have HIV-1 and hepatitis-B infections. Please consult your doctor for any concerns.
Do not stop taking Spegra Tablet without consulting your doctor as it may reduce the effectiveness of anti-HIV therapy. Continue taking Spegra Tablet for as long as your doctor has prescribed it to you to treat your condition effectually. Do not be reluctant to speak with your doctor if you experience any difficulty while taking Spegra Tablet .
Spegra Tablet might cause lactic acidosis (excess of lactic acid in the blood). Consult a doctor immediately if you experience stomach pain, vomiting, nausea, drowsiness, or deep rapid breathing.
Take the missed dose as soon as you remember, unless it's almost time for your next dose. In this case, skip the missed dose and take your next dose at the regular time. Never take a double dose to make up for a missed one.
Avoid nursing while receiving Spegra Tablet therapy. Avoid alcohol consumption. It is critical to engage in safe sex to avoid transferring HIV to your partner.
Before taking the Spegra Tablet , let your doctor know about all your medical conditions, sensitivities, and all the medications you are using. And inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding.
Yes, Spegra Tablet is an anti-retroviral drug used in the treatment of HIV-1 infection.
The duration of treatment depends on including medical condition and response to the treatment.
The recommended dosage of Spegra Tablet is one tablet taken orally once daily. But dosage may vary depending on various factors including medical condition and response to the treatment.
Dolutegravir, Emtricitabine and Tenofovir Alafenamide are the key active components present in it.
Spegra Tablet is not recommended for use in children under 12 years of age. Please consult your doctor in case of any concerns.
Taking more than the recommended dosage does not provide additional pain relief and can increase the risk of adverse effects.
Avoid consuming alcohol along with Spegra Tablet as it could lead to adverse effects.

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