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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Spamp-E 50 Injection is used to treat severe fungal infections. It contains Amphotericin B, which kills fungi by destroying the fungal outer cell membrane. In some cases, this medicine may cause side effects such as fever, chills, nausea, vomiting, headache, muscle cramps or pain. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.
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Whats That

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Synonym :

LIPOSOMAL AMPHOTERICIN B

Composition :

AMPHOTERICIN B-5MG

Manufacturer/Marketer :

Spal Private Limited

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About Spamp-E 50 Injection

Spamp-E 50 Injection belongs to a class of medication called 'antifungal' used to treat severe fungal infections like leishmaniasis. A fungal infection is a disease in which fungi attack the tissue and cause infection. Fungi are commonly present in nature but do not cause infections normally. However, if the person has a weak immune system, certain types of fungi may infect them. 

Spamp-E 50 Injection contains Amphotericin B, which kills fungi by destroying the fungal outer cell membrane. The fungal cell membranes are essential for their survival as they prevent the entry of unwanted substances into the cells and stop the leakage of cell contents.

Spamp-E 50 Injection is given by a doctor or nurse. In some cases, you may experience fever, chills, irregular heartbeat, high or low blood pressure, breathing problems, nausea, vomiting, headache, shaking, muscle cramps or pain. Most of these side effects of Spamp-E 50 Injection do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are allergic to Spamp-E 50 Injection or any other medicines, please tell your doctor. If you are pregnant or breastfeeding, it is advised to inform your doctor before using Spamp-E 50 Injection. Spamp-E 50 Injection is not recommended for children below one month as the safety and effectiveness were not established. Avoid driving after taking Spamp-E 50 Injection as it may affect your ability to drive. If you experience severe adverse effects such as chest pain or difficulty in breathing, or encephalopathy (a brain disease which may cause you to behave strangely, be confused or feel drowsy), seek immediate medical help.

Uses of Spamp-E 50 Injection

Treatment of Severe fungal infections

Directions for Use

Spamp-E 50 Injection will be administered by a healthcare professional; do not self-administer.

Medicinal Benefits

Spamp-E 50 Injection contains Amphotericin B, an antifungal used to treat severe fungal infections. The fungal cell membranes are essential for their survival as they prevent the entry of unwanted substances into the cells and stop the leakage of cell contents. Spamp-E 50 Injection damages fungal cell membranes and kills fungi. Spamp-E 50 Injection is used to treat infections such as blood infection with candida, cryptococcus, fusarium, zygomycetes, aspergillus, coccidiodes or blastomycetes, or cryptococcal meningitis (inflammation of the brain).

How Spamp-E 50 Injection Works

Spamp-E 50 Injection contains Amphotericin B, which kills fungi by destroying the fungal outer cell membrane. The fungal cell membranes are essential for their survival as they prevent the entry of unwanted substances into the cells and stop the leakage of cell contents.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Spamp-E 50 Injection

  • Fever

  • Chills
  • Irregular heartbeat
  • High or low blood pressure
  • Breathing problems
  • Nausea
  • Vomiting
  • Headache
  • Shaking
  • Muscle cramps or pain

What if I have taken an overdose of Spamp-E 50 Injection

Since Spamp-E 50 Injection is administered by a healthcare professional, an overdose is unlikely to occur. However, seek medical attention if you experience any unusual symptoms.

Drug Warnings

If you are allergic to Amphotericin B or any other medicines, please tell your doctor. If you are pregnant or breastfeeding, it is advised to consult a doctor before using Spamp-E 50 Injection. Spamp-E 50 Injection is not recommended for children below one month as the safety and effectiveness were not established. Avoid driving after taking Spamp-E 50 Injection as it may affect your ability to drive. If you experience severe adverse effects such as chest pain, difficulty breathing, or encephalopathy (a brain disease that may cause you to behave strangely, be confused or feel drowsy), seek immediate medical help. If you have diabetes, electrolyte imbalance (low magnesium or potassium levels in the blood), kidney, liver or heart problems, inform your doctor before taking Spamp-E 50 Injection.

Drug-Drug Interactions

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Amphotericin bStreptozocin
Critical
Amphotericin bDroperidol
Severe

Drug-Drug Interactions

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Amphotericin bStreptozocin
Critical
How does the drug interact with Spamp-E 50 Injection 10 ml:
Taking Spamp-E 50 Injection 10 ml and streptozocin together can enhance kidney injury and can cause damage to the ear.

How to manage the interaction:
Taking Streptozocin with Spamp-E 50 Injection 10 ml is not recommended as it can result in an interaction, it can be taken if a doctor has advised it.
Amphotericin bDroperidol
Severe
How does the drug interact with Spamp-E 50 Injection 10 ml:
Using droperidol together with Spamp-E 50 Injection 10 ml can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Although taking Spamp-E 50 Injection 10 ml and Droperidol together can cause an interaction, it can be taken if a doctor has suggested it. If you notice any of these symptoms - an irregular heart rhythm, a heart condition, a condition called congenital long qt syndrome, problems with your heart's conduction, severe or long-lasting diarrhea, vomiting, complications, sudden dizziness, feeling lightheaded, fainting, difficulty breathing, heart palpitations, feeling weak, feeling sleepy, feeling confused, muscle pain, feeling nauseous or vomiting - make sure to call a doctor right away. Do not discontinue any medications without consulting a doctor.
Amphotericin bEverolimus
Severe
How does the drug interact with Spamp-E 50 Injection 10 ml:
Coadministration of Spamp-E 50 Injection 10 ml and Everolimus can increase the risk of kidney problems.

How to manage the interaction:
Taking Spamp-E 50 Injection 10 ml with Everolimus together can result in an interaction, but it can be taken if a doctor has advised it. However, consult a doctor if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, or irregular heart rhythm. Do not discontinue any medications without a doctor's advice.
Amphotericin bCidofovir
Severe
How does the drug interact with Spamp-E 50 Injection 10 ml:
Taking cidofovir with Spamp-E 50 Injection 10 ml can increase the risk of kidney problems.

How to manage the interaction:
Although taking Spamp-E 50 Injection 10 ml and cidofovir together can cause an interaction, it can be taken if a doctor has suggested it. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Amphotericin bDeferasirox
Severe
How does the drug interact with Spamp-E 50 Injection 10 ml:
Deferasirox can cause kidney issues, and mixing it with Spamp-E 50 Injection 10 ml, can enhance that risk.

How to manage the interaction:
Taking Spamp-E 50 Injection 10 ml with Deferasirox together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, fluid retention, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, or irregular heart rhythm, seek immediate medical attention. Drink plenty of water if you experience diarrhea or vomiting while taking these medications, as dehydration can potentially affect the kidneys. Do not stop using any medications without talking to a doctor.
Amphotericin bAmiodarone
Severe
How does the drug interact with Spamp-E 50 Injection 10 ml:
Coadministration of amiodarone together with Spamp-E 50 Injection 10 ml may raise the risk of an abnormal heart rhythm.

How to manage the interaction:
Even though Amiodarone and Spamp-E 50 Injection 10 ml interact, they can be used if prescribed by a doctor. If you have heart issues or electrolyte imbalances, you may be at greater risk. If you experience unexpected dizziness, lightheadedness, fainting, shortness of breath, weakness, tiredness, drowsiness, confusion, muscle pain, dizziness, nausea, or vomiting, or heart palpitations, get medical attention. Do not discontinue any medications without consulting a doctor.
Amphotericin bIopromide
Severe
How does the drug interact with Spamp-E 50 Injection 10 ml:
Coadministration of Spamp-E 50 Injection 10 ml and Iopromide may increase the risk of kidney problems.

How to manage the interaction:
There may be a possibility of interaction between Spamp-E 50 Injection 10 ml and Iopromide, but it can be taken if prescribed by a doctor. If you notice any changes, like nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm let the doctor know right away. Do not stop using any medications without a doctor's advice.
Amphotericin bIoversol
Severe
How does the drug interact with Spamp-E 50 Injection 10 ml:
Coadministration of Spamp-E 50 Injection 10 ml and Ioversol may increase the risk of kidney damage.

How to manage the interaction:
There may be a possibility of interaction between Spamp-E 50 Injection 10 ml and Ioversol, but it can be taken if prescribed by a doctor. If you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. Do not stop using any medications without talking to a doctor.
Amphotericin bZiprasidone
Severe
How does the drug interact with Spamp-E 50 Injection 10 ml:
Co-administration of Ziprasidone with Spamp-E 50 Injection 10 ml may raise the chance of a significantly abnormal heart rhythm.

How to manage the interaction:
There may be a possibility of interaction between Spamp-E 50 Injection 10 ml and Ziprasidone, but it can be taken if prescribed by a doctor. However, if you experience abrupt dizziness, lightheadedness, fainting, or rapid or pounding heartbeats, weakness, tiredness, drowsiness, confusion, muscle pain, cramps, nausea, or vomiting, contact a doctor immediately. You may need regular monitoring of your electrolyte (magnesium, potassium) levels. Do not stop using any medications without talking to a doctor.
Amphotericin bMetrizamide
Severe
How does the drug interact with Spamp-E 50 Injection 10 ml:
Coadministration of Spamp-E 50 Injection 10 ml and Metrizamide may increase the risk of kidney damage.

How to manage the interaction:
Co-administration of Spamp-E 50 Injection 10 ml with Metrizamide can result in an interaction, but it can be taken if a doctor has advised it. If you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm, let the doctor know. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Wash your hands regularly and keep your hands clean to prevent the spread of germs.

  • Avoid dusty activities and digging in the soil.
  • Wear shoes, a long-sleeved t-shirt and long pants while doing outdoor activities such as yard work, gardening or visiting wooded areas to protect from fungus commonly present in the environment.
  • Maintain a diet that is low in sugar, refined carbohydrates, mould-containing foods and yeast.

Habit Forming

No

Therapeutic Class

ANTIFUNGALS

Spamp-E 50 Injection Substitute

Substitutes safety advice
  • Amphogen Emulsion 10 ml

    by Others

    144.00per tablet
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Alcohol

Caution

The interaction of Spamp-E 50 Injection with alcohol is unknown. Please consult your doctor if you have any concerns regarding this.

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Pregnancy

Consult your doctor

Spamp-E 50 Injection is a Category B pregnancy drug and is given to a pregnant woman if the doctor thinks the benefits outweigh the risks. Please consult your doctor if you are pregnant or planning pregnancy.

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Breast Feeding

Consult your doctor

It is unknown whether Spamp-E 50 Injection is excreted in human milk. If you are breastfeeding, inform your doctor before receiving this injection.

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Driving

Caution

Avoid driving after taking Spamp-E 50 Injection as it may affect your ability to drive or operate machinery.

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Liver

Consult your doctor

Inform your doctor if you have a history of liver diseases/conditions before receiving Spamp-E 50 Injection.

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Kidney

Consult your doctor

Inform your doctor if you have a history of kidney diseases/conditions before receiving Spamp-E 50 Injection.

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Children

Caution

Spamp-E 50 Injection is not recommended for children below one month as the safety and effectiveness were not established.

FAQs

Spamp-E 50 Injection is used to treat severe fungal infections like leishmaniasis.

Spamp-E 50 Injection contains Amphotericin B, an antifungal that works by damaging fungal cell membranes, thereby killing fungi.

You are not recommended to take Spamp-E 50 Injection with furosemide as co-administration of these medicines may increase the risk of hypokalaemia (low potassium levels in the blood), and in severe cases, it may lead to paralysis, muscle weakness, irregular heart rhythm, difficulty in breathing or swallowing. However, please consult your doctor before taking Spamp-E 50 Injection with other medicines.

Spamp-E 50 Injection may cause blue lips and skin, probably during infusion or in the initial 2 days of treatment. However, your doctor or nurse may arrange certain simple treatments to control such adverse effects.

Yes, a test dose of Spamp-E 50 Injection may be given in smaller amounts before starting the treatment to check if you are sensitive to any of the ingredients.

You are recommended to use Spamp-E 50 Injection for as long as your doctor has prescribed it. However, the usual treatment is for a minimum of 14 days. Please consult a doctor if you experience any difficulty while taking Spamp-E 50 Injection.

Spamp-E 50 Injection is not used to treat viral infections. Spamp-E 50 Injection is an antifungal that kills fungi and is used to treat severe fungal infections.

Spamp-E 50 Injection is an antifungal medication used to treat severe fungal infections like leishmaniasis. It kills fungi by destroying the fungal outer cell membrane.

Spamp-E 50 Injection will be administered intravenously by a healthcare professional; do not self-administer.

Spamp-E 50 Injection is fungicidal in nature, it works by killing the infection-causing fungus.

Inform the doctor if you are allergic to any of the components in Spamp-E 50 Injection or if you experience allergic reactions during treatment with Spamp-E 50 Injection. Let the doctor know if you have kidney problems, diabetes, or if you are taking any other medicines.

Spamp-E 50 Injection is an antifungal medication used to treat severe fungal infections like leishmaniasis

Spamp-E 50 Injection may cause side effects like fever, chills, nausea, vomiting, headache, muscle cramps or pain. Most of these side effects of Spamp-E 50 Injection do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

Country of origin

India

Manufacturer/Marketer address

504, 5th Floor Kubera Towers,Narayanaguda, Hyderabad-500029,Telangana,India
Other Info - SPA0380

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