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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Solonex Tablet is used to treat and prevent tuberculosis (TB). It contains isoniazid, which prevents bacteria from producing mycolic acid, an enzyme required for cell wall formation (protective coating). Thus, kills bacteria and inhibits the spread of infection. It may cause side effects such as fever, dizziness, nausea, stomach upset, loss of appetite, constipation, tiredness, numbness, or tingling in the feet or hands. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.
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Composition :

ISONIAZID-300MG

Manufacturer/Marketer :

Macleods Pharmaceuticals Ltd

Consume Type :

ORAL

Return Policy :

3 Days Returnable

Expires on or after :

Jan-27

About Solonex Tablet

Solonex Tablet belongs to a group of medicines called anti-tubercular agents, which are primarily used to treat and prevent tuberculosis (TB). Tuberculosis is an infectious bacterial disease that mainly affects the lungs, but it can also spread to other body parts such as the kidneys, brain, spine, and bone marrow. Solonex Tablet does not work against infections caused by the virus.

Solonex Tablet contains isoniazid, an antibiotic that prevents bacteria from producing mycolic acids, an enzyme required for cell wall formation (protective coating). As a result of the disturbance in their metabolism, bacteria that lack a cell wall die and burst. Thus, Solonex Tablet inhibits the spread of infection by acting against the bacteria Mycobacterium tuberculosis, which causes tuberculosis.

Take Solonex Tablet as prescribed. Use Solonex Tablet for as long as your doctor has prescribed it based on your medical condition. Sometimes, you may experience fever, dizziness, nausea, stomach upset, loss of appetite, constipation, tiredness, numbness, or tingling in the feet or hands as side effects of Solonex Tablet . Most of these side effects do not require medical attention and gradually resolve over time. However, if any of these side effects persist or worsen, please consult your doctor.

Please tell your doctor if you are allergic to Solonex Tablet or any other medicines. If you are pregnant or breastfeeding, please inform your doctor before taking Solonex Tablet . Solonex Tablet may cause mental health problems, fits, or optic neuritis (swelling of the optic nerve that may cause vision loss) in some people. Therefore, avoid driving if you experience any of these symptoms after taking Solonex Tablet .  Avoid foods and drinks containing histamine or tyramine, such as cured meat, matured cheese, soya, tuna, salmon, mackerel, wine, and beer, while on treatment with Solonex Tablet as they might interact with this medicine. If you have fits, diabetes, HIV infection, malnutrition, kidney or liver problems, or have suffered from psychosis (mental disturbances), inform your doctor before taking Solonex Tablet .

Uses of Solonex Tablet

Treatment of Tuberculosis (TB).

Directions for Use

Take Solonex Tablet on an empty stomach at least one hour before or two hours after a meal or as your doctor advises. Do not take it with food. Tablet: Swallow it whole with a glass of water. Do not crush, break, or chew it.Syrup: Shake the bottle well before use. Take the prescribed dose by mouth using the measuring cup/dosing syringe/dropper provided by the pack.

Medicinal Benefits

Solonex Tablet contains isoniazid, an antibiotic used to treat and prevent tuberculosis. Solonex Tablet prevents bacteria from producing mycolic acids, which are required to form cell walls (protective coating). Additionally, Solonex Tablet may combine with an enzyme that interferes with bacterial cell metabolism. Bacteria die as a result of the disruption in their metabolism and the lack of a cell wall. As a result, it kills Mycobacterium tuberculosis bacteria that causes tuberculosis (TB) and eliminates the infection.

How Solonex Tablet Works

Solonex Tablet contains isoniazid, an antibiotic that prevents bacteria from producing mycolic acids, an enzyme required for cell wall formation (protective coating). As a result of the disturbance in their metabolism, bacteria that lack a cell wall die and burst. Thus, Solonex Tablet inhibits the spread of infection by acting against the bacteria Mycobacterium tuberculosis, which causes tuberculosis.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Solonex Tablet

  • Fever
  • Dizziness
  • Nausea
  • Stomach upset
  • Loss of appetite
  • Constipation
  • Tiredness
  • Numbness or tingling in the feet or hands

What if I have taken an overdose of Solonex Tablet

Do not take more than the prescribed dose of Solonex Tablet as it may cause overdose. The symptoms of overdose include diziness, nausea, vertigo, fits and acidosis (upset of acid balance in the body). If you suspect you have taken overdose or notice signs of overdose, please consult a doctor immediately.

Drug Warnings

If you are known to be allergic to Solonex Tablet , please inform your doctor. If you are pregnant or breastfeeding, please inform your doctor before taking Solonex Tablet . Solonex Tablet may cause mental health problems, fits or optic neuritis (swelling of the optic nerve that may cause vision loss) in some people. Therefore, avoid driving if you experience any of these symptoms after taking Solonex Tablet . Avoid foods and drinks containing a high level of tyramine, such as fermented foods, cheese, cured meat, soya, tuna, salmon, mackerel, wine, and beer, while taking Solonex Tablet as they might cause drug-food interaction. Avoid alcohol consumption with Solonex Tablet as it may cause liver damage. If you have fits, diabetes, HIV infection, malnutrition, kidney or liver problems or have suffered from psychosis (mental disturbances), inform your doctor before taking Solonex Tablet .

Drug-Drug Interactions

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IsoniazidLovastatin
Critical
IsoniazidRegorafenib
Critical

Drug-Drug Interactions

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IsoniazidLovastatin
Critical
How does the drug interact with Solonex Tablet 10's:
When Lovastatin is taken with Solonex Tablet 10's, can increase the risk of myopathy (muscles problems), including rhabdomyolysis (a condition that causes your muscles to break down, which leads to muscle death).

How to manage the interaction:
Taking Solonex Tablet 10's with Lovastatin is not recommended but can be taken if a doctor has prescribed it.
IsoniazidRegorafenib
Critical
How does the drug interact with Solonex Tablet 10's:
When Solonex Tablet 10's is taken with Regorafenib, it can increase the levels of Regorafenib leading to side effects.

How to manage the interaction:
Taking Regorafenib with Solonex Tablet 10's is not recommended, it taken can be taken if prescribed by the doctor.
IsoniazidLomitapide
Critical
How does the drug interact with Solonex Tablet 10's:
When Lomitapide is taken with Solonex Tablet 10's, Solonex Tablet 10's may increase the blood levels of lomitapide which leads to side effects.

How to manage the interaction:
Taking Solonex Tablet 10's with Lomitapide is not recommended but can be taken if prescribed by a doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, exhaustion, nausea, vomiting, dark urine, light stools, and skin or eye yellowing, decreased hunger, consult the doctor.
IsoniazidHalothane
Severe
How does the drug interact with Solonex Tablet 10's:
When Halothane is taken with Solonex Tablet 10's, can increase the side affects of liver.

How to manage the interaction:
Co-administration of Solonex Tablet 10's with Halothane can possibly result in an interaction, but it can be taken if a doctor has advised it. However, if you experience symptoms such as fever, chills, joint pain or swelling, unusual bleeding or bruising, a skin rash or itching, appetite loss, nausea, vomiting, or yellowing of the skin or the whites of your eyes, consult a doctor right away. Do not stop using any medications without talking to a doctor.
IsoniazidAlfuzosin
Severe
How does the drug interact with Solonex Tablet 10's:
Co-administration of Solonex Tablet 10's will enhance the amount or action of alfuzosin when taken together.

How to manage the interaction:
Although taking Solonex Tablet 10's with Alfuzosin together can possibly result in an interaction, it can be taken if a doctor has prescribed it. Do not discontinue any medications without a doctor's advice.
IsoniazidCholera, live attenuated
Severe
How does the drug interact with Solonex Tablet 10's:
Taking Solonex Tablet 10's and Cholera, live attenuated together may reduce the effectiveness of the vaccine.

How to manage the interaction:
Although taking Solonex Tablet 10's and Cholera, live attenuated together can cause an interaction, it can be taken if a doctor has suggested it. You shouldn't receive the cholera vaccination until at least 14 days after finishing your Solonex Tablet 10's therapy in order to ensure an appropriate immune response. Do not stop using any medications without a doctor's advice.
IsoniazidRifabutin
Severe
How does the drug interact with Solonex Tablet 10's:
Co-administration of Rifabutin with Solonex Tablet 10's can increase the risk of liver problems.

How to manage the interaction:
Although taking Rifabutin and Solonex Tablet 10's together can cause an interaction, it can be taken if a doctor has suggested it. However, if you experience any symptoms like fever, chills, joint pain or swelling, unusual bleeding or bruising, a skin rash or itching, appetite loss, nausea, vomiting, or yellowing of the skin or the whites of your eyes, consult a doctor. Do not discontinue any medications without consulting a doctor.
IsoniazidMipomersen
Severe
How does the drug interact with Solonex Tablet 10's:
Taking Solonex Tablet 10's and Mipomersen can increase the risk and severity of side effects of liver.

How to manage the interaction:
Although taking Solonex Tablet 10's and Mipomersen together can cause an interaction, it can be taken if a doctor has suggested it. If you notice any of these symptoms -fatigue, decreased hunger, nausea, vomiting, abdominal discomfort, dark urine, pale feces, yellowing of the skin or eyes, joint pain or swelling, fever, chills, unusual bleeding or bruises, skin rash, itching, and/or skin itchiness, please contact a doctor right away. Do not stop using any medications without talking to a doctor.
IsoniazidSonidegib
Severe
How does the drug interact with Solonex Tablet 10's:
The combined use of Solonex Tablet 10's and Sonidegib will enhance the amount of Sonidegib, which increases the risk of side effects.

How to manage the interaction:
Although there is a possible interaction between Sonidegib and Solonex Tablet 10's, you can take these medicines together if prescribed by a doctor. Do not stop using any medications without a doctor's advice.
IsoniazidBCG vaccine
Severe
How does the drug interact with Solonex Tablet 10's:
When BCG vaccine is used with Solonex Tablet 10's, its effectiveness may be reduced.

How to manage the interaction:
Although there is a possible interaction between Solonex Tablet 10's and BCG vaccine, you can take these medicines together if prescribed by a doctor. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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ISONIAZID-300MGCaffeine containing foods/drinks

Drug-Food Interactions

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ISONIAZID-300MGCaffeine containing foods/drinks
Common Foods to Avoid:
Dark Chocolate, Cocoa, Coffee, Energy Drinks With Caffeine, Green Tea, Kola Nut, Tea, Tiramisu

How to manage the interaction:
Taking caffeine containing products including chocolates(which contains caffeine) during Solonex Tablet 10's treatment may lead to an interaction. Avoid caffiene and its products during treatment with Solonex Tablet 10's.

Diet & Lifestyle Advise

 

  • Pineapple juice might help soothe the symptoms of cough and cold. It also has anti-inflammatory and mucolytic properties.
  • Vitamin C-rich foods such as kiwi, broccoli, and bell pepper help improve the immune system.
  • Avoid processed and fried foods.
  • Warm ginger tea or warm soup can help relieve a cough.
  • Avoid foods and drinks containing histamine or tyramine, such as cured meat, matured cheese, soya, tuna, salmon, mackerel, wine, and beer.
  • Quit smoking and avoid alcohol consumption.

Habit Forming

No

Therapeutic Class

ANTI- TUBERCULOSIS

Solonex Tablet Substitute

Substitutes safety advice
  • PYZINA KID TABLET

    5.49per tablet
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Alcohol

Unsafe

Avoid alcohol consumption while on treatment with Solonex Tablet as it may increase the risk of liver damage. Please consult your doctor in case of any concerns.

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Pregnancy

Safe if prescribed

If you are pregnant, consult your doctor before taking Solonex Tablet . Your doctor may prescribe this medicine if only the benefits outweigh the risks.

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Breast Feeding

Safe if prescribed

Solonex Tablet is excreted in breast milk in low quantities. If you are breastfeeding, consult your doctor before taking Solonex Tablet . Your doctor may prescribe this medicine if only the benefits outweigh the risks.

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Driving

Unsafe

Solonex Tablet may cause mental health problems, fits or optic neuritis (swelling of the optic nerve that may cause vision loss) in some people. Therefore, avoid driving if you experience any of these symptoms after taking Solonex Tablet .

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Liver

Caution

Take Solonex Tablet with caution, especially if you have a history of Liver diseases/conditions. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.

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Kidney

Caution

Take Solonex Tablet with caution, especially if you have a history of Kidney diseases/conditions. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.

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Children

Caution

Solonex Tablet is not recommended for children below 3 months of age. However, in children above 3 months, Solonex Tablet should be used under medical supervision.

FAQs

Solonex Tablet is used to treat and prevent tuberculosis (TB).
Solonex Tablet contains isoniazid, an antibiotic used to treat and prevent tuberculosis. Solonex Tablet prevents bacteria from producing mycolic acids, which are required to form cell walls (protective coating). Additionally, Solonex Tablet may combine with an enzyme that interferes with bacterial cell metabolism. Bacteria die due to the disruption in their metabolism and the lack of a cell wall. As a result, it kills Mycobacterium tuberculosis bacteria that causes tuberculosis (TB) and eliminates the infection.
It is not recommended to take Solonex Tablet with food. You are advised to take Solonex Tablet on an empty stomach at least 1 hour before a meal or 2 hours after a meal for better absorption.
You are recommended to avoid foods and drinks containing histamine or tyramine such as cured meat, matured cheese, soya, tuna, salmon, mackerel, wine, and beer as they may interact with Solonex Tablet and cause adverse effects such as sweating, headache, dizziness, light-headedness, flushing (reddening of the skin), fainting due to low blood pressure, uneven, fast or forceful heartbeat.
Yes, Solonex Tablet may cause liver problems in some patients. However, please consult your doctor if you notice symptoms such as yellowing of eyes or skin, dark urine, pale stools, weakness, loss of appetite, nausea or vomiting. Your doctor may monitor your liver function while on treatment with Solonex Tablet .
You are advised to consult a doctor before taking phenytoin with Solonex Tablet as taking these medicines together may increase the levels of phenytoin in the blood and cause toxic effects. However, if you experience dizziness, vomiting, confusion or nausea, please consult your doctor.
Please do not stop taking Solonex Tablet suddenly without consulting your doctor as it may cause withdrawal symptoms such as irritation, nervousness, difficulty in sleeping, headache or having more dreams. Therefore, take Solonex Tablet for as long as your doctor has prescribed it, and if you experience any difficulty while taking Solonex Tablet , please consult your doctor.
Solonex Tablet is not recommended for patients suffering from fits as it may increase the risk of recurring fits. Therefore, it is advised to inform your doctor if you have a history of fits before taking Solonex Tablet .
Inform your doctor if your symptoms are not relieved after completing the full course of Solonex Tablet . If you notice any undesirable effects that bother you while taking Solonex Tablet , consult your doctor.
If you miss taking a dose Solonex Tablet , then take it as soon as you remember and if it is the time for the next dose, skip the missed dose and continue with the regular dose. Avoid taking more to make up for the missed one.
You are not recommended to stop taking Solonex Tablet even if you feel better, as you may experience unwanted side effects. Take Solonex Tablet as long as advised by a doctor for the effective response. However, contact a doctor if you have any concerns.
Solonex Tablet causes side effects such as fever, dizziness, nausea, stomach upset, loss of appetite, constipation, tiredness, and numbness in feet or hands. Most of these are temporary and do not require any medical attention, as they will gradually reduce over time. Please, contact a doctor if these persist for longer durations.

Country of origin

India

Manufacturer/Marketer address

Atlanta Arcade, Marol Church Road, Andheri (East), Mumbai - 400059, INDIA.
Other Info - SOL0028

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