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Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Sitazit D 5/50 mg Tablet is used to treat type-2 diabetes mellitus. It contains Dapagliflozin and Sitagliptin. Dapagliflozin lowers blood glucose levels and increases glucose excretion in the urine. By improving insulin levels and lowering glucagon levels (the hormone that raises blood glucose levels), sitagliptin decreases the amount of glucose the liver produces. Thus, it helps control blood sugar levels. Common side effects of this medicine include diarrhoea, hypoglycaemia, headache, nausea, and vomiting.

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Manufacturer/Marketer :

Glenmark Pharmaceuticals Ltd

Consume Type :

ORAL

Return Policy :

3 Days Returnable

Expires on or after :

Jan-27

About Sitazit D 5/50 mg Tablet

Sitazit D 5/50 mg Tablet is used to treat type-2 diabetes mellitus. Type-2 diabetes mellitus (also known as non-insulin-dependent diabetes or adult-onset diabetes) is a medical condition in which blood glucose levels are above normal due to insulin deficiency, insulin resistance, or both.

Sitazit D 5/50 mg Tablet contains Dapagliflozin (sodium-glucose cotransporter-2 inhibitors) and Sitagliptin (dipeptidyl peptidase-4 inhibitor). Dapagliflozin lowers blood glucose levels and increases the excretion of glucose in the urine. By increasing insulin levels and lowering glucagon levels (the hormone that raises blood glucose levels), sitagliptin decreases the amount of glucose the liver produces. Thus, Sitazit D 5/50 mg Tablet helps control blood sugar levels.

Sitazit D 5/50 mg Tablet may cause side effects such as diarrhoea, hypoglycaemia, headache, nausea, and vomiting. These effects do not require medical attention and gradually resolve over time. Inform your doctor if any of these side effects persist or bother you. Take Sitazit D 5/50 mg Tablet as prescribed by your doctor.

Sitazit D 5/50 mg Tablet should be avoided if you are allergic to any of the components in it. Inform your doctor if you are pregnant or breastfeeding. Let your doctor know about all the medicines you are taking and your health condition to rule out any unpleasant side effects/interactions.

Uses of Sitazit D 5/50 mg Tablet

Treatment of Type-2 diabetes mellitus

Directions for Use

Take Sitazit D 5/50 mg Tablet with or after food. Swallow Sitazit D 5/50 mg Tablet as a whole with a glass of water; do not break, chew or crush it.

Medicinal Benefits

Sitazit D 5/50 mg Tablet is a combination medicine containing Dapagliflozin and Linagliptin as active ingredients. Dapagliflozin helps in removing excess sugar from the body via urine. Linagliptin works by decreasing the hormones that raise blood glucose levels and increasing insulin release from the pancreas. Together, Sitazit D 5/50 mg Tablet helps control blood sugar levels.

How Sitazit D 5/50 mg Tablet Works

Sitazit D 5/50 mg Tablet contains Dapagliflozin (sodium-glucose cotransporter-2 inhibitors) and Sitagliptin (dipeptidyl peptidase-4 inhibitor). Dapagliflozin lowers blood glucose levels and increases the excretion of glucose in the urine. By increasing insulin levels and lowering glucagon levels (the hormone that raises blood glucose levels), sitagliptin decreases the amount of glucose the liver produces. Thus, Sitazit D 5/50 mg Tablet helps control blood sugar levels.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Sitazit D 5/50 mg Tablet

  • Stomach upset
  • Hypoglycaemia (low blood sugar levels)
  • Nausea
  • Vomiting
  • Diarrhea
  • Headache
  • Constipation
  • Dizziness
  • Runny nose
  • Sore throat

What if I have taken an overdose of Sitazit D 5/50 mg Tablet

Please do not exceed the recommended dose, as it might cause an overdose. Signs and symptoms of an overdose of Sitazit D 5/50 mg Tablet may include hypoglycemia and severe gastrointestinal problems. Seek immediate medical attention if you observe these symptoms or think you might have taken too much. Do this even if there are no signs of discomfort or poisoning.

Drug Warnings

Do not take Sitazit D 5/50 mg Tablet if you are allergic to any of its components. Inform your doctor about all the medicines you are taking and your health condition to rule out any unpleasant side effects. Inform your doctor if you have any liver/kidney disease, heart problems, and hypertension before taking Sitazit D 5/50 mg Tablet . Sitazit D 5/50 mg Tablet is not recommended for children as safety and effectiveness have not been established. Avoid alcohol consumption while taking Sitazit D 5/50 mg Tablet as it might cause unpleasant side effects. It is unknown whether Sitazit D 5/50 mg Tablet can be given to pregnant women or breastfeeding mothers. Hence, inform your doctor if you are pregnant or breastfeeding. It is not recommended for use in children below 18 years of age.

Drug-Drug Interactions

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SitagliptinGatifloxacin
Critical
DapagliflozinGatifloxacin
Critical

Drug-Drug Interactions

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SitagliptinGatifloxacin
Critical
How does the drug interact with Sitazit-D 5 mg/50 mg Tablet 10's:
Co-administration of Sitazit-D 5 mg/50 mg Tablet 10's with Gatifloxacin may sometimes affect blood glucose levels. Both high blood glucose and, less frequently, low blood glucose have been reported.

How to manage the interaction:
Taking Sitazit-D 5 mg/50 mg Tablet 10's with Gatifloxacin is not recommended as it can lead to a possible interaction, However, it can be taken if advised by the doctor. Consult the prescriber if you experience symptoms such as nervousness, confusion, headache, dizziness, drowsiness, tremors, nausea, hunger, weakness, perspiration, palpitation, rapid heartbeat, increased urination, increased thirst, and increased hunger. Maintaining blood glucose levels is advised. Do not stop using any medications without a doctor's advice.
DapagliflozinGatifloxacin
Critical
How does the drug interact with Sitazit-D 5 mg/50 mg Tablet 10's:
Co-administration of Sitazit-D 5 mg/50 mg Tablet 10's with Gatifloxacin may sometimes affect blood glucose levels. Both low blood glucose and, less frequently, high blood glucose have been reported.

How to manage the interaction:
Although there is a possible interaction, Gatifloxacin can be taken with Sitazit-D 5 mg/50 mg Tablet 10's if prescribed by the doctor. Consult the prescriber if you experience symptoms such as nervousness, confusion, headache, dizziness, drowsiness, tremor, nausea, hunger, weakness, perspiration, palpitation, rapid heartbeat, increased urination, increased thirst, and increased hunger. Maintaining blood glucose levels is advised. Do not discontinue the medication without consulting a doctor.
SitagliptinIvacaftor
Severe
How does the drug interact with Sitazit-D 5 mg/50 mg Tablet 10's:
When Sitazit-D 5 mg/50 mg Tablet 10's is taken with Ivacaftor, the amount of Sitazit-D 5 mg/50 mg Tablet 10's in the blood can go up.

How to manage the interaction:
Taking Sitazit-D 5 mg/50 mg Tablet 10's with Ivacaftor together can possibly result in an interaction, but it can be taken if a doctor has advised it. Do not discontinue any medications without consulting a doctor.
DapagliflozinAliskiren
Severe
How does the drug interact with Sitazit-D 5 mg/50 mg Tablet 10's:
Co-administration of Sitazit-D 5 mg/50 mg Tablet 10's with Aliskiren may increase the risk of dehydration and low blood pressure.

How to manage the interaction:
If you are supposed to use Sitazit-D 5 mg/50 mg Tablet 10's and Aliskiren together, a doctor may adjust the dose and monitor you more frequently. However, if you experience dizziness, fainting, headache, lightheadedness, and/or changes in pulse or heart rate, contact a doctor. Do not discontinue the medication without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Eat foods rich in healthy carbohydrates and fibre, fruits, whole grains, and vegetables.
  • Try eating food at regular intervals. Do not skip meals. Also, try not to overeat.
  • Follow a healthy diet and walk/exercise for at least 45 minutes.
  • Maintain a healthy weight by exercising regularly.
  • Rest properly and avoid stress by doing meditation or yoga.

Habit Forming

No

Therapeutic Class

ANTIDIABETICS

Sitazit D 5/50 mg Tablet Substitute

Substitutes safety advice
  • Istavel D 5 mg/50 mg Tablet 15's

    17.34per tablet
  • Oxra-S 5/50 mg Tablet 15's

    17.34per tablet
  • Sitaxa D 5 mg/50 mg Tablet 10's

    15.71per tablet
  • Dapefy-S 5/50 Tablet 15's

    17.34per tablet
  • Stalix D 5 mg/50 mg Tablet 10's

    15.71per tablet
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Alcohol

Unsafe

Avoid consumption of alcohol during treatment with Sitazit D 5/50 mg Tablet as it may cause serious side effects.

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Pregnancy

Consult your doctor

If you are pregnant or planning pregnancy, inform your doctor before starting treatment with Sitazit D 5/50 mg Tablet . Your doctor may prescribe this medicine if the benefits outweigh the risks.

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Breast Feeding

Consult your doctor

Limited data is available on the effect of Sitazit D 5/50 mg Tablet on breastfeeding. Hence, if you are a nursing mother, inform your doctor before taking Sitazit D 5/50 mg Tablet . Your doctor may prescribe this medicine if the benefits outweigh the risks.

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Driving

Caution

Sitazit D 5/50 mg Tablet may occasionally cause dizziness. Hence, drive only if you are alert after taking this medicine.

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Liver

Consult your doctor

If you have a pre-existing or a history of liver disease, inform your doctor before taking Sitazit D 5/50 mg Tablet . Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.

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Kidney

Consult your doctor

If you have a pre-existing or a history of kidney disease, inform your doctor before taking Sitazit D 5/50 mg Tablet . Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.

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Children

Unsafe

Sitazit D 5/50 mg Tablet is not recommended for use in children below 12 years of age as the safety and efficacy are not established.

FAQs

Sitazit D 5/50 mg Tablet is used to treat type-2 diabetes mellitus. Type-2 diabetes mellitus (also known as non-insulin-dependent diabetes or adult-onset diabetes) is a medical condition in which blood glucose levels are above normal due to insulin deficiency, insulin resistance, or both.
Low-fibre diets, high-fat diets, sugary diets, obesity, smoking, stress, lack of exercise, age, genetic factors, and certain medical conditions are the common causes of diabetes.
Sitazit D 5/50 mg Tablet is a combination medicine containing Sitagliptin that enhances glucose-mediated insulin secretion, thereby reducing fasting and post-prandial blood sugar concentrations. Dapagliflozin lowers blood glucose levels and increases the excretion of glucose in the urine. By increasing insulin levels and lowering glucagon levels (the hormone that raises blood glucose levels), sitagliptin decreases the amount of glucose the liver produces.

Country of origin

India

Manufacturer/Marketer address

Glenmark Pharmaceuticals Limited, B/2, Mahalaxmi Chambers, 22, Bhulabhai Desai Road, Mumbai €“ 400 026.
Other Info - SIT0197

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