What is the use of Sitaliptin-50 M SR Tablet ?

Sitaliptin-50 M SR Tablet is used to treat Type 2 Diabetes Mellitus.

What are the signs of diabetes?

Increased hunger, increased thirst, frequent urination (usually at night), unexplained weight loss, fatigue, blurred vision, slow wound/sore healing, and frequent infections are the signs of type 2 diabetes. Please consult your doctor if you notice such symptoms.

Is Sitaliptin-50 M SR Tablet used for the treatment of type 1 diabetes?

No. Sitaliptin-50 M SR Tablet is only prescribed for the treatment of type 2 diabetes, also called non-insulin-dependent diabetes.

Why Sitaliptin-50 M SR Tablet needs to be taken with food?

Sitaliptin-50 M SR Tablet needs to be taken with food to avoid stomach upset. Take it as prescribed by your doctor.

Can I take crushed Sitaliptin-50 M SR Tablet ?

Do not crush or chew Sitaliptin-50 M SR Tablet as it may release all of the medicine at once and cause side effects. It should be taken as a whole, with food, or as advised by your doctor.

Does Sitaliptin-50 M SR Tablet cause low blood sugar?

Generally, Sitaliptin-50 M SR Tablet does not cause hypoglycemia. It can cause low blood sugar if taken along with other antidiabetic medications, especially when engaging in strenuous exercise or consuming low-calorie foods. Symptoms of low blood sugar include sudden sweating, blurred vision, shaking, hunger, increased heart rate, dizziness, or tingling sensations in the hands or feet. If you experience low blood sugar while taking Sitaliptin-50 M SR Tablet , consult your doctor.

What should I do if I have low blood sugar after taking Sitaliptin-50 M SR Tablet with other anti-diabetic medicines?

To quickly increase your blood sugar, eat sugar, candy, honey, or drink fruit juice or non-diet soda if you have sudden sweating, blurry vision, shaking, dizziness, increased heartbeat, or hunger.

Can the use of Sitaliptin-50 M SR Tablet lead to Vitamin B12 deficiency?

Long-term use of Sitaliptin-50 M SR Tablet can lead to Vitamin B12 deficiency. It interferes with the absorption of Vitamin B12 in the stomach. If left untreated, it may lead to anaemia and nerve problems, which can cause the patient to experience tingling sensations and numbness in the hands and feet, urinary problems, weakness, changes in mental status, and difficulty maintaining balance (ataxia). Some researchers recommend the intake of vitamin B12 from external sources at least once a year to avoid such problems.

What are the possible side effects of Sitaliptin-50 M SR Tablet ?

Sitaliptin-50 M SR Tablet may cause side effects such as headache, nausea, vomiting, diarrhoea, low blood sugar, or upper respiratory tract infection. If these side effects persist or worsen, please consult your doctor.

Are there any specific conditions in which Sitaliptin-50 M SR Tablet should not to be taken?

Sitaliptin-50 M SR Tablet should be avoided in patients with known allergy to any of the components or excipients in it and in patients with severe liver impairment, kidney impairment, congestive heart failure, diabetic ketoacidosis or lactic acidosis.

Is it safe to take alcohol while I am taking Sitaliptin-50 M SR Tablet ?

No, it is not safe to take alcohol while using Sitaliptin-50 M SR Tablet as it may increase the chance of a life-threatening condition known as lactic acidosis.

What are the instructions for storage and disposal of Sitaliptin-50 M SR Tablet ?

Store Sitaliptin-50 M SR Tablet at room temperature. Protect from light and moisture. Keep it out of reach of children.

Can the use of Sitaliptin-50 M SR Tablet lead to lactic acidosis?

Yes, the use of Sitaliptin-50 M SR Tablet can lead to lactic acidosis. It is a life threatening condition caused by the increased levels of lactic acid in the blood. It is also known as MALA (Metformin associated lactic acidosis). It is a rare side effect of metformin and thus, it is avoided in patients with underlying kidney disease, elderly patients or who take large amounts of alcohol. Symptoms of lactic acidosis may include muscle pain or weakness, tiredness, dizziness, difficulty in breathing, feeling of cold in arms and legs, stomach pain, nausea, vomiting, or slow heart rate. If you have these symptoms, stop taking Sitaliptin-50 M SR Tablet and consult your doctor immediately.

What are the benefits of taking Sitaliptin-50 M SR Tablet ?

Sitaliptin-50 M SR Tablet can lower the chance of severe complications such as nerve problems, kidney damage, blindness, limb amputations, and heart diseases by controlling high blood sugar.

Can I take other medications with Sitaliptin-50 M SR Tablet ?

You are recommended to consult your doctor before taking other medications with Sitaliptin-50 M SR Tablet to avoid drug interactions.

What precautions should I follow while taking Sitaliptin-50 M SR Tablet ?

Avoid alcohol consumption while taking Sitaliptin-50 M SR Tablet and ensure regular monitoring of kidney function. Always take Sitaliptin-50 M SR Tablet as prescribed by your doctor.

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About Sitaliptin-50 M SR Tablet

Sitaliptin-50 M SR Tablet is a combination drug used in the treatment of type 2 diabetes mellitus. Type 2 diabetes develops when the body does not produce enough insulin or when the body's insulin does not work as well as it should. It can also develop if the body produces too much glucagon. Insulin is a substance which helps to lower the level of sugar in your blood, especially after meals.

Sitaliptin-50 M SR Tablet contains metformin and vildagliptin, which help control blood sugar levels. It works by causing the pancreas to produce more insulin and less glucagon (the effect of vildagliptin) and also by helping the body utilise insulin more effectively (the effect of metformin).

Not everyone who is taking Sitaliptin-50 M SR Tablet will get these side effects. The most common side effect of Sitaliptin-50 M SR Tablet is hypoglycemia (low blood glucose levels) characterised by dizziness, sweating, hunger pangs, dry mouth and skin, etc. Other side effects include changes in taste, nausea, diarrhoea, stomach pain, headache, and upper respiratory symptoms.

Sitaliptin-50 M SR Tablet should be taken with food to avoid an upset stomach. It is advised to take it at the same time each day for best results. For better advice, your doctor will determine the appropriate dose, which can change quickly depending on your condition. Do not skip your meals, and also carry a form of sugar with you to prevent low blood sugar levels.

Avoid taking Sitaliptin-50 M SR Tablet if you are allergic to it. Sitaliptin-50 M SR Tablet should not be stopped even if you feel better without consulting your doctor, as sugar levels may change. If you stop taking Sitaliptin-50 M SR Tablet abruptly, it may increase your sugar levels, which could further increase the risk of eyesight loss (retinopathy), kidney damage and nerve damage. Sitaliptin-50 M SR Tablet should not be taken if you have type 1 diabetes mellitus or severe kidney or liver disease. Please inform your doctor if you have any heart disease or are planning to get pregnant or breastfeed. You must continue following the diet and exercise recommended for you while on treatment with Sitaliptin-50 M SR Tablet .

Uses of Sitaliptin-50 M SR Tablet

Sitaliptin-50 M SR Tablet is used in the treatment of Type 2 Diabetes Mellitus. The detailed uses of Sitaliptin-50 M SR Tablet are as follows:

Management of Diabetes: Sitaliptin-50 M SR Tablet is commonly prescribed to help regulate blood sugar levels in patients with type 2 diabetes, particularly those who may require additional medication alongside lifestyle changes.
Improvement of Glycemic Control: Sitaliptin-50 M SR Tablet aids in improving overall glycemic control by enhancing insulin sensitivity and decreasing hepatic glucose production.
Weight Management: In some cases, Sitaliptin-50 M SR Tablet can assist in weight management for diabetic patients, as it may help reduce appetite or modify fat metabolism.
Prevention of Diabetes Complications: Regular use of Sitaliptin-50 M SR Tablet can contribute to the prevention of long-term complications associated with diabetes, such as neuropathy, nephropathy, and retinopathy.

Have a query?

Side effects of Sitaliptin-50 M SR Tablet

Swelling Of The Feet And Ankles

Wear compression garments like stockings, sleeves, or gloves to apply pressure and help stop fluid from building up, especially after the swelling goes down.
Move around and do exercises to help the fluid circulate, especially in swollen limbs. Ask your doctor for specific exercises.
Raise the swollen area above your heart level several times a day, even while sleeping, to help reduce swelling.
Gently massage the swollen area with firm but not painful pressure.
Keep the swollen area clean and moisturized to prevent injury and infection.
Reduce salt intake to help prevent fluid from building up and worsening the swelling, as advised by a doctor.
If the swelling does not get better after a few days of home treatment or worsens, consult your doctor right away.

Loose And Watery Stools

Here are the precise steps to cope with diarrhoea caused by medication usage:

Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.

Nausea

Overcome Medication-Induced Nausea: A 9-Step Plan

Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
Divide your daily food intake into smaller, more frequent meals to reduce nausea.
Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
Use ginger (tea, ale, or candies) to help relieve nausea.
Get adequate rest and also avoid strenuous activities that can worsen nausea.
Talk to your doctor about taking anti-nausea medication if your nausea is severe.
Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.

Gas Or Fart

Here are the steps to manage Gastrointestinal Air and Swelling (GAS) caused by medication:

Tell your doctor about your GAS symptoms. They may change your medication regimen or prescribe additional drugs to help you manage them.
To manage GAS symptoms, eat a balanced diet of fibre, vegetables, and fruits.
Drink enough water throughout the day to avoid constipation and treat GAS symptoms.
Regular exercise like yoga and walking may help stimulate digestion and alleviate GAS symptoms.
Take probiotics only if your doctor advises, as they may help alleviate GAS symptoms by promoting gut health.
Take medication for GAS symptoms only if your doctor advises, as certain medications can interact with your existing prescriptions or worsen symptoms.
If symptoms persist, worsen, or are accompanied by severe abdominal pain, vomiting, or bleeding, seek immediate medical attention.

Vomiting

To prevent, manage, and treat Constipation caused by medication usage, follow these steps:

Preventing Vomiting (Before it Happens)
Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
Having a small meal before taking your medication can help reduce nausea and vomiting.
Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
Managing Vomiting (If it Happens)
Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
What to Do if Vomiting Persists
Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.

Headache

Dealing with Medication-Induced Headache:

Hydrate your body: Drink enough water to prevent dehydration and headaches.
Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
Take rest: lie down in a quiet, dark environment.
Cold or warm compresses can help reduce tension.
Stay Upright: Maintain good posture to keep symptoms from getting worse.
To treat headaches naturally, try acupuncture or massage therapy.
Over-the-counter pain relievers include acetaminophen and ibuprofen.
Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
Frequent Headaches: If you get reoccurring headaches, consult your doctor.
Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.

Viral Infection Of The Nose And Throat

Focus on eating nutrient-rich foods such as citrus fruits, spinach, ginger, garlic, turmeric, and fermented foods to improve immunity and general health.
Drink plenty of water to stay hydrated, and think about taking probiotics, zinc, vitamin C, and vitamin D supplements.
Adopt healthful practices such as leading a balanced lifestyle and remaining at home when necessary.
Avoid smoking and drinking alcohol as it can worsen your condition.

Directions for Use

Sitaliptin-50 M SR Tablet should be taken with meals to avoid stomach upset.
It is usually taken twice daily; however, your doctor may adjust the dosage based on your blood sugar levels.
Swallow Sitaliptin-50 M SR Tablet as a whole with a glass of water.
Do not crush, chew, or break it.

Key Benefits

Sitaliptin-50 M SR Tablet helps your pancreas produce more insulin, effectively utilise insulin, and decrease the excess sugar that your liver makes.
It helps control the rise of blood sugar levels in your body after a meal.
Sitaliptin-50 M SR Tablet plays a vital role in controlling blood sugar levels and prevents serious complications of diabetes like eyesight loss (retinopathy), kidney (nephropathy), nerve damage (neuropathy), diabetic foot ulcer and delayed wound healing.

How Sitaliptin-50 M SR Tablet Works

Sitaliptin-50 M SR Tablet is a combination of Sitagliptin and Metformin. Metformin slows the release of stored sugar from the liver, decreases the amount of sugar absorbed from the stomach, and improves how your body uses sugar. Sitagliptin increases the body's production of chemicals that stimulate the pancreas to release more insulin, thereby helping to regulate blood sugar levels. Thus, Sitaliptin-50 M SR Tablet controls blood glucose levels from rising to very high after meals.

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

What if I have taken an overdose of Sitaliptin-50 M SR Tablet

Do not take more than the prescribed dose of Sitaliptin-50 M SR Tablet as it may cause an overdose. If you suspect you have taken an overdose, please consult a doctor immediately.

Drug Warnings

Inform your doctor if you are allergic to Sitaliptin-50 M SR Tablet .
This medicine should not be used in patients with type 1 diabetes or with diabetic ketoacidosis.
Some diabetic patients, while taking Sitaliptin-50 M SR Tablet , might develop a rare but serious condition called lactic acidosis (too much lactic acid accumulated in the blood) that can damage the working of your liver and kidneys, which are required for the elimination of excess lactic acid from the blood.
Before you start taking Sitaliptin-50 M SR Tablet , tell your doctor if you’ve ever had pancreatitis (inflammation of the pancreas), kidney disease, or a low vitamin B12 level.
Sitaliptin-50 M SR Tablet , when used with insulin, may significantly lower the blood sugar level, leading to a hypoglycemic condition, which can be fatal.
Inform your doctor if you are pregnant, planning for a pregnancy or breastfeeding before starting the treatment.
Prolonged intake of Sitaliptin-50 M SR Tablet may lower your thyroid-stimulating hormone (TSH); hence, an annual checkup of TSH is recommended.
In rare cases, you may also develop a severe skin reaction known as bullous pemphigoid that requires immediate medical attention.
Inform your doctor if you are scheduled to undergo a diagnostic test that involves an injection of dye or an X-ray contrast agent. The use of Sitaliptin-50 M SR Tablet should be stopped for a short time before having an X-ray procedure.
It is always important to check for the expiry of the medicine. Discard the medicine if it reaches the expiry date.

Drug-Drug Interactions

MetforminIobitridol

Critical

MetforminIopanoic acid

Critical

Drug-Drug Interactions

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MetforminIobitridol

Critical

How does the drug interact with Sitaliptin-50 M SR Tablet:
Co-administration of Sitaliptin-50 M SR Tablet and Iobitridol can increase the risk of lactic acidosis (when the body produces too much lactic acid).

How to manage the interaction:
Taking Sitaliptin-50 M SR Tablet with Iobitridol is generally avoided as it can result in an interaction. Please consult your doctor before taking it.

MetforminIopanoic acid

Critical

How does the drug interact with Sitaliptin-50 M SR Tablet:
Co-administration of Iopanoic acid with Sitaliptin-50 M SR Tablet can increase the risk of side effects.

How to manage the interaction:
Taking Sitaliptin-50 M SR Tablet with Iopanoic acid is not recommended, please consult your doctor before taking it.

MetforminIopamidol

Critical

How does the drug interact with Sitaliptin-50 M SR Tablet:
Co-administration of Iopamidol with Sitaliptin-50 M SR Tablet can increase the risk of side effects.

How to manage the interaction:
Taking Sitaliptin-50 M SR Tablet with Iopamidol is not recommended, please consult a doctor before taking it. Do not discontinue the medications without consulting a doctor.

MetforminIohexol

Critical

How does the drug interact with Sitaliptin-50 M SR Tablet:
Co-administration of Iohexol with Sitaliptin-50 M SR Tablet can increase the risk of side effects.

How to manage the interaction:
Taking Sitaliptin-50 M SR Tablet with Iohexol is generally avoided as it can result in an interaction, please consult your doctor before taking it.

MetforminIocarmic acid

Critical

How does the drug interact with Sitaliptin-50 M SR Tablet:
Co-administration of Sitaliptin-50 M SR Tablet and Iocarmic acid can increase the risk of lactic acidosis (when the body produces too much lactic acid).

How to manage the interaction:
Taking Sitaliptin-50 M SR Tablet with Iocarmic acid is generally avoided as it can result in an interaction. please consult your doctor before taking it.

MetforminIotroxic acid

Critical

How does the drug interact with Sitaliptin-50 M SR Tablet:
Co-administration of Iotroxic acid with Sitaliptin-50 M SR Tablet can increase the risk of side effects.

How to manage the interaction:
Taking Sitaliptin-50 M SR Tablet with Iotroxic acid is not recommended, please consult your doctor before taking it.

MetforminMetrizamide

Critical

How does the drug interact with Sitaliptin-50 M SR Tablet:
Co-administration of Sitaliptin-50 M SR Tablet with Metrizamide together can cause the risk of lactic acidosis (when the body produces too much lactic acid ).

How to manage the interaction:
Taking Sitaliptin-50 M SR Tablet with Metrizamide is generally avoided as it can possibly result in an interaction, it can be taken if a doctor has advised it. However, if you experience headaches, muscle cramps or pain, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.

MetforminIoversol

Critical

How does the drug interact with Sitaliptin-50 M SR Tablet:
Co-administration of Ioversol with Sitaliptin-50 M SR Tablet can increase the risk of side effects.

How to manage the interaction:
Taking Sitaliptin-50 M SR Tablet with Ioversol is not recommended, please consult your doctor before taking it.

MetforminIomeprol

Critical

How does the drug interact with Sitaliptin-50 M SR Tablet:
Co-administration of Iomeprol with Sitaliptin-50 M SR Tablet can increase the risk of side effects.

How to manage the interaction:
Taking Sitaliptin-50 M SR Tablet with Iomeprol is not recommended, please consult a doctor before taking it. Do not discontinue the medications without consulting a doctor.

MetforminIodamide

Critical

How does the drug interact with Sitaliptin-50 M SR Tablet:
Co-administration of Sitaliptin-50 M SR Tablet and Iodamide can increase the risk of lactic acidosis (when the body produces too much lactic acid).

How to manage the interaction:
Taking Sitaliptin-50 M SR Tablet with Iodamide is generally avoided as it can result in an interaction, please consult your doctor before taking it.

Drug-Food Interactions

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

Include starchy veggies, proteins, and whole grains in your diet.
Eat at regular intervals. Do not take a long gap between a meal or snack.
Monitor your blood sugar level regularly.
If you feel that your blood sugar level is going down and you are feeling weak, immediately eat sugar candies or drink sugary beverages. It will help to balance the blood sugar level in your body. So, it is advisable to keep sugar candies with you.
Invest in at least 150 min of moderate-intensity physical activity or one hour and 15 minutes of high-intensity exercise every week.
Lose weight gradually to achieve a healthy body mass index (18.5 to 24.9).
Replace refined carbohydrate-containing foods with whole grain foods and increase the intake of fruits, veggies, and other fibre-enriched foods.
Reduce intake of saturated fat (or hidden fats) in food like chips, crisps, pastries, biscuits, and samosas. Choose omega-3 fatty acid-containing oils for daily cooking. For frying, you can use palm oil, mustard oil, groundnut oil, rice bran oil, and safflower oil.
Do not take stress as it may elevate your blood sugar level. You can adopt stress management techniques like mindfulness to control stress-related blood sugar changes.
Opt for low-fat dairy products (low-fat yoghurt, fat-free milk, cheese, etc.).
Keep your blood pressure as normal (140/90) as possible. As it reduces the risk of cardiovascular diseases in diabetes patients.

Habit Forming

No

Therapeutic Class

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Alcohol

Unsafe

Avoid consumption of alcohol while on treatment with Sitaliptin-50 M SR Tablet .

Pregnancy

Consult your doctor

Sitaliptin-50 M SR Tablet is only recommended during pregnancy when the benefit outweighs the risk. Please consult your doctor before starting Sitaliptin-50 M SR Tablet if you are pregnant or planning to conceive.

Breast Feeding

Consult your doctor

Consult your doctor; Sitaliptin-50 M SR Tablet should be used in breastfeeding mothers only if the benefits outweigh the risks.

Driving

Caution

Drive only if you are physically stable and mentally focussed, If you experience drowsiness after taking these medications you should not drive or operate any machinery or vehicles.

Liver

Consult your doctor

If you have or have a history or evidence of any liver-related diseases, please consult the doctor before taking medicine.

Kidney

Consult your doctor

If you have or had a history or evidence of any kidney-related diseases, please consult the doctor before taking medicine.

Children

Consult your doctor

It is advisable to consult a doctor before using it.

Heart

Sitaliptin-50 M SR Tablet should be used with caution if you have any cardiac problems. This medicine is contraindicated in patients with severe heart failure.

Geriatrics

Caution

Caution should be exercised in geriatric patients while taking Sitaliptin-50 M SR Tablet .

FAQs

Country of origin

India

Manufacturer/Marketer address

Leeford Healthcare Limited , Leo House, Shaheed Bhagat Singh Nagar, Dugri-Dhandra Road, Near Joseph School , Ludhiana-141116.

Other Info - SIT0418

Author Details

Written By

Bayyarapu Mahesh Kumar

M Pharmacy

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Nov 18, 2025 | 7:35 AM IST

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