Simponi 50mg Injection

Simponi 50mg Injection belongs to the Anti-monoclonal TNF (Tumor necrosis factor) class of medicines that help reduce signs and symptoms of autoimmune disorders. It is primarily used in the treatment of moderate to severe rheumatoid arthritis, active ankylosing spondylitis, active ulcerative colitis, and active psoriatic arthritis in adult patients. This medicine is used in combination with methotrexate for the treatment of autoimmune disorders.

Simponi 50mg Injection consists of Golimumab, which works by inhibiting the TNF-α and TNF-β binding to the cell surface, thereby making the TNF cytokine inactive. This helps reduce inflammation and pain caused by various autoimmune diseases.

Simponi 50mg Injection may cause certain side effects such as nausea, headache, upper respiratory tract infections, dizziness, constipation, rash, and injection site reactions. Most of these side effects do not require medical attention or resolve over time. However, if these side effects persist for longer, please consult your doctor. A trained healthcare doctor will administer Simponi 50mg Injection. Hence, do not self-administer. Your physician will decide the dose and duration of the medicine based on the type and severity of the condition.

Simponi 50mg Injection should be avoided if you are allergic to any of its components. Inform your doctor if you have any history of serious infections, invasive fungal infections, optimistic infections, cancer, hepatitis B virus infection, heart failure, liver or kidney diseases, or a weak immune system, as it can worsen your health condition. Simponi 50mg Injection may cause dizziness, so drive only if you are alert and focused. Simponi 50mg Injection is not recommended for use in children below 18 years of age as safety has not been established. If you are pregnant or breastfeeding, consult your doctor before taking Simponi 50mg Injection.

Simponi 50mg Injection contains Golimumab, as an active ingredient that belongs to the class of monoclonal TNF inhibitors. It works by inhibiting the TNF-α and TNF-β binding to the cell surface, thereby making the TNF cytokine inactive. This helps reduce inflammation, pain and redness caused by various autoimmune diseases.

• Tingling or numbness
• Injection site reactions
• Headache
• Nausea
• Upper respiratory tract infections.
• Dizziness
• Constipation
• Rash

Simponi 50mg Injection should be avoided if you are allergic to any of its components.  Inform your doctor if you have any history of serious infections, invasive fungal infections, optimistic infections, cancer, hepatitis B virus infection, heart failure, blood disorders, nervous system problems, liver or kidney diseases, or a weak immune system, as it can worsen your health condition. Simponi 50mg Injection may cause dizziness, so drive only if you are alert and focused. Simponi 50mg Injection is not recommended for use in children below 18 years of age as safety has not been established. It is not known whether Simponi 50mg Injection can be given to pregnant and breastfeeding women. Hence, consult your doctor if you are pregnant, planning to become pregnant or are breastfeeding. Do not take live vaccines while being treated with Simponi 50mg Injection to prevent any serious consequences.

Drug-Drug Interaction: Simponi 50mg Injection may interact with other immunosuppressants (certolizumab, infliximab, rituximab), medicines used to treat rheumatoid arthritis (anakinra), live vaccines, and other TNF inhibitors (abatacept).

Drug-Food Interaction: No interactions found.

Drug-Disease Interaction: Simponi 50mg Injection should be used with caution in patients with liver or kidney disease, heart failure, diabetes, weak immune system (HIV), hepatitis B, cancer, and active serious infections.

• ABATACEPT
• ANAKINRA
• INFLIXIMAB
• CERTOLIZUMAB
• CHOLERA VACCINE
• TYPHOID VACCINE

• Exercising regularly helps in muscle stretching that is less likely to spasm, tear and sprain. Mild exercises such as jogging and walking are helpful for muscle stretching.
• Massages can also be helpful.
• Avoid freezing and hot temperatures.
• Avoid wearing tight-fitting clothes; instead, wear loose garments.
• Rest well and get plenty of sleep.
• Stay hydrated; drink plenty of water.

• It is advised to closely monitor the patient for the development of any active infections during and after the treatment.
• It is essential to inform your doctor if you have any active viral, bacterial, and fungal infections before starting Simponi 50mg Injection.

Rheumatoid arthritis: It is an auto-immune disease (the body's immune system attacks its tissue) that causes joint pain and damage. It occurs when the immune system does not work properly. Symptoms of rheumatoid arthritis include pain, swelling, stiffness, deformities and loss of joint function. 

Psoriatic arthritis: It is a type of inflammatory arthritis which occurs in patients with psoriasis. It could also occur in patients without psoriasis, particularly in those with a family history of psoriasis. It affects large joints in the lower extremities, the distal joints of toes and fingers, and the back and pelvis. Symptoms include inflammation of joints, difficulty moving, swelling, patches of red, scaly skin and pain.

Ankylosing spondylitis: It is an autoimmune condition that causes pain and stiffness in the spine. The pain generally starts in the lower back and can spread to the neck, damaged joints, or other body parts. Ankylosing spondylitis symptoms include decreased flexibility, which usually leads to a hunched-forward posture and pain in the back and joints.

Ulcerative colitis: Ulcerative colitis is a serious inflammatory bowel disease causing inflammation in the digestive tract. It produces ulcers on the inner lining of the large intestine, which may cause bleeding and discharge of pus and mucus. The common symptoms include bloody stools, stomach pain, rectal pain, diarrhoea, fever, or weight loss. Additionally, it may cause other problems such as joint pain or swelling, mouth sores, skin problems, decreased appetite, or nausea. Ulcerative Colitis mostly occurs in people between the age of 15 to 30 years.