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Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Last Updated Jan 1, 2025 | 9:32 AM IST

Simponi 50mg Injection is primarily used in treating moderate to severe rheumatoid arthritis, active ankylosing spondylitis, active ulcerative colitis, and active psoriatic arthritis in adult patients. This medicine is used in combination with methotrexate for the treatment of autoimmune disorders. It consists of Golimumab, which works by inhibiting the TNF-α and TNF-β binding to the cell surface, thereby making the TNF cytokine inactive; this helps reduce inflammation and pain caused by various autoimmune diseases.

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Composition :

GOLIMUMAB-50MG

Manufacturer/Marketer :

Johnson & Johnson Pvt Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

About Simponi 50mg Injection

Simponi 50mg Injection belongs to the Anti-monoclonal TNF (Tumor necrosis factor) class of medicines that help reduce signs and symptoms of autoimmune disorders. It is primarily used in the treatment of moderate to severe rheumatoid arthritis, active ankylosing spondylitis, active ulcerative colitis, and active psoriatic arthritis in adult patients. This medicine is used in combination with methotrexate for the treatment of autoimmune disorders.

Simponi 50mg Injection consists of Golimumab, which works by inhibiting the TNF-α and TNF-β binding to the cell surface, thereby making the TNF cytokine inactive. This helps reduce inflammation and pain caused by various autoimmune diseases.

Simponi 50mg Injection may cause certain side effects such as nausea, headache, upper respiratory tract infections, dizziness, constipation, rash, and injection site reactions. Most of these side effects do not require medical attention or resolve over time. However, if these side effects persist for longer, please consult your doctor. A trained healthcare doctor will administer Simponi 50mg Injection. Hence, do not self-administer. Your physician will decide the dose and duration of the medicine based on the type and severity of the condition.

Simponi 50mg Injection should be avoided if you are allergic to any of its components. Inform your doctor if you have any history of serious infections, invasive fungal infections, optimistic infections, cancer, hepatitis B virus infection, heart failure, liver or kidney diseases, or a weak immune system, as it can worsen your health condition. Simponi 50mg Injection may cause dizziness, so drive only if you are alert and focused. Simponi 50mg Injection is not recommended for use in children below 18 years of age as safety has not been established. If you are pregnant or breastfeeding, consult your doctor before taking Simponi 50mg Injection.

Uses of Simponi 50mg Injection

Treatment of Rheumatoid arthritis, Ankylosing spondylitis, Psoriatic arthritis, and Ulcerative colitis

Medicinal Benefits

Simponi 50mg Injection contains Golimumab, as an active ingredient that belongs to the class of monoclonal TNF inhibitors. It works by inhibiting the TNF-α and TNF-β binding to the cell surface, thereby making the TNF cytokine inactive. This helps reduce inflammation, pain and redness caused by various autoimmune diseases.

Side Effects of Simponi 50mg Injection

  • Tingling or numbness
  • Injection site reactions
  • Headache
  • Nausea
  • Upper respiratory tract infections.
  • Dizziness
  • Constipation
  • Rash

Directions for Use

Simponi 50mg Injection will be administered by a healthcare professional. Do not self-administer.

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

Simponi 50mg Injection should be avoided if you are allergic to any of its components.  Inform your doctor if you have any history of serious infections, invasive fungal infections, optimistic infections, cancer, hepatitis B virus infection, heart failure, blood disorders, nervous system problems, liver or kidney diseases, or a weak immune system, as it can worsen your health condition. Simponi 50mg Injection may cause dizziness, so drive only if you are alert and focused. Simponi 50mg Injection is not recommended for use in children below 18 years of age as safety has not been established. It is not known whether Simponi 50mg Injection can be given to pregnant and breastfeeding women. Hence, consult your doctor if you are pregnant, planning to become pregnant or are breastfeeding. Do not take live vaccines while being treated with Simponi 50mg Injection to prevent any serious consequences.

Therapeutic Class

IMMUNOSUPPRESSANTS

Diet & Lifestyle Advise

  • Exercising regularly helps in muscle stretching that is less likely to spasm, tear and sprain. Mild exercises such as jogging and walking are helpful for muscle stretching.
  • Massages can also be helpful.
  • Avoid freezing and hot temperatures.
  • Avoid wearing tight-fitting clothes; instead, wear loose garments.
  • Rest well and get plenty of sleep.
  • Stay hydrated; drink plenty of water.

Habit Forming

No

How Simponi 50mg Injection Works

Simponi 50mg Injection consists of Golimumab, which works by inhibiting the TNF-α and TNF-β binding to the cell surface, thereby making the TNF cytokine inactive. This helps reduce inflammation and pain caused by various autoimmune diseases.

What if I have taken an overdose of Simponi 50mg Injection

Since Simponi 50mg Injection is given in a controlled medical setting by a healthcare professional, an overdose is not likely to occur. If you think there has been an overdose or experiencing any adverse events, get medical care right away. In a medical setting, an overdose would be treated quickly.
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Alcohol

Unsafe

It is not known if alcohol interacts with Simponi 50mg Injection. Please consult the doctor.

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Pregnancy

Consult your doctor

If you are pregnant or planning pregnancy, inform your doctor before receiving Simponi 50mg Injection. Your doctor may prescribe this medicine if the benefits outweigh the risks.

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Breast Feeding

Consult your doctor

It is not known whether Simponi 50mg Injection passes into human milk. Hence, if you are breastfeeding, inform your doctor before receiving Simponi 50mg Injection.

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Driving

Caution

Simponi 50mg Injection will be administered in the hospital setting. Hence, driving is not recommended.

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Liver

Caution

Simponi 50mg Injection may cause liver disease. Inform your doctor if you have a poor appetite, yellow discolouration of the skin or eyes, and abdominal pain. If you have pre-existing or a history of liver problems, let your doctor know, as this medicine may worsen your condition.

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Kidney

Consult your doctor

Limited data on the effects of Simponi 50mg Injection in patients with kidney impairment is available. If you have a pre-existing or a history of kidney disease, inform your doctor before taking Simponi 50mg Injection.

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Children

Unsafe

Simponi 50mg Injection is not recommended for use in children below 18 years of age as safety and efficacy are not established.

Country of origin

Switzerland
Other Info - SI17953

Author Details

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FAQs

Simponi 50mg Injection is used to treat Rheumatoid arthritis, Ankylosing spondylitis, Psoriatic arthritis, and Ulcerative colitis.
Simponi 50mg Injection contains Golimumab, which works by inhibiting the TNF-α and TNF-β binding to the cell surface, thereby making the TNF cytokine inactive.
Simponi 50mg Injection affects your immune system and makes you more susceptible to infections. It is not recommended in people with active infections, invasive fungal infections, optimistic infections, cancer, hepatitis B virus infection, heart failure, or weak immune system. Hence, inform your doctor if you have any history of these conditions beforehand.

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