Simir 15mg Tablet is used to treat major depressive disorder. Additionally, Simir 15mg Tablet is sometimes used to treat obsessive-compulsive disorder (OCD) and anxiety disorders. Depression is a mood disorder characterised by sadness, unhappiness, anger, hopelessness or loss that interferes with a person’s daily activities.

Simir 15mg Tablet contains ‘Mirtazapine’, which increases the activity of mood-enhancing chemical messengers such as serotonin and norepinephrine in the brain, which communicate between brain cells. Thus, it regulates mood and treats depression.

You are advised to take Simir 15mg Tablet for as long as your doctor has prescribed it for you, depending on your medical condition and response to the treatment. In some cases, you may experience certain common side effects such as sleepiness, drowsiness, weight gain, dry mouth, headache, nausea, vomiting, and tiredness. Talk to your doctor if you experience these side effects persistently.

Please do not stop taking Simir 15mg Tablet without consulting your doctor, as it could lead to recurring symptoms. Consult your doctor if you are pregnant or breastfeeding. Simir 15mg Tablet is not recommended for children below 18 years as the safety and effectiveness have not been established. Avoid consuming alcohol along with Simir 15mg Tablet as it could lead to increased drowsiness and dizziness. Keep your doctor informed about your health condition and medicines to rule out any side effects.

Simir 15mg Tablet belongs to a group of medicines called tetracyclic anti-depressants. Simir 15mg Tablet is used to treat major depressive disorder. Additionally, Simir 15mg Tablet is sometimes used to treat obsessive-compulsive disorder (OCD) and anxiety disorders. Simir 15mg Tablet  works by increasing mood-enhancing chemical messengers such as serotonin and norepinephrine in the brain, which communicate between brain cells, thereby regulating mood and treating depression.

• Sleepiness
• Drowsiness
• Weight gain
• Dry mouth
• Headache
• Nausea
• Vomiting
• Tiredness

Do not take Simir 15mg Tablet if you are allergic to any of its contents; if you are taking monoamine oxidase inhibitors (MAOI) such as moclobemide, tranylcypromine, selegiline or have taken them in the last 14 days. Inform your doctor if you have/had epilepsy, low blood pressure, urination problems or enlarged prostate, glaucoma, diabetes, schizophrenia, mania, dementia (memory loss), heart, kidney or liver problems. Consult your doctor immediately if you have suicidal thoughts, such as killing or harming yourself. Consult your doctor if you are pregnant or breastfeeding. Simir 15mg Tablet is not recommended for children below 18 years as safety and effectiveness have not been established. Avoid consuming alcohol along with Simir 15mg Tablet as it could lead to increased drowsiness and dizziness. Rise slowly from sitting or lying position as Simir 15mg Tablet may cause dizziness on standing suddenly.

Drug-Drug Interactions: Simir 15mg Tablet may interact with anti-depressants (moclobemide, tranylcypromine, selegiline, nefazodone, duloxetine, sertraline, escitalopram), antibiotics (erythromycin, linezolid), anti-fungal (ketoconazole), anti-TB (rifampicin), antipsychotic (olanzapine, aripiprazole, quetiapine), anti-convulsant (carbamazepine, phenytoin, pregabalin), pain killer (tramadol, morphine, acetaminophen, hydrocodone), antihistamine (cetirizine), antacid (cimetidine), blood thinner (warfarin), anti-anxiety (alprazolam), and anti-hypertensive (metoprolol).

Drug-Food Interactions: Do not take St. John’s wort (herbal supplement to treat depression) along with Simir 15mg Tablet . Avoid consuming alcohol along with Simir 15mg Tablet as it may increase the sedative effects.

Drug-Disease Interactions: Inform your doctor if you have epilepsy, low blood pressure, urination problems or enlarged prostate, glaucoma, diabetes, schizophrenia, mania, dementia (memory loss), pheochromocytoma (tumour of the adrenal gland), heart, kidney or liver problems.

• TRANYLCYPROMINE
• SELEGILINE
• NEFAZODONE
• DULOXETINE
• SERTRALINE
• ESCITALOPRAM
• ERYTHROMYCIN
• LINEZOLID
• KETOCONAZOLE
• RIFAMPICIN
• OLANZAPINE
• ARIPIPRAZOLE
• QUETIAPINE
• CARBAMAZEPINE
• PHENYTOIN
• PREGABALIN
• TRAMADOL
• MORPHINE
• ACETAMINOPHEN
• HYDROCODONE
• CETIRIZINE
• CIMETIDINE
• WARFARIN
• ALPRAZOLAM
• METOPROLOL
• MOCLOBEMIDE

• Maintain a healthy diet and exercise regularly as it helps in improving overall health and boosts self-esteem.

• Regularly attend therapy sessions.

• Perform meditation and yoga. This helps in relieving stress and provides relaxation.

• Follow a regular sleep pattern to improve the amount and quality of sleep you get.

• Include foods rich in omega-fatty acids such as fish, nuts, fresh fruits, vegetables and olive oils.

• Neurotransmitters are made up of amino acids. Amino acid-rich foods such as meat, dairy products, and certain fruits and vegetables help in the proper maintenance of neurotransmitters. 

• Complex carbohydrates help in stimulating serotonin (a feel-good neurotransmitter). These include whole grains, legumes, spinach, broccoli, oranges and pears.

• Exercising helps in the production of the body’s natural anti-depressants. It also helps in relieving stress, improving mood, boosting self-esteem, and providing restful sleep.

• Avoid smoking and alcohol consumption.

• Learn about your condition, understand the risk factors and follow the doctor’s treatment plan.

• Your doctor may suggest regular cardiac check up as Simir 15mg Tablet  may cause a condition that affects the heart rhythm (QT prolongation).

• Regularly monitor blood sugar levels as Simir 15mg Tablet may cause fluctuation in blood glucose level.

• You should not discontinue Simir 15mg Tablet  abruptly; your doctor will reduce the dose slowly over a few weeks.

Major depressive disorder: Major depressive disorder, also known as clinical depression, is a mental health disorder characterised by a persistent and intense feeling of sadness for an extended duration of time. It mainly impacts mood, behaviour, and other physical functions, such as sleep and appetite. Symptoms include sadness, loss of interest, appetite changes, sleep problems, restlessness, lack of energy, feeling worthless or guilty, thoughts of harming oneself, difficulty concentrating, making decisions, and thinking. The exact cause of depression is unknown. However, factors such as stress, changes in hormone levels, alcohol or drug abuse, abuse during childhood, certain medical conditions and medications might increase the risk of developing depression.