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Written By ,
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
Last Updated Oct 22, 2024 | 7:38 PM IST
Sevneph-400 Tablet is used to control high phosphate levels in the body (hyperphosphataemia) in adult patients on dialysis (a blood clearance technique), patients undergoing hemodialysis (using a blood filtration machine), and patients with chronic kidney disease. It is also used for the treatment of bone disease. It contains Sevelamer, which effectively reduces excess phosphate levels in the blood, prevents the unsafe build-up of phosphate in your body, helps keep your bones strong, and decreases the risk of heart disease and strokes. It may cause common side effects such as vomiting, upper abdominal pain, nausea, diarrhoea, stomach ache, indigestion, and flatulence.
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Prescription drug

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Synonym

SEVELAMER CARBONATE

Composition

SEVELAMER-400MG

Manufacturer/Marketer

Enphamed Biotech Pvt Ltd

Consume Type

ORAL

Return Policy

Not Returnable

Expires on or after

Jan-27

for this medicine

About Sevneph-400 Tablet

Sevneph-400 Tablet is used to control high phosphate levels in the body (hyperphosphataemia) in adult patients on dialysis (a blood clearance technique), patients undergoing hemodialysis (using a blood filtration machine), and patients with chronic kidney disease. It is also used for the treatment of bone disease.

Sevneph-400 Tablet contains sevelamer that works by binding phosphate in the gastrointestinal tract and decreasing absorption. It effectively reduces excess phosphate levels in the blood, prevents the unsafe build-up of phosphate in your body, helps keep your bones strong, and decreases the risk of heart disease and strokes.

Take Sevneph-400 Tablet exactly as directed by your doctor. The most common side effects of Sevneph-400 Tablet are vomiting, upper abdominal pain, nausea, diarrhoea, stomach ache, indigestion, and flatulence. However, if the side effects persist, contact your doctor.

The use of Sevneph-400 Tablet is restricted in persons with a known history of allergic to any of the ingredients present in this medicine, have low levels of phosphate in their blood, and have a bowel obstruction. Sevneph-400 Tablet contains lactose (milk sugar). If you have an intolerance to some sugars, contact your doctor before taking Sevneph-400 Tablet . Tell your doctor if you are facing swallowing problems, motility (movement) in your stomach and bowel, being sick frequently, active inflammation of the bowel,  have undergone major surgery on your stomach or bowel, or have serious inflammatory bowel disease. If you are pregnant or breastfeeding, please consult your doctor before taking Sevneph-400 Tablet .

Uses of Sevneph-400 Tablet

Treatment of Hyperphosphatemia (high phosphorus level in blood).

Medicinal Benefits

Sevneph-400 Tablet belongs to a group of medications called phosphate binder, which works by binding phosphate in the gastrointestinal tract and decreasing its absorption. This lowers the phosphate concentration in the body. It effectively reduces excess phosphate levels in the blood, prevents the unsafe buildup of phosphate in your body, helps keep your bones strong, and decreases the risk of heart disease and strokes. Sevneph-400 Tablet controls hyperphosphataemia (high blood phosphate levels) in adult patients on dialysis (a blood clearance technique), patients undergoing hemodialysis (using a blood filtration machine) or peritoneal dialysis (where the fluid is pumped into the abdomen and an internal body membrane filters the blood), and patients with chronic kidney disease.

Directions for Use

Tablet: Sevneph-400 Tablet should be taken as prescribed by the doctor. Swallow it as a whole with water; do not crush, break or chew it.Dispersible Tablet: Take Sevneph-400 Tablet as prescribed by the doctor. Before taking, disperse the tablet in the prescribed amount of water, mix well and then swallow it. Do not crush, chew or swallow as a whole.Powder/granules: Firstly, shake the container and open the cap. Add the powder of the packet to a cup containing two teaspoonfuls (30 ml) of water. Mix well and make your child drink within 30 minutes. It is advised not to give more than the prescribed dose of medicine.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Sevneph-400 Tablet

  • Headache

  • Diarrhoea

  • Stomach upset

  • Constipation

Drug Warnings

You should avoid taking Sevneph-400 Tablet if you are allergic to Sevneph-400 Tablet . Speak to your doctor if you have swallowing disorders, digestive tract surgery, severe constipation, have undergone major surgery on your stomach or bowel, or have serious inflammatory bowel disease. It should be used with caution if you are pregnant or planning to become pregnant. Sevneph-400 Tablet should not be recommended for breastfeeding mothers as it passes into breast milk. Avoid alcohol consumption while taking Sevneph-400 Tablet as it might cause unpleasant side effects. The safety and effectiveness of children under six years of age have not been established, so a Sevneph-400 Tablet should not be given to them. Sevneph-400 Tablet contains lactose (milk sugar). If you have an intolerance to some sugars, contact your doctor before taking Sevneph-400 Tablet . Regular monitoring of serum phosphate levels, vitamin D, A, E, K, and folic acid is advised while taking Sevneph-400 Tablet .

Drug Interactions

Drug-Drug Interactions: Sevneph-400 Tablet interacts with antibiotics (ciprofloxacin), immunosuppressive agents (mycophenolate), thyroid medications  (levothyroxine), and medication used to treat bladder cancer (erdafitinib).

Drug-Food Interactions: Avoid taking high-phosphate additives and alcohol as this makes it harder for your body to absorb Sevneph-400 Tablet and increases side effects. Using Sevneph-400 Tablet together with multivitamins with minerals may decrease the effects of multivitamins with minerals. So, Multivitamins with minerals should be administered at least 4 hours before Sevneph-400 Tablet .

Drug-Disease Interactions: The use of Sevneph-400 Tablet is restricted in people with hypophosphatemia (low phosphate level in blood), bowel obstruction and perforation, and severe liver disease.

Drug-Drug Interactions Checker List

  • CIPROFLOXACIN
  • MYCOPHENOLATE SODIUM
  • LEVOTHYROXINE SODIUM
  • ERDAFITINIB

Habit Forming

No

Diet & Lifestyle Advise

  • Take fresh fruits, vegetables, rice, milk, un-enriched corn and rice cereals, and soda without phosphate additives in your regular diet.

  • Avoid or limit high phosphorus addictive foods (processed meats, instant puddings, sauces, spreadable cheeses, and beverage products).

  •  Avoid intake of alcoholic beverages with Sevneph-400 Tablet as it can make you dehydrated and may increase the side effects. 

  • Make sure you drink plenty of fluids. This will help you clear out the extra phosphate and will help you overcome some.

  • Sevneph-400 Tablet is preferably taken with meals as it can bind to dietary phosphate and prevent its absorption into the bloodstream. Drink it with a full glass of water.

  • Do not stop taking the Sevneph-400 Tablet dose until your doctor says so.

  • Do not use Sevneph-400 Tablet if you have a history of bowel obstruction.

Special Advise

  • Regular monitoring of serum phosphate levels, vitamin D, A, E, K, and folic acid is recommended while taking Sevneph-400 Tablet .

Disease/Condition Glossary

Hyperphosphatemia: Hyperphosphatemia is defined as an increased phosphate level in the blood. This condition is often a complication of chronic kidney disease. Phosphate is an important electrolyte. It strengthens your bones and teeth and produces energy.  When phosphate levels increase in the blood due to kidney impairment (the kidney does not remove extra phosphate out of the body), this can cause muscle problems and increase the risk of weak bones, heart attacks, and strokes. It is more common in people with chronic kidney disease and people on dialysis. Symptoms may include itchy skin, red eyes, bone pain, and fractures.

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Alcohol

Caution

You are recommended to avoid alcohol consumption while taking Sevneph-400 Tablet to avoid unpleasant side effects.

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Pregnancy

Caution

Sevneph-400 Tablet is Category C pregnancy medicine. Please consult your doctor if you have any concerns; your doctor will prescribe you Sevneph-400 Tablet only if the benefits outweigh the risks.

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Breast Feeding

Caution

The safety of Sevneph-400 Tablet has not been established in breastfeeding women. Please consult your doctor if you have any concerns regarding this; your doctor will decide whether the Sevneph-400 Tablet can be given to breastfeeding mothers or not.

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Driving

Safe if prescribed

Sevneph-400 Tablet has no or negligible influence on the ability to drive or operate any machinery.

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Liver

Caution

Sevneph-400 Tablet should be used with caution in patients with liver impairment/liver disease. Please consult your doctor if you have a liver impairment or any concerns regarding this.

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Kidney

Safe if prescribed

Dose adjustment may be needed. Sevneph-400 Tablet should be used with caution in patients with kidney impairment/kidney disease. Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Caution

For children, SEVELAMER is available in pouches for oral suspension. Please consult your paediatrician for further information. The paediatrician will decide the dose of this medicine.

Country of origin

India
Other Info - SEV0129

FAQs

Sevneph-400 Tablet is used to control high phosphate levels in the body (hyperphosphataemia)Â in adult patients on dialysis (a blood clearance technique), patients undergoing hemodialysis (using a blood filtration machine), and patients with chronic kidney disease. It is also used for the treatment of bone disease.
No, ciprofloxacin may interfere with the working of Sevneph-400 Tablet ; therefore, it should not be taken simultaneously as Sevneph-400 Tablet .
Sevneph-400 Tablet works by holding onto phosphate from the food so that it can pass out of your body. Decreasing blood phosphate levels can help keep your bones strong, prevent unsafe buildup of minerals in your body, and possibly decrease the risk of heart disease and strokes that can result from high phosphate levels.
Yes, constipation is the common side effect of Sevneph-400 Tablet , though it does not occur in everyone. Please consult your doctor if the side effect becomes severe and disturb you.
Yes, serum phosphate levels should be monitored regularly while you are taking Sevneph-400 Tablet . The use of Sevneph-400 Tablet may decrease the levels of vitamin D, A, E, K, and folic acid and hence the levels need to be monitored during the treatment.
No, Sevneph-400 Tablet is a class of medications called phosphate binder used to control the phosphate level in blood. If you stop taking Sevneph-400 Tablet , your phosphate levels may elevate again. Please consult your doctor.
The side effects of Sevneph-400 Tablet include diarrhoea, headache, stomach upset, and constipation. If these side effects persist or worsen, please consult your doctor.
Take Sevneph-400 Tablet for as long as it is prescribed by your doctor. The dose and duration will depend on the response to treatment. Follow your doctor's instructions and do not stop taking Sevneph-400 Tablet on your own.
No, Sevneph-400 Tablet does not contain a steroid. It contains Sevelamer, which belongs to the class of drugs called phosphate binders.
Yes, Sevneph-400 Tablet can be taken with food as it works by binding to phosphate from food. Take it exactly as prescribed by your doctor.
It is important to take Sevneph-400 Tablet as phosphate levels in the blood cannot be controlled in patients undergoing dialysis, especially after a meal. When phosphate level exceeds above the range in the blood, it may cause problems such as red eyes, itchy skin, high blood pressure, bone pain, and also increase the risk of fractures. Sevneph-400 Tablet lowers these increased serum phosphate levels by binding phosphate from food in the digestive tract.
Sevneph-400 Tablet should be avoided by patients who are allergic to it and who have low phosphate levels in blood. Additionally, patients having intestinal obstruction should also avoid taking Sevneph-400 Tablet .
Take Sevneph-400 Tablet for as long as it is advised by your doctor. It lowers your levels of dietary phosphate but does not cure your disease. Therefore, you might need to take it lifelong, as stopping Sevneph-400 Tablet may increase your phosphate levels.
You are recommended to consult your doctor before taking other medicines with Sevneph-400 Tablet to avoid drug interactions.
If you miss a dose of Sevneph-400 Tablet , do not worry. Take it as soon as you remember. But, if it is time for your next dose, skip the missed dose and take your regular dose. Do not take a double dose to make up for the missed dose.

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