Sebri H 100mg/12.5mg Tablet is an 'anti-hypertensives' medication primarily used for lowering high blood pressure (hypertension) by removing extra fluid (electrolytes) from the body. High blood pressure is a chronic condition in which the blood's force against the artery wall is high. As a result, it increases the risk of heart-related diseases like heart attack, heart failure, stroke, irregular heartbeat, and other complications.

Sebri H 100mg/12.5mg Tablet is a combination of two medicines, namely: Irbesartan and Hydrochlorothiazide. Irbesartan is an angiotensin receptor blocker (ARB) that blocks the hormone angiotensin, thereby relaxing and widening the narrowed blood vessels. This allows the blood to flow more smoothly in the blood vessels, and the heart can pump more efficiently. On the other hand, Hydrochlorothiazide is a diuretic or water pill that works by removing extra water/fluid and certain electrolyte overload from the body. Together, Sebri H 100mg/12.5mg Tablet lowers fluid overload, raised blood pressure, improves blood flow, and reduces the future risk of a heart attack and stroke.

Take Sebri H 100mg/12.5mg Tablet as prescribed. Your doctor will advise you on how often you take your tablets based on your medical condition. You may experience nausea, taste change, upset stomach, diarrhoea, dizziness, headache, electrolyte imbalance, and decreased blood pressure in some cases. Most of these side effects of Sebri H 100mg/12.5mg Tablet do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

Do not use potassium supplements or salt substitutes unless the doctor has told you. If you notice unexplained muscle pain, dark colour urine, tenderness, or weakness, especially if you also have a fever or unexplained tiredness, immediately contact the doctor. Try not to stop taking this medicine of your own. Let your doctor know about this, as it may cause a rise in blood pressure and increase heart disease and stroke risk. Inform your doctor if you are suffering from any kidney or liver or heart disease or are diabetic. Do not use Sebri H 100mg/12.5mg Tablet if you cannot urinate, are dehydrated, have low blood pressure (hypotension), and have or have had cardiogenic shock (sudden stopping of blood flow to the heart). Please tell your doctor if you are taking any other medicines or are allergic to this medicine. Reducing table salt (sodium chloride) in your food often helps lower blood pressure. Do not take Sebri H 100mg/12.5mg Tablet if you are more than 3 months pregnant, if you have diabetes or impaired kidney function; if you suffer from potassium deficiency (hypokalaemia)/sodium deficiency (hyponatraemia), gout (Pain and inflammation occur when a high amount of uric acid crystallises and deposits in the joints). Check your serum electrolytes, creatinine and urea, serum lipids (cholesterol and triglycerides), uric acid, and blood sugar levels regularly as advised by your doctor.

Sebri H 100mg/12.5mg Tablet is primarily used to reduce high blood pressure. It is a combination of two medicines, namely: Irbesartan and Hydrochlorothiazide. Irbesartan is an angiotensin receptor blocker (ARB) that blocks the hormone angiotensin, thereby relaxing and widening the narrowed blood vessels. This allows the blood to flow more smoothly in the blood vessels, and the heart can pump more efficiently. On the other hand, Hydrochlorothiazide is a diuretic or water pill that works by removing extra water/fluid and certain electrolyte overload from the body. Together, Sebri H 100mg/12.5mg Tablet lowers fluid overload, raised blood pressure, improves blood flow, and reduces the future risk of a heart attack and stroke.

• Nausea
• Taste change
• Upset stomach
• Diarrhoea
• Dizziness
• Headache
• Electrolyte imbalance
• Decreased blood pressure

Inform your doctor before taking Sebri H 100mg/12.5mg Tablet, if you are already taking medicine that has aliskiren in it if you have diabetes or kidney problems, if you have severe liver disease, if you suffer from gout, potassium deficiency (hypokalaemia)/sodium deficiency (hyponatremia). Stop taking Sebri H 100mg/12.5mg Tablet if you experience pronounced gastrointestinal troubles, blood count changes, disorders of the central nervous system, or allergic reactions.  Inform your doctor before taking Sebri H 100mg/12.5mg Tablet about all your ongoing medications. Your doctor may check your blood pressure, kidney function, and the number of electrolytes in the blood at regular intervals. Sebri H 100mg/12.5mg Tablet should not be given to children and adolescents under 18 years of age. Drink sufficient quantities of liquid while on this medication. If you are pregnant or breastfeeding, do not take Sebri H 100mg/12.5mg Tablet as it is a category D pregnancy drug and can harm the baby.

Drug-Drug Interactions: This medicine may interact with aliskiren (medicine for high blood pressure), lithium (medicine for major depressive disorder), painkillers, Metformin (diabetes medicine), Allopurinol (medicine for jaundice), Cholestyramine (medicine for diarrhoea), Vitamin D supplements, Carbamazepine (medicine for epilepsy), and Methyldopa (medicine for hypertension).

Drug-Food Interactions: Sebri H 100mg/12.5mg Tablet may interact with high potassium-containing food and drinks. So, if you are using any of the OTC items, please tell your doctor. Also, alcohol should not be consumed while taking Sebri H 100mg/12.5mg Tablet.

Drug-Disease Interactions: The efficacy of Sebri H 100mg/12.5mg Tablet is affected, and the disease condition may even worsen if taken in patients with a recent or history of heart attack, low blood pressure, low potassium level, low electrolytes (sodium, potassium, calcium, etc.), severe liver disease, anuria (non-passage of urine), angioedema (an allergic condition with swelling under the skin), kidney disease, asthma, diabetes.

• ALISKIREN
• LITHIUM
• METFORMIN
• ALLOPURINOL
• CHOLESTYRAMINE
• VITAMIN D
• CARBAMAZEPINE
• METHYLDOPA

• Keep your weight under control with a BMI of 19.5-24.9.
• Do regular physical activity or exercise for at least 150 minutes per week, or about 30 minutes most days of the week. Doing this can help you to lower your raised blood pressure by about 5 mm of Hg.
• Limit intake of sodium chloride (table salt) in your daily diet to 2300 mg per day or less than 1500 mg is ideal for most adults.
• If you are taking alcohol, then only one serving for women and two servings for men is advisable.
• Quitting smoking is the best strategy to lower the risk of heart disease.
• Avoid chronic stress as it can raise your blood pressure. Try to enjoy and spent time with your loved ones to cope with stress and practice mindfulness techniques.
• Monitor your blood pressure daily and if there is too much fluctuation, then immediately contact your doctor.
• Try to include heart-healthy omega-3 fatty acids containing food and drinks in your daily diet. You can also use low-fat cooking oil like olive oil, soybean oil, canola oil, and coconut oil to lower your elevated blood pressure.

Do not use potassium supplements or salt substitutes while using Sebri H 100mg/12.5mg Tablet unless your doctor has told you to do so.

Hypertension: It is a chronic condition when blood pressure is too high. This condition can lead to hardened arteries (blood vessels), decreasing the blood and oxygen flow to the heart. Blood pressure is the measurement of the force that our heart uses to pump blood to all parts of the body. Raised blood pressure can cause chest pain (angina) and heart attack (when the blood supply to the heart is blocked). Additionally, high blood pressure also causes brain damage (stroke) and kidney failure. High blood pressure can be diagnosed with the help of a blood pressure monitor or sphygmomanometer. Systolic pressure is the pressure when the heart pumps blood out. On the other hand, diastolic pressure is when your heart is at the resting stage between heartbeats. If your blood pressure is 140/90 mm of Hg, it means the systolic pressure is 140 mm of Hg, and diastolic pressure is 90 mm of Hg. Ideal blood pressure should be between 90/60 mm of Hg and 120/80 mm of Hg.