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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Last Updated Jan 1, 2025 | 2:46 PM IST
Rubuphine 10 mg Injection 1 ml contains nalbuphine which is an opiod analgesic. It is mainly used to relieve severe pain caused due to various reasons This medicine works by reducing the production of prostaglandins, thus, reducing pain. You may experience certain common side effects such as drowsiness, dry mouth, nausea, vomiting, and constipation.
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Composition :

NALBUPHINE-10MG

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

Apr-26

About Rubuphine 10 mg Injection 1 ml

Rubuphine 10 mg Injection 1 ml belongs to the group of opioid analgesics used to relieve severe pain. It may also be used as an adjunct to balanced anaesthesia for pre/post-operative analgesia, during labour and delivery. Pain is defined as an unpleasant sensation produced in the body in response to external changes, stress, or trauma.

Rubuphine 10 mg Injection 1 ml contains 'Nalbuphine' that works by reducing the production of inflammatory substances (prostaglandins) and thus, relieves the body of swelling and subsequent pain. Rubuphine 10 mg Injection 1 ml also blocks pain-producing nerve transmitters, leading to a reduced sensation of pain and offering massive pain relief.

Rubuphine 10 mg Injection 1 ml will be administered by a qualified health care professional. Do not self-inject. Rubuphine 10 mg Injection 1 ml may cause certain common side effects such as drowsiness, dry mouth, nausea, vomiting, and constipation. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if these side effects persist.

It is advisable to inform the doctor if you are allergic to any of the components of Rubuphine 10 mg Injection 1 ml. Consult your doctor if you are pregnant, planning to get pregnant, or breastfeeding as Rubuphine 10 mg Injection 1 ml should be used with caution in these states. Rubuphine 10 mg Injection 1 ml may cause drowsiness, so avoid driving or operating machinery.

Uses of Rubuphine 10 mg Injection 1 ml

Treatment of Pain

Medicinal Benefits

Rubuphine 10 mg Injection 1 ml is an analgesic that is used as a painkiller for short-term management of severe pain. Rubuphine 10 mg Injection 1 ml blocks pain signals, so the brain doesn't perceive the severity of pain, hence increasing the body's threshold for pain. Rubuphine 10 mg Injection 1 ml may also be used as an adjunct to balanced anaesthesia for pre/post-operative analgesia, during labour and delivery.

Side Effects of Rubuphine 10 mg Injection 1 ml

  • Drowsiness
  • Nausea
  • Constipation
  • Vomiting
  • Dry mouth

Directions for Use

A qualified healthcare professional will administer Rubuphine 10 mg Injection 1 ml. Do not self-administer.

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

Do not take Rubuphine 10 mg Injection 1 ml if you are allergic to any of the contents; if you have acute or severe asthma, respiratory depression, gastrointestinal obstruction, or paralytic ileus. Rubuphine 10 mg Injection 1 ml should not be taken with other opioid analgesics, CNS depressant drugs, or benzodiazepines as it might lead to life-threatening respiratory depression. Inform your doctor if you have asthma, COPD, adrenal insufficiency, severe hypotension, increased intracranial pressure, brain problems, head injury, gastrointestinal problems, seizures, kidney or liver problems. Avoid driving or operating machinery as Rubuphine 10 mg Injection 1 ml may impair your mental and physical ability. You are advised not to take alcohol with Rubuphine 10 mg Injection 1 ml as it might cause increased sedation and respiratory depression. Keep your doctor informed if you or anyone in your family have a history of substance abuse as Rubuphine 10 mg Injection 1 ml may cause addiction, abuse, and misuse.

Therapeutic Class

ANALGESICS

Drug-Drug Interactions

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NalbuphineDiazepam
Severe
NalbuphinePentazocine
Severe

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Diet & Lifestyle Advise

  • Stay hydrated by drinking plenty of water.
  • Invest in a balanced diet. Load up on lean meats, fruits, green leafy vegetables, nuts, oily fish etc. Limit your intake of sweets and sugars as these can worsen inflammation. 
  • Cut back on alcohol as this can have an adverse effect on pain states as well as the quality of your sleep.
  • Try meditation and deep breathing to reduce overall stress and pain. 
  • Stop smoking as smoking is known to worsen pain conditions. 
  • Engage in mild physical exercise daily and keep your body active.

Habit Forming

Yes

How Rubuphine 10 mg Injection 1 ml Works

Rubuphine 10 mg Injection 1 ml contains 'Nalbuphine' that works by reducing the production of inflammatory substances (prostaglandins) and thus, relieves the body of swelling and subsequent pain. Rubuphine 10 mg Injection 1 ml also blocks pain-producing nerve transmitters, leading to a reduced sensation of pain and offering massive pain relief.

What if I have taken an overdose of Rubuphine 10 mg Injection 1 ml

Since Rubuphine 10 mg Injection 1 ml is administered by a healthcare professional, an overdose is unlikely to occur. However, seek medical attention if you experience symptoms of overdose such as severe drowsiness, slow heart rate and breathing, muscle weakness, pinpoint pupils, cold/clammy skin, and fainting.
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Alcohol

Unsafe

You are advised not to take alcohol with Rubuphine 10 mg Injection 1 ml as it might cause increased sedation and respiratory depression.

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Pregnancy

Caution

Rubuphine 10 mg Injection 1 ml is not recommended for use during pregnancy unless absolutely indicated. Please consult your doctor if you have any concerns.

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Breast Feeding

Caution

Rubuphine 10 mg Injection 1 ml should be used with caution during breastfeeding. Please consult your doctor if you have any concerns.

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Driving

Unsafe

Rubuphine 10 mg Injection 1 ml may cause dizziness and drowsiness, which may affect your ability to drive.

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Liver

Caution

Exercise caution before using Rubuphine 10 mg Injection 1 ml in case of established liver disease. Please consult your doctor to address any concerns.

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Kidney

Caution

Exercise caution before using Rubuphine 10 mg Injection 1 ml in case of kidney problems. Please consult your doctor to address any concerns.

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Children

Unsafe

Rubuphine 10 mg Injection 1 ml is not recommended for use in children below 12 years of age. Please consult your physician if you have any concerns.

Country of origin

India

Manufacturer/Marketer address

58-D, Government Industrial Estate, Charkop, Kandivli (W), Mumbai 400 067 (India).
Other Info - RUB0163

Author Details

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FAQs

Rubuphine 10 mg Injection 1 ml belongs to the group of opioid analgesics used to relieve severe pain. It may also be used as an adjunct to balanced anaesthesia for pre/post-operative analgesia, during labour and delivery.
Rubuphine 10 mg Injection 1 ml works by blocking the impulses of pain and increasing the threshold of pain in the body.
Rubuphine 10 mg Injection 1 ml is not recommended in those suffering from asthma as there may be a reaction. Consult your doctor before use.
Rubuphine 10 mg Injection 1 ml is not indicated to treat headaches due to migraines. It is best to get your headache checked by a professional. Please consult your doctor in case of any concerns.
No, Rubuphine 10 mg Injection 1 ml should not be taken with other opioid analgesics, CNS depressant drugs, or benzodiazepines as it might lead to life-threatening respiratory depression.
While on therapy with Rubuphine 10 mg Injection 1 ml, avoid it if you are allergic to any of its active substances. Be cautious if you experience drowsiness and dizziness, or if you have breathing problems, and avoid driving or operating heavy machinery. Be aware of the potential for dependence or withdrawal symptoms with prolonged use of Rubuphine 10 mg Injection 1 ml. Inform your doctor if you have a history of liver, kidney or heart diseases, gastrointestinal high blood pressure, and breathing problems (asthma, chronic obstructive pulmonary disease-COPD) before starting Rubuphine 10 mg Injection 1 ml.
Rubuphine 10 mg Injection 1 ml cause side effects such as drowsiness, nausea, constipation, vomiting and dry mouth. Most of these side effects are temporary and do not require any medical attention, as they will gradually reduce over time. Please, contact a doctor if these persist for longer durations.

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