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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Rolimus 5 Tablet is used to treat cancer and to prevent organ rejection. It contains Everolimus which works by stopping cancer cells from reproducing and decreasing the activity of the immune system. In some cases, this medicine may cause side effects such as weakness, infection, cough, diarrhoea, fever, and fatigue. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.
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Composition :

EVEROLIMUS-5MG

Manufacturer/Marketer :

Cipla Ltd

Consume Type :

ORAL

Return Policy :

3 Days Returnable

Expires on or after :

Jan-27

About Rolimus 5 Tablet

Rolimus 5 Tablet belongs to the group of medicine called ‘anti-cancer’. It is primarily used to treat breast cancer, pancreatic cancer, lung cancer and kidney cancer. Breast cancer is a type of cancer that develops in breast cells stimulated by the female sex hormone known as estrogen. Pancreatic cancer is described as a cancerous growth in the pancreas which normally begins in the cells that generate the juices that help break down food and the hormones which help in controlling blood sugar levels. Lung cancer is the uncontrolled growth of abnormal cells in one or both lungs. 

Rolimus 5 Tablet contains 'Everolimus' which belongs to the group of medicines known as 'kinase inhibitors'. It works by decreases the activity of the immune system of the body and prevents rejection of the transplanted organ. It works by stopping the action of an abnormal protein that causes the multiplication of cancerous cells. In this way, it stops the spread of cancerous cells.

Take Rolimus 5 Tablet as prescribed by your doctor. You are advised to take Rolimus 5 Tablet for as long as your doctor has prescribed it for you depending on your medical conditions. You may experience weakness, infection, sinus inflammation, cough, diarrhea, fever, fatigue, otitis media (infection of the ear), stomatitis (Inflammation of the mouth) and upper respiratory tract infection. Most of these side effects of Rolimus 5 Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

To treat your condition effectually, continue taking Rolimus 5 Tablet for as long as your doctor has prescribed. If you are known to be allergic to Rolimus 5 Tablet or any other medicines, please tell your doctor. Do not take Rolimus 5 Tablet if you are pregnant or planning for pregnancy as Rolimus 5 Tablet may harm the unborn baby. Rolimus 5 Tablet should not be taken by breastfeeding mothers as it may cause harm to the newborn baby. Rolimus 5 Tablet causes tiredness, thus, it is advisable not to drive unless you are alert. Elderly people are more sensitive to medicine so they may adjust the dosage according to their condition.

Uses of Rolimus 5 Tablet

Treatment of Breast cancer, pancreatic cancer, lung cancer and kidney cancer.

Directions for Use

Take Rolimus 5 Tablet with or without food as advised by the doctor. Swallow it as a whole with water; do not crush, break or chew it.

Medicinal Benefits

Rolimus 5 Tablet is indicated to the patients dealing with breast cancer, pancreatic cancer, lung cancer, kidney cancer and stomach/ intestinal cancer. Cancer of this type tends to spread quickly in other parts of the body. Rolimus 5 Tablet travels through the bloodstream and effectively destroys cancerous cells and other parts of the body. It works by decreases the activity of the immune system of the body and prevents rejection of the transplanted organ. It works by stopping the action of an abnormal protein that causes the multiplication of cancerous cells. In this way, it stops the spread of cancerous cells. Besides this, it is also effective in people with genetic disorders to treat some types of tumors in the brain or kidney.

How Rolimus 5 Tablet Works

Rolimus 5 Tablet contains 'Everolimus' which belongs to the group of medicines known as 'kinase inhibitors'. It works by decreases the activity of the immune system of the body and prevents rejection of the transplanted organ. It works by stopping the action of an abnormal protein that causes the multiplication of cancerous cells. In this way, it stops the spread of cancerous cells.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Rolimus 5 Tablet

  • Tiredness
  • Breathlessness
  • Dizziness
  • Headache
  • Loss of appetite
  • Infection
  • Mouth ulcers 
  • Sinus inflammation
  • Cough
  • Diarrhea
  • Fever
  • High level of sugar in the blood (hyperglycemia)
  • Signs of low level of red blood cells (anemia) 
  • Otitis media (infection of the ear)
  • Stomatitis (Inflammation of the mouth)
  • Upper respiratory tract infection.
  • Swelling of arms, hands, feet, and ankles

What if I have taken an overdose of Rolimus 5 Tablet

Avoid exceeding the recommended dose as it might cause an overdose. Seek immediate medical attention if you experience any unusual symptoms.

Drug Warnings

If you are known to be allergic to Rolimus 5 Tablet or any other medicines, please tell your doctor. Rolimus 5 Tablet should not be taken in the conditions like liver disease, diabetes and high level of cholesterol. Do not take Rolimus 5 Tablet if you have recent surgery, infection and hepatitis B. Rolimus 5 Tablet may weaken your immune system, inform your doctor before taking Rolimus 5 Tablet. Rolimus 5 Tablet may also impair your kidney function. Therefore, monitor your kidney function regularly while taking Rolimus 5 Tablet. Rolimus 5 Tablet may cause cough, fever and shortness of breathing, thereby inform your doctor while taking your Rolimus 5 Tablet. Rolimus 5 Tablet may cause skin cancer, if you observe night sweating, weight loss, or change in color and size of the mole inform your doctor. Do not take Rolimus 5 Tablet if you are pregnant or planning for pregnancy as Rolimus 5 Tablet may harm the unborn baby. Rolimus 5 Tablet should not be taken by breastfeeding mothers as it may cause harm to the newborn baby. Rolimus 5 Tablet causes tiredness, thus, it is advisable not to drive unless you are alert. Elderly people are more sensitive to medicine so they may adjust the dosage according to their condition.

Drug-Drug Interactions

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EverolimusErythromycin
Severe
EverolimusBoceprevir
Severe

Drug-Drug Interactions

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EverolimusErythromycin
Severe
How does the drug interact with Rolimus 5 Tablet:
Erythromycin may considerably raise Rolimus 5 Tablet levels in the blood. This can increase the risk or severity of side effects (pneumonitis - lung inflammation, infection, mouth ulcers, anemia, or bleeding).

How to manage the interaction:
Although taking erythromycin and Rolimus 5 Tablet together can result in an interaction, they can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms contact a doctor immediately. Do not stop using any medications without talking to a doctor.
EverolimusBoceprevir
Severe
How does the drug interact with Rolimus 5 Tablet:
Taking Rolimus 5 Tablet with Boceprevir can considerably raise blood levels of Rolimus 5 Tablet, increasing your risk of serious side effects (pneumonitis - lung inflammation, infection, mouth ulcers, anemia, or bleeding).

How to manage the interaction:
Although there is a possible interaction between Rolimus 5 Tablet and Boceprevir, you can take these medicines together if prescribed by a doctor. Do not discontinue any medications without a doctor's advice.
EverolimusMifepristone
Severe
How does the drug interact with Rolimus 5 Tablet:
Co-administration of Rolimus 5 Tablet with mifepristone may significantly increase the risk of side effects.

How to manage the interaction:
Taking Rolimus 5 Tablet with mifepristone together can result in an interaction, it can be taken if a doctor has advised it. Contact a doctor if you experience any unusual symptoms. Do not discontinue any medications without consulting a doctor.
EverolimusAtazanavir
Severe
How does the drug interact with Rolimus 5 Tablet:
Taking Rolimus 5 Tablet with atazanavir can considerably raise blood levels of Rolimus 5 Tablet, increasing the risk of serious side effects such as pneumonitis (lung inflammation), infection, mouth ulcers, anemia, or bleeding.

How to manage the interaction:
Co-administration of Rolimus 5 Tablet with Atazanavir can result in an interaction, but it can be taken if the doctor has advised it. Do not stop using any medications without a doctor's advice.
EverolimusPolymyxin b
Severe
How does the drug interact with Rolimus 5 Tablet:
Taking Rolimus 5 Tablet and Polymyxin b together may increase the risk of kidney problems.

How to manage the interaction:
There may be a possibility of interaction between Rolimus 5 Tablet and Polymyxin b, but it can be taken if prescribed by a doctor. However, if you experience nausea, vomiting, a decrease in hunger, increased or decreased urine, weight gain or loss that occurs suddenly, swelling, difficulty breathing, bone pain, muscle pain, fatigue, weakness, dizziness, confusion, and irregular heartbeat, consult a doctor. Do not discontinue any medications without a doctor's advice.
EverolimusVoriconazole
Severe
How does the drug interact with Rolimus 5 Tablet:
Taking Rolimus 5 Tablet with Voriconazole may significantly increase the blood levels of Rolimus 5 Tablet which increases risk of side effects.

How to manage the interaction:
Although taking Rolimus 5 Tablet and Voriconazole together can result in an interaction, they can be taken together if prescribed by a doctor. However, if you experience pneumonitis (inflammation of the lungs), infection consult a doctor immediately. Do not discontinue using any medications without consulting a doctor.
EverolimusDarunavir
Severe
How does the drug interact with Rolimus 5 Tablet:
Taking Rolimus 5 Tablet with Darunavir can considerably raise blood levels of Rolimus 5 Tablet, increasing the risk of serious side effects (pneumonitis - lung inflammation, infection, mouth ulcers, anemia, or bleeding).

How to manage the interaction:
Although there is a possible interaction between Darunavir and Rolimus 5 Tablet, you can take these medicines together if prescribed by a doctor. Do not discontinue any medications without a doctor's advice.
EverolimusIohexol
Severe
How does the drug interact with Rolimus 5 Tablet:
Injections of iohexol and related contrast agents can occasionally cause kidney damage, and mixing them with other medication that might adversely harm the kidney, such as Rolimus 5 Tablet, may enhance the risk.

How to manage the interaction:
Taking Rolimus 5 Tablet with Iohexol together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, If you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, or an irregular heart rhythm, consult your doctor immediately. Drink lots of fluid after the procedure to stay hydrated and to flush the contrast agent out of your kidneys. Do not stop using any medications without first talking to your doctor.
EverolimusTenofovir alafenamide
Severe
How does the drug interact with Rolimus 5 Tablet:
Tenofovir alafenamide can cause kidney issues, and taking it with Rolimus 5 Tablet, can enhance the risk.

How to manage the interaction:
Although there is a possible interaction between Rolimus 5 Tablet and Tenofovir alafenamide, you can take these medicines together if prescribed by a doctor. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, or an irregular heart rhythm, consult a doctor. Do not stop using any medications without talking to a doctor.
EverolimusPentamidine isethionate
Severe
How does the drug interact with Rolimus 5 Tablet:
Rolimus 5 Tablet can cause kidney issues and taking it with pentamidine isethionate, can enhance the risk.

How to manage the interaction:
There may be a possibility of interaction between Rolimus 5 Tablet and Pentamidine isethionate, but it can be taken if prescribed by a doctor. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, or an irregular heart rhythm, consult a doctor. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

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EVEROLIMUS-5MGGrapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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EVEROLIMUS-5MGGrapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Grapefruit Juice

How to manage the interaction:
Taking Rolimus 5 Tablet with grapefruit juice can raise blood levels and enhance the effects of Rolimus 5 Tablet. Since the co-administration of Rolimus 5 Tablet along with grapefruit juice can lead to an interaction, You should not consume grapefruit juice or eat grapefruits while taking Rolimus 5 Tablet.

Diet & Lifestyle Advise

  • Avoid smoking and alcohol consumption.
  • Include leafy vegetables, citrus fruits, fatty fish, berries, yogurt, apples, peaches, cauliflower, cabbage, broccoli, beans, herbs and spices in your diet.
  • Avoid fast food, fried food, processed meats, refined carbs and added sugar.
  • Get optimal sleep, rest well.
  • Performing yoga and other relaxation techniques may also improve physical and mental health and may reduce your stress levels.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.

Habit Forming

No

Therapeutic Class

ANTINEOPLASTIC

Rolimus 5 Tablet Substitute

Substitutes safety advice
  • Evermil 5 Tablet 10's

    by AYUR

    463.30per tablet
  • Afinitor 5 mg Tablet 10's

    930.72per tablet
  • EVERTOR 5MG TABLET

    1621.77per tablet
  • Volantis 5Mg Tablet 10'S

    by AYUR

    1025.00per tablet
  • Torinat 5 Tablet 7's

    2870.00per tablet
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Alcohol

Caution

You are recommended to avoid alcohol consumption while taking Rolimus 5 Tablet to avoid unpleasant side-effects.

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Pregnancy

Unsafe

Rolimus 5 Tablet is belonging to pregnancy C category. It is not safe in pregnancy as it may causes harm to the unborn baby. Do not conceive a baby while taking Rolimus 5 Tablet.

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Breast Feeding

Unsafe

Rolimus 5 Tablet should not be taken by breastfeeding mothers as it may harm to the new-born baby.

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Driving

Caution

Rolimus 5 Tablet may cause tiredness (fatigue), do not drive or operate heavy machinery if you feel dizzy.

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Liver

Caution

Rolimus 5 Tablet should be taken with caution in patients dealing with liver disease. The doctor may adjust the dose according to the medical condition of the patient.

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Kidney

Caution

Rolimus 5 Tablet is likely unsafe in patients with severe kidney disease as it may cause kidney failure which can be dangerous, use Rolimus 5 Tablet only when prescribed by a doctor.

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Children

Unsafe

Rolimus 5 Tablet is not recommended for children below 18 years as the safety and effectiveness were not established.

FAQs

Rolimus 5 Tablet is used to treat breast cancer, pancreatic cancer, lung cancer and kidney cancer.
Rolimus 5 Tablet is an anticancer medicine. It belongs to a group of medicines known as a kinase inhibitor. It works by lowering the blood supply to the tumor, which reduces the growth and spread of cancer cells.
There is no specific duration of treatment with Rolimus 5 Tablet. Rolimus 5 Tablet is continued till benefit is seen or undesirable toxicity or side effects occur.
You should prevent grapefruit or grapefruit juice while taking Rolimus 5 Tablet. This is because taking them together may rise the levels of Rolimus 5 Tablet in your blood to toxic levels. Avoid the use of live vaccinations and any probable contact with people who have received live vaccinations.
Rolimus 5 Tablet can lead to serious side effects that consist of severe allergic reactions, angioedema (painless swelling under the skin) and kidney failure which can be dangerous and can lead to death. It is possible that you may develop an infection or problems associated to lungs like breathing problems.
It usually takes three to six months for most types of lung cancer to double their size. It will take a long time for lung cancer to reach a size that could be diagnosed in X-Ray.
Rolimus 5 Tablet contains Everolimus, which belongs to the group of medicines known as kinase inhibitors.
Regular monitoring is essential when using Rolimus 5 Tablet. Your doctor may check your blood tests, blood sugar, blood pressure, and kidney function. They may also adjust your dose based on your response to treatment or any side effects that occur. It's essential to report any changes or concerns to your doctor to ensure safe and effective treatment.
While taking Rolimus 5 Tablet, avoiding certain things is essential to ensure your safety. Avoid consuming grapefruit juice and products and St. John's Wort, as they can interact with the medication. Certain antibiotics, antifungals, and medications can also interact with Everolimus, so consult your doctor before taking any new medications. Additionally, consult your doctor before receiving any vaccinations and avoid high-risk activities that may increase the risk of infections and bleeding. It's also important to avoid getting pregnant or fathering a child while taking Everolimus, as well as breastfeeding. Finally, limit your sun exposure to avoid increasing the risk of skin cancer. Always consult your doctor or pharmacist for a comprehensive list of medications and activities to avoid while taking Everolimus.
Before using any medication, including Rolimus 5 Tablet, you should know its purpose, usage, safety profile, precautions, and limitations.
Rolimus 5 Tablet is administered orally in the form of a tablet. Take Everolimus with or without food, as advised by your doctor. Swallow the tablet whole with water; do not crush, break, or chew it. Note: It's important to follow your doctor's instructions and take Rolimus 5 Tablet exactly as prescribed
By regularly monitoring your progress through brain scans and other evaluations, your doctor can determine if Rolimus 5 Tablet is effectively shrinking your brain tumor.
Rolimus 5 Tablet is indeed considered a cytotoxic medication, but it's a targeted therapy that specifically targets cancer cells and inhibits their growth. It's not a traditional chemotherapy medication, but it can still have side effects and be harmful to healthy cells to some extent. If you have any concerns or questions, please consult your doctor or healthcare team to discuss potential risks and benefits and manage any side effects.
Common side effects of Rolimus 5 Tablet may include weakness, infection, sinus inflammation, cough, diarrhoea, fever, fatigue, otitis media (infection of the ear), stomatitis (Inflammation of the mouth) and upper respiratory tract infection. Most of these side effects of Rolimus 5 Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

Country of origin

India

Manufacturer/Marketer address

Cipla House, Peninsula Business Park, Ganpatrao Kadam Marg, Lower Parel, Mumbai-400013
Other Info - ROL0112

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