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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Riphen Forte 10mg/2mg Tablet is used to treat schizophrenia. It contains Trifluoperazine and Trihexyphenidyl which work by inhibiting a chemical messenger (dopamine) in the brain that regulates mood. In some cases, this medicine may cause side effects such as nausea, constipation, dryness in the mouth, sedation, weight gain, and dizziness. Before taking this medicine, inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.
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Manufacturer/Marketer :

Ryon Pharma

Consume Type :

ORAL

Return Policy :

Not Returnable

About Riphen Forte 10mg/2mg Tablet

Riphen Forte 10mg/2mg Tablet belongs to a class of drugs called 'antipsychotics' used to prevent and treat schizophrenia (a mental illness). Additionally, Riphen Forte 10mg/2mg Tablet may be used to anxiety and depression over a short period. Schizophrenia is a mental disorder that affects a person's ability to feel, think and behave clearly. Anxiety is a mental health disorder associated with fear, worry, and excessive nervousness that may interfere with daily activities. Depression is a mood disorder associated with symptoms such as sadness, unable to sleep properly or enjoy life as you used to do.

Riphen Forte 10mg/2mg Tablet combination composed of two different medicines, namely, Trifluoperazine and Trihexyphenidyl. Trifluoperazine inhibits the dopamine (chemical messenger) receptors in the brain. Dopamine is involved in regulating mood, behaviour, and emotions. Thereby, Riphen Forte 10mg/2mg Tablet helps in controlling psychotic illness, relieving depression, lightening the mood, and relieving anxiety symptoms such as fear and panic. On the other hand, Trihexyphenidyl is an anticholinergic agent that acts on the nervous system and corrects some of the chemical imbalances that cause some side effects such as shaking of hands and muscle spasms due to Trifluoperazine.

Take Riphen Forte 10mg/2mg Tablet as prescribed by your doctor. You are advised to take Riphen Forte 10mg/2mg Tablet for as long as your doctor has prescribed it for you based on your medical condition. Some people may experience nausea, constipation, dryness in the mouth, sedation, weight gain, orthostatic hypotension (sudden lowering of blood pressure on standing), urinary retention, increased prolactin level in the blood, dizziness, blurred vision, and nervousness. Most of these side effects of Riphen Forte 10mg/2mg Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are allergic to Riphen Forte 10mg/2mg Tablet or any other medicines, please tell your doctor. Avoid taking Riphen Forte 10mg/2mg Tablet if you are pregnant, especially in the third trimester, as it may cause adverse effects in the baby such as breathing problems, muscle stiffness or weakness, shaking, etc. Please consult a doctor if you are pregnant or breastfeeding. Riphen Forte 10mg/2mg Tablet should be used with caution in elderly patients above 65 years, as there is an increased risk of adverse reactions. Avoid consuming alcohol along with Riphen Forte 10mg/2mg Tablet as it could lead to increased drowsiness and dizziness. Consult your doctor before giving this medicine to your child. Keep your doctor informed about your medicines and health condition and rule out any side effects. 

Uses of Riphen Forte 10mg/2mg Tablet

Treatment of Schizophrenia, Anxiety, Depression.

Directions for Use

Swallow Riphen Forte 10mg/2mg Tablet as a whole with water; do not crush, break or chew it.

Medicinal Benefits

Riphen Forte 10mg/2mg Tablet combination composed of two different medicines, namely; Trifluoperazine and Trihexyphenidyl used to prevent and treat relapses of schizophrenia (a mental illness). Additionally, Riphen Forte 10mg/2mg Tablet may be used to anxiety and depression over a short period. Trifluoperazine inhibits the dopamine (chemical messenger) receptors in the brain. Dopamine is involved in regulating mood, behavior, and emotions. Thereby, Riphen Forte 10mg/2mg Tablet helps in controlling psychotic illness, relieving depression, lighten the mood, and relieve anxiety symptoms such as fear and panic. However, it may cause side effects such as involuntary movements (shaking of hands, muscle spasms, etc.). On the other hand, Trihexyphenidyl is used to treat and prevent side effects such as involuntary movements (shaking of hands, muscle spasms) caused by Trifluoperazine. Trihexyphenidyl exerts a direct inhibitory effect upon the parasympathetic nervous system. It works by relaxing the muscles and nerve impulses that control muscle functioning. Riphen Forte 10mg/2mg Tablet improves muscle control and reduces stiffness, thereby helps the muscles move naturally. 

How Riphen Forte 10mg/2mg Tablet Works

Riphen Forte 10mg/2mg Tablet combination composed of two different medicines, namely, Trifluoperazine and Trihexyphenidyl. Trifluoperazine inhibits the dopamine (chemical messenger) receptors in the brain. Dopamine is involved in regulating mood, behaviour, and emotions. Thereby, Riphen Forte 10mg/2mg Tablet helps in controlling psychotic illness, relieving depression, lightening the mood, and relieving anxiety symptoms such as fear and panic.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Riphen Forte 10mg/2mg Tablet

  • Nausea
  • Constipation
  • Dry mouth
  • Sedation
  • Weight gain
  • Orthostatic hypotension (sudden lowering of blood pressure on standing)
  • Urinary retention
  • Increased prolactin level in the blood
  • Dizziness
  • Abdominal Pain
  • Excessive sweating
  • Decreased blood pressure
  • Urine retention
  • Blurred vision
  • Nervousness

What if I have taken an overdose of Riphen Forte 10mg/2mg Tablet

Take Riphen Forte 10mg/2mg Tablet only as prescribed by the physician. Do not exceed the recommended dose, as it might cause an overdose. If you suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

If you are allergic to Riphen Forte 10mg/2mg Tablet or any other medicines, please tell your doctor. Avoid taking Riphen Forte 10mg/2mg Tablet if you are pregnant, especially in the third trimester, as it may cause adverse effects in the baby such as breathing problems, muscle stiffness or weakness, shaking, etc. Please consult a doctor if you are pregnant or breastfeeding. Riphen Forte 10mg/2mg Tablet should be used with caution in elderly patients above 65 years, as there is an increased risk of adverse reactions. Do not discontinue Riphen Forte 10mg/2mg Tablet on your own. Inform your doctor before taking Riphen Forte 10mg/2mg Tablet if you have glaucoma, prostate problems, urination problems, stomach ulcers, acidity, myasthenia gravis (muscle problems), tardive dyskinesia (involuntary facial movements), alcoholism, high blood pressure, heart, liver, or kidney problems. Talk to your doctor immediately if you experience hallucinations. Riphen Forte 10mg/2mg Tablet may make you sweat less, making you more likely to get heatstroke. Avoid doing things that may cause you to overheat, such as hard work or exercise in hot weather or using hot tubs. When the weather is hot, drink a lot of fluids and dress lightly. Riphen Forte 10mg/2mg Tablet may cause drowsiness and dizziness, do not drive unless you are alert. Avoid consuming alcohol along with Riphen Forte 10mg/2mg Tablet as it could lead to increased drowsiness and dizziness. 

Drug-Drug Interactions

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TrihexyphenidylPotassium citrate
Critical
TrihexyphenidylPotassium chloride
Critical

Drug-Drug Interactions

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TrihexyphenidylPotassium citrate
Critical
How does the drug interact with Riphen Forte 10mg/2mg Tablet:
Co-administration of Riphen Forte 10mg/2mg Tablet with potassium citrate may increase the risk of stomach ulcers, bleeding, and gastrointestinal injury.

How to manage the interaction:
Taking Riphen Forte 10mg/2mg Tablet with potassium citrate is not recommended as it can possibly result in an interaction, it can be taken if prescribed by a doctor. However, if you experience abdominal pain, bloating, sudden dizziness or lightheadedness, nausea, vomiting (especially with blood), loss of appetite, or black stools contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
TrihexyphenidylPotassium chloride
Critical
How does the drug interact with Riphen Forte 10mg/2mg Tablet:
Co-administration of Riphen Forte 10mg/2mg Tablet with potassium chloride can increase the risk of stomach ulcers, bleeding, and gastrointestinal injury.

How to manage the interaction:
Taking Riphen Forte 10mg/2mg Tablet with potassium chloride is not recommended as it can possibly result in an interaction, it can be taken if prescribed by a doctor. However, if you experience abdominal pain, bloating, sudden dizziness or lightheadedness, nausea, vomiting (especially with blood), loss of appetite, black stools contact a doctor immediately. Do not discontinue any medications without consulting to a doctor.
TrifluoperazineZiprasidone
Critical
How does the drug interact with Riphen Forte 10mg/2mg Tablet:
Co-administration of Riphen Forte 10mg/2mg Tablet with Ziprasidone can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Riphen Forte 10mg/2mg Tablet with Ziprasidone together can possibly result in an interaction, but it can be taken if a doctor has advised it. However, consult a doctor immediately if you experience any symptoms such as sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not discontinue any medications without consulting a doctor.
TrifluoperazineMetoclopramide
Critical
How does the drug interact with Riphen Forte 10mg/2mg Tablet:
Co-administration of Metoclopramide with Riphen Forte 10mg/2mg Tablet can increase the risk of side effects like uncontrolled movement disorder.

How to manage the interaction:
Taking Metoclopramide with Riphen Forte 10mg/2mg Tablet is generally avoided as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience muscle spasms or movements that you can't stop or control, such as lip smacking, chewing, puckering, frowning or scowling, tongue thrusting, teeth clenching, jaw twitching, blinking, eye-rolling, shaking or jerking of arms and legs, tremor, jitteriness, restlessness, pacing, and foot tapping., contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
TrihexyphenidylTopiramate
Severe
How does the drug interact with Riphen Forte 10mg/2mg Tablet:
Taking Riphen Forte 10mg/2mg Tablet with topiramate can increase the risk of increase body temperature and reduced sweating.

How to manage the interaction:
Co-administration of Riphen Forte 10mg/2mg Tablet with Topiramate can result in an interaction, but it can be taken if your doctor has advised it. However, if you experience dizziness or lightheaded, increase body temperature contact your doctor right away. Do not discontinue any medications without first consulting your doctor.
TrihexyphenidylAmantadine
Severe
How does the drug interact with Riphen Forte 10mg/2mg Tablet:
Coadministration of Allopurinol with Riphen Forte 10mg/2mg Tablet may increase side effects such as heat intolerance, dry mouth, confusion, constipation, difficulty urinating, and blurred vision especially in the elderly or those with a debilitating (physically weak) condition.

How to manage the interaction:
If you are supposed to take Allopurinol and Riphen Forte 10mg/2mg Tablet together, your doctor may adjust the dose or monitor you more frequently to safely use both medications.
TrihexyphenidylKetamine
Severe
How does the drug interact with Riphen Forte 10mg/2mg Tablet:
Taking Riphen Forte 10mg/2mg Tablet with Ketamine can increase the risk of side effects.

How to manage the interaction:
Although there is a interaction between Riphen Forte 10mg/2mg Tablet and ketamine, but it can be taken together if prescribed by your doctor. However, if you experience drowsiness, confusion, difficulty concentrating, and impairment in thinking contact your doctor right away. Do not stop using any medications without talking to your doctor.
TrihexyphenidylZonisamide
Severe
How does the drug interact with Riphen Forte 10mg/2mg Tablet:
Coadministration of Riphen Forte 10mg/2mg Tablet with Zonisamide can increase the risk or severity of Zonisamide side effects like increased body temperature and decreased sweating especially in warm weather.

How to manage the interaction:
Taking Riphen Forte 10mg/2mg Tablet with Zonisamide together is not recommended as it can result in an interaction, but it can be taken if your doctor has advised it. However, if you experience increased heart rate, fever, or excessive sweating, contact a doctor immediately. Make sure to hydrate yourself during warm weather or after exercise. Do not discontinue any medications without consulting a doctor.
TrihexyphenidylEsketamine
Severe
How does the drug interact with Riphen Forte 10mg/2mg Tablet:
Taking Riphen Forte 10mg/2mg Tablet with esketamine can increase the risk of other side effects.

How to manage the interaction:
Although there is a interaction between Riphen Forte 10mg/2mg Tablet and esketamine, but can be taken together if prescribed by your doctor. However, if you experience drowsiness, confusion, difficulty concentrating, and impairment in thinking contact your doctor right away. Do not stop using any medications without talking to your doctor.
TrifluoperazineSotalol
Severe
How does the drug interact with Riphen Forte 10mg/2mg Tablet:
Using sotalol together with Riphen Forte 10mg/2mg Tablet can increase the risk or severity of irregular heart rhythms which can be severe. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Although there is a possible interaction between Sotalol and Riphen Forte 10mg/2mg Tablet, you can take these medicines together if prescribed by a doctor. If you experience dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations consult a doctor. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Maintain a healthy diet and exercise regularly.

  • Include a diet rich in iron, folate, and magnesium. 

  • Regularly attend therapy sessions.

  • Perform meditation and yoga.

  • Follow a regular sleep pattern.

  • Avoid smoking and alcohol consumption.

  • Learn about your condition, understand the risk factors and follow the doctor’s treatment plan.

Habit Forming

No

Therapeutic Class

ANTIPSYCHOTICS

Riphen Forte 10mg/2mg Tablet Substitute

Substitutes safety advice
  • Fluhex Tablet 10's

    3.46per tablet
  • Sizonorm Plus 10 Tablet 10's

    2.34per tablet
  • Relicalm Plus 10 mg Tablet 10's

    3.69per tablet
  • Kivicalm 10 mg Tablet 10's

    2.88per tablet
  • Tridyl-10 mg/2 mg Tablet 10's

    4.41per tablet
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Alcohol

Unsafe

Avoid consumption of alcohol with Riphen Forte 10mg/2mg Tablet as it may increase the risk of drowsiness and other adverse effects.

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Pregnancy

Unsafe

Riphen Forte 10mg/2mg Tablet is not recommended for use during pregnancy, especially in the third trimesters as it may cause adverse effects in the baby. Please consult a doctor if you are pregnant or planning for pregnancy.

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Breast Feeding

Caution

Riphen Forte 10mg/2mg Tablet may be unsafe to use during breastfeeding. Please consult a doctor if you are breastfeeding.

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Driving

Unsafe

Riphen Forte 10mg/2mg Tablet may cause dizziness, double vision or drowsiness in some people. Therefore, avoid driving if you feel drowsy, dizzy or experience any vision problems after taking Riphen Forte 10mg/2mg Tablet.

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Liver

Unsafe

Riphen Forte 10mg/2mg Tablet is not recommended for patients suffering from Liver diseases/conditions. Please consult a doctor if you have any concerns regarding this.

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Kidney

Caution

Take Riphen Forte 10mg/2mg Tablet with caution, especially if you have a history of Kidney diseases/conditions. The dose may be adjusted by your doctor as required.

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Children

Unsafe

Please consult your paediatrician. Your child's doctor may weigh the benefits and risks before prescribing this medicine to your child.

FAQs

Riphen Forte 10mg/2mg Tablet is used to prevent and treat schizophrenia (a mental illness). Additionally, it may be used for anxiety and depression over a short period.
Riphen Forte 10mg/2mg Tablet contains Trifluoperazine and Trihexyphenidyl. Trifluoperazine is a typical antipsychotic which works by blocking the action of a chemical messenger (dopamine) in the brain that affects thoughts and mood. However, it may cause side effects such as involuntary movements (shaking of hands, muscle spasms). Trihexyphenidyl is used to treat and prevent side effects such as involuntary movements (shaking of hands, muscle spasms) caused by Trifluoperazine.
Dry mouth could be a side-effect of Riphen Forte 10mg/2mg Tablet. Limiting caffeine intake, avoiding smoking and mouthwashes containing alcohol, drinking water regularly, and chewing sugar-free gum/candy might help in stimulating saliva and thereby prevents drying of the mouth.
Antidepressants should be avoided while taking Riphen Forte 10mg/2mg Tablet as it might increase sedative effects. Consult your doctor before taking Riphen Forte 10mg/2mg Tablet if you are using depressants.
Riphen Forte 10mg/2mg Tablet can cause decreased sweating which results in rising in body temperature (hyperthermia). This serious side effect is greater in hot weather so it is advisable to drink plenty of water fluids, especially in summer. However, kidney patients should consult a doctor before drinking any fluid.
Hallucination is a medical condition in which the person may feel, hear or believe things that are not true, see things that are not there, feel unusually suspicious or confused. Trihexyphenidyl in Riphen Forte 10mg/2mg Tablet may cause hallucination in some cases if taken for a prolonged time. So, if you experience hallucinations while taking Riphen Forte 10mg/2mg Tablet, please talk to your doctor immediately.
Riphen Forte 10mg/2mg Tablet should be avoided by dementia (decline in memory, behaviour, thinking and ability to do daily activities) patients as it may increase the risk of severe adverse effects. Therefore, inform your doctor if you are suffering from dementia before taking Riphen Forte 10mg/2mg Tablet.
Though Riphen Forte 10mg/2mg Tablet starts working within a few hours, it might take 2-3 weeks to notice the full benefits. Keep taking Riphen Forte 10mg/2mg Tablet for the prescribed duration for effective treatment.
No, you should not stop taking Riphen Forte 10mg/2mg Tablet even though you feel better as it may cause withdrawal symptoms. Consult the doctor if you experience any difficulties while taking Riphen Forte 10mg/2mg Tablet; the doctor might lower the dose gradually.
Riphen Forte 10mg/2mg Tablet does not cause sleepiness. However, it may cause sleepiness if you take alcohol with Riphen Forte 10mg/2mg Tablet. Therefore, avoid consuming alcohol while taking Riphen Forte 10mg/2mg Tablet. Riphen Forte 10mg/2mg Tablet might cause dizziness and drowsiness in some people. Avoid driving or operating machinery if you experience these symptoms.
Yes, Riphen Forte 10mg/2mg Tablet may cause dry mouth as a side effect. If you experience dry mouth manage it by limiting caffeine intake, staying hydrated, and using a humidifier.
Riphen Forte 10mg/2mg Tablet can be stored in a cool and dry place away from sunlight. Keep it out of sight and reach of children.
The side effects of Riphen Forte 10mg/2mg Tablet include dizziness, nausea, abdominal pain, blurred vision, constipation, decreased blood pressure, urine retention, dry mouth, weight gain, and excessive sweating. Consult the doctor if any of these side effects persist or worsen.

Country of origin

India
Other Info - RI90462

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