RGM Tablet belongs to a class of medicines called antidiabetic drugs used in the treatment of type 2 diabetes, especially in patients whose blood sugar levels are not controlled by diet and exercise alone. Type 2 diabetes is a chronic (long-lasting) condition that affects the way our body processes glucose. People with type 2 diabetes either do not produce enough insulin or the insulin produced is unable to perform its function in the body (insulin resistance).

RGM Tablet is a combination of three antidiabetic drugs, namely: Glibenclamide, Metformin, and Rosiglitazone. Glibenclamide works by stimulating beta cells in the pancreas that produce insulin. Thus, insulin helps to remove sugar from the blood. Metformin works by reducing the sugar production by cells in the liver and delays sugar absorption from the intestines. Rosiglitazone works by increasing the sensitivity of liver, muscle, and fat cells to insulin and enables cells to remove glucose from blood more effectively. Thereby, RGM Tablet helps to control blood sugar levels.

Take RGM Tablet as prescribed by your doctor. You are advised to take RGM Tablet for as long as your doctor has prescribed it for you based on your medical condition. In some cases, you may experience stomach pain, nausea, diarrhea, vomiting, headache, or low blood sugar. Most of these side effects of RGM Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are allergic to RGM Tablet or any other medicines, please tell your doctor. RGM Tablet is not recommended for children below 18 years of age. Avoid breastfeeding while taking RGM Tablet as it may be excreted in human milk. If you are pregnant or planning for pregnancy, please inform your doctor before taking RGM Tablet as it may harm an unborn baby. RGM Tablet should be used with caution in elderly patients. Avoid alcohol consumption with RGM Tablet as it may increase the risk of lactic acidosis (accumulation of lactic acid in the body). Drive only if you are alert after taking RGM Tablet .

RGM Tablet contains three antidiabetic drugs (Glibenclamide, Metformin, and Rosiglitazone) used in the treatment of type 2 diabetes. Glibenclamide stimulates cells in the pancreas that produce insulin which helps to remove sugar from the blood. Metformin reduces sugar production by cells in the liver and delays sugar absorption from the intestines. Also, it increases the sensitivity of muscle cells to insulin which enables these cells to remove sugar more effectively from the blood. Rosiglitazone increases the sensitivity of liver, muscle, and fat cells to insulin and enables cells to remove glucose from blood more effectively. Also, it decreases the amount of glucose produced by the liver and preserves the functioning of beta cells in the pancreas that produce insulin. Thereby, RGM Tablet helps to control blood sugar levels.

• Stomach pain
• Nausea
• Diarrhoea
• Vomiting
• Headache
• Low blood sugar

If you are allergic to RGM Tablet or any other medicines, please tell your doctor. RGM Tablet is not recommended for children. Avoid breastfeeding while taking RGM Tablet as it may be excreted in human milk. If you are pregnant or planning for pregnancy, please inform your doctor before taking RGM Tablet as it may harm the unborn baby. RGM Tablet should be used with caution in elderly patients. Avoid alcohol consumption with RGM Tablet as it may increase the risk of lactic acidosis (accumulation of lactic acid in the body). Drive only if you are alert after taking RGM Tablet . Take short, frequent meals and avoid prolonged fasting while taking RGM Tablet . Beware of symptoms of hypoglycemia (low blood sugar) which include sweating, dizziness, palpitations, shivering, intense thirst, dry mouth, dry skin, frequent urination, etc. Whenever you experience any of these symptoms, immediately consume 5-6 candies or 3 glucose biscuits, or 3 teaspoons of honey/sugar, and also consult your doctor. Make sure to carry these with you at all times, especially during long travels.

Drug-Drug Interaction: RGM Tablet may have interaction with drugs used to treat high blood pressure in the lungs (bosentan), other antidiabetic drugs (insulin, sitagliptin), water pill (furosemide), antithyroid drugs (levothyroxine), anticonvulsant (pregabalin).

Drug-Food Interaction: RGM Tablet may interact with alcohol. Therefore, avoid the consumption of alcohol with RGM Tablet as it may increase the risk of lactic acidosis (accumulation of lactic acid in the body).

Drug-Disease Interaction: If you have type 1 diabetes, lactic acidosis, diabetic ketoacidosis (accumulation of ketone bodies in the blood), or eye problems caused by diabetes, liver, kidney, or heart problems, inform your doctor before taking RGM Tablet .

• BOSENTAN
• INSULIN
• SITAGLIPTIN
• FUROSEMIDE
• LEVOTHYROXINE
• PREGABALIN

• Do regular exercise such as cycling, walking, jogging, dancing, or swimming for a minimum of 30 minutes per day. Invest at least 150 minutes of your week in exercise.
• Maintain healthy body weight as obesity is also related to the onset of diabetes.
• Maintain a low-fat and low-sugar diet. Replace carbohydrates-containing foods with whole grains, fruits, and vegetables as carbohydrates turn to sugars leading to high blood sugar.
• Avoid consumption of alcohol and quit smoking.

• Regular blood tests are recommended while taking RGM Tablet to monitor blood sugar levels.

Type 2 diabetes: It is a chronic (long-lasting) condition that keeps the body away from properly utilizing insulin. Hence, people affected with type 2 diabetes either do not produce enough insulin, or there is resistance to the action of insulin. Middle-aged or older are most likely to suffer from type 2 diabetes, so it is also known as adult-onset diabetes. Symptoms of type 2 diabetes include frequent urination at night, increased thirst, slow wound healing, increased hunger, fatigue, and blurred vision. In some cases, there may be weight gain while in rare cases weight loss may be observed. The complication of type 2 diabetes also includes nerve problems, kidney problems, the damaged retina of eyes or blindness, loss of limbs, sexual dysfunction, and increase the chance of heart attack or stroke.