Retrozole AP 100mg/325mg/20mg Capsule belongs to a class of drugs called analgesics (pain relievers) used to reduce pain and swelling in conditions such as osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis (pain and stiffness in the backbone). Arthritis is a condition that causes swelling of one or more joints resulting in pain and stiffness of joints that worsen over time. The symptoms of arthritis include joint pain, stiffness, redness, tenderness, swelling in and around joints, and reduced movement of joints.

Retrozole AP 100mg/325mg/20mg Capsule is a combination of three drugs, namely: Aceclofenac (nonsteroidal anti-inflammatory drug), Paracetamol (analgesic and antipyretic), and Rabeprazole (proton pump inhibitor).  Aceclofenac and Paracetamol work by inhibiting the production of certain chemical substances such as prostaglandins that cause pain and swelling. Thereby, it helps in relieving pain and swelling associated with different types of arthritis. Rabeprazole works by blocking the action of proton pumps that are involved in producing stomach acid. Thereby, it reduces the amount of acid produced by the stomach and prevents excess acid from flowing back into the food pipe.

Take Retrozole AP 100mg/325mg/20mg Capsule as prescribed by your doctor. You are advised to take Retrozole AP 100mg/325mg/20mg Capsule for as long as your doctor has prescribed it for you based on your medical condition. In some cases, you may experience indigestion, stomach pain, constipation, dizziness, nausea, and diarrhea. Most of these side effects of Retrozole AP 100mg/325mg/20mg Capsule do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are allergic to Retrozole AP 100mg/325mg/20mg Capsule or any other medicines, please tell your doctor. If you are pregnant or planning for pregnancy, please inform your doctor before taking Retrozole AP 100mg/325mg/20mg Capsule as it may cause adverse effects in the baby if taken during the last 3 months of pregnancy. Retrozole AP 100mg/325mg/20mg Capsule may be excreted in breast milk. Therefore, avoid breastfeeding and consult a doctor. Retrozole AP 100mg/325mg/20mg Capsule is not recommended for children below 18 years of age as the safety and effectiveness were not established. Avoid consumption of alcohol with Retrozole AP 100mg/325mg/20mg Capsule as it may increase the risk of stomach bleeding. Drive only if you are alert as Retrozole AP 100mg/325mg/20mg Capsule may cause dizziness, tiredness, drowsiness, or vision problems.

Retrozole AP 100mg/325mg/20mg Capsule contains Aceclofenac, Paracetamol and Rabeprazole.  Aceclofenac and Paracetamol inhibit the production of certain chemical substances such as prostaglandins that cause pain and swelling. Thereby, it helps in relieving pain and swelling associated with different types of arthritis such as osteoarthritis, rheumatoid arthritis and ankylosing spondylitis (pain and stiffness in the backbone). Rabeprazole blocks the action of proton pumps that are involved in producing stomach acid. Thereby, it reduces the amount of acid produced by the stomach and prevents excess acid from flowing back into the food pipe.

• Indigestion
• Stomach pain
• Constipation
• Dizziness
• Nausea
• Diarrhoea

If you are allergic to Retrozole AP 100mg/325mg/20mg Capsule or any other medicines, please tell your doctor. If you are pregnant or planning for pregnancy, please inform your doctor before taking Retrozole AP 100mg/325mg/20mg Capsule as it may cause adverse effects in the baby if taken during the last 3 months of pregnancy. Retrozole AP 100mg/325mg/20mg Capsule may be excreted in breast milk. Therefore, avoid breastfeeding and consult a doctor. Retrozole AP 100mg/325mg/20mg Capsule is not recommended for children below 18 years of age as the safety and effectiveness were not established. Avoid consumption of alcohol with Retrozole AP 100mg/325mg/20mg Capsule as it may increase the risk of stomach bleeding. Drive only if you are alert as Retrozole AP 100mg/325mg/20mg Capsule may cause dizziness, tiredness, drowsiness or vision problems.

Drug-Drug Interaction: Retrozole AP 100mg/325mg/20mg Capsule may interact with pain killers (ibuprofen, naproxen, celecoxib, etoricoxib, aspirin), antifungals (ketoconazole, itraconazole), high blood pressure-lowering medicines (propranolol, enalapril, lisinopril, losartan, candesartan, methyldopa, clonidine, moxonidine), water pills (furosemide, amiloride), blood thinners (heparin, warfarin, clopidogrel), antidiabetics (glibenclamide, gliclazide, tolbutamide), antibiotics (moxifloxacin, ciprofloxacin, ofloxacin, levofloxacin, chloramphenicol), anti- HIV drug (zidovudine), antidepressants (fluvoxamine, paroxetine, citalopram, escitalopram, sertraline, fluoxetine), antimanic drug (lithium), anticancer drug (methotrexate), abortion drug (mifepristone), anti-sickness drugs (domperidone, metoclopramide), steroids (hydrocortisone, prednisolone), immunosuppressants (ciclosporin, tacrolimus).

Drug-Food Interaction: Retrozole AP 100mg/325mg/20mg Capsule may interact with alcohol. Therefore, avoid alcohol intake while taking Retrozole AP 100mg/325mg/20mg Capsule as it may increase the risk of stomach bleeding.

Drug-Disease Interaction: If you have diabetes, stomach ulcer, blood clotting disorders, asthma, kidney, liver, or heart problems, high blood pressure, high cholesterol, systemic lupus erythematosus (an autoimmune condition that causes joint pain, fever, and skin rashes), porphyria (disorder in the formation of red blood pigment), colitis or Crohn’s disease (conditions causing swelling of the bowel, diarrhea, bowel pain, vomiting, and weight loss), inform your doctor before taking Retrozole AP 100mg/325mg/20mg Capsule.

• IBUPROFEN
• NAPROXEN
• CELECOXIB
• ETORICOXIB
• ASPIRIN
• KETOCONAZOLE
• ITRACONAZOLE
• PROPRANOLOL
• ENALAPRIL
• LISINOPRIL
• LOSARTAN
• CANDESARTAN
• METHYLDOPA
• CLONIDINE
• FUROSEMIDE
• AMILORIDE
• HEPARIN
• WARFARIN
• CLOPIDOGREL
• GLIBENCLAMIDE
• GLICLAZIDE
• TOLBUTAMIDE
• MOXIFLOXACIN
• CIPROFLOXACIN
• OFLOXACIN
• LEVOFLOXACIN
• CHLORAMPHENICOL
• ZIDOVUDINE
• FLUVOXAMINE
• PAROXETINE
• CITALOPRAM
• ESCITALOPRAM
• SERTRALINE
• FLUOXETINE
• LITHIUM
• METHOTREXATE
• MIFEPRISTONE
• DOMPERIDONE
• METOCLOPRAMIDE
• HYDROCORTISONE
• PREDNISOLONE
• CICLOSPORIN
• TACROLIMUS

• Physical activity helps in strengthening muscles and relieves joint stiffness. Gentle activities like 20-30minutes of walking or swimming would be helpful.
• Performing yoga may also help in improving joint flexibility and pain management.
• Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
• Get adequate sleep as resting the muscles can help in reducing inflammation and swelling.
• Follow heat or cold therapy, apply a cold or hot compress on the joints for 15-20minutes regularly.
• Acupuncture, massage and physical therapy may also be helpful.
• Eat foods rich in antioxidants such as berries, spinach, kidney beans, dark chocolate, etc.
• Foods containing flavonoids such as soy, berries, broccoli, grapes and green tea help in reducing inflammation.
• Avoid smoking and alcohol consumption.

If you are elderly, a smoker, had a stroke previously, or have high blood pressure, diabetes or high cholesterol, please inform your doctor as these conditions may increase the risk of heart problems.

Osteoarthritis: It is a degenerative joint disease in which the two ends of the joints come together due to the breakdown of a protective covering of cartilage. Due to the absence of this protective covering, the joints rub against each other, leading to pain and stiffness. Symptoms of osteoarthritis include pain, stiffness, inflammation, and tenderness. The main reason for osteoarthritis is age, the older you are, the more likely you could get osteoarthritis, thus known as degenerative disease, meaning that the joints wear out as a person ages. Other reasons include past injuries such as torn cartilage, dislocated joints, and ligament injuries.

Rheumatoid arthritis: It is an auto-immune disease (the body's immune system attacks its tissue) that leads to joint pain and damage. Symptoms include pain, swelling, stiffness, deformities, and loss of joint function.

Ankylosing spondylitis: It causes pain and stiffness in the spine. The pain usually starts in the lower back and can spread to the neck, damaged joints, or other parts of the body. Symptoms of ankylosing spondylitis include decreased flexibility which usually leads to a hunched-forward posture, pain, and back and joints.