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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Last Updated Jan 1, 2025 | 2:44 PM IST

RETEFUSE KIT INJECTION is used in the treatment of ST-elevation myocardial infarction (STEMI) to lower the risk of heart failure and death. It contains Reteplase, which works by dissolving the blood clot that is blocking the heart's blood vessels. It may also treat a recent left bundle branch block (a delay/blockage of electrical impulses to the left side of the heart). Common side effects of RETEFUSE KIT INJECTION are bleeding, bruising at the injection site, nausea or vomiting.

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Synonym :

RECOMBINANT TISSUE PLASMINOGEN ACTIVATOR

Composition :

RETEPLASE-18GM

Manufacturer/Marketer :

Lupin Ltd

Consume Type :

PARENTERAL

Return Policy :

3 Days Returnable

Expires on or after :

Jan-27

About RETEFUSE KIT INJECTION

RETEFUSE KIT INJECTION is a tissue plasminogen activator indicated for the treatment of acute ST-elevation myocardial infarction (STEMI) to lower the risk of heart failure and death. STEMI is a very serious type of heart attack that occurs due to blockage of the heart’s major arteries.

RETEFUSE KIT INJECTION contains Reteplase, which works by dissolving the blood clot that is blocking the heart blood vessel.

In some cases, RETEFUSE KIT INJECTION may cause side effects such as bleeding, bruising at the injection site, nausea or vomiting. You are advised to talk to your doctor if any of the side effects persist or worsen.

Consult your doctor if you are pregnant or breastfeeding. The efficacy and safety of RETEFUSE KIT INJECTION in children have not been established. Inform your doctor about all the medicines you are taking and your health condition to rule out any unpleasant side effects/interactions.

Uses of RETEFUSE KIT INJECTION

Treatment of ST-elevation myocardial infarction (STEMI)

Medicinal Benefits

RETEFUSE KIT INJECTION is a tissue plasminogen activator indicated for the treatment of acute ST-elevation myocardial infarction (STEMI) to reduce the risk of heart failure and death. RETEFUSE KIT INJECTION contains Reteplase that works by dissolving the blood clot that is blocking the heart blood vessel. It may also be indicated in the treatment of a recent left bundle branch block (a delay/blockage of electrical impulses to the left side of the heart).

Side Effects of RETEFUSE KIT INJECTION

  • Bleeding
  • Bruising at the injection site
  • Vomiting
  • Nausea

Directions for Use

RETEFUSE KIT INJECTION will be administered by a healthcare professional; do not self-administer.

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

RETEFUSE KIT INJECTION should not be used if you are allergic to any of the components in RETEFUSE KIT INJECTION, in patients with active internal bleeding, recent stroke, recent intracranial or intraspinal surgery or serious head trauma, intracranial neoplasm (brain tumour), arteriovenous malformation, or aneurysm (ballooning and weakened area in an artery), known bleeding diathesis (tendency to bleed or bruise easily), or severe uncontrolled hypertension. RETEFUSE KIT INJECTION may cause bleeding, hypersensitivity reactions, or cholesterol embolism. Inform your doctor if you have/had recent major surgery, cerebrovascular disease, recent gastrointestinal/genitourinary bleeding, hypertension, subacute bacterial endocarditis, severe hepatic or renal disease, if you are over 75 years or if you are taking any oral anticoagulants. Consult your doctor if you are pregnant or breastfeeding. The safety and effectiveness of RETEFUSE KIT INJECTION in children have not been established.

Therapeutic Class

MISCELLANEOUS

Drug-Drug Interactions

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ReteplaseEnoxaparin
Severe
ReteplaseApixaban
Severe

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Diet & Lifestyle Advise

  • Include vegetables, fruits and whole grains in your diet.
  • Stop smoking.
  • Be physically active every day.
  • Aim for a healthy weight.
  • Limit the consumption of alcohol.
  • Manage stress with meditation.

Habit Forming

No

How RETEFUSE KIT INJECTION Works

RETEFUSE KIT INJECTION contains Reteplase, which works by dissolving the blood clot that is blocking the heart blood vessel.

What if I have taken an overdose of RETEFUSE KIT INJECTION

Since RETEFUSE KIT INJECTION is given in a controlled medical setting by a healthcare professional, an overdose is not likely to occur. If you think there has been an overdose or experiencing any adverse events, get medical care right away. In a medical setting, an overdose would be treated quickly.
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Alcohol

Consult your doctor

Limited information is available. Please consult your doctor.

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Pregnancy

Caution

Please consult your doctor if you are pregnant. Your doctor will prescribe only if the potential benefits outweigh the potential risk to the foetus.

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Breast Feeding

Caution

Please consult your doctor if you are breastfeeding. Caution should be exercised whilst administering RETEFUSE KIT INJECTION to a nursing mother.

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Driving

Consult your doctor

Limited information is available. Please consult your doctor.

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Liver

Caution

The potential risks with the therapy of RETEFUSE KIT INJECTION may be increased in patients with severe liver dysfunction and should be weighed against the anticipated benefits. Please consult your doctor.

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Kidney

Caution

The potential risks of RETEFUSE KIT INJECTION therapy may be increased in patients with severe renal dysfunction and should be weighed against the anticipated benefits. Please consult your doctor.

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Children

Caution

The efficacy and safety of RETEFUSE KIT INJECTION in children have not been established.

Country of origin

India

Manufacturer/Marketer address

Lupin Ltd, 3rd floor Kalpataru Inspire, Off. W E Highway, Santacruz (East), Mumbai 400 055. India Country of Origin: India
Other Info - RET0089

Author Details

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FAQs

RETEFUSE KIT INJECTION is used to treat ST-elevation myocardial infarction (STEMI).
RETEFUSE KIT INJECTION works by dissolving the blood clot that is blocking the heart's blood vessels.
RETEFUSE KIT INJECTION may increase the risk of bleeding. The sites of bleeding could be internal or external. Talk to your doctor if you have any concerns.
Heparin and RETEFUSE KIT INJECTION are incompatible. RETEFUSE KIT INJECTION should not be administered through an intravenous line containing heparin. Please consult your doctor if you have any concerns.
RETEFUSE KIT INJECTION will be administered by a healthcare professional in a clinical setting. Do not attempt to administer it yourself. A trained healthcare professional will ensure safe and proper administration.
Yes, RETEFUSE KIT INJECTION is safe when used under the doctor’s supervision. It is used in the treatment of ST-elevation myocardial infarction (STEMI). However, it may cause some side effects like bleeding, bruising at the injection site, nausea, or vomiting in some cases. You are advised to talk to your doctor if any of the side effects persist or worsen.
RETEFUSE KIT INJECTION may interact with anti-coagulants like heparin, enoxaparin, warfarin, phenindione, aspirin, dipyridamole, ticlopidine, clopidogrel, and vitamin K antagonists. So, it’s best to consult your doctor before taking anti-coagulants or any other medications along with RETEFUSE KIT INJECTION.
RETEFUSE KIT INJECTION helps prevent blood clots from forming in your legs, lungs, heart, and brain. You may not feel any immediate effects after taking the medicine, but that doesn't mean it's not working. Continue taking the medicine exactly as prescribed by your doctor, even if you don't notice any difference.
The common side effects of RETEFUSE KIT INJECTION may include bleeding, bruising at the injection site, nausea, or vomiting. You are advised to talk to your doctor if any of the side effects persist or worsen.

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