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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Refid Plus Syrup is used to treat cough associated with mucus. It works by thinning and loosening phlegm (mucus) in the lungs, windpipe, and nose. Also, it increases the volume of fluid in the airways, reduces the stickiness of mucus, and removes it from the airways. It relaxes muscles and widens the airways. Thus, it makes breathing easier. Some people may experience side effects such as nausea, vomiting, drowsiness, headache, dizziness, skin rash, nervousness, tremors, stomach upset, and fast heartbeats. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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About Refid Plus Syrup

Refid Plus Syrup is used to treat cough associated with mucus. Coughing (dry or productive) is the body’s way of clearing irritants (like allergens, mucus, or smoke) from airways and preventing infection. There are two types of coughs, namely: Dry cough and chesty cough. A dry cough is tickly and doesn't produce any vicious or thick mucus, while a chesty cough (wet cough) means mucous or sputum is produced to help clear your airways.

Refid Plus Syrup is a combination of three drugs: Ambroxol (mucolytic agent), Guaifenesin (expectorant), and Terbutaline (bronchodilator). Ambroxol belongs to the class of mucolytic agents (cough/sputum thinner) that work by thinning and loosening phlegm (mucus) in the lungs, windpipe, and nose. Guaifenesin belongs to the class of expectorants that increase the volume of fluid in the airways, reduce the stickiness of mucus, and remove it from the airways. Terbutaline belongs to the class of bronchodilators that relax muscles and widen the airways. Thus, it makes breathing easier.

Take Refid Plus Syrup as prescribed. Your doctor will recommend how often you take Refid Plus Syrup based on your medical condition. Some people may experience nausea, vomiting, drowsiness, headache, dizziness, skin rash, nervousness, tremors, stomach upset, and fast heartbeats. Most of these side effects of Refid Plus Syrup do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are allergic to Refid Plus Syrup or any other medicines, please tell your doctor. If you are pregnant or breastfeeding, it is advised to inform your doctor before using Refid Plus Syrup. Use Refid Plus Syrup with caution in children if prescribed by a doctor. If you are suffering from fits or have a history of fits, please inform your doctor before taking Refid Plus Syrup as it may increase the risk of recurrent fits. If you have diabetes, regular monitoring of blood sugar levels is recommended while taking Refid Plus Syrup. If you have diabetes, fits, high blood pressure, overactive thyroid, stomach ulcers, phenylketonuria (a congenital disability that causes accumulation of amino acid, phenylalanine in the body), kidney, liver, or heart problems, inform your doctor before taking Refid Plus Syrup.

Uses of Refid Plus Syrup

Treatment of Chesty cough.

Directions for Use

Shake the bottle well before use. Check the label for directions before use. Take Refid Plus Syrup with or without food in doses as prescribed by your doctor with the help of a measuring cup that is provided with the pack.

Medicinal Benefits

Refid Plus Syrup is a combination of three drugs, namely: Ambroxol, Guaifenesin, and Terbutaline. Ambroxol belongs to the class of mucolytic agents (cough/sputum thinner) that work by thinning and loosening phlegm (mucus) in the lungs, windpipe, and nose for coughing out easily. Guaifenesin belongs to the class of expectorants that increase the volume of fluid in the airways, reduce the stickiness of mucus, and remove it from the airways. Terbutaline is a bronchodilator that relaxes muscles and widens the airways. Thus, it makes breathing easier.

How Refid Plus Syrup Works

Refid Plus Syrup is a combination of three drugs: Ambroxol (mucolytic agent), Guaifenesin (expectorant), and Terbutaline (bronchodilator). Ambroxol belongs to the class of mucolytic agents (cough/sputum thinner) that work by thinning and loosening phlegm (mucus) in the lungs, windpipe, and nose. Guaifenesin belongs to the class of expectorants that increase the volume of fluid in the airways, reduce the stickiness of mucus, and remove it from the airways. Terbutaline belongs to the class of bronchodilators that relax muscles and widen the airways. Thus, it makes breathing easier.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Refid Plus Syrup

  • Nausea
  • Vomiting
  • Stomach upset
  • Stomach pain
  • Drowsiness
  • Dizziness
  • Headache
  • Skin rash
  • Rash
  • Hives
  • Nervousness
  • Tremor
  • Fast heartbeats
  • Palpitations

What if I have taken an overdose of Refid Plus Syrup

Do not take more than the prescribed dose of Refid Plus Syrup as it may cause overdose. If you suspect you have taken overdose, please consult a doctor immediately.

Drug Warnings

If you are allergic to Refid Plus Syrup or any other medicines, please tell your doctor. If you are pregnant or breastfeeding, it is advised to inform your doctor before using Refid Plus Syrup. If you are suffering from fits or have a history of fits, please inform your doctor before taking Refid Plus Syrup as it may increase the risk of recurrent fits. If you have diabetes, regular monitoring of blood sugar levels is recommended while taking Refid Plus Syrup. Drink plenty of fluids while taking Refid Plus Syrup to loosen mucus. Drive only if you are alert after taking Refid Plus Syrup as it may cause dizziness or drowsiness in some people. If you have diabetes, fits, high blood pressure, overactive thyroid, stomach ulcers, phenylketonuria (a congenital disability that causes accumulation of amino acid, phenylalanine in the body), kidney, liver or heart problems, inform your doctor before taking Refid Plus Syrup.

Drug-Drug Interactions

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GuaifenesinProcarbazine
Severe
TerbutalineAmisulpride
Severe

Drug-Drug Interactions

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GuaifenesinProcarbazine
Severe
How does the drug interact with Refid Plus Syrup:
-

How to manage the interaction:
Co-administration of Refid Plus Syrup with Procarbazine can possibly result in an interaction, but it can be taken if your doctor has advised it. Do not discontinue any medications without first consulting your doctor.
TerbutalineAmisulpride
Severe
How does the drug interact with Refid Plus Syrup:
Using Refid Plus Syrup together with amisulpride can increase the risk of severe irregular heart rhythm.

How to manage the interaction:
Amisulpride and Refid Plus Syrup can cause an interaction, but it can be taken if prescribed by a doctor. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not stop using any medications without talking to a doctor.
TerbutalineDisopyramide
Severe
How does the drug interact with Refid Plus Syrup:
The combined use of Refid Plus Syrup and Disopyramide can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Co-administration of Refid Plus Syrup and Disopyramide can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, heart palpitations, diarrhea, or vomiting, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
TerbutalineNilotinib
Severe
How does the drug interact with Refid Plus Syrup:
Combining Refid Plus Syrup and nilotinib can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Refid Plus Syrup and nilotinib together can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, heart palpitations, diarrhea, or vomiting, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
TerbutalineSotalol
Severe
How does the drug interact with Refid Plus Syrup:
Using sotalol together with Refid Plus Syrup may reduce the benefits of both medications since they have opposing effects in the body.

How to manage the interaction:
Taking Sotalol with Refid Plus Syrup together can result in an interaction, but it can be taken if a doctor has advised it. Do not stop using any medications without a doctor's advice.
TerbutalineCeritinib
Severe
How does the drug interact with Refid Plus Syrup:
Taking Refid Plus Syrup with ceritinib can increase the risk of irregular heart rhythm.

How to manage the interaction:
Although there is a interaction between Ceritinib and Refid Plus Syrup, you can take these medicines together if prescribed by your doctor. However, consult your doctor immediately if you experience symptoms such as dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not stop using any medications without talking to a doctor.
TerbutalineEfavirenz
Severe
How does the drug interact with Refid Plus Syrup:
Taking Efavirenz and Refid Plus Syrup can increase the risk or severity of irregular heart rhythms. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Taking Efavirenz and Refid Plus Syrup together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
TerbutalineGatifloxacin
Severe
How does the drug interact with Refid Plus Syrup:
Taking Gatifloxacin and Refid Plus Syrup can increase the risk or severity of irregular heart rhythms. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Taking Gatifloxacin and Refid Plus Syrup together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
TerbutalineLinezolid
Severe
How does the drug interact with Refid Plus Syrup:
Using Refid Plus Syrup together with linezolid may increase cardiovascular side effects (heart palpitations, chest pain, increased heart and pulse rates, and blood pressure elevations).

How to manage the interaction:
Although taking linezolid with Refid Plus Syrup together can result in an interaction, they can be taken if a doctor has prescribed it. However, if you're diagnosed with a history of heart disease or high blood pressure, see your doctor before taking these medications. Do not discontinue any medication without consulting a doctor. Do not exceed the doses, frequency, or duration of usage advised by a doctor.
TerbutalineMoxifloxacin
Severe
How does the drug interact with Refid Plus Syrup:
Using moxifloxacin together with Refid Plus Syrup can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Although there is a possible interaction between Moxifloxacin and Refid Plus Syrup, you can take these medicines together if prescribed by your doctor. However, consult the doctor immediately if you experience symptoms such as dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not discontinue any medications without first consulting your doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Avoid dairy products such as milk, as they may increase mucus production. Also, avoid processed or refined foods to relieve cough. Instead, replace baked foods, fried foods, white bread, white pasta, French fries, sugary desserts, and chips with green leafy vegetables.
  • Drink plenty of fluids to avoid dry throat while you have a cough and loosen mucus.
  • Avoid citrus fruits as they may worsen the cough. Eat fruits rich in water content, such as pears, watermelon, peaches and pineapples.

Habit Forming

No

Therapeutic Class

EXPECTORANT AND COUGH PRODUCTS

Refid Plus Syrup Substitute

Substitutes safety advice
  • AMBROTUS SYRUP 100ML

    42.42per tablet
  • Muscarin Syrup

    0.32per tablet
  • Satroxin Syrup

    0.65per tablet
  • Kofil A Syrup

    0.68per tablet
  • Bcuff AX Syrup

    0.52per tablet
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Alcohol

Caution

The interaction of alcohol with Refid Plus Syrup is unknown. Please consult a doctor before consuming alcohol with Refid Plus Syrup.

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Pregnancy

Caution

The safety of Refid Plus Syrup in pregnant women is unknown. Therefore, it is given to pregnant women only if the doctor thinks the benefits outweigh the risks.

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Breast Feeding

Caution

It is unknown whether Refid Plus Syrup is excreted in human milk. Refid Plus Syrup is given to breastfeeding mothers only if the doctor thinks the benefits are greater than the risks.

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Driving

Caution

Refid Plus Syrup may cause dizziness or drowsiness in some people. Therefore, drive only if you are alerted after taking the Refid Plus Syrup.

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Liver

Caution

Take Refid Plus Syrup with caution, especially if you have a history of liver diseases. Your doctor may adjust the dose as required.

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Kidney

Caution

Take Refid Plus Syrup with caution, especially if you have a history of Kidney diseases. Your doctor may adjust the dose as required.

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Children

Caution

Refid Plus Syrup should be used with caution in children if prescribed by a doctor.

FAQs

Refid Plus Syrup belongs to the class of medicines called expectorants used to treat cough associated with mucus.
Refid Plus Syrup contains Ambroxol, Guaifenesin and Terbutaline. Ambroxol is a mucolytic agent (cough/sputum thinner) that thins and loosens phlegm (mucus) in the lungs, helping to cough out easily. Guaifenesin is an expectorant that increases the volume of fluid in the airways, reduces the stickiness of mucus, and helps to remove it from the airways. Terbutaline is a bronchodilator that relaxes muscles and widens the airways, making breathing easier.
Refid Plus Syrup should be used with caution in hyperthyroid (overactive thyroid) patients as it may worsen the condition. Inform your doctor if you have hyperthyroidism before taking Refid Plus Syrup so that the dose may be adjusted appropriately. However, regular monitoring of thyroid hormone levels is recommended while taking Refid Plus Syrup.
Yes, Refid Plus Syrup may cause drowsiness or dizziness. It is not necessary for everyone taking Refid Plus Syrup to experience this side effect. Therefore, avoid driving if you feel drowsy or dizzy after taking Refid Plus Syrup.
Refid Plus Syrup should be used with caution in diabetic patients if prescribed by a doctor. However, regular monitoring of blood sugar levels is recommended while taking Refid Plus Syrup as it may increase blood sugar levels.
You are recommended to take Refid Plus Syrup for as long as your doctor has prescribed it. However, if the symptoms persist or worsen, such as rash, fever, or persistent headache, after one week of using Refid Plus Syrup, please consult your doctor.
No, you are not recommended to stop taking Refid Plus Syrup without consulting your doctor, as it may worsen your cough or cause recurring symptoms. Therefore, take Refid Plus Syrup for as long as your doctor has prescribed it, and if you experience any difficulty while taking Refid Plus Syrup, please consult your doctor.
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