Ref Koff Syrup

Ref Koff Syrup is a combination medication which promotes the secretion of sputum (phlegm) by the airways (bronchi), used to treat coughs. It treats respiratory conditions, including chronic obstructive pulmonary diseases (COPD) like bronchitis (inflammation of bronchial tubes), emphysema (shortness of breath), and upper respiratory tract infections. COPD is a chronic inflammatory lung disease caused by obstructed airflow in the lungs. An upper respiratory tract infection is a contagious infection caused by a bacteria or virus infecting the nose, throat, pharynx, larynx, and bronchi.

Ref Koff Syrup consists of Ambroxol, Terbutaline, Guaifenesin, and Menthol. Ambroxol is an 'expectorant' that promotes the secretion of sputum/cough. It is also a 'mucolytic agent' that makes sputum less viscous and makes breathing easier. Terbutaline is a bronchodilator and works by widening and relaxing the airways (bronchi) of the lungs. Guaifenesin is also an 'expectorant'. It reduces the thickness or viscosity of bronchial secretions (phlegm) and increases mucus flow, making it easier to cough. Menthol is an organic flavour additive which produces a sensation of coolness and relieves throat irritation.

Your doctor will decide the dose and duration of the course based on the severity of your medical condition. Like every other medication, Ref Koff Syrup also has common side effects like nausea, diarrhoea, vomiting, stomach discomfort, sweating and muscle cramps, dizziness, headache, rash, tremor (shakiness), palpitations (uneven heartbeat), and increased heart rate. These side effects, if occurred, generally go away during the treatment. However, if the side effects are persistent, reach out to your doctor.

Let your doctor know if you have any allergic reactions to Ref Koff Syrup or any other medication. It is mandatory to inform your doctor if you have heart, liver, kidney diseases, stomach ulcers, seizures (fits), high blood pressure, thyroid disorders, diabetes, inflammation of air passages, lung disorders, and difficulty breathing before taking Ref Koff Syrup. Check with your doctor if you plan to conceive, are pregnant or breastfeeding. Avoid alcohol while taking Ref Koff Syrup since it can worsen dizziness and sleepiness.

Ref Koff Syrup is an expectorant (cough syrup), which contains Ambroxol, Terbutaline, Guaifenesin, and Menthol. Ambroxol is an 'expectorant' that promotes the secretion of sputum/cough and a 'mucolytic agent' that makes sputum less viscous and makes breathing easier. Terbutaline is a bronchodilator and works by widening and relaxing the airways (bronchi) of the lungs. Guaifenesin is also an 'expectorant'. It reduces the thickness or viscosity of bronchial secretions (phlegm) and increases mucus flow, making it easier to cough. Menthol is an organic flavour additive which produces a sensation of coolness and relieves throat irritation.

• Nausea

• Diarrhoea

• Vomiting

• Stomach discomfort

• Dizziness

• Headache

• Rash

• Tremor (shakiness)

• Sweating

• Muscle cramps

• Palpitations (uneven heartbeat)

• Increased heart rate

Ref Koff Syrup should be used with caution in patients with heart, liver, kidney diseases, stomach ulcers, high blood pressure, thyroid disorders, inflammation of air passages, lung disorders, seizures, diabetes, hypokalemia (low potassium levels in the blood), and difficulty breathing. Pregnant and breastfeeding women should use Ref Koff Syrup with proper consultation and caution. Avoid consuming alcohol with Ref Koff Syrup as it could lead to increased drowsiness or dizziness. Do not drive if you feel sleepy or have an increased heart rate or shakiness after taking Ref Koff Syrup. Ref Koff Syrup is not recommended in children below two years of age.

Drug-Drug Interaction: Ref Koff Syrup may interact with hormones (epinephrine, oxytocin), heart-related drugs (digoxin), Parkinson's disease medication (safinamide), blood pressure medicines (propranolol), vomiting medication (ondansetron, promethazine), corticosteroids (budesonide), respiratory-related medicines (aminophylline, formoterol), fluid retention drugs (furosemide), and antidepressants.

Drug-Food Interaction: Limit alcohol intake since it may worsen the side effects like dizziness and shakiness.

Drug-Disease Interaction: Ref Koff Syrup should be administered with caution in patients with pre-existing ischaemic heart, liver, kidney diseases, thyroid disorders, bronchospasm, stomach ulcer, fits, high blood pressure, diabetes, inflammation of air passages, lung disorders, and difficulty breathing.

• EPINEPHRINE
• OXYTOCIN
• DIGOXIN
• SAFINAMIDE
• PROPRANOLOL
• ONDANSETRON
• PROMETHAZINE
• BUDESONIDE
• AMINOPHYLLINE
• FORMOTEROL
• FUROSEMIDE

• Take the medication as directed by the doctor and at regular intervals. Do not use other over the counter medications, herbal or vitamin supplements without informing your pharmacist or doctor when you take Ref Koff Syrup.

• Know your triggers like allergens, such as pollen, dust, and food items that make your asthma and other respiratory diseases severe.

• Quit smoking and avoid passive smoking. Smoking also reduces the effectiveness of the medicine.

• Drink warm fluids while you take Ref Koff Syrup to help loosen congestion and lubricate the throat.

• Eat a healthy diet and exercise regularly to strengthen your breathing muscles and boost your immune system.

• Learning breathing exercises will help you move more air in and out of your lungs.

Cough: Coughing is a body's way of clearing irritants (like allergens, mucus or smoke) from airways and preventing infection. Coughs may be dry or productive. A productive cough (wet cough) brings up sputum (phlegm, mucus and other matter) from the lungs. Dry cough does not produce sputum. Cough is commonly caused as a response to allergy or viral infection but coughing up mucus is possibly an indication of infection in the respiratory tract. If you are coughing thick, solid white mucus, it indicates a bacterial infection in the airways. If the mucus is clear or light-coloured, it indicates allergies or a minor infection in the respiratory tract, and yellow or green mucus indicates a respiratory infection.

Chronic obstructive pulmonary disease (COPD): It is a chronic inflammatory lung disease caused by the obstructed airflow in the lungs. Emphysema is a lung condition caused by shortness of breath, and chronic bronchitis is the inflammation of the lining of bronchial tubes. An upper respiratory tract infection is a contagious infection caused by a bacteria or virus infecting nose, throat, pharynx, larynx, and bronchi.