How does PZA CIBA 750MG work?

PZA CIBA 750MG contains 'Pyrazinamide.' It is bactericidal and works by stopping the growth of Mycobacterium tuberculosis, a bacteria that causes tuberculosis.

In which conditions should I avoid PZA CIBA 750MG?

PZA CIBA 750MG is not recommended for use in the medical history of liver or kidney diseases, diabetes, gout, high uric acid level in the blood, alcohol use and undergoing dialysis treatment. Please let your doctor know if you have any other medical problems before starting PZA CIBA 750MG.

I am undergoing vaccination for typhoid this week, can I use PZA CIBA 750MG?

PZA CIBA 750MG can affect the live vaccines like typhoid vaccine and decrease its effectiveness. Please consult a doctor before you start PZA CIBA 750MG if you are undergoing any vaccinations.

Can I take PZA CIBA 750MG with food?

It is advised to take PZA CIBA 750MG 30 minutes before food or 2 hours after food. Please consult your doctor for more information.

Why should I avoid PZA CIBA 750MG in gout?

PZA CIBA 750MG gets converted in the body to Pyrazinoic acid that blocks the excretion of urates (salt form of uric acid) by the kidneys. Increased blood levels of uric acid (hyperuricemia) causes pain, swelling, redness and stiffness in joints (gout). Hence, PZA CIBA 750MG should be avoided if you have a history of gout.

What is PZA CIBA 750MG?

PZA CIBA 750MG is an antibiotic that belongs to the group of anti-tuberculosis (TB) drugs. It is used for the treatment of tuberculosis which is an infectious disease that mainly affects lungs but can also impact other parts of the body.

Is PZA CIBA 750MG bactericidal?

Yes, PZA CIBA 750MG is bactericidal. It works by inhibiting the growth of Mycobacterium tuberculosis, the bacteria that is responsible for causing tuberculosis.

How does PZA CIBA 750MG cause hyperuricemia and gout?

PZA CIBA 750MG causes hyperuricemia and gout by inhibiting the renal excretion of uric acid, which can lead to the precipitation or worsening of gout. It should be used with caution in individuals with hyperuricemia or a history of gout.

What are the side effects of PZA CIBA 750MG?

The side effects of PZA CIBA 750MG include nausea, vomiting, muscle/joint pain, nausea and loss of appetite. Consult the doctor if any of these symptoms persist or worsen.

PZA CIBA 750MG

Written By Veda Maddala , M Pharmacy

Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy

PZA CIBA 750MG is used to treat and prevent tuberculosis. It contains Pyrazinamide which converts a special enzyme to an active form that inhibits the synthesis of fatty acids; this disrupts the cell membrane and disables energy production necessary for the survival of the TB bacteria. It may cause common side effects such as muscle/joint pain, nausea, vomiting and loss of appetite. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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About PZA CIBA 750MG

PZA CIBA 750MG is used to treat and prevent tuberculosis. Tuberculosis is an infectious disease that mainly affects the lungs, but it can also spread to other body parts such as kidneys, brain, spine and bone marrow. PZA CIBA 750MG does not work against infections caused by the virus, such as the common cold and flu.

PZA CIBA 750MG contains 'Pyrazinamide'. Pyrazinamide is a chemically synthesised bacteriocidal antibiotic. It converts a special enzyme to an active form that inhibits the synthesis of fatty acids; this disrupts the cell membrane and disables energy production necessary for the survival of the TB bacteria.

Your doctor will decide the dose and duration based on the severity of your disease. Common side effects of PZA CIBA 750MG include muscle/joint pain, nausea, vomiting and loss of appetite. These side effects are not familiar to everyone and vary individually. If you notice any side effects that are not manageable, please consult your doctor.

Let your doctor know if you use any prescription and non-prescription medications you are taking, including other vitamins, before starting PZA CIBA 750MG. Please tell your doctor if you are allergic to PZA CIBA 750MG or its components. Inform your doctor beforehand if you have a history of liver or kidney diseases, diabetes, gout, high uric acid level in the blood, alcohol use and are undergoing dialysis. It is essential to let your doctor know if you are pregnant, planning to conceive or are a breastfeeding mother. Avoid consuming alcohol along with PZA CIBA 750MG as it might lead to liver problems.

Uses of PZA CIBA 750MG

Treatment of Tuberculosis (TB).

Directions for Use

Swallow PZA CIBA 750MG as a whole with water; do not crush, break or chew it.

Medicinal Benefits

PZA CIBA 750MG contains 'Pyrazinamide', which is used to treat and prevent tuberculosis. Pyrazinamide is a chemically synthesised bacteriocidal antibiotic. It converts a special enzyme to an active form that inhibits the synthesis of fatty acids; this disrupts the cell membrane and disables energy production necessary to survive the TB bacteria. It is usually given in alone or combined with other antitubercular agents to treat tuberculosis.

How PZA CIBA 750MG Works

PZA CIBA 750MG contains 'Pyrazinamide'. Pyrazinamide is a chemically synthesised bacteriocidal antibiotic. It converts a special enzyme to an active form that inhibits the synthesis of fatty acids; this disrupts the cell membrane and disables energy production necessary for the survival of the TB bacteria.

Storage

Store in a cool and dry place away from sunlight

Side Effects of PZA CIBA 750MG

Muscle/joint pain
Nausea
Vomiting
Loss of appetite
Hepatitis, liver dysfunction

What if I have taken an overdose of PZA CIBA 750MG

Do not take more than the prescribed dose of PZA CIBA 750MG as it may cause overdose. If you suspect you have taken overdose, please consult a doctor immediately.

Drug Warnings

Brief your medical history to the doctor if you have any liver or kidney diseases, diabetes, gout, high uric acid level in the blood, lactose intolerance, alcohol use and are undergoing dialysis treatment before starting PZA CIBA 750MG. Let your doctor know if you are undergoing any vaccinations with live bacterial vaccines (like typhoid vaccine) since PZA CIBA 750MG may affect vaccine's activity. Please consult your doctor know if you are pregnant, planning to conceive or are a breastfeeding mother before starting PZA CIBA 750MG. Avoid consuming alcohol along with PZA CIBA 750MG as it might lead to liver problems. Store PZA CIBA 750MG below 25°C away from direct sunlight.

Drug-Drug Interactions

PyrazinamideLeflunomide

Severe

PyrazinamideRifampicin

Severe

Drug-Drug Interactions

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PyrazinamideLeflunomide

Severe

How does the drug interact with PZA CIBA 750MG:
Co-administration of leflunomide with PZA CIBA 750MG may increase the risk or severity of liver problems.

How to manage the interaction:
Although taking Leflunomide and PZA CIBA 750MG together can cause an interaction, they can be taken together if prescribed by a doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, or yellowing of the skin or eyes, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.

PyrazinamideRifampicin

Severe

How does the drug interact with PZA CIBA 750MG:
Taking rifampicin together with PZA CIBA 750MG can cause liver problems.

How to manage the interaction:
Although there is an interaction between PZA CIBA 750MG and rifampicin, they can be taken together if prescribed by a doctor. However, if you experience fever, rash, less desire to eat, nausea, vomiting, fatigue, right upper abdominal pain, or dark urine, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.

PyrazinamideLomitapide

Severe

How does the drug interact with PZA CIBA 750MG:
Co-administration of Lomitapide with PZA CIBA 750MG may increase in the risk or severity of liver problems.

How to manage the interaction:
Although taking Lomitapide and PZA CIBA 750MG together can evidently cause an interaction, it can be taken if a doctor has suggested it. If you have any of these symptoms, it's important to contact your doctor immediately: fever, chills, joint pain, swelling, bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark-colored urine, or bleeding. Do not stop using any medications without a doctor's advice. Do not discontinue the medication without consulting a doctor.

PyrazinamideTeriflunomide

Severe

How does the drug interact with PZA CIBA 750MG:
Co-administration of Teriflunomide with PZA CIBA 750MG may increase the risk or severity of liver damage.

How to manage the interaction:
Although taking Teriflunomide and PZA CIBA 750MG together can evidently cause an interaction, it can be taken if a doctor has suggested it. If you have any of these symptoms, it's important to contact your doctor immediately: fever, chills, joint pain, swelling, bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark-colored urine, or bleeding. Do not stop using any medications without a doctor's advice. Do not discontinue the medication without consulting a doctor.

PyrazinamideKetoconazole

Severe

How does the drug interact with PZA CIBA 750MG:
Co-administration of Ketoconazole with PZA CIBA 750MG may increase the risk or severity of liver damage.

How to manage the interaction:
Although taking Ketoconazole and PZA CIBA 750MG together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you have any of the following symptoms: fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, fatigue, lack of appetite, nausea, vomiting, abdominal pain, dark urine, light stools, and/or yellowing of the skin or eyes, consult a doctor immediately. Do not discontinue the medication without consulting a doctor.

Drug-Food Interactions

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

Pineapple juice might help soothe the symptoms of cough and cold. It also has anti-inflammatory and mucolytic properties.
Foods rich in vitamin C, such as kiwi, broccoli and bell pepper, help improve the immune system.
Avoid processed and fried foods.
Warm ginger tea or warm soup can help in providing relief from the cough.
Avoid foods and drinks, such as cured meat, matured cheese, soya, tuna, salmon, mackerel, wine and beer.
Quit smoking and avoid alcohol consumption.

Habit Forming

No

Therapeutic Class

ANTI- TUBERCULOSIS

PZA CIBA 750MG Substitute

P-Zide 750mg Tablet 10's
₹6.80per tablet
Pyzina 750 Tablet 10's
₹6.80per tablet
Macrozide-750 Tablet 10's
₹6.80per tablet

Alcohol

Unsafe

You are recommended to avoid alcohol consumption while taking PZA CIBA 750MG. Alcohol intake, along with PZA CIBA 750MG, may cause increased liver damage. Please consult your doctor for more information.

Pregnancy

Caution

PZA CIBA 750MG should be used with caution during pregnancy. Please consult your doctor before taking PZA CIBA 750MG if you are pregnant or planning to conceive.

Breast Feeding

Caution

PZA CIBA 750MG is not recommended for use during breastfeeding since it is excreted into the breast milk and may harm a nursing baby. Please consult your doctor if you are a breastfeeding mother.

Driving

Caution

It is not known if PZA CIBA 750MG alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to drive or operate machinery.

Liver

Caution

PZA CIBA 750MG is not recommended in patients with severe liver damage. Please consult your doctor since PZA CIBA 750MG should be used with caution in patients with liver impairment/liver disease. Regular monitoring of the liver with liver function tests is also advised.

Kidney

Caution

Please consult your doctor since PZA CIBA 750MG should be used with caution in patients with kidney impairment/kidney disease. Your doctor may adjust the dosage in case of renal dysfunction.

Children

Caution

PZA CIBA 750MG is recommended in children below 12 years of age only after doctor's advice.

FAQs

Country of origin

INDIA

Manufacturer/Marketer address

Sandoz House, Shiv Sagar Estate, Worli Mumbai -400 018, India

Other Info - PZA0004

Author Details

Written By

Veda Maddala

M Pharmacy

Reviewed By

Bayyarapu Mahesh Kumar

M Pharmacy

Last Updated

Jan 1, 2025 | 2:48 PM IST

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PZA CIBA 750MG Substitute

P-Zide 750mg Tablet 10's

Pyzina 750 Tablet 10's

Macrozide-750 Tablet 10's

P-Zide 750mg Tablet 10's

Pyzina 750 Tablet 10's

Macrozide-750 Tablet 10's

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