Pyril-D Tablet is used for the symptomatic treatment of migraine and any medical condition with concomitant nausea/vomiting and fever/pain. Migraine is a neurological condition that can cause severe throbbing pain or a pulsing sensation, usually on one side of the head, eyes, face, and neck. Symptoms may include nausea, vomiting, difficulty speaking, numbness or tingling, and sensitivity to light and sound.

Pyril-D Tablet is a combination of two drugs: Domperidone and Paracetamol. Domperidone prevents nausea and vomiting symptoms by blocking certain receptors (like dopamine and serotonin) that stimulate the vomiting centre (chemoreceptor trigger zone –CTZ) located in the brain. It also acts as a prokinetic agent that increases the upper gastrointestinal tract's motility and helps in decreasing the stomach emptying time. Paracetamol is an NSAID that works by blocking the effect of a chemical messenger in your body, known as cyclo-oxygenase (COX) enzymes that make another chemical ‘prostaglandins’(PG). These prostaglandins are produced at injury sites and cause pain and swelling. By blocking the effect of COX enzymes, fewer PGs are produced, which reduces mild to moderate pain and inflammation at the injured or damaged site.

Take Pyril-D Tablet as prescribed. Your doctor will recommend how often you take Pyril-D Tablet based on your medical condition. Some people may experience some side effects, dry mouth, skin rash, anxiety, diarrhoea, and drowsiness. Most of these side effects of Pyril-D Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

You can increase the efficacy of Pyril-D Tablet by taking a small meal or snacks frequently. Do not take Pyril-D Tablet if you are allergic to Pyril-D Tablet and other medicines. If you are pregnant or breastfeeding, it is advised to inform your doctor before taking Pyril-D Tablet. Inform your doctor if you have heart, kidney, and liver disease. Prolonged intake of Pyril-D Tablet may be associated with an increased risk of heart rhythm disorder (arrhythmia) and cardiac arrest (heart attack). This risk may be more likely in the elderly (those over 60 years old) or taking a higher dose. If you experience heart rhythm disorders like palpitations, trouble in breathing, or loss of consciousness after taking Pyril-D Tablet, immediately contact your doctor.

Pyril-D Tablet is a combination of two drugs, Domperidone and Paracetamol, used to treat vomiting and pain in people with migraines. Domperidone belongs to a class of prokinetic agents that prevent nausea and vomiting symptoms by blocking certain receptors (like dopamine and serotonin) that stimulate the vomiting centre (chemoreceptor trigger zone –CTZ) located in the brain. It also acts as a prokinetic agent that increases the upper gastrointestinal tract's motility and helps in decreasing the stomach emptying time. Paracetamol is an NSAID that works by blocking the effect of a chemical messenger in your body, known as cyclo-oxygenase (COX) enzymes that make another chemical ‘prostaglandins’(PG). These prostaglandins are produced at injury sites and cause pain and swelling. By blocking the effect of COX enzymes, fewer PGs are produced, which reduces mild to moderate pain and inflammation at the injured or damaged site. Pyril-D Tablet together used to prevent nausea, vomiting, pain, and fever associated with migraine.

• Dry mouth
• Skin rash
• Anxiety
• Diarrhea
• Drowsiness

Do not take Pyril-D Tablet if you are allergic to any of its contents or any other medicines, have a history of gastrointestinal bleeding, heart disease, liver/ kidney problem. Prolonged intake of Pyril-D Tablet may be associated with an increased risk of heart rhythm disorder (arrhythmia) and cardiac arrest (heart attack). So, if you experience heart rhythm disorders like palpitations, trouble in breathing, or loss of consciousness after taking Pyril-D Tablet, immediately contact your doctor. This risk may be more likely in the elderly (those over 60 years old) or taking a higher dose. If you are pregnant or breastfeeding, inform your doctor before using Pyril-D Tablet. Avoid consumption of alcohol while using Pyril-D Tablet as it may increase the side effects and make worse your condition. Pyril-D Tablet should not be given to children below five years of age. The use of Pyril-D Tablet is safe in children above five years of age if prescribed by the doctor. Do not exceed dose paracetamol more than 4 gm per day as it can damage your liver.

Drug-Drug Interaction: Pyril-D Tablet interact with medicines used to treat heart problems (amiodarone, dronedarone, quinidine, sotalol, diltiazem, verapamil), antibiotics (erythromycin, clarithromycin, moxifloxacin), gastrointestinal disorder (cisapride, dolasetron), blood thinners (warfarin), vomiting and nausea related pills (metoclopramide), and bile related medicines (cholestyramine),

Drug-Food Interaction: No interaction found.

Drug-Disease interaction: The use of Pyril-D Tablet is restricted in people with liver disease, a history of gastrointestinal bleeding, or any problem involving the bowels.

• AMIODARONE
• DRONEDARONE
• QUINIDINE
• SOTALOL
• DILTIAZEM
• VERAPAMIL
• ERYTHROMYCIN
• CLARITHROMYCIN
• MOXIFLOXACIN
• CISAPRIDE
• DOLASETRON
• WARFARIN
• METOCLOPRAMIDE
• CHOLESTYRAMINE

• Eat a healthy diet and a low-fat diet, especially in small portions, as it will be easy for digestion. Avoid eating over sweet food and include more salty food, especially if you have been vomiting.

• Also, if you like vomiting at a specific time, avoid eating your favorite food at that particular time as your taste for that food may get turned off.

• Include more cool beverages in your food like clear soup, flavored gelatin, carbonated beverages. Also, when you drink with a stray, sip slowly to avoid swallowing air that may lead to gas and acidity.

• Drink after or any other liquid at least 30 minutes after eating food. 

• Avoid smoking and alcohol intake.

• Avoid chronic stress as it can raise your migraine pain. Try to enjoy and spending time with your friends to cope with stress and practice mindfulness techniques.

• Prolonged intake of Pyril-D Tablet can increase the risk of cardiac arrhythmia (irregular heartbeat), so close monitoring of heartbeat is required.

Migraine: is a neurological condition that can cause severe throbbing pain or a pulsing sensation, usually on one side of the head. People may experience migraine pain in the eyes face and neck. Symptoms may include nausea, vomiting, difficulty speaking, numbness or tingling, and sensitivity to light and sound. Migraine attacks can last for hours to days, and the pain and symptoms can be so severe that it interferes with your daily activities.