Pyrigesic MR Tablet is a combination medicine used to relieve pain and inflammation associated with osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, muscle pain, and bone and joint pain. Pain is a symptom triggered by the nervous system, causing uncomfortable sensations in the body. Muscle spasm is the sudden involuntary contractions of the muscle, which can be painful and uncomfortable. Arthritis is tenderness and swelling in the joints.

Pyrigesic MR Tablet contains Thiocolchicoside (muscle relaxant), Aceclofenac (NSAID), and Paracetamol (Analgesic). Thiocolchicoside works on the centres of the spinal cord and brain. This helps relieve muscle stiffness and improves muscle movements. Aceclofenac and Paracetamol work by blocking the effect of chemical messengers that cause pain and inflammation.  Together, Pyrigesic MR Tablet helps in relieving pain due to muscle spasms.

You are advised to take Pyrigesic MR Tablet as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, you may experience certain common side effects, such as nausea, vomiting, stomach pain, loss of appetite, heartburn, and diarrhoea. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Consult your doctor if you are pregnant or breastfeeding. Pyrigesic MR Tablet may cause drowsiness and dizziness, so drive with caution. Pyrigesic MR Tablet should not be given to children as safety and efficacy have not been established. Avoid consuming alcohol with Pyrigesic MR Tablet as it could lead to increased drowsiness and dizziness; it might also increase the risk of stomach bleeding. Keep your doctor informed about your health condition and medicines to rule out any side effects/interactions.

Pyrigesic MR Tablet is a combination of three drugs, namely: Thiocolchicoside, Aceclofenac, and Paracetamol. Pyrigesic MR Tablet is used to relieve pain and inflammation associated with osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, muscle pain, bone and joint pain. Pyrigesic MR Tablet increases the pain threshold and blood flow across the skin. Thiocolchicoside is a muscle relaxant which works on the centres of the spinal cord and brain. This helps relieve muscle stiffness and improves muscle movements. Aceclofenac and Paracetamol are analgesics that block the effect of a chemical messenger known as cyclo-oxygenase (COX) enzymes that make another chemical, prostaglandins. These prostaglandins are produced at injury sites and cause pain and swelling. By blocking COX enzymes' effect, lesser prostaglandins are produced, which reduces mild to moderate pain and inflammation at the injured or damaged site. Together, Pyrigesic MR Tablet helps in relieving pain due to muscle spasms.

• Nausea
• Vomiting
• Stomach pain
• Diarrhoea
• Loss of appetite
• Heartburn

Do not take Pyrigesic MR Tablet if you are allergic to any of its contents; if you have/had severe heart problems, stomach ulcer or perforation, and bleeding problems such as bleeding from the stomach, intestine or brain, bypass surgery, heart attack, blood circulation problems, or inflammation of intestines. Inform your doctor if you have high blood pressure, heart problems, high cholesterol, diabetes, asthma, inflammatory bowel disease, liver or kidney problems. Consult your doctor if you are pregnant or breastfeeding. Pyrigesic MR Tablet may cause drowsiness and dizziness, so drive only if you are alert. Pyrigesic MR Tablet is not recommended for children as safety and effectiveness have not been established. Avoid consuming alcohol with Pyrigesic MR Tablet as it could lead to increased drowsiness and increased risk of stomach bleeding. Stop taking Pyrigesic MR Tablet and consult your doctor immediately if you have stomach pain or any signs of bleeding in the intestine or stomach, such as blood in stools. Do not take any other NSAIDs for pain relief along with Pyrigesic MR Tablet unless prescribed.

Drug-Drug Interactions: Inform your doctor if you are taking painkillers (aspirin, ibuprofen, naproxen, celecoxib, etoricoxib), anti-depressants (citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine, sertraline, lithium), cardiac glycoside (digoxin), anti-hypertensives (enalapril, lisinopril, losartan, candesartan, hydralazine, methyldopa, clonidine, moxonidine, propranolol), antibiotics (ciprofloxacin, ofloxacin, levofloxacin moxifloxacin), diuretics (furosemide, amiloride hydrochloride), blood thinners (warfarin, heparin, clopidogrel), anti-rheumatoid (methotrexate), steroids (mifepristone), glucocorticoids (hydrocortisone, prednisolone), immunosuppressants (ciclosporin, tacrolimus), anti-HIV (zidovudine), anti-diabetic (glibenclamide, gliclazide, tolbutamide).

Drug-Food Interactions: No interactions found/established.

Drug-Disease Interactions: Inform your doctor if you have/had a stomach ulcer or perforation, bleeding problems, bypass surgery, heart attack, blood circulation problems, inflammation of intestines, anaemia, heart, kidney or liver problems.

• ASPIRIN
• IBUPROFEN
• NAPROXEN
• CELECOXIB
• ETORICOXIB
• CITALOPRAM
• ESCITALOPRAM
• FLUOXETINE
• FLUVOXAMINE
• PAROXETINE
• SERTRALINE
• LITHIUM
• DIGOXIN
• ENALAPRIL
• LISINOPRIL
• LOSARTAN
• CANDESARTAN
• HYDRALAZINE
• METHYLDOPA
• CLONIDINE
• MOXONIDINE
• PROPRANOLOL
• CIPROFLOXACIN
• OFLOXACIN
• LEVOFLOXACIN
• MOXIFLOXACIN
• FUROSEMIDE
• AMILORIDE
• WARFARIN
• HEPARIN
• CLOPIDOGREL
• METHOTREXATE
• MIFEPRESTONE
• HYDROCORTISONE
• PREDNISOLONE
• CYCLOSPORINE
• TACROLIMUS
• ZIDOVUDINE
• GLIBENCLAMIDE
• GLICLAZIDE
• TOLBUTAMIDE

• Exercising regularly helps in muscle stretching so that they are less likely to spasm, tear and sprain. Mild exercises such as jogging and walking are helpful for muscle stretching.

• Massages can also be helpful.

• Avoid freezing and hot temperatures.

• Avoid wearing tight-fitting clothes, instead, wear loose garments.

• Rest well, and get plenty of sleep.

• To avoid developing pressure sores, change your position every two hours.

• Hot or cold therapy can help treat muscle spasms. Apply an ice-pack or hot-pack on the muscle for 15-20minutes.

• Stay hydrated, drink plenty of water.

Pain: Pain is a symptom triggered by the nervous system, causing uncomfortable sensations in the body. Pain may be dull or sharp; it might be constant or may come and go. The tolerance level of pain might vary from person to person. Pain can be generalised (overall body aches) or localised (affecting a specific area of the body). The common causes of pain include headache, muscle strain, cramps, cuts, bone fractures, and arthritis.

Osteoarthritis: It is a joint disease in which the two ends of the joints come together due to the breakdown of a protective covering called cartilage. Due to the absence of this protective covering, the joints rub against each other, leading to pain and stiffness. Symptoms include pain, stiffness, inflammation and tenderness.

Rheumatoid arthritis: It is an auto-immune disease (the body's immune system attacks its tissue), leading to joint pain and damage. Symptoms of rheumatoid arthritis include pain, swelling, stiffness, deformities and loss of joint function.

Ankylosing spondylitis: It causes pain and stiffness in the spine. The pain generally starts in the lower back and can spread to the neck, damaged joints, or other body parts. Ankylosing spondylitis includes decreased flexibility which usually leads to a hunched-forward posture, pain in the back and joints.