Pymet 5mg/500mg Tablet is used to treat signs of migraine such as headache, being sick (vomiting), and feeling sick (nausea). Migraine is a neurological condition which is characterised by an intense pulsating, throbbing, pounding, debilitating headache which generally occurs on one side of the head; however, it can occur on both sides or shift.

Pymet 5mg/500mg Tablet is a combination of two drugs: Metoclopramide (anti-emetics) and Paracetamol (analgesics). Metoclopramide works on the part of the brain and prevents the symptoms of nausea and vomiting. It also works on the muscles in the upper part of the digestive system, which helps empty the stomach. Paracetamol works by blocking the effect of a chemical messenger known as prostaglandins, which cause pain. Together, Pymet 5mg/500mg Tablet helps relieve the symptoms of migraine.

Take Pymet 5mg/500mg Tablet as prescribed. You are advised to take Pymet 5mg/500mg Tablet as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, you may experience certain common side effects such as dizziness, sleepiness, diarrhoea, irregular periods, weakness, nervousness and breast enlargement in men. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Consult your doctor before taking Pymet 5mg/500mg Tablet if you are pregnant or breastfeeding. Pymet 5mg/500mg Tablet should not be taken during the first 6 months of pregnancy. Pymet 5mg/500mg Tablet may cause drowsiness and sleepiness, so drive with caution. Pymet 5mg/500mg Tablet is not recommended for children below 18 years as safety and efficacy have not been established. Avoid consuming alcohol with Pymet 5mg/500mg Tablet as it could lead to increased drowsiness and sleepiness. Inform your doctor about your health condition and medicines you are taking to rule out unpleasant side effects.

Pymet 5mg/500mg Tablet is a combination of two drugs: Metoclopramide and Paracetamol. Pymet 5mg/500mg Tablet is used to treat migraine signs such as headache, being sick (vomiting) and feeling sick (nausea). Metoclopramide is an anti-emetic that works on the part of the brain, thereby preventing the symptoms of nausea and vomiting. It also works on the muscles in the upper part of the digestive system, which helps empty the stomach. Paracetamol is an analgesic that works by blocking the effect of a chemical messenger known as prostaglandins, which cause pain. Thereby, helps in relieving pain. Together, Pymet 5mg/500mg Tablet helps relieve the symptoms of migraines such as headache, nausea, and vomiting.

• Dizziness
• Sleepiness
• Diarrhoea
• Irregular periods
• Weakness
• Nervousness
• Breast enlargement in men

Do not take Pymet 5mg/500mg Tablet if you are allergic to any of its contents; if you have/had a blockage or bleeding in your stomach, epilepsy/fits, phaeochromocytoma (tumour of the adrenal gland), uncontrollable movements of the face, arms or legs after taking metoclopramide or medicines used to calm mental problems, if you had an operation on stomach or intestine or if you are taking levodopa. Inform your doctor before taking Pymet 5mg/500mg Tablet if you have/had severe kidney or liver problems; if you are 65 years or older. Consult your doctor if you are pregnant or breastfeeding. Pymet 5mg/500mg Tablet should not be taken during the first six months of pregnancy.  Pymet 5mg/500mg Tablet may cause sleepiness and dizziness, so drive only if you are alert. Pymet 5mg/500mg Tablet is not recommended for children below 18 years as safety and effectiveness have not been established. Avoid consuming alcohol with Pymet 5mg/500mg Tablet as it could lead to increased sleepiness. Pymet 5mg/500mg Tablet contains paracetamol; do not take any other medicines containing paracetamol along with Pymet 5mg/500mg Tablet unless prescribed.

Drug-Drug Interactions: Pymet 5mg/500mg Tablet may interact with anti-Parkinson (levodopa), anti-depressants (mirtazapine, trazodone), antibiotic (chloramphenicol), blood thinner (warfarin), immunosuppressant (cyclosporine), anti-hypertensive (clonidine), pain killers (codeine, dihydrocodeine, dextropropoxyphene), anti-histamines (chlorphenamine, promethazine), cardiac glycoside (digoxin), anti-emetic (domperidone), bile acid sequestrants (cholestyramine), anti-cholinergic (mebeverine, hyoscine, oxybutynin, propiverine, tolterodine), antipsychotics, hypnotics, and anxiolytics.

Drug-Food Interactions: No interactions found/established.

Drug-Disease Interactions: Inform your doctor if you have a blockage or bleeding in your stomach, epilepsy/fits, phaeochromocytoma (tumour of the adrenal gland), uncontrollable movements, or severe kidney or liver problems.

• LEVODOPA
• MIRTAZAPINE
• TRAZODONE
• CHLORAMPHENICOL
• WARFARIN
• CYCLOSPORINE
• CLONIDINE
• CODEINE
• CHLORPHENIRAMINE
• PROMETHAZINE
• DIGOXIN
• DOMPERIDONE
• CHOLESTYRAMINE
• MEBEVERINE
• HYOSCYAMINE
• OXYBUTYNIN
• TOLTERODINE
• DIHYDROCODEINE
• DEXTROPROPOXYPHENE
• PROPIVERINE

• Maintain a healthy diet and exercise regularly as it helps in improving overall health and boosts self-esteem.
• Avoid bright lights, loud noise, and extreme temperatures.
• Perform meditation and yoga. This helps in relieving stress and provides relaxation.
• Follow a regular sleep pattern to improve the amount and quality of sleep you get.
• Massage your scalp to ease the pain.
• Lie down in a quiet, dark room.
• Place a cold cloth over your forehead or neck.
• Avoid smoking, alcohol, and caffeinated drinks. 
• Learn what triggers your migraine and try avoiding them.
• Stay hydrated. Drink plenty of fluids.
• Learn relaxation skills as they help in reducing stress.

• Metoclopramide in Pymet 5mg/500mg Tablet may decrease the gastric absorption of digoxin. Therefore, inform your doctor if you take digoxin.

Migraine: Migraine is a neurological condition which is characterised by an intense, debilitating headache. Hormonal changes, stress, lack or excess of sleep, bright lights, loud sounds, and certain foods and drinks can trigger migraine headaches. Warning symptoms precede migraine headache one or two days before the headache itself. The warning symptoms include food cravings, depression, fatigue, hyperactivity, irritability and neck stiffness. Symptoms of migraine include throbbing pain in one particular area with varying intensity, nausea, vomiting, numbness or tingling sensation, difficulty speaking, and sensitivity to sound and light.