Pylokit Kit is a combination medicine indicated for the eradication of Helicobacter pylori-associated with peptic ulcer disease. Helicobacter pylori weaken the protective lining of the stomach and intestine; this allows the acid to get through the sensitive lining beneath. Both the bacteria and acid irritate the mucosal lining leading to ulcers. Symptoms include burning sensation in the stomach, frequent burping, bloating, and abdominal pain.
 
Pylokit Kit contains Clarithromycin, Lansoprazole, and Tinidazole. Clarithromycin kills the bacteria by preventing the synthesis of necessary proteins required for vital bacterial functions. Lansoprazole works by blocking the action of an enzyme called gastric proton pump, which is responsible for acid production, thereby preventing acid-related ulcers. Tinidazole damages the DNA of bacteria, thereby kills them. Together, Pylokit Kit helps treat peptic ulcer disease.
 
You are advised to take Pylokit Kit for as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, you may experience certain common side-effects such as nausea, stomach pain, constipation, and diarrhoea. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.
 
Consult your doctor if you are pregnant or breastfeeding. Pylokit Kit may cause drowsiness, so drive only if you are alert. Pylokit Kit is not recommended for children. Avoid consuming alcohol whilst taking Pylokit Kit and for 3 days after discontinuation. On long-term treatment, Pylokit Kit may cause bone fractures, hypomagnesemia (low levels of magnesium), and low levels of vitamin B12. 

Pylokit Kit is a combination of three drugs, namely: Clarithromycin, Lansoprazole, and Tinidazole. Pylokit Kit is indicated for the eradication of Helicobacter pylori-associated peptic ulcer disease. Clarithromycin is an antibiotic that kills bacteria by preventing the synthesis of necessary proteins required for vital bacterial functions. Lansoprazole is a proton pump inhibitor that works by blocking the action of an enzyme called gastric proton pump, which is responsible for the production of acid, thereby prevents acid-related ulcers. Tinidazole is an antibiotic that damages the DNA of bacteria and infectious microorganisms, thereby kills them. Together, Pylokit Kit helps treat peptic ulcer disease.

• Diarrhoea
• Nausea
• Stomach pain
• Constipation

Do not take Pylokit Kit if you are allergic to any of its contents; if you are taking any proton pump inhibitors, nitroimidazole derivatives, erythromycin or macrolide antibiotics, or rilpivirine; if you have a history of heart problems such as QT prolongation or ventricular cardiac arrhythmia, or if you have both kidney and liver problems. Inform your doctor if you have low magnesium levels, liver or kidney problems. On long-term treatment, Pylokit Kit may cause bone fractures, hypomagnesemia (low levels of magnesium), and low levels of vitamin B12. Consult your doctor if you are pregnant or breastfeeding. Pylokit Kit may cause drowsiness, so drive only if you are alert. Pylokit Kit is not recommended for children. Avoid consuming alcohol whilst taking Pylokit Kit and for 3 days after discontinuation. 

Drug-Drug Interactions: Pylokit Kit may interact with anti-retroviral (rilpivirine, atazanavir), ergot alkaloid (ergotamine, dihydroergotamine), antacid (cisapride), neuroleptic (pimozide), anti-platelet (cilostazol), anti-gout (colchicine), statin (simvastatin, lovastatin).

Drug-Food Interactions: No interactions found/established.

Drug-Disease Interactions: Inform your doctor if you have QT prolongation or ventricular cardiac arrhythmia, kidney and liver problems.

• RILPIVIRINE
• ATAZANAVIR
• ERGOTAMINE
• DIHYDROERGOTAMINE
• CISAPRIDE
• PIMOZIDE
• CILOSTAZOL
• COLCHICINE
• SIMVASTATIN
• LOVASTATIN

• Eat smaller meals more often.
• Avoid smoking and alcohol consumption. Alcohol intake leads to increased production of stomach acid, thereby increasing acidity and heartburn.
• Maintain a healthy weight by regular exercising.
• Avoid lying down after eating to prevent acid reflux.
• Avoid tight-fitting clothes as it might increase the pressure on the abdomen leading to acid reflux.
• Practise relaxation techniques and avoid stress by doing yoga or meditation.
• Avoid foods such as high-fat food, spicy food, chocolates, citrus fruits, pineapple, tomato, onion, garlic, tea and soda. 
• Avoid sitting continuously, as it may trigger acidity. Take a break of 5 minutes every hour by doing brisk walking or stretching.

Helicobacter pylori infection: Helicobacter pylori is a type of bacteria that weakens the protective lining of the stomach and intestine; this allows the acid to get through the sensitive lining beneath. Both the bacteria and acid irritate the mucosal lining leading to ulcers. In most cases, people having peptic ulcers also have H.pylori in their stomachs. If the bacteria are killed, it is unlikely that the ulcer will come back. Symptoms include burning sensation in the stomach, frequent burping, bloating, nausea, and abdominal pain.